ライフサイエンスコーパス: triterpenoid

1 the X-ray crystal structure of a fluorinated triterpenoid.

2 train that no longer produced any polycyclic triterpenoids.

3 pation in the biosynthesis of fruit-specific triterpenoids.

4 sinosteroid phytohormones, and non-steroidal triterpenoids.

5 tive promise of targeting Nrf2 pathways with triterpenoids.

6 entive and chemotherapeutic potential of the triterpenoids.

7 iminate promoter activity in response to the triterpenoids.

8 or sustainable production of bioactive plant triterpenoids.

9 eading to the synthesis of highly oxygenated triterpenoids.

10 vity (IC(50) = 0.07 microM) in this group of triterpenoids.

11 ifications for the biosynthesis of bioactive triterpenoids.

12 programs toward the production of bioactive triterpenoids.

13 Pharmacologic activation of Nrf2 by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9 (11)-dien-

14 We show that the triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-

15 Additionally, two new baccharane-type triterpenoids, 17,24-epoxy-25-hydroxybaccharan-3-one (3)

16 The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic

17 Here we report that the synthetic triterpenoid 2-cyano-3,12 dioxooleana-1,9 dien-28-imidaz

18 The novel oleanane triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic aci

19 We examined the effects of CDDO (triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic aci

20 The oleanane triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic aci

21 The new synthetic oleanane triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic aci

22 the ethyl amide derivative of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oi

23 The semisynthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oi

24 The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oi

25 e found that administration of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-C28-m

26 The novel oleanane triterpenoid 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic a

27 The C-28 methyl ester of the oleane triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic ac

28 f apoptosis induction by the novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic ac

29 The synthetic oleanane triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic ac

30 The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic ac

31 f collagenase gene expression, the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic ac

32 The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-ac

33 Synthetic triterpenoids 2-cyano-3, 12-dioxooleana-1, 9-(11)-dien-2

34 on the basis of the structure of a synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-o

35 We report that a novel triterpenoid, 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic

36 ave studied the effects of two new synthetic triterpenoids, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic

37 The highest concentration of triterpenoids (3460.5 mug/g DM) was determined in pear p

38 nolic acids, 9 flavonols, 7 flavan-3-ols), 3 triterpenoids, 7 carotenoids, 5 chlorophylls and 4 tocop

39 This triterpenoid accumulation caused a significant reduction

40 creating the immense structural diversity of triterpenoids across the plant kingdom.

41 We have synthesized more than 80 novel triterpenoids, all derivatives of oleanolic and ursolic

42 The 8,14-seco-triterpenoid alpha-onocerin is only known from the evolu

43 resulted in the identification of the lupane triterpenoid alphitolic acid as the main antibiofilm met

44 The triterpenoids also reduce the formation of reactive oxyg

45 Synthetic triterpenoid analogues of oleanolic acid are potent indu

46 ng cyclization to produce unique 6/4/8-fused triterpenoid analogues.

47 In addition, the synthetic triterpenoid and peroxisome proliferator-activated recep

48 Sugar, organic acid, triterpenoid and phenolic composition as well as antioxi

49 ichments of (13)C2-isotopologues in both the triterpenoid and the hydroxystearate moieties of 1.

50 The combination of triterpenoids and monoclonal anti-TRAIL receptor-1 (DR4)

51 t enhancement of Smad signaling by synthetic triterpenoids and should further their optimal use for a

52 reversible nature of the interaction between triterpenoids and thiols has hindered attempts to identi

53 uction of two classes of defenses, saponins (triterpenoids) and flavans (phenolics), in Pentaclethra

54 Cyclic triterpenoids are a broad class of polycyclic lipids pro

55 Synthetic triterpenoids are a class of small molecules that suppre

56 Triterpenoids are a class of small molecules with potent

57 We further provide evidence that triterpenoids are accumulated to high levels in cells th

58 ivity relationships of these novel synthetic triterpenoids are also discussed.

59 Cyclic triterpenoids are also geobiologically significant as th

60 8,14-seco-Triterpenoids are characterized by their unusual open C-

61 Synthetic triterpenoids are multitarget compounds exhibiting promi

62 Triterpenoids are widespread bioactive plant defence com

63 , but new and more potent ligands, including triterpenoids, are being investigated as therapeutic age

64 and informing the continuing development of triterpenoids as novel drug candidates.

65 mly synthesized about 60 oleanane and ursane triterpenoids as potential anti-inflammatory and cancer

66 It may be possible to develop triterpenoids as useful agents for chemoprevention of ca

67 Oats (Avena spp) synthesize antimicrobial triterpenoids (avenacins) that provide protection agains

68 report that Nrf2 activation by the synthetic triterpenoids, bardoxolone methyl (BARD) and 2-cyano-3,1

69 lpropanoid biosynthesis, sesquiterpenoid and triterpenoid biosynthesis for protective cuticle and wax

70 ots the CYP716s evolved specifically towards triterpenoid biosynthesis.

71 ransformation leading to the tissue-specific triterpenoid biosynthesis.

72 cyclization of 2,3-oxidosqualene for varied triterpenoid biosynthesis.

73 t a model of the subcellular organization of triterpenoid biosynthesis.

74 red these phenotypes and further showed that triterpenoid biosynthetic and glucosinolate catabolic ge

75 tes squalene, consistent with a block in the triterpenoid biosynthetic pathway.

76 ersity-oriented strategy, whereby the parent triterpenoids bryonolic acid and lanosterol are converte

77 n pathways and demonstrate this approach for triterpenoids by functionally characterizing three cytoc

78 ray of biologically active steroidal lactone triterpenoids called withanolides.

79 The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28

80 qual or greater potency than the pentacyclic triterpenoid CDDO in inflammation and carcinogenesis rel

81 It has been shown that the novel synthetic triterpenoid CDDO inhibits proliferation and induces dif

82 These data suggest that the synthetic triterpenoid CDDO should be further explored as a possib

83 Exposure of DCs to the new class of triterpenoid CDDO-DFPA (RTA-408) results in the inductio

84 We conclude that the triterpenoid CDDO-Me has potent anti-diabetic action in

85 The selected oleanane triterpenoid, CDDO (26), was found to be a potent, multi

86 We have identified the triterpenoid Celastrol as a potent low-molecular-weight

87 After pretreatment with single triterpenoids, cells were stimulated with pro-inflammato

88 g body for converting lanostane to ergostane triterpenoids, coenzymes Q (COQ) for antroquinonol biosy

89 s study, the antiproliferative effect of the triterpenoid compound cucurbitacin B was tested in vitro

90 n be terminated by glycyrrhizic acid (GA), a triterpenoid compound earlier shown to inhibit the lytic

91 Avicins comprise a class of triterpenoid compounds that exhibit tumor inhibitory act

92 Triterpenoids comprise a very diverse family of polycycl

93 Therefore, triterpenoids constitute an attractive target for medici

94 their feeding dependence on the tetracyclic triterpenoid cucurbitacins.

95 e convergent construction of the tetracyclic triterpenoids cucurbitacins B and D are described.

96 mically characterized a novel, semisynthetic triterpenoid derivative, 3-cinnamoyl-11-keto-beta-boswel

97 The triterpenoid derivatives were identified as 34-carboxyl-

98 tes introgression line population, we mapped triterpenoid differences to a genomic region that includ

99 tor antagonist RU-486, indicating that these triterpenoids do not act through the glucocorticoid rece

100 rationale for pharmaceutical development of triterpenoid dual-function proteosome/NF-kappaB inhibito

101 le structure is more potent than pentacyclic triterpenoids (e.g., CDDO and bardoxolone methyl) and tr

102 nt and the biosynthesis of sesquiterpenoids, triterpenoids, ergostanes, antroquinonol, and antrocamph

103 and dinitrile derivatives are novel oleanane triterpenoids exhibiting promise as both therapeutic and

104 ting the potential of small molecules of the triterpenoid family as effective agents for the chemopre

105 ality, and mass: ursolic acid (a pentacyclic triterpenoid found in apples) and tomatidine (a steroida

106 e effect of ursolic acid (UA), a pentacyclic triterpenoid found in rosemary and holy basil, on apopto

107 ous ursanic, oleanic and lupanic pentacyclic triterpenoids found in apple peel were studied for anti-

108 t the identification of escin, a pentacyclic triterpenoid from horse chestnut that exhibits antitumor

109 omics and elucidation of the biosynthesis of triterpenoid from this important tree.

