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1 epresented the head domain, 1 complete and 1 truncated.
2 rotein interactions because key residues are truncated.
8 fter the removal of the PTP, the recombinant truncated AaIPPI1 isomerized isopentenyl pyrophosphate (
14 sis of the conformational ensembles of amino-truncated Abeta10-40 peptide produced with five force fi
15 ity locus (StCDF1) revealed introgression of truncated alleles from wild species, particularly Smicro
16 we compared the accumulation of N-terminally truncated amyloid-beta and full-length amyloid-beta, dep
18 e stages and brain areas, while N-terminally truncated amyloid-beta40 and full-length amyloid-beta40
21 rds showed that accumulation of N-terminally truncated amyloid-beta42 in cortical areas was associate
22 ry analysis showed that several N-terminally truncated amyloid-beta42 species, represented by pyroglu
28 proteasome-dependent degradation of both the truncated and wild-type proteins, leading to a dramatic
29 cranioskeletal phenotype due to monoallelic truncating and frameshift BMP2 variants and deletions in
30 and AR also applied to constitutively active truncated AR variants (ARV), as GRHL2 interacted with an
31 d in vitro nuclease assays with C-terminally truncated ARTEMIS showing DNA-PKcs-independent hairpin o
32 related methods that can amplify cDNAs that truncate at crosslink sites and we show that computation
34 se in skin temperature during infection, the truncated bacteriophage endolysin CHAPK and the staphylo
37 d impressive relief of pain, their impact is truncated by loss of efficacy (analgesic tolerance).
38 t study generated 3 mutant mouse models with truncated C termini in 2 different mouse strains, C57BL/
39 ely due to accumulation of NOTCH2 carrying a truncated C terminus that escapes FBW7-mediated ubiquiti
40 We found that the CARD8-FS variant led to a truncated CARD8 protein lacking the FIIND and CARD domai
44 Schizosaccharomyces octosporus We show that truncated Chp1 loses the property of heterochromatin loc
46 high resolution NMR structure of N-terminal truncated ComGC revealing a highly flexible and structur
47 nificant fraction of natural populations are truncated, conducting only one or two steps of the pathw
48 full-length CXCR1 (1-350) and to N-terminal truncated construct NT-CXCR1 (39-350) identify specific
49 antagonists has mainly been performed with a truncated construct of FimH locked in one particular con
50 nomeric IL-8 (1-66) bound to full-length and truncated constructs of CXCR1 in phospholipid bilayers u
53 el normalization (mixnorm) that accommodates truncated data and estimates per-metabolite batch and ru
54 the plasma membrane, whereas the C-terminus truncated (DeltaC) form localized in the cytoplasm and t
67 the LMNA gene, resulting in production of a truncated farnesylated-prelamin A protein (progerin).
68 pendent guanylyl cyclase activity, whereas a truncated form lacking the 17- to 20-kDa N-terminal doma
69 ts forced to express full length ICAM-1 or a truncated form lacking the cytoplasmic domain of ICAM-1.
70 ed fluorescent protein domains, as well as a truncated form of herpes simplex virus 1 thymidine kinas
75 ngth tyrosine kinase receptor B (trkB) and a truncated form of this neurotrophin receptor, favoring t
77 ulation of Rab11, Rab7, or RILP, but not its truncated form RILP-C33, rescued LAMP2A-defective traffi
78 MHC molecules such as H-K(b), we produced a truncated form termed K(b)-t harboring properties favora
79 tion of limited versions of both proteins in truncated form, a complete picture of the E1E2 complex i
82 ine and human full-length CLEC3As as well as truncated forms of CLEC3A in HEK-293 Epstein-Barr nuclea
85 , and determined the protein sequence of the truncated forms of TSLP using Edman protein sequencing a
87 age of development and reintroduced variably truncated fragments of the pxr region to test for their
89 ons result in the expression of C-terminally truncated G-CSFRs that promote strong cell proliferation
90 We also determined that despite encoding a truncated Gag protein, only the full-length Gag protein
91 in the formation of Region D' containing the truncated galE2 locus and the capture of the cps island
93 tural and functional role in stabilizing the truncated GFP by substituting as a surrogate beta-strand
95 However, the transcriptional activity of the truncated GLI1 factor was found to be severely impaired
96 ent to FcgammaRIIIa binding, compared to the truncated glycoforms, suggesting a role of IgG1 Fc N-gly
97 d proteins of T. brucei procyclic forms have truncated GPI anchor side chains in TbRFT1 null parasite
98 Here we report structures of two variants of truncated green fluorescent protein (GFP), i.e., split G
101 mics simulations of a series of sequentially truncated high-mannose IgG1 Fc glycoforms, we found that
