ライフサイエンスコーパス: tropomyosin

1 phil secretory responses to rPen a 1 (shrimp tropomyosin).

2 sassembly by severing, which is modulated by tropomyosin.

3 e-like regulatory mechanism through troponin/tropomyosin.

4 cture reveals a myosin-induced transition of tropomyosin.

5 rimp extract is worse digested than purified tropomyosin.

6 coiled-coils of myosin and the stereotypical tropomyosin.

7 actin and myosin and the regulatory protein tropomyosin.

8 Arp2/3-generated networks competent to bind tropomyosin.

9 n networks are insulated from the effects of tropomyosin.

10 omposed of the proteins actin, troponin, and tropomyosin.

11 e mutations in TPM1, the gene encoding alpha-tropomyosin.

12 form-specific localizations and functions of tropomyosin.

13 the slowing is exacerbated by smooth muscle tropomyosin.

14 ctin close to the low Ca(2+) binding site of tropomyosin.

15 ough direct interaction with actin and alpha-tropomyosin.

16 halves of the periodic repeats (periods) in tropomyosin.

17 contexts not previously associated with beta-tropomyosin.

18 identified in the extreme N-terminus of beta-tropomyosin.

19 n reducing allergic responses towards shrimp tropomyosin.

20 ly site of interaction between leiomodin and tropomyosin.

21 pmental functions for the sarcomeric protein Tropomyosin 2 (Tm2).

22 rged motifs of the actin-binding residues of tropomyosin 3, thus disrupting the electrostatic interac

23 ated proteins, a marked increase in cellular Tropomyosin-3, plasma membrane blebbing, and release of

24 ne encoding the actin cytoskeletal regulator tropomyosin 4 (TPM4) exert an effect on the count and vo

25 erminus of the alpha-helices of dimeric beta-tropomyosin, a change predicted to alter protein-protein

26 in, which changes conformation and displaces tropomyosin, a filamentous protein that wraps around the

27 tting low-energy cost regulatory movement of tropomyosin across the filament during muscle activation

28 combined local positive charge, diminishing tropomyosin-actin interaction and facilitating regulator

29 Here, the D292V mutation may predispose tropomyosin-actin positioning to a myosin-blocking state

30 l changes in the troponin complex, displaces tropomyosin along the actin filament and allows myosin-a

31 Conversely, protein bands assigned to tropomyosin alpha-1 chain, fast myotomal muscle troponin

32 alpha-Tropomyosin (alpha-TM) has a conserved, charged Asp-137

33 ytoskeletal organisation (vinculin p<0.0001, tropomyosin alpha4 p=0.0108), antioxidative (peroxiredox

34 Tropomyosin also binds to F-actin in smooth muscle and i

35 nI interaction through structural effects on tropomyosin and cTnI.

36 d, proteins involved in actin ring assembly (tropomyosin and formin) and membrane trafficking (myosin

37 the formation of a selective complex between tropomyosin and immobilized aptamerTROP probe on the sur

38 in but increased strongly the flexibility of tropomyosin and kept its strands near the inner domain o

39 Sequence similarities with tropomyosin and myosin from mollusks were detected.

40 Interestingly, tropomyosin and myosin light chains in comminuted sausag

41 o alter protein-protein binding between beta-tropomyosin and other molecules and to disturb head-to-t

42 obility and spatial rearrangements of actin, tropomyosin and the myosin heads at different stages of

43 ce myosin binding to actin locally displaces tropomyosin and thereby facilitates binding of nearby my

44 E-based representation of cross-bridge (XB), tropomyosin and troponin within a contractile regulatory

45 rs to actin filaments is mainly regulated by tropomyosin and troponin.

46 o Ascaris extract, Asc s 1 (ABA-1), Asc l 3 (tropomyosin) and GST (glutathione transferase).

47 nstructions, computational modeling of actin-tropomyosin, and docking of atomic resolution structures

48 ysical interactions of OGA with alpha-actin, tropomyosin, and myosin light chain 1, along with reduce

49 new reconstructions clearly showed F-actin, tropomyosin, and troponin densities.