110 Two new triterpenoids, garcinielliptones Q (1) and S (3), and a

111 y here the biosynthetic pathway of the sweet triterpenoid glycoside mogroside V, which has a sweeteni

112 synthetic analog of the naturally occurring triterpenoid glycyrrhetinic acid, which contains a 2-cya

113 Oleanolic acid (OA), a pentacyclic triterpenoid, has been shown to modulate multiple signal

114 These triterpenoids have been tested for their ability to supp

115 A novel triterpenoid, holophyllane A (1), featuring a B-nor-3,4-

116 water loss with and without added cuticular triterpenoids in Arabidopsis leaf waxes.

117 target of the immune modulating activity of triterpenoids in the context of EAE.

118 ations of flavonoids, spatholosineside A and triterpenoids in the oven-dried samples compared with th

119 ts tissue-specific accumulation of the major triterpenoids in this important tree.

120 Notably, cytotoxic triterpenoids including pristimerin inhibit NF-kappaB ac

121 We have identified synthetic triterpenoids, including 2-cyano-3,12-dioxooleana-1,9-di

122 Finally, these triterpenoids induce expression of the transcriptional c

123 Herein we show that these triterpenoids induce normal and malignant B-lymphoid cel

124 Moreover, triterpenoid-induced cell death was abolished by caspase

125 (a) suggest a novel mechanism of action for triterpenoid-induced cell death; (b) are among the first

126 of the 6-6-6-5 tetracyclic lanosterol (a key triterpenoid intermediate in the biosynthesis of cholest

127 s, which makes the biosynthesis of this seco-triterpenoid intriguing from an evolutionary standpoint.

128 emonstrate that Nrf2 activation by synthetic triterpenoids is a promising candidate target to protect

129 9-dien-28-oic acid (CDDO), a novel synthetic triterpenoid, is a ligand for PPARgamma.

130 Here, we show that nimbolide, a triterpenoid isolated from Azadirachta indica, enhanced

131 Acetyl-keto-beta-boswellic acid (AKBA), a triterpenoid isolated from Boswellia carterri Birdw and

132 n varied in the occurrence of wax esters and triterpenoid isomers.

133 cluding a cyclization reaction, leading to a triterpenoid lactone.

134 The subtle differences between parent triterpenoids led to dramatically different spatial arra

135 nols content, two relevant secoiridoids, and triterpenoids levels increased with rotor speed.

136 Tetrahymanol is a polycyclic triterpenoid lipid first discovered in the ciliate Tetra

137 Celastrol (Cel), a triterpenoid MAE isolated from Tripterygium wilfordii, e

138 erved that Bcl-X(L) overexpression inhibited triterpenoid-mediated killing of prostate cancer cell li

139 hway (via mitochondria) also participates in triterpenoid-mediated killing.

140 The synthetic triterpenoid methyl-2-cyano-3,12-dioxoolean-1,9-dien-28-

141 Structurally related pentacyclic triterpenoids methyl 2-cyano-3,12-dioxoolean-1,9-dien-28

142 The interactions of triterpenoid monodesmosidic saponins, alpha-hederin and

143 ynthetic precursor to a variety of oxacyclic triterpenoid natural products, has been efficiently synt

144 are functional targets of the electrophilic triterpenoid nucleus of CDDO and its derivatives.

145 strating that this effect is mediated by the triterpenoid nucleus of these agents.

146 commonly known as Neem, is the reservoir of triterpenoids of economic importance.

147 nthesis of many isomeric naturally occurring triterpenoids of formula C 30H 50O.

148 ve plant natural products, are glycosides of triterpenoid or steroidal aglycones (sapogenins).

149 ed yeasts and report ten hitherto unreported triterpenoid oxidation activities, including a cyclizati

150 However, for many triterpenoid oxidation reactions, the corresponding enzy

151 s formononetin and medicarpin but not by two triterpenoids present in alfalfa.