102 ntly, a 0.95-A resolution X-ray structure of truncated HjLPMO9A revealed that the linker forms an int
103 e expression of dominant-negative C-terminus-truncated human DISC1 (mutant DISC1) in astrocytes would
105 ilicon-based devices are shaped into maps of truncated icosahedron and fabricated on flexible sheets
106 hopoietin (TSLP) is known to be elevated and truncated in nasal polyps (NPs) of patients with chronic
107 s highly conserved, Tas3 is lost and Chp1 is truncated in Schizosaccharomyces cryophilus and Schizosa
109 ttering data for the complex of TRN-SR2 with truncated integrase, we propose a molecular model of the
112 characterized a novel alternatively spliced, truncated isoform of human Musashi2 (variant 2) that lac
114 We show that in contrast to C-terminally truncated isoforms, which do not co-fibrillize, deletion
116 show that kidney-specific WNK1 (KS-WNK1), a truncated kinase-defective WNK1 isoform that is highly e
119 indicated that an evolutionarily conserved, truncated leucine zipper motif near the N terminus as we
121 with sliding when its range is limited by a truncated linking segment, and the chromodomains, which
123 Effective adaptive deep brain stimulation truncated long beta bursts shifting the distribution of
125 dency to accumulate suggest that, over time, truncated M1 could damage the corticospinal tracts of hu
127 t generates full-length M1 and M87 proteins, truncated M1 was notably more detrimental to neurite out
129 y more detrimental to neurite outgrowth than truncated M87, and this was true for both N184X and S245
130 ption factor Islet1, resulting in a distally truncated mandible via unbalanced cell apoptosis and dec
131 a spontaneous mutant mouse that expresses a truncated MAP7 and found a gain-of-function phenotype bo
134 -side-out membrane vesicles as well as for a truncated, membrane-integrated variant, confirming that
137 When stratified by mutation type, women with truncating MLH1 mutations had later ages of onset of end
140 osttranslational and identify a C-terminally truncated MRE11, which is formed after HDAC inhibition a
143 esized PTC-containing mRNAs, indicating that truncated mutant proteins originated primarily in the pi
144 ome sequencing, we identified a heterozygous truncating mutation (c.279delG, p.Trp93fs*) of the nucle
145 c.104T>C carrier revealed a second, somatic, truncating mutation affecting PALB2, and the tumor displ
147 d five individuals with de novo heterozygous truncating mutations in CIC who share similar clinical f
149 Here, we have identified 6 heterozygous truncating mutations in PSENEN, encoding presenilin enha
150 show the consequences of germline final-exon-truncating mutations in REST for organismal development
151 ere we report three families with homozygous truncating mutations in TBC1D23 who display moderate to
152 25% of inherited DCM has been attributed to truncating mutations in the sarcomeric structural protei
154 wide spectrum of human pathologies linked to truncating mutations of SYNE1 [13-15] may originate in p
155 of cells derived from individuals with PPM1D truncating mutations to ionizing radiation resulted in n
157 o account for more cases of autism than gene-truncating mutations, most research has focused on the l
158 iated genes revealed that, compared with two truncating mutations, two missense mutations associated
159 was myofilament associated in the atria, and truncated MyBP-HL protein failed to incorporate into the
161 l end of the tail (M10(Full)LZ) and the tail-truncated myosin-X without artificial dimerization motif
162 demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matrix-metalloprot
163 OCs) and leads to the production of abnormal truncated N-linked glycan structures instead of the typi
164 fy the bioactive region(s) of Ov-GRN-1, four truncated N-terminal analogues were synthesized and char
165 GSDMD at the Q193-G194 pair, resulting in a truncated N-terminal fragment disrupted for inducing cel
166 erted total synthesis and the preparation of truncated natural products optimised for biological acti
168 broblasts from patients with IP carrying the truncated NEMO form (as also observed in HOIL-1(-/-) cel
170 ibition of NF-kappaB signaling, although the truncated NEMO protein interacted with proteins involved
171 proximity ligation assay to characterize the truncated NEMO protein interactions with IKK-alpha, IKK-
172 ur identification of RBA1 demonstrates that "truncated" NLRs can function as pathogen sensors, expand
173 de the disease and gene names, with allelic (truncating/nontruncating) information included for PKD1
174 Our approach assumes that the data follow a truncated normal distribution with the truncation point
177 stal has a core-shell structure containing a truncated octahedral core with bulk face-centered cubic-