50 riated muscle thin filament comprises actin, tropomyosin, and troponin.

51 no acids in length, and comprise alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2

52 Whereas Tmods have alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2

53 ffects derived from the long-range action of tropomyosin are a major factor in cooperative activation

54 Tropomyosins are coiled-coil proteins that bind actin fi

55 Among them, invertebrate tropomyosin, arginine kinase, myosin light chain, sarcop

56 Different variants or isoforms of tropomyosin, arginine or creatine kinase, glyceraldehyde

57 (-1)) coincides with the azimuthal motion of tropomyosin around the thin filament.

58 to the highly allergenic and cross-reactive tropomyosins Asc l 3, Blo t 10 and Der p10 (aORs: 1.76;

59 Elongated tropomyosin, associated with actin-subunits along the su

60 tin at a resolution of 3.7 A in complex with tropomyosin at a resolution of 6.5 A, determined by elec

61 igh pressure steaming where the intensity of tropomyosin band was reduced.

62 nsmitted through related changes in cTnI and tropomyosin) become diminished by decreases in sarcomere

63 static interactions that facilitate accurate tropomyosin binding with actin necessary to prevent the

64 dulin 1 (Tmod1) is a pointed-end capping and tropomyosin-binding protein that controls thin-filament

65 rsal of charged residues about the conserved tropomyosin-binding region of TnT1 may perturb critical

66 ucial TnT1 (N-terminal domain of troponin-T)-tropomyosin-binding region, cause cardiomyopathy.

67 The arrangement of the N-terminal actin- and tropomyosin-binding sites in leiomodin is contradictory

68 Introduction of mutations in both actin- and tropomyosin-binding sites of leiomodin affected its loca

69 lds that at relaxing (low-Ca(2+)) conditions tropomyosin blocks myosin binding sites on F-actin, wher

70 evel structure of alphaalpha-striated muscle tropomyosin bound to an actin filament that includes the

71 hich is regulated through a translocation of tropomyosin by the troponin complex in response to Ca(2+

72 subunits along F-actin, the structure of the tropomyosin cable on actin is uncertain.

73 ther to provide a comprehensive model of the tropomyosin cable running continuously on F-actin.

74 monstrate that decreasing phosphorylation of tropomyosin can rescue a hypertrophic cardiomyopathic ph

75 allergenic protein domain families (EF-hand, Tropomyosin, CAP, Profilin, Lipocalin, Trypsin-like seri

76 Deletion of Glu139 in beta-tropomyosin caused by a point mutation in TPM2 gene is a

77 By focusing on the stabilizing protein tropomyosin Cdc8, bundling protein fimbrin Fim1, and sev

78 ocessive motor whose activity is enhanced by tropomyosin (Cdc8p).

79 filamentous beta-actin with these different tropomyosin cofilaments affects the actin-mediated activ

80 structures merge seamlessly onto the ends of tropomyosin coiled-coils.

81 essure steaming reduced the allergenicity of tropomyosin compared with other heat treatments methods.

82 increased Ca(2+) sensitivity of the troponin-tropomyosin complex, resulting in abnormally active inte

83 e pathophysiological mechanisms of the actin-tropomyosin complex.

84 cling on actin by the thin filament troponin-tropomyosin complex.

85 Here, we report the properties of actomyosin-tropomyosin complexes containing filamentous beta-actin,

86 Tropomyosins comprise a large family of actin-binding pr

87 Tumour cells rely on specific tropomyosin-containing actin filament populations for gr

88 In contrast, how tropomyosins contribute mechanistically to cable formati

89 C and the activation and relaxation rates of tropomyosin/crossbridge binding kinetics differ most sig

90 The major heat-stable shellfish allergen, tropomyosin, demonstrates immunological cross-reactivity

91 has significant implications for perturbing tropomyosin-dependent actin filament function in the con

92 s pteronyssinus, Blomia tropicalis and their tropomyosins Der p 10 and Blo t 10 was measured.

93 eating of shellfish has a profound effect on tropomyosin detection.

94 oelectrochemical (PEC) aptasensor for shrimp tropomyosin determination was fabricated by using graphi

95 disturb head-to-tail polymerization of beta-tropomyosin dimers.

96 ch is significantly enhanced at high Ca(2+), tropomyosin does not block myosin binding sites on F-act

97 As a result of troponin-tropomyosin dysinhibition, upheld(101) hearts exhibited

98 We examined seven mutant tropomyosins, E62Q, D84N, I172T, L185R, S215L, D230N, an

99 Actin binds to tropomyosin electrostatically at two points, through Asp

100 ular genetic approaches, we identified three tropomyosins expressed in Drosophila S2 cells: Tm1A, Tm1

101 Our findings outline a mechanism by which tropomyosin facilitates sorting of transport to specific

102 Tropomyosin fails to bind dendritic actin networks creat

103 p.K7del beta-tropomyosin fails to localize properly within the thin f

104 The tropomyosin family of proteins form end-to-end polymers

105 lopodia/microvilli formation; these included tropomyosin, fascin, and Rab7.

106 and sufficient cues to model the whole actin-tropomyosin filament assembly in atomic detail.

107 The actin-tropomyosin filament structure is unknown, but there are

108 /9 so that it can cross-link and slide actin-tropomyosin filaments relative to one another, functions

109 n are unable to produce force on R258C actin-tropomyosin filaments, suggesting that tropomyosin occup

110 hereas myosin-dependent motility of troponin/tropomyosin-free D292V F-actin is normal, motility is dr

111 filament activity, by physically displacing tropomyosin from its low Ca(2+) position on actin, and g

112 The beta-tropomyosin gene encodes a component of the sarcomeric t

113 fects caused by insertion of P-elements near tropomyosin genes imply the existence of additional, non

114 tion did diminish, but not eliminate, HDM or tropomyosin IgE cross-reactivity.

115 Tropomyosin II, which functions with Staufen in oskar mR

116 opomyosin models show the mutation localizes tropomyosin in a blocked-state position on actin defined

117 To dissect out the role of tropomyosin in actin filament regulation we use the smal

118 Comparison of the position of tropomyosin in F-actin-tropomyosin with its position in

119 h mollusc allergy reacted more frequently to tropomyosin in immunoblots than did patients without it

120 ry domain was positioned where it could hold tropomyosin in its blocking position on actin, thus sugg

121 Tropomyosin in shrimp extract is worse digested than pur

122 sor was used for the determination of shrimp tropomyosin in the concentration range of 1-400ngmL(-1)

123 ent heat treatments and the allergenicity of tropomyosin in the extracts.

124 ins in Drosophila, 2) reveals a function for tropomyosin in the mitotic spindle, and 3) uncovers sequ

125 with the residues in the repeating motif on tropomyosin in the models.

126 d characterizes previously unknown nonmuscle tropomyosins in Drosophila, 2) reveals a function for tr

127 Previous work demonstrated that tropomyosins inhibit actin nucleation by the Arp2/3 comp

128 The combined effects of CR-tropomyosin interactions and the modulating effect of th

129 t alpha-tropomyosinslow likely impacts actin-tropomyosin interactions and, indeed, co-sedimentation a

130 g effect of the N-terminal end of cTnT on CR-tropomyosin interactions may lead to the emergence of a

131 We also confirm that negatively charged tropomyosin interacts with a positively charged groove o

132 l support for the atomic models of the actin-tropomyosin interface.

133 s, derived from structural data of the actin-tropomyosin interface.

134 Tropomyosin is known to be the main allergen in crustace

135 at either relaxing or activating conditions tropomyosin is not constrained in one structural state,

136 lated thin filaments in cardiac muscle where tropomyosin is treated as a continuous elastic chain con

137 ic profile of extracted proteins showed that tropomyosin is very stable under the different heat trea

138 Although tropomyosin is well defined in electron microscopy helic

139 ental to tumor cell viability based on their tropomyosin isoform composition.

