ライフサイエンスコーパス: trophectoderm

1 onic inner cell mass and the extra-embryonic trophectoderm.

2 g the development of endoderm, mesoderm, and trophectoderm.

3 to embryonic tissues but not extraembryonic trophectoderm.

4 educed potential that contribute more to the trophectoderm.

5 , that this lagging cell is the precursor of trophectoderm.

6 envelope protein production in the conceptus trophectoderm.

7 ressed only in the inner cell mass and polar trophectoderm.

8 the oocyte and embryo defines the lineage to trophectoderm.

9 ing the blastocyst cavity and its associated trophectoderm.

10 cleavage cycle tends to contribute to mural trophectoderm.

11 ration of extraembryonic ectoderm from polar trophectoderm.

12 ere also detected in binucleate cells of the trophectoderm.

13 ng and forming both an inner cell mass and a trophectoderm.

14 cysts, coincident with the appearance of the trophectoderm.

15 oss of pluripotency and dedifferentiation to trophectoderm.

16 he uterine luminal epithelium and blastocyst trophectoderm.

17 tropin (hCG) is first expressed in embryonic trophectoderm.

18 ocyst, producing the inner cell mass and the trophectoderm.

19 rimate embryos resulted in a failure to form trophectoderm.

20 e transporter SLC7A1 mRNA in ovine conceptus trophectoderm.

21 , mediating preferential localization to the trophectoderm.

22 ripotent inner cell mass and differentiating trophectoderm.

23 al adhesion by PKC can regulate migration of trophectoderm.

24 the inner cell mass, primitive endoderm and trophectoderm.

25 rise to cells of the inner cell mass and the trophectoderm.

26 uence development and differentiation of the trophectoderm.

27 surrounded by an extra-embryonic layer, the trophectoderm.

28 nd could potentially transduce the conceptus trophectoderm.

29 into viral particles and transmitted to the trophectoderm.

30 the determination of the inner cell mass and trophectoderm.

31 n of the pluripotent inner cell mass and the trophectoderm, a process regulated by cell polarity prot

32 ement that drives reporter expression in the trophectoderm, a subset of cells in the extraembryonic r

33 ts, MOEP19 localized in both mural and polar trophectoderm and a subset of embryos showed inner cell

34 pressed at high levels on the surface of the trophectoderm and anandamide (N-arachi-donoylethanolamin

35 ndular epithelia as well as in the conceptus trophectoderm and are essential for conceptus elongation

36 to remove Cited2 from overlapping subsets of trophectoderm and extra-embryonic mesoderm.

37 ncreased differentiation of cells toward the trophectoderm and hypoblast lineages compared with that

38 mRNAs for both isoforms were detected in trophectoderm and ICM cells.

39 Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs

40 the Grp78 promoter is activated in both the trophectoderm and inner cell mass (ICM) of embryos at em

41 without a protein source reduced blastocyst trophectoderm and inner cell mass cell number compared w

42 tocyst stage at day 7 and reduced numbers of trophectoderm and inner cell mass cells.

43 in growth arrest and cell death of both the trophectoderm and inner cell mass.

44 cRHOXF1 and which is abundantly expressed in trophectoderm and primitive endoderm cells of human blas

45 nce of the effects of parthenogenesis on the trophectoderm and primitive endoderm lineages.

46 y derived parthenogenetically, whereas their trophectoderm and primitive endoderm tissues were derive

47 eferential terminal differentiation of their trophectoderm and primitive endoderm.

48 whose progeny contributes more to the mural trophectoderm and that show compromised development when

49 e is differentiated into two cell types, the trophectoderm and the inner cell mass.

50 distinct histone methylation patterns in the trophectoderm and the pluripotent epiblast.

51 -embryonic tissues that are derived from the trophectoderm and the primitive endoderm upon reintroduc

52 Two-way interactions between the blastocyst trophectoderm and the uterine luminal epithelium are ess

53 l division: symmetric that gives rise to the trophectoderm and then placenta or asymmetric that gives

54 ibute to the inner cell mass (ICM) and polar trophectoderm and undertake full development when combin

55 e attachment reaction between the blastocyst trophectoderm and uterine luminal epithelium that occurs

56 e viable, hatch, form an inner cell mass and trophectoderm, and implant (roughly 4.5 dpc), indicating

57 able, hatched, formed an inner cell mass and trophectoderm, and implanted (E4.5), suggesting that the

58 ally cells with characteristics of endoderm, trophectoderm, and inner cell mass were observed in the

59 hment of the first differentiated cells, the trophectoderm, and of the pluripotent epiblast cells.

60 om three lineages: the maternal decidua, the trophectoderm, and the extra-embryonic mesoderm.

