ライフサイエンスコーパス: tritium

1 vity 50 microCi/micromol for the transferred tritium).

2 choline and measuring 5-HT-evoked release of tritium.

3 ikely origin, location, and phases that trap tritium.

4 clear fusion reactions between deuterium and tritium.

5 f Nav1.7 blockers has been radiolabeled with tritium.

6 oncentrations of other radionuclides such as tritium, (14)C, or (85)Kr will become blurred in the sig

7 ic composition (delta(13)C-CH4), groundwater tritium ((3)H) and dissolved organic carbon (DOC) concen

8 Tritium ((3)H) is produced in nuclear reactors via sever

9 e relative ease and low cost associated with tritium ((3)H) make it an ideal radioisotope with which

10 f glyceroneogenesis was quantified using the tritium ([(3)H(2)]O) labeling of body water, and the con

11 accurately and reproducibly for analysis of tritium (3H) content by accelerator mass spectrometry (A

12 nt assay and amino acid transport assayed by tritium (3H)-labeled amino acid uptake.

13 hich the terminal hydroxyl was replaced with tritium ([3H]-sT-CoA).

14 ellular membrane fractions revealed that the tritium accumulation observed in the caveolin-rich membr

15 iments with normal acetone did not result in tritium activity or neutron emissions.

16 soralen exhibited a 4- to 7-fold increase in tritium activity relative to untreated controls.

17 A tritium-adenine suicide procedure was used to select for

18 t and then coupled to either methotrexate or tritium and either fluorescein or 6-carboxytetramethylrh

19 atural recharge successfully predicted plume tritium and nitrate concentrations.

20 mixing model was developed to predict plume tritium and nitrate concentrations.

21 exane (trans-NPCO-DSC) was radiolabeled with tritium, and its binding characteristics to K(v)1.3 chan

22 Radioactivity from radioiodine, tritium, and uranium is not expected to create a signifi

23 Controlled amounts of liquid tritium are discharged as tritiated water (HTO) by the n

24 ly adaptable for the facile incorporation of tritium at C-4 of the diphosphate.

25 potency, a suitable photoreactive group, and tritium at high specific activity.

26 L-Proline labeled with deuterium or tritium at the diastereotopic C-5 methylene loci was sho

27 ange or selective retention of deuterium (or tritium) at the level of the triose-isomerase reaction o

28 holoenzyme bound approximately 2-3 atoms of tritium/atom of C-14.

29 DT fusion, neutrino mass measurements using tritium beta-decay or photonuclear experiments where HD

30 The kinetics of the turnover of tritium between seawater HTO, biota HTO, and OBT was inv

31 been used to investigate the partitioning of tritium between substrate and product in the reaction ca

32 2-ketoglutarate undergoes rapid exchange of tritium between the 5'-position of the coenzyme and C-4

33 whole-organism OBT is a slow process with a tritium biological half-life on the order of months.

34 The weakly bound form of tritium can be liberated at significantly lower temperat

35 Without an appreciation that two forms of tritium can exist in reactor bioshields, the (3)H conten

36 In irradiated metals, an additional type of tritium can form internally through neutron capture reac

37 ing a backbone hydrogen atom in glucose with tritium can significantly increase or decrease the equil

38 Despite the improved tritium chemical shift dispersion, this method is not us

39 Tritium concentrations measured in seawater HTO, as well

40 s allows the prediction of selectivities for tritium-containing isotopologues.

41 e in the steady state leads to protein-bound tritium corresponding to 11% of the active sites.

42 itation experiments with deuterated acetone, tritium decay activity above background levels was detec

43 ssed annually for heavy-water production and tritium decontamination.

44 Labeled tritium dilution and total-body potassium were used to e

45 of thigh sections, total body potassium, and tritium dilution techniques were used to measure increas

46 owledged that the radiological impact of the tritium discharges into the Estuary was small, public co

47 ger (DPI) was used with a portable deuterium-tritium (DT) neutron generator to detect neutrons and ga

48 An observed tritium effect upon V/K for reduction of dihydrofolate a

49 esaturase and the development of an in vitro tritium efficacy radioassay.

50 This externally derived tritium enters metals by diffusion with a rate controlle

51 The pattern of tritium evolution derived from simple thermal desorption

52 in using photoaffinity labeling and hydrogen-tritium exchange (HX).