140 cle myosin-2B (NM-2B) constructs, and either tropomyosin isoform Tpm1.8cy (b.-.b.d), Tpm1.12br (b.-.b

141 TR100 directed against the C terminus of the tropomyosin isoform Tpm3.1.

142 muscle contained normal ratios of the three tropomyosin isoforms and normal fibre-type expression of

143 wn how the dynamic association with specific tropomyosin isoforms generates actin filament population

144 expanding our understanding of how specific tropomyosin isoforms influence actin dynamics.

145 Asp25 interacts with tropomyosin K6, next to K7 that was mutated in the other

146 The tropomyosin-like protein, DivIVA, is targeted to the neg

147 chimeras, we identified the determinants of tropomyosin localization near the C-terminus.

148 lar mechanism and physiological relevance of tropomyosin-mediated regulation of Myo52p transport, usi

149 Energy landscapes based on F-actin-tropomyosin models show the mutation localizes tropomyos

150 blish that leiomodin interacts with only one tropomyosin molecule, and this is the only site of inter

151 ance on actin filaments, adjacent 42-nm-long tropomyosin molecules are joined together by a 9- to 10-

152 Adjacent tropomyosin molecules can then be joined together to pro

153 t the pointed end, while also contacting two tropomyosin molecules on each side of the filament.

154 cement by Tmod3 and Tmod4 may impair initial tropomyosin movement over actin subunits during thin-fil

155 s through the identification of a novel beta-tropomyosin mutation in two clinical contexts not previo

156 phenotype is core-rod myopathy, with a beta-tropomyosin mutation uncovered by whole exome sequencing

157 regulate actin-myosin interactions and beta-tropomyosin mutations have been associated with nemaline

158 osition in our previously determined F-actin-tropomyosin-myosin structure reveals a myosin-induced tr

159 Reactivity to proteins other than tropomyosin (n = 14) was not different between the two g

160 Using fluorescence microscopy, we show that tropomyosin (non-muscle Drosophila Tm1A) polymerizes alo

161 actin-tropomyosin filaments, suggesting that tropomyosin occupies an inhibitory position on actin.

162 Smooth muscle tropomyosin offers little protection from cofilin cleava

163 ions to reveal the azimuthal movement of the tropomyosin on the surface of the native cardiac TF upon

164 ree-dimensional organization of troponin and tropomyosin on the thin filament must be determined.

165 shorter N-terminal fragment did not displace tropomyosin or activate the thin filament at low Ca(2+)

166 patients showed cross-reactivity to mealworm tropomyosin or alpha-amylase, hexamerin 1B precursor and

167 hydrolysis, and neither did the addition of tropomyosin or of GOLPH3, a myosin-18A binding partner.

168 ation to the cross-reactive Ascaris and mite tropomyosins partially underlies this finding.

169 e mutation interferes with head-to-tail beta-tropomyosin polymerization and with overall sarcomeric s

170 At high Ca(2+), cMyBP-C had little effect on tropomyosin position and caused slowing of thin filament

171 ine directly whether cMyBP-C binding affects tropomyosin position, we have used electron microscopy a

172 sin formation during diastole due to altered tropomyosin position, which blocks myosin binding to act

173 nsional reconstruction resolved destabilized tropomyosin positioning and aberrantly exposed myosin-bi

174 We show that two of these tropomyosin positions restrain actomyosin interactions,

175 of brain-derived neurotropic factor (BDNF), tropomyosin receptor kinase (Trk) signaling, and activat

176 Lhx8 expression modulated tropomyosin receptor kinase A (TrkA) expression in septa

177 Anti-tropomyosin receptor kinase A (TrkA)-targeted treatment

178 Tropomyosin receptor kinase A was expressed on MCC tumor

179 Tropomyosin receptor kinase A was found in all 36 evalua

180 ther the nerve growth factor receptor, TrkA (tropomyosin receptor kinase A), or the neuregulin recept

181 For example, activation of the BDNF receptor tropomyosin receptor kinase B (TrkB) in the DLS reduces

182 Treatments with two-small molecule tropomyosin receptor kinase B (trkB) ligands, 7,8 dihydr

183 ry reactivation increases proBDNF, BDNF, and tropomyosin receptor kinase B (TrkB) phosphorylation lev

184 Here, we show that the tropomyosin receptor kinase B (TrkB) receptor is a direc

185 Finally, pharmacological blockade of BDNF-tropomyosin receptor kinase B (TrkB) signaling in the AC

186 actor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB), have important rol

187 that was dependent on BDNF and its receptor tropomyosin receptor kinase B (TrkB).

188 NF mice or by systemic administration of the tropomyosin receptor kinase B agonist, LM22A-4.

189 ith increased activated caspase3 and altered tropomyosin receptor kinase B isoform expression.

190 lamine-induced behavioral responses and BDNF-tropomyosin receptor kinase B signaling, suggesting that

191 y impaired brain-derived neurotrophic factor-tropomyosin receptor kinase B-dependent synaptic plastic

192 polamine rapidly stimulates BDNF release and tropomyosin receptor kinase B-extracellular signal-regul

193 aptic density protein 95, NMDA receptor, and tropomyosin receptor kinase B.

194 ed by directly activating the BDNF receptor, tropomyosin receptor kinase B.

195 Tropomyosin receptor kinase C (TrkC) is involved in cell

196 Tropomyosin receptor kinase C (TrkC) targeted ligand-pho

197 The binding of neurotrophins to tropomyosin receptor kinase receptors initiates several

198 show that BDNF signaling through the cognate tropomyosin receptor kinase type B (trkB) receptor occur

199 male rats activates signaling downstream of tropomyosin receptor kinase type B (trkB), namely, phosp

200 The proto-oncogenes NTRK1/2/3 encode the tropomyosin receptor kinases TrkA/B/C which play pivotal

201 -derived neurotrophic factor, phosphorylated tropomyosin-receptor kinase B, and methyl CpG binding pr

202 Systemic injections of a BDNF tropomyosin-receptor-kinase (TrkB) receptor antagonist r

203 eficits in brain-derived neurotrophic factor/tropomyosin-receptor-kinase B (TrkB) signaling contribut

204 ock down the expression of the BDNF receptor tropomyosin-receptor-kinase type B in rats and mice, we

205 Rod-shaped dimers of tropomyosin regulate actin-myosin interactions and beta-

206 Tropomyosin regulates a wide variety of actin filament f

207 e thin filament activity by interfering with tropomyosin regulatory movements on actin.

208 Neurotrophins signal through the tropomyosin related kinase (Trk) family of tyrosine kina

209 -HT treatment increases BDNF receptor, TrkB (tropomyosin related kinase B), levels in mouse primary c

210 idual mutations in the genesis of actin- and tropomyosin-related diseases and will serve as a strong

211 of neurogenesis during which the majority of tropomyosin-related kinase A (TrkA(+)) nociceptors and t

212 ate expression of high-affinity NT receptors tropomyosin-related kinase A (TrkA) for nerve growth fac

213 though originally identified as an oncogene, Tropomyosin-related kinase A (TrkA) is linked to pain an

214 ly involves further co-receptors such as the tropomyosin-related kinase A (TrkA) receptor.