178 kinetics of (100) facets at the vertices of truncated octahedral particles promote preferential deli
179 correlated approach, it is observed that the truncated octahedron shape adopted by bare Pt nanopartic
180 ylation may be impacted when Env trimers are truncated or produced in CHO cells.IMPORTANCE A protecti
182 ate that the expression levels and length of truncated ORF1 proteins influence their ability to suppr
185 raction was detected between RTA and the non-truncated P2-P2 homodimer, suggesting that the structura
186 memory (LTM) in Aplysia can be reinstated by truncated (partial) training following its disruption by
188 lacking the specific regions for CD1 or CD3, truncated Pcdh15a that contains the so-called common reg
189 etermination limit; a limited reagent amount truncates peaks from high analyte concentrations but doe
194 -kDa outer membrane-embedded protein or as a truncated phospholipase domain that remains associated w
197 lacements of these seals were described by a truncated power law distribution across several spatial
202 indicated that NP extracts generated 2 major truncated products, TSLP (residues 29-124) and TSLP (131
205 rmination codon (PTC), that leads to a 65kDa truncated protein isoform that opposes full-length eIF2B
206 ads to aberrant mRNA splicing, but no stable truncated protein was detected in the corresponding pati
211 of DNMT3A mutations are predicted to produce truncated proteins that could either have dominant negat
212 in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enzyme funct
213 rticularly the MT-2 cell line, which harbors truncated proviruses and expresses aberrant forms of the
215 th in vitro and in vivo Because N-terminally truncated pyroglutamate (pE)-modified Abeta species (Abe
218 ew carbon framework derived from convergent (truncated red cluster and exogenous hbn cluster) biosynt
220 re, we show that the ectopic expression of a truncated RocA derivative, harboring the membrane-spanni
221 -DNA knock-out mutants of At3g57630 showed a truncated root hair phenotype, as seen for mutants of al
222 eorganization and decreased stability of the truncated RRM2 domain compared to the full-length domain
223 ability and structural reorganization in the truncated RRM2 result in a higher probability of protein
226 nfirm that individuals heterozygous for BMP2 truncating sequence variants or deletions display a cons
228 a so-called 'superclamp' mutation bound to a truncated SNARE complex lacking the C-terminus of the sy
230 s, 107_A07 competes with both HGF/SF and its truncated splice variant NK1 for MET binding, despite th
232 ng a series of N-terminally and C-terminally truncated Swr1 subunits reveal further details about int
234 ds based on the chemical identities of their truncated tails, including decreased bilayer packing, de
237 ations in Caenorhabditis elegans mafr-1 that truncate the C-box retain the ability to inhibit the tra
239 be due to one nucleotide deletion that would truncate the deduced product and remove three of the six
240 it also features negative feedback by PDF to truncate the s-LNv Ca(2+) wave and terminate PDF release
243 chemically induced splice-site mutation that truncates the C-terminal region (CTR) domain of RELN pro
244 reading frame (ORF) of the target gene which truncates the coding sequence (CDS) and targets the corr
245 peptidase 4/CD26 (DPP4/CD26), an enzyme that truncates the neurotransmitter neuropeptide Y (NPY).
246 ctivity and reduce off-target binding by (a) truncating the original scaffold or (b) introducing a hy
247 ct to strong synaptic depression, presumably truncating the postsynaptic response to afferent stimuli
249 hat a vasopressin receptor (V2R) mutant with truncated third intracellular loop (V2R(DeltaICL3)) can
250 ts on myofibrils substituted with C-terminal truncated TnI showed similar compromised relaxation effe
252 LTM and prevents its subsequent induction by truncated training; moreover, later inhibition of DNMT e
253 08-CFTR, to produce functional rescue of the truncated translation product of the W1282X mutation, CF
254 rwise neurotoxic extracellular Glu through a truncated tricarboxylic acid cycle under hypoglycemic co
255 Meanwhile, viral-mediated overexpression of truncated trkB in the ventral hippocampus reduced local
256 ial melastatin-8 (TRPM8) and an N-terminally truncated TRPM8 variant (TRPM8-Delta801) are activated b
259 main (the stability core of TDP-43) and of a truncated variant (where residues 189-207 are deleted to
260 and biochemical analyses, we found that this truncated variant exhibited reduced binding to and activ
262 ing stopped-flow study on a fully functional truncated variant of human peroxidasin 1 comprising four
263 aracterize the interaction of TRN-SR2 with a truncated variant of the HIