ライフサイエンスコーパス: trityl

1 "FBr" gives 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole (15).

2 ivity to produce 4-(2-bromo-1-fluoroethyl)-1-trityl-1H-imidazole (8).

3 fluorenyl (1(C)), diphenylmethyl (2(C)), and trityl (3(C)) lithium was studied computationally.

4 We demonstrate that "FBr" addition to 1-trityl-4-vinyl-1H-imidazole (7) provides a convenient ro

5 the di-triethylammonium salt of 5[prime]-O -trityl-6-N-pivaloyladenosine-2[prime]-(H -phosphonate)-3

6 These phosphoramidites contained trityl (A, G, C, and U), dimethoxytrityl (A and G), or t

7 rotection of the side chain thiol group with trityl alcohol and alpha-amine function with Fmoc-OSu fu

8 th trityl chloride and triethylamine or with trityl alcohol and catalytic trifluoroacetic acid, and a

9 s 15 steps starting from D-proline-derived N-trityl aldehyde 11 and proceeds in approximately 9% over

10 nished fully protected (S)- and (R)-N-Fmoc-S-trityl-alpha-methylcysteine in overall 20% yield.

11 the same overall binding configuration as S-trityl analogues at an allosteric site formed by loop L5

12 cally improves on potency: the most potent C-trityl analogues exhibit K(i)(app) </= 10 nM and GI(50)

13 vely strong exchange interaction between the trityl and nitroxide moieties determines the magnetic fi

14 A series of trityl-based photolabile hydroxyl protecting groups have

15 a wider application of the growing number of trityl-based reactions in organic syntheses.

16 ion from Cp*2Zr(CH3)OCH2CH2N(i)Pr2 (13) with trityl cation generates [Cp*2Zr(OCH2CH2N(i)Pr2)](+) (14)

17 her by a new water-assisted tritylation with trityl chloride and triethylamine or with trityl alcohol

18 d C-terminal cysteine esters are anchored to trityl chloride resin and extended by standard solid-pha

19 a matter of minutes by treating resin-bound trityl chloride with triethyloxonium tetrafluoroborate f

20 6-diaminopurine and then converted to the N9-trityl derivative to increase solubility.

21 Various esterified trityl derivatives were synthesized and characterized, a

22 otection of the gamma-cyano alcohol 6 as the trityl ether by a new water-assisted tritylation with tr

23 The ester-derivatized trityls exhibited higher sensitivity to O2 concentration

24 ry was synthesized using a polymer-supported trityl group at the 5'-position.

25 Reductive cleavage of the N-trityl group in 34 allows access to tetracyclic aziridin

26 itrogen is supported by the finding that the trityl group in the 2-position of the pyrrolidine increa

27 is protected as the DPC derivative, and the trityl group is removed.

28 yields are obtained by employing a temporary trityl group protection strategy.

29 on with azide, reduction, and removal of the trityl group provide beta-fluorohistamine (1) as the dih

30 negative hyperconjugative interaction of the trityl group with the lone pair of the enamine nitrogen

31 g as a rotator and two m-methoxy-substituted trityl groups acting as a stator.

32 lar substituents, or compass needle, and two trityl groups axially connected by acetylene linkages to

33 a gyroscope wheel, while the alkyne bond and trityl groups can act as an axle and shielding framework

34 In the case of peroxide 2, the bulky trityl groups may be viewed as the external static rotor

35 nkshaft rotation rather than slippage of the trityl groups was obtained from molecular mechanics calc

36 es in nonpolar solvents were modified with S-trityl groups, allowing the reversible formation of disu

37 ile N-TBDPS hemiaminal and the more stable N-trityl hemiaminal resemble the mitomycin K substitution

38 he process involves the reaction of a ketone trityl hydrazone with tBuOCl to give a diazene which rea

39 elding Lewis acid promoted deprotection of O-trityl hydroxylamine derivatives is described.

40 For example, S-trityl-l-cysteine (STC) and monastrol are HsEg5 inhibito

41 We previously identified S-trityl-l-cysteine (STLC) and related analogues as select

42 We previously identified S-trityl-L-cysteine (STLC) as a potent allosteric inhibito

43 e altered by deletion of L5 or addition of S-trityl-l-cysteine (STLC), an allosteric inhibitor that b

44 s incubated with the kinesin Eg5 inhibitor S-Trityl-l-cysteine (STLC).

45 Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and de

46 sequences (Diels-Alder, [1,3]-H shift, [1,3]-trityl migration and Diels-Alder, [1,3]-H shift, [1,3]-t

47 ration and Diels-Alder, [1,3]-H shift, [1,3]-trityl migration, Michael reaction) leading to architect

48 een shown to undergo sterically driven N-->N trityl migrations, in disagreement with previously publi

49 ge an increase of the positive charge in the trityl moiety and of the spin density on the ArS group i

50 o)alkylamine, subsequent deprotection of the trityl moiety with TFA, and immediate treatment with aq.

51 etric exchange-coupled biradicals, e.g., the trityl-nitroxides (TNs), possess particular magnetic pro

52 for 'trityl on' and approximately 32 h for 'trityl off' methods, respectively.

53 -uridine residues is approximately 46 h for 'trityl on' and approximately 32 h for 'trityl off' metho

54 e highest enhancements were achieved using a trityl OX063 radical combined with a gadolinium relaxati

55 employ a recently developed multifunctional trityl paramagnetic probe and electron paramagnetic reso

56 and recently reported mono- and polymetallic trityl perfluoroarylhalometalates Ph3C+FB(C6F5)3- (9), P

57 le to acquire the entire EPR spectrum of the trityl probe and assess these microenvironmental paramet

58 Thus, the silyl or trityl protected aziridinomitosene reacted with Cs(2)CO(

59 he syntheses and reactivity of N-TBDPS and N-trityl protected derivatives of an aziridinomitosene cor

60 enzaldehydes or o-nitrobenzyl bromides and S-trityl-protected 1 degrees -aminothioalkanes are reporte

61 ent, via an aziridine, to give predominantly trityl-protected alpha-iodo-beta-alanines, and hence nor

62 N-Trityl-protected amino ketones can be reduced selectivel

63 les, a novel reductive amination utilizing a trityl-protected aminoimidazole was developed.

64 rated that the synthesis of lanthionine from trityl-protected beta-iodoalanines is prone to rearrange

65 Structure 25 is the N-trityl-protected derivative of the proposed intermediate

66 this reaction has been elucidated, using the trityl-protected derivative, to involve initial formatio

67 Modified Appel reactions at C6 of trityl-protected hypoxanthine and guanine derivatives fo

68 ture of diastereoisomers, and one utilized a trityl-protected iodoalanine, formed via a Mitsunobu rea

69 anaidal and suffrutine A from the respective trityl-protected omega-amino alkanoates.

70 Removal of the N-trityl protecting group could not be achieved without az

71 PPGs evolve from the traditional acid-labile trityl protecting group with proper electron-donating su

72 nthesis was accomplished by switching to the trityl protecting group.

73 2-iminato) titanium(III) methyl complex, the trityl radical ((*)CPh(3)), the anionic MeB(C(6)F(5))(4)

74 The discovery in 1900 by Gomberg that the trityl radical (Ph(3)C(.)) exists at room temperature is

75 a-scission step that released the persistent trityl radical and a 3-nitrosoindolin-2-one derivative.

76 MTriPols, in which a nitroxide (TEMPO) and a trityl radical are chemically tethered.

77 n that the recently synthesized phosphonated trityl radical possesses long relaxation times that are

78 ubstitution on the aromatic ring affects the trityl radical's stability (tricarboxylate salt 1-CO(2)(

79 udying direct DNP of (13)C using SA-BDPA and trityl radical, and achieve (13)C enhancements above 600

80 s of a deuterated derivative of phosphonated trityl radical, pTAM.

81 theses of the tetraoxygenated triarylmethyl (trityl) radical 14 and the tetrathiatriarylmethyl (trity

82 ntermediate (presumably a cobalt hydride) by trityl radicals (Ar(3)C*) or by TEMPO.

83 To enhance the capability of trityl radicals as oxygen sensors, encapsulation into oi

84 monstrates that cellular permeability of the trityl radicals can be achieved by varying the type and

85 Therefore, ester-derivatized trityl radicals show great potential as intracellular EP

86 ried out to assess the susceptibility of the trityl radicals to oxidation and reduction.

87 d aid in the future design of more biostable trityl radicals.

88 ) radical 14 and the tetrathiatriarylmethyl (trityl) radicals 15 and 16.

89 addition to various TAM-type triarylmethyl (trityl) radicals were theoretically investigated.

90 atriarylmethyl and tetrachlorotriarylmethyl (trityl) radicals.

91 xyethyl GlcN derivative was immobilized on a trityl resin support and subjected to regioselective dep

92 anilines onto a polystyrene triphenylmethyl (trityl) resin.

93 A novel cysteine derivative, N(alpha)-trityl-S-(9H-xanthen-9-yl)-l-cysteine [Trt-Cys(Xan)-OH]

94 chemistry effected by NO(g) with the use of trityl-S-nitrosothiol (Ph3CSNO) as the nitric oxide sour

95 hase peptide synthetic methodology that uses trityl side-chain anchoring for the preparation of pepti

96 Among all of the ester-derivatized trityls studied, facile hydrolysis of the acetoxymethoxy

97 Carbazole and trityl substrates with two groups show saturating, incom

98 he use of the cocatalyst triphenylcarbenium (trityl) tetra(pentafluorophenyl)borate totally inhibits

99 2NiCl2, has been developed for tropylium and trityl tetrafluoroborate salts.

100 ived species by reacting trimethylsilane and trityl tetrakis(pentafluorophenyl)borate (Ph(3)C(+) TPFP

101 sitivity to O2 concentration compared to the trityl tricarboxylate CT-03.

102 behavior of two series of novel substrates: trityl (triphenylmethyl) and carbazole derivatives.

103 thiol (StBu), thiol-trimethoxyphenyl (STmp), trityl (Trt), 4-methoxytrityl (Mmt), S-acetamidomethyl (

104 radicals constitute a major advance over the trityl-type narrow-line polarization agents.