215 to bind to the nerve growth factor receptor, tropomyosin-related kinase A (TrkA), and to thereby exer

216 involving the nerve growth factor receptors (tropomyosin-related kinase A [TrkA]/neurotrophin recepto

217 he role of brain-derived neurotrophic factor-tropomyosin-related kinase B (BDNF-TrkB) signaling in th

218 The neurotrophin receptor tropomyosin-related kinase B (TrkB) is thought to be cri

219 othalamic neurons exhibited reduced receptor tropomyosin-related kinase B (TRKB) levels and decreased

220 increased expression of BDNF or its receptor tropomyosin-related kinase B (TrkB) parallel a markedly

221 hat activation of a primary BDNF target, the tropomyosin-related kinase B (TrkB) receptor, enhances t

222 mulates cell migration through activation of tropomyosin-related kinase B (TrkB; also called NTRK2).

223 A tropomyosin-related kinase B agonist, 7,8-dihydroxyflavo

224 v-1, MLRs, and MLR-localization of Cav-1 and tropomyosin-related kinase B receptor independent of age

225 pendent on adenosine A2A receptor (A2AR) and tropomyosin-related kinase B signaling, suggesting incre

226 otein 95, to enhance downstream signaling of tropomyosin-related kinase B, a receptor for BDNF, can i

227 liced truncated isoform of the BDNF receptor tropomyosin-related kinase B.T1 (trkB.T1).

228 We show that the neurotrophin receptor tropomyosin-related kinase C (TrkC) is required for dend

229 human NGFbeta or its high-affinity receptor tropomyosin-related kinase receptor A (TRKA) were associ

230 eurotrophic factor (BDNF) acting through the tropomyosin-related kinase receptor B (TrkB).

231 matergic receptor expression is regulated by tropomyosin-related kinase receptor subtype B (TrkB) sig

232 the target-derived nerve growth factor (NGF)-tropomyosin-related kinase type 1 (TrkA, also called Ntr

233 tudy, we expand the allelic spectrum of beta-tropomyosin-related myopathies through the identificatio

234 TrkB.T1 is the only isoform of tropomyosin-related receptor kinase type B (trkB) recept

235 eins, including Myosin Heavy Chain (MHC) and Tropomyosin, require Hoip for their expression.

236 nalyses, we determined residues of actin and tropomyosin required for complex formation.

237 Rather, regulation of F-actin stability by tropomyosin requires fidelity of information communicate

238 The mutation did not alter tropomyosin's affinity for actin but increased strongly

239 Tropomyosin's attraction to pointed ends reflects a stro

240 Yet, despite the apparent simplicity of tropomyosin's coiled-coil structure and its well-known p

241 Heat-shock cognate 70 (HSC-70) and tropomyosin showed IgE reactivity with 60% of the sera,

242 tors interact with each other indirectly via tropomyosin, since myosin binding to actin locally displ

243 interactions may be caused by an increase in tropomyosin stiffness.

244 he ability of hC0C1f to bind actin and alpha-tropomyosin, suggesting that cleaved C0-C1f could act as

245 The troponin/tropomyosin system is also present and essential for ovu

246 ltiple isoforms of the actin-binding protein tropomyosin that help construct a variety of cytoskeleta

247 ation had been limited to known movements of tropomyosin that sterically block and unblock myosin bin

248 entify the immunodominant T cell epitopes of tropomyosin, the major shrimp allergen of Metapenaeus en

249 Tropomyosin therefore dictates fundamental steps of myog

250 These mutations are clustered in the tropomyosin (Tm) binding region of TnT, TNT1 (residues 8

251 The causal link between disparate tropomyosin (Tm) functions and the structural instabilit

252 Tropomyosin (Tm) is a coiled-coil protein that binds to

253 Tropomyosin (Tm) is a key factor in the molecular mechan

254 Tropomyosin (Tm) is an actin-binding, thin filament, two

255 Studies indicate that tropomyosin (Tm) phosphorylation status varies in differ

256 The actin-binding protein nonmuscle tropomyosin (Tm) provides spatially specific regulation

257 investigated the functional impact of alpha-tropomyosin (Tm) substituted with one (D137L) or two (D1

258 in a position to activate the TF by shifting tropomyosin (Tm) to the "open" structural state.

259 Tmods have alternating tropomyosin (TM)- and actin-binding sites (TMBS1, ABS1,

260 rom non-transgenic mice that expressed alpha-tropomyosin (Tm).