53 ins, BSA and myoglobin (MGB), using hydrogen-tritium exchange and light scattering.

54 Tritium exchange from solvent into pyruvate is catalyzed

55 ircular dichroism spectroscopy, and hydrogen-tritium exchange measurements to study the effect of the

56 th those determined by (1)H NMR and hydrogen-tritium exchange methods.

57 ethylADP is a very effective promoter of the tritium exchange reaction between [5'-3H2]adenosylcobala

58 We measured the tritium exchange reaction on cytosine C(5) in the presen

59 arlier highly accurate but much more limited tritium exchange results, extend the analysis to the ent

60 lie anesthetic actions, analysis of hydrogen/tritium exchange was used to measure effects on the stab

61 By tritium exchange, Tbeta(4) slows the exchange rate of ap

62 the "classical" mechanism, 98% of the pro-R tritium exchanges with solvent from Glu-165 at the inter

63 mately depends on the metal composition, its tritium exposure history, integrated neutron flux, sampl

64 tions are suitable for compressing deuterium-tritium-filled capsules, with the goal of achieving burn

65 linking experiments analyzed by SDS-PAGE and tritium fluorography have identified a approximately 160

66 g step may be altered by the substitution of tritium for hydrogen in the reaction.

67 Methods for tagging bile acids with tritium for metabolic or transport studies are summarize

68 0-900 degrees C is indicative of neutrogenic tritium formed via neutron capture by trace Li and B.

69 ere analyzed following addition of 2 mg of a tritium-free-hydrogen carrier.

70 adicals is rapid relative to the transfer of tritium from 5'-deoxyadenosine to either substrate or pr

71 determined for the ALAS-catalyzed removal of tritium from [2-(3)H(2)]glycine.

72 ereas the wild-type enzyme catalyzes loss of tritium from [2-3H2]-glycine, mutation of K313 to glycin

73 leotide reduction, catalyzes the exchange of tritium from [5'-3H]-AdoCbl with solvent.

74 tritium isotope effects for the transfer of tritium from adenosylcobalamin to product in each direct

75 TIM reaction, approximately 2% of the pro-R tritium from C1 of DHAP is conserved and appears at C2 o

76 duction of pure deuterium and the removal of tritium from nuclear waste are the key challenges in sep

77 t the center that contains the deuterium and tritium fuel.

78 apping' required to accelerate the deuterium-tritium fusion burn to eventually 'run away' and ignite.

79 mount of energy deposited into the deuterium-tritium fusion fuel and hotspot during the implosion pro

80 euticals by hydrogen isotope exchange, using tritium gas as the source of the radioisotope.

81 ction frequency was 2.6% in groundwater with tritium >/=1 pCi/L, depth <30 m, and anoxic conditions.

82 l and copper), it was found that significant tritium had become incorporated following prolonged expo

83 ntium isotope ratios, along with groundwater tritium-helium and radiogenic (4)He in-growth age-dating

84 e river was 1.3 +/- 0.8 years, determined by tritium-helium dating.

85 d exposure to tritiated water vapor (HTO) or tritium/hydrogen gas (HT) in nuclear facilities.

86 ent in yield performance over past deuterium-tritium implosion experiments.

87 d to the high incorporation of deuterium and tritium in 18 drug molecules, which meet the requirement

88 e four soman diastereomers, all labeled with tritium in Calpha.

89 ipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue.

90 derstanding the association and retention of tritium in metals has significance in nuclear decommissi

91 gh levels of FAAH, showed an accumulation of tritium in the caveolin-rich membrane fraction only when

92 etabolism blocked the observed enrichment of tritium in the caveolin-rich membranes.

93 y RBL-2H3 cells, we found an accumulation of tritium in the caveolin-rich membranes.

94 ) gas leads to incorporation of deuterium or tritium in the dihydrogen ligand.

95 used to determine the depth distribution of tritium in the tracheal mucosa.

96 ified prebeta-1 HDL, labeled covalently with tritium, in plasma samples, to label the prebeta-1 HDL p

97 Tritium, incorporated into the proteins, was quantitated

98 In contrast, tritium incorporation experiments with purified carboxyl

99 hiol groups of Keap1 have been determined by tritium incorporation from [(3)H]dexamethasone mesylate

100 an accommodate the classical measurements of tritium incorporation from DHAP into GAP.

101 Introduction of 1 mole-atom of tritium into aldehyde 5b was required during radioligand

102 Using phospholipase D, we incorporated tritium into each analogue.

103 inhibition of catalysis and incorporation of tritium into the enzyme.

104 onsists of a compact 44 mm drift tube with a tritium ionization source and a resolving power of 70.

105 fusion reactor a hot plasma of deuterium and tritium is confined by a strong magnetic field to produc

106 The tritium is normally trapped in hydrated oxides lying alo

107 This intramolecular transfer of tritium is therefore predicted to be independent of DHAP

108 ch techniques to measure the alpha-secondary tritium isotope effect associated with the formation of

109 Specifically, the equilibrium tritium isotope effects are 1.027 +/- 0.002, 0.927 +/- 0

110 y measurements have been used to measure the tritium isotope effects for the transfer of tritium from

111 ve deuterium isotope effects and competitive tritium isotope effects leads to the conclusion that the

112 We have utilized tritium isotope effects to probe the in vitro binding eq

113 ch techniques to measure the alpha-secondary tritium kinetic and equilibrium isotope effects associat

114 te synthase is demonstrated by measuring the tritium kinetic isotope effect on the enzyme's second or

115 the substrate pair, inverse alpha-secondary tritium kinetic isotope effects are observed, and a Swai

116 The alpha-secondary tritium kinetic isotope effects are reduced to values ne

117 The alpha-secondary tritium kinetic isotope effects are slightly higher than

118 The calculated deuterium and tritium kinetic isotope effects for the overall rate agr

119 Alpha-secondary tritium kinetic isotope effects were measured with NAD+

120 sequencing of the labeled peptide, only the tritium label was in evidence at C221, with a stoichiome

121 -S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the for

122 Tritium labeled FK506 (FK) was used to identify and quan

123 assays to measure lymphocyte proliferation (tritium labeled thymidine incorporation and flow cytomet

124 n homogenates were measured in vitro against tritium-labeled 6 (Pittsburgh compound B).

125 Compound 6b was demonstrated to be >/=95% tritium-labeled at the imine position by NMR spectroscop

126 Using a tritium-labeled FA in batch experiments made it possible

127 omene-2-carboxylic acid (12) was obtained in tritium-labeled form, designated [(3)H]PSB-13253, with a

128 ymatic preparation of high-specific-activity tritium-labeled Fru-2,6-P(2).

129 charides, the solubilized fraction contained tritium-labeled high molecular weight material.

130 A tritium-labeled isotopomer (18.8 Ci/mmol) of this nonter

131 The tritium-labeled JNJ-63533054 bound to cell membranes exp

132 ion of ester 3 with custom synthesized, 100% tritium-labeled lithium triethylborotritide, followed by

133 Incubation of tritium-labeled lysosomes with phagosomes containing sci

134 ween the biodistribution determined by using tritium-labeled particles and that using optical imaging

135 oproteins gave rise to an approximate 10 kDa tritium-labeled peptide, each of which was a distinct po

136 Deuterium- and tritium-labeled pharmaceutical compounds are pivotal dia

137 HEMA-co-SS) was established in rodents using tritium-labeled polymer.

138 n was performed on paraffin sections using a tritium-labeled probe for cathepsin G or alpha 1-PI.

139 e obtained by countercurrent distribution of tritium-labeled products and their identification by sci

140 human dermal fibroblasts were incubated with tritium-labeled psoralen without TFO to maximize detecta

141 iodistribution and tumor accumulation of the tritium-labeled PTX nanocrystals were determined immedia

142 Tritium-labeled PTX nanocrystals were further produced w

143 formerly called PAI-2), was studied by using tritium-labeled signals.