61 veloping mouse blastocyst, the growth of the trophectoderm, and/or the function of the embryonic epit

62 sage the inner cell mass and extra-embryonic trophectoderm are established when eight blastomeres com

63 that formed under these conditions expressed trophectoderm-associated genes.

64 is demonstrates that Ron is expressed in the trophectoderm at embryonic day (E) 3.5 and is maintained

65 Outside cells become committed to the trophectoderm at the blastocyst stage through Cdx2 activ

66 cyst, laminin 1 is strongly expressed in the trophectoderm basement membrane, whereas laminin 10/11 i

67 t gold-standard methodology, especially when trophectoderm biopsy becomes a preferred option and geno

68 Genes expressed in the trophectoderm but not in embryos prior to blastocyst for

69 a-embryonic lineages, primitive endoderm and trophectoderm, but not the embryonic lineage, before imp

70 pport the hypothesis that LGALS15 stimulates trophectoderm cell migration and attachment via integrin

71 in the inner-cell mass without any change in trophectoderm cell number.

72 ocoel expansion and increasing the number of trophectoderm cells compared to controls.

73 on in mammalian embryos segregates polarized trophectoderm cells from an apolar inner cell mass (ICM)

74 ope reduced the proliferation of mononuclear trophectoderm cells isolated from day 15 conceptuses.

75 successful molecular interaction between the trophectoderm cells of the blastocyst stage embryo and t

76 It is first expressed by trophectoderm cells of the late blastocyst and by all tr

77 At the late blastocyst stage, the epithelial trophectoderm cells of the mammalian embryo undergo a ph

78 ateral membrane contact site between nascent trophectoderm cells usually during the early 32-cell sta

79 By contrast, in the differentiating trophectoderm cells where Oct4 expression is progressive

80 nts of this process are cell-cell contact of trophectoderm cells with uterine luminal epithelial cell

81 phosphorylation and nuclear translocation in trophectoderm cells without influencing Ca2+ channels, a

82 ncreasingly associated with cell membrane in trophectoderm cells, while at E4.5, Dishevelled 3 is hig

83 exhibited an apical staining pattern in the trophectoderm cells.

84 in is expressed at the apical surface of the trophectoderm cells.

85 ectly required for gene silencing in ESCs or trophectoderm cells.

86 potent stem cells (PSCs) toward progeny with trophectoderm characteristics, we produced transcriptome

87 discovery of the TEtra circuit indicates how trophectoderm commitment is regulated in human embryogen

88 Desmosomes first assemble in the E3.5 mouse trophectoderm, concomitant with establishment of epithel

89 Desmosomes first assemble in the E3.5 mouse trophectoderm, concomitant with establishment of epithel

90 ed to hatch or attach in vitro, indicating a trophectoderm defect, although the inner cell mass could

91 otransposon is upregulated in hypomethylated trophectoderm-derived cells that normally express Tex19.

92 Radiation sensitivity was demonstrated in trophectoderm-derived cells.

93 implying the importance of Grhl2 activity in trophectoderm-derived cells.

94 similar mechanisms operate in hypomethylated trophectoderm-derived components of the mammalian placen

95 ) trophoblast stem cells and in cells of the trophectoderm-derived extra-embryonic ectoderm in Eed(-/

96 Loss of Dp1 compromises the trophectoderm-derived tissues - specifically, the expans

97 derm cells of the late blastocyst and by all trophectoderm descendants in the early postimplantation

98 y has a developmental regulatory function in trophectoderm differentiation that may serve to coordina

99 o post-implantation derivatives of the polar trophectoderm - early-streak extra-embryonic ectoderm an

100 de novo synthesis of tight junctions during trophectoderm epithelial differentiation.

101 and segregation of inner cell mass (ICM) and trophectoderm epithelium (TE) during blastocyst morphoge

102 Because cell-cell contact between the trophectoderm epithelium and the luminal epithelium is e

103 The trophectoderm epithelium is the first differentiated cel

104 ifferentiation and transport function of the trophectoderm epithelium which forms the wall of the bla

105 yst formation via direct contribution to the trophectoderm epithelium.

106 unction assembly and paracellular sealing in trophectoderm epithelium.

107 l mass, although under these conditions, the trophectoderm exhibits a 25% cellular accretion.

108 Although the key trophectoderm factors Id2, Elf5 and Eomes are exclusivel

109 lastocysts that upon dissection of the mural trophectoderm form egg cylinders in only 3 d.

110 sion of Cdx2, a transcription factor key for trophectoderm formation and cell polarity.

111 nd implicate Ras-MAPK signaling in promoting trophectoderm formation from mouse embryos.

112 at it participates only in the late stage of trophectoderm formation.

113 nscription factors, coined collectively the "trophectoderm four" (TEtra), which are also present in h

114 s downregulated not only for extra-embryonic trophectoderm genes, such as CDX2, but also for regulato

115 d are essential for conceptus elongation and trophectoderm growth and development.

116 ekte sheep retroviruses (enJSRVs), regulates trophectoderm growth and differentiation in the periimpl

117 monstrate that the enJSRV envelope regulates trophectoderm growth and differentiation in the periimpl

118 ur" (TEtra), which are also present in human trophectoderm in vivo.

119 eloped a 3D model of the inner cell mass and trophectoderm in which individual cells were mapped into

120 In the trophectoderm, in which cells go through endocycles, the

121 However, ICM/polar trophectoderm intimacy is not maintained during post-imp

122 We suggest that silencing of Oct-3/4 in trophectoderm is a prerequisite for hCG up-regulation in

123 vidence that the developmental switch to the trophectoderm is accompanied by the loss of Oct-4 silenc

124 The trophectoderm is the first extraembryonic tissue and doe

125 In blastocysts, rafts were detectable in the trophectoderm layer, but could not be detected in the in

126 show that this reflects the accumulation of trophectoderm-like cells in both Rb and Rb;E2f4 mutant p

127 nies reproducibly differentiated to an outer trophectoderm-like ring, an inner ectodermal circle and

128 e, Eomes is essential for development of the trophectoderm lineage and Eomes loss-of-function mutants

129 in embryonic stem cells (ESCs) and prevents trophectoderm lineage differentiation.

130 hanisms that operate upstream to specify the trophectoderm lineage have not been established.

131 TEAD4 is essential for specification of the trophectoderm lineage required for producing a blastocys

132 results demonstrate that TFAP2C facilitates trophectoderm lineage specification by functioning as a

133 nd 16-cell stage and then the maintenance of trophectoderm lineage-specific differentiation.

134 e uniquely required for specification of the trophectoderm lineage.

135 ryo and in stem cells of the extra-embryonic trophectoderm lineage.

136 ative of both isoforms was restricted to the trophectoderm lineage.

137 AD4 is not required for specification of the trophectoderm lineage.

138 y blastocyst), and later within both ICM and trophectoderm lineages (mid/late blastocyst), apparently

139 tribute both to the embryo proper and to the trophectoderm lineages in a chimaera assay.

140 HRas1(Q61L) in ES cells in vitro induces the trophectoderm marker Cdx2 and enables derivation of trop

141 with the active transport of ions across the trophectoderm mediated by the sodium pump (Na+, K+, ATPa

142 ion leads to cell differentiation toward the trophectoderm, mesoderm, and germ cell lineages.

143 o cell lineages (the inner cell mass and the trophectoderm), migrates within the reproductive tract,

144 In contrast, in the trophectoderm, miRNAs maintain the trophoblast stem cell

145 immunostaining was most concentrated in the trophectoderm of blastocysts.

146 nes), which are expressed exclusively in the trophectoderm of bovine embryos.

147 IFN-tau is a secretory product of trophectoderm of cattle, sheep, and their relatives and

148 (ES) cells and in inner cell mass (ICM) and trophectoderm of cultured blastocysts.

149 AMOTL2 mRNA and protein was expressed in the trophectoderm of human and mouse blastocysts.

150 u (IFN-tau) genes is restricted to embryonic trophectoderm of ruminant ungulate species for a few day

151 TS) cells in the mouse derive from the polar trophectoderm of the blastocyst and persist through earl

152 es to differentiating primitive endoderm and trophectoderm of the blastocyst.

153 Analysis of microdissected trophectoderm of the bovine conceptuses revealed the pre

154 The enJSRV envelope gene is expressed in the trophectoderm of the elongating ovine conceptus after da

155 in the outer epithelial cell layer (chorion/trophectoderm) of the placenta.

156 rulae do not produce trophoblast stem cells, trophectoderm or blastocoel cavities, and therefore do n

157 sts, but is not required for the survival of trophectoderm or Sertoli cells.

158 ution of the resulting labeled clones to the trophectoderm or the inner cell mass in a subset of embr

159 ni1-null blastocysts fail to hatch, form the trophectoderm, or expand the inner cell mass when cultur

160 These results indicate that tissues of trophectoderm origin are unable to restore genomic impri

161 moderately increased proliferation of ovine trophectoderm (oTr) cells.

162 This approach retarded trophectoderm outgrowth during conceptus elongation and

163 n, delays blastocyst development and reduces trophectoderm outgrowth from embryo explants.

164 nt of three cell lineages in the blastocyst: trophectoderm, primitive endoderm, and epiblast.

165 Sendai virus infection of human trophectoderm progenitor cells increased lncRHOXF1 RNA l

166 ompartments of in vitro differentiated human trophectoderm progenitor cells.

167 ing small interfering RNAs (siRNAs) in human trophectoderm progenitors increased expression of viral

168 ading but may also play a role in regulating trophectoderm proliferation and differentiation.

169 ckdown blastocysts exhibit a failure of both trophectoderm proliferation as well as a conspicuous lac

170 GF4 rescues primitive endoderm formation and trophectoderm proliferation in Suds3 knockdown blastocys

171 that mTOR is required for the initiation of trophectoderm protrusive activity.

172 Moreover, lack of Xm-XCI in the trophectoderm, rather than loss of paternally expressed

173 0d was internalized by mouse embryos via the trophectoderm, resulting in an indirect overexpression o

174 pecific genes, Gata3 and Eomes, and also the trophectoderm-specific cytokeratin intermediate filament

175 pected role of Notch signaling in regulating trophectoderm-specific expression of Cdx2 in cooperation

176 Furthermore, expression of trophectoderm-specific genes, Gata3 and Eomes, and also

177 Tead4(-/-) embryos do not express trophectoderm-specific genes, such as Cdx2, but do expre

178 Elimination of zygotic expression of trophectoderm-specific transcription factor Cdx2 leads t

179 at Cdx2 participates in two steps leading to trophectoderm specification: appropriate polarisation of

180 ndicate that neither the inner cell mass nor trophectoderm survives.

181 Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in

182 These lineages derive from outer trophectoderm (TE) and internal primitive endoderm (PE)

183 is achieved by epithelial differentiation of trophectoderm (TE) and its segregation from the inner ce

184 The formation of trophectoderm (TE) and pluripotent inner cell mass (ICM)

185 l lineage commitment is the formation of the trophectoderm (TE) and the inner cell mass (ICM) lineage

186 at Klf5 is required for the formation of the trophectoderm (TE) and the inner cell mass (ICM), and fo

187 lian development is the establishment of the trophectoderm (TE) and the inner cell mass (ICM).

188 mammalian development are the extraembryonic trophectoderm (TE) and the primitive endoderm (PrE).

189 d the crosstalk between the epiblast and the trophectoderm (TE) during pig embryo elongation.

190 The segregation of the trophectoderm (TE) from the inner cell mass (ICM) in the

191 Intriguingly, the trophectoderm (TE) in preimplantation monkey blastocysts

192 em (ES) cells undergo differentiation to the trophectoderm (TE) lineage by repression of the ES cell

193 last stem cells (TS cells), derived from the trophectoderm (TE) of blastocysts, require transcription

194 ammalian embryo must differentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by

195 stocyst activation, the process by which the trophectoderm (TE) receives extrinsic cues that initiate

196 two cell lineages, inner cell mass (ICM) and trophectoderm (TE), is dependent upon functions of key t

197 ast and therefore the future embryo, and the trophectoderm (TE), which will build the placenta.

198 In the trophectoderm (TE), X inactivation was nonrandom with th

199 The trophectoderm (TE)-associated transcription factor CDX2

200 mbryo, TEAD4 is critical to establishing the trophectoderm (TE)-specific transcriptional program and

201 consisting of the inner cell mass (ICM) and trophectoderm (TE).

202 e first lineage decision and form functional trophectoderm (TE).

203 expression between inner cell mass (ICM) and trophectoderm (TE).

204 nic inner cell mass (ICM) and the supportive trophectoderm (TE).

205 t inner cell mass (ICM) from differentiating trophectoderm (TE).

206 oplasmic crystalline structures of conceptus trophectoderm (Tr).

207 the arginine transporter in ovine conceptus trophectoderm (Tr).

208 ed through Hippo and Notch in the blastocyst trophectoderm, unexpectedly finding that it is inactive

209 The presence of Ets-2 in nuclei of embryonic trophectoderm was confirmed immunocytochemically.

210 Once the trophectoderm was specified, Tead4 was not essential for

211 e phenotype cannot be rescued by a wild-type trophectoderm, we propose that UNC5B-mediated signaling

212 pment is the formation of an epithelium, the trophectoderm, we tested the hypothesis that one such em

213 me and cell number (both inner cell mass and trophectoderm) were also increased when the distance apa

214 isions, thereby allocating more cells to the trophectoderm, whereas reducing Cdx2 promotes asymmetric

215 he assembly of TJ-associated proteins within trophectoderm which, from our previous data, spans from

216 with formation of a blastocyst consisting of trophectoderm, which contributes exclusively to the plac

217 mammalian embryogenesis is that between the trophectoderm, which gives rise to the trophoblast of th

218 Subsequently, outer cells differentiate into trophectoderm while inner cells retain pluripotency to b

219 on mouse development, close contact of polar trophectoderm with the inner cell mass (ICM) promotes pr