261 pathy-linked mouse model expressing a mutant tropomyosin (Tm-E54K) for 3 months with either TRV120067

262 actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filame

263 mouse model with an E180G mutation in alpha-tropomyosin (Tm180) that demonstrates increased myofilam

264 Only one nonmuscle tropomyosin (Tm1A) has previously been described in Dros

265 of the actin filaments of cancer cells, the tropomyosin Tm5NM1, regulates the proliferation of norma

266 nted end capping proteins that interact with tropomyosins (TMs) and cap TM-coated filaments with high

267 in filament (F-actin) pointed ends and binds tropomyosins (TMs), regulating actin polymerization and

268 g proteins (ABPs), including the formins and tropomyosins (Tms).

269 d docking of atomic resolution structures of tropomyosin to actin filament models.

270 nd cofilin, in turn, regulate the binding of tropomyosin to actin filaments.

271 ereospecific but necessarily weak binding of tropomyosin to F-actin is required for effective thin fi

272 actin filament is thereby not sufficient for tropomyosin to fulfil its function.

273 ns that work together with steric effects of tropomyosin to inhibit force generation.

274 is dramatically inhibited after addition of tropomyosin to the mutant actin.

275 der low Ca(2+) conditions, cMyBP-C displaces tropomyosin toward its high Ca(2+) position, and that th

276 ectively, was increased, and the movement of tropomyosin towards the blocked position at low Ca(2+) w

277 ends to which the actin-stabilizing protein tropomyosin (Tpm) can bind [8].

278 Tropomyosin (Tpm) isoforms decorate actin with distinct

279 ia the regulatory proteins troponin (Tn) and tropomyosin (Tpm), which are associated with actin filam

280 Exon 3 of the rat alpha-tropomyosin (Tpm1) gene is repressed in smooth muscle ce

281 ressed this question in S. cerevisiae, where tropomyosins (Tpm1 and Tpm2), profilin (Pfy1), and formi

282 and several actin-binding factors including tropomyosins (TPM3 and TPM4) and tropomodulin 3.

283 traction can be rescued by overexpression of tropomyosin tpm4 but not by troponin tnnt2, indicating t

284 comere length and indirect modulation of the tropomyosin transition rates by Ca(2+) and troponin.

285 ereas at activating (high-Ca(2+)) conditions tropomyosin translocation only partially exposes myosin

286 When Myo51-Rng8/9 was bound to actin-tropomyosin, two attachment sites were observed: the typ

287 dent by the enhanced recognition of multiple tropomyosin variants in the analysed shellfish species.

288 hrimp was 20%, to new shrimp was 40%, and to tropomyosin was 0%.

289 p was 54.8%, to new shrimp was 55.0%, and to tropomyosin was 19.4%.

290 Cross-reactive tropomyosin was detected in all crustacean species, with

291 s used after July 2012 for ImmunoCAP(R)) and tropomyosin was determined with ImmunoCAP(R) (CAP-FEIA,

292 The protein tentatively identified as tropomyosin, was also detected in krill oil products, bu

293 The sites of mutations in tropomyosin were based on an evolutionary analysis and r

294 stics of sauropsid-specific beta-keratin and tropomyosin were detected in tissues containing remnant

295 oponin C, actin, bovine serum albumin (BSA), tropomyosin) were deposited onto a polymer surface, foll

296 a), which together span the entire length of tropomyosin, were weak secretagogues.

297 rsal actin filament regulator is the protein tropomyosin, which binds end-to-end along the length of

298 Muscle contraction is regulated by troponin-tropomyosin, which blocks and unblocks myosin binding si

299 noncanonical residues in the central part of tropomyosin with canonical ones, G126R and D137L, and es

300 on of the position of tropomyosin in F-actin-tropomyosin with its position in our previously determin

301 After the incubation of tropomyosin with TROP aptamer probe, the photocurrent si