152 The present study confirms that triterpenoids present in apple peel and beta-damascone m

153 er steroid-like molecules, such as the plant triterpenoids pristimerin and lupeol, affect sperm ferti

154 The top-ranked compound was a natural triterpenoid, pristimerin.

155 d in border cells, while many flavonoid- and triterpenoid-related metabolite and transcript levels we

156 Triterpenoids represent a class of naturally occurring a

157 activation of the human HO-1 promoter by the triterpenoids requires an antioxidant response element (

158 In addition, several triterpenoid saponin glycosides accumulated in M. trunca

159 Avicin D, a natural triterpenoid saponin, inhibits cell growth and induces a

160 isolation and partial purification of novel triterpenoid saponins [Fraction 35 (F035)] and two pure

161 The triterpenoid saponins also partially inhibited phosphati

162 We demonstrate that the mixture of triterpenoid saponins and avicins induce apoptosis in th

163 Triterpenoid saponins are bioactive metabolites that hav

164 o control the production of anti-nutritional triterpenoid saponins found in quinoa seeds, including a

165 bition of nuclear factor kappaB suggest that triterpenoid saponins from A. victoriae have potential a

166 Avicins, a family of triterpenoid saponins from Acacia victoriae, can regulat

167 e tested the ability of avicins, a family of triterpenoid saponins obtained from Acacia victoriae (Be

168 growth inhibitory properties of a mixture of triterpenoid saponins obtained from an Australian desert

169 orted the extraction of avicins, a family of triterpenoid saponins obtained from the Australian deser

170 Triterpenoid saponins, which are present in leguminous p

171 findings suggest CDDO and related synthetic triterpenoids should be further evaluated as potential n

172 enoids, diterpenoids, quassinoids, steroids, triterpenoids, simple and complex phenolics, and several

173 ith high percentages of alicyclic compounds (triterpenoids, steroids, or tocopherols) largely restric

174 ential of CYP716s as a source for generating triterpenoid structural diversity and expand the toolbox

175 olic acid, a naturally occurring pentacyclic triterpenoid, successfully inhibited binding of Abeta to

176 Semisynthetic triterpenoids such as bardoxolone methyl (methyl-2-cyano

177 main active ingredients are diterpenoids and triterpenoids, such as triptolide and celastrol, respect

178 by electrophoretic mobility shift assay, the triterpenoid suppressed nuclear factor-kappaB (NF-kappaB

179 Next, we ectopically expressed the triterpenoid synthase gene AtLUP4 (for lupeol synthase4

180 To predict functions and specificity of triterpenoid synthases, a mechanism-based, multi-interme

181 nthesis of mogroside V: squalene epoxidases, triterpenoid synthases, epoxide hydrolases, cytochrome P

182 lanosterol synthases and distinct from plant triterpenoid synthases.

183 t provides valuable mechanistic insight into triterpenoid synthesis and reveals diagnostic amino acid

184 t the C-3 position are a subset of bacterial triterpenoids that are readily preserved in modern and a

185 Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits su

186 Sedimentary hopanes are pentacyclic triterpenoids that serve as biomarker proxies for bacter

187 We report the first use of new synthetic triterpenoids to prevent lung cancer in experimental ani

188 ing indicated a differential localization of triterpenoids to the periderm and sesquiterpene alkaloid

189 was to determine whether derivatives of the triterpenoid (TP) 2-cyano-3,12-dioxooleana-1,9-dien-28-o

190 A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerf

191 ession of death receptor (DR)4 and DR5 after triterpenoid treatment.

192 Induction of the death receptor by the triterpenoid was found to be p53-independent but require

193 In addition to tannin, triterpenoids were also identified and can be quantified

194 OA is an attractive, dietary nontoxic plant triterpenoid, which suppresses the production of proinfl

195 the precursor of all known angiosperm cyclic triterpenoids, which include membrane sterols, brassinos

196 Isoarborinol is one such triterpenoid whose only known biological sources are cer

197 Consequently, a new lanostane triterpenoid with a cyano-enone functionality in ring A

198 ture of B-15, 19 novel olean- and urs-12-ene triterpenoids with a 1-en-3-one functionality having a s

199 (OA) and maslinic (MA) acids are two natural triterpenoids with a wide range of beneficial effects fo

200 of iNOS and COX-2 expression) of a series of triterpenoids with Michael reaction centers were closely

201 synthesized 16 new olean- and urs-1-en-3-one triterpenoids with various modified rings C as potential

202 Oleanolic acid (OA) is a ubiquitous triterpenoid, with potent antioxidant and anti-inflammat

203 The major compounds are triterpenoids, with a relative concentration of 74.0%; s