144 ntent, were specifically photolabeled with a tritium-labeled Taxol analog, 2-(m-azidobenzoyl)taxol, a

145 ation (>10-fold) of the dissociation rate of tritium-labeled THRX-160209 from M2 receptors by competi

146 For synthesis of the tritium-labeled version of this trifluoromethyldiaziriny

147 Tritium-labelled PAI ([3H]PAI) was synthesized and used

148 Any weakly bound tritium liberated at temperatures of ~100 degrees C is i

149 Any strongly bound tritium liberated over the range of 600-900 degrees C is

150 tion frequency was 13.0% in groundwater with tritium <1 pCi/L, specific conductance >1600 muS/cm, and

151 0 x 10(-15), which is equivalent to 0.02 dpm tritium/mg of material.

152 ditosylamide can be used in conjunction with tritium NMR spectroscopy to assign the configuration of

153 Despite the rapid absorption of most of the tritium, NNK was nonetheless extensively metabolized in

154 n is a quark-level analogue of the deuterium-tritium nuclear fusion reaction (DT --> (4)He n).

155 cal shift difference of these diastereotopic tritium nuclei are found to be in agreement with predict

156 between 3H and H is small, organically bound tritium (OBT) and HTO should show the same T/H ratio und

157 enic tritium (specifically organically bound tritium, OBT).

158 achidonic acids labeled with a single chiral tritium on the methylene groups at carbons 10 or 13.

159 Xenopus IRBP antisense RNA, labeled with tritium or digoxigenin, was used for in situ hybridizato

160 involved reduction of the diiodofiprole with tritium, Pd/C, and triethylamine in ethyl acetate and af

161 n CO(2), and a proportional increase in both tritium release and Gla formation occurred over a range

162 However, both HPLC analysis and a tritium release assay indicated that these mutants had n

163 traditionally and most reliably assessed by tritium release end-point assays using radiolabeled coll

164 Glu deprotonation monitored by tritium release from the glutamyl gamma-carbon was depen

165 H160A showed a 10-fold lower ratio of tritium release to vitamin K epoxidation than wild-type

166 astolytic activity as assessed by a standard tritium-release assay, but, importantly, prevented the p

167 , 2, or 3 represents hydrogen, deuterium, or tritium, respectively.

168 Even higher efficiency is expected for tritium separation.

169 cinate isomers based on loss or retention of tritium showed that inversion of configuration at the me

170 Wild-type and nonglycosylated V2R yielded tritium signals at 45-55 and 40 kDa, respectively, demon

171 Tritium speciation in metals was inferred through increm

172 ic input to the estuary has been technogenic tritium (specifically organically bound tritium, OBT).

173 In this study, we have used tritium substitution and high pH to probe the glucose le

174 By chemical mutagenesis followed by a tritium suicide procedure, we obtained three conditional

175 Using tritium suicide, we have isolated a variant of the Chine

176 ly and selectively install deuterium (D) and tritium (T) at alpha-amino sp(3) carbon-hydrogen bonds i

177 of hydrogen (hydrogen -H, deuterium -D, and tritium -T).

178 at C221, with a stoichiometry of 2 atoms of tritium/tetrameric holoenzyme.

179 Earlier tritium tracer experiments have implicated the 5'-deoxya

180 This process accounts for the results of tritium tracer experiments, it explains the radical rear

181 At 50% conversion to GAP, triphasic tritium transfer behavior was found.

182 The extent of intermolecular tritium transfer in the criss-cross mechanism would be p

183 n 0.03 and 0.3 mM DHAP, a constant extent of tritium transfer of 1.19 +/- 0.03% occurred.

184 The extent of tritium transfer was studied as a function of initial DH

185 s well as in biota HTO and OBT, confirm that tritium transfers from HTO to OBT result in conservation

186 deling is thus more realistic for predicting tritium transfers to biota OBT under nonsteady-state con

187 However, the overall tritium turnover between HTO and the whole-organism OBT

188 Liberating this kind of tritium typically requires temperatures above 800 degree

189 required for efficient thermal desorption of tritium ultimately depends on the metal composition, its

190 ion doses from external sources and internal tritium uptakes were derived from dosimetry records thro

191 n of Ser-180 was tritiated, was photocleaved tritium was released from the protein suggesting that cl

192 and wild-type YPK, only background levels of tritium were trapped with K240M.

193 icient is greater for the incorporation of 2-tritium (which occurs exclusively by the direct pathway)

194 The strongly bound tritium, which originates from neutron capture on trace

195 e, nascent transcripts became saturated with tritium with similar kinetics (t1/2 approximately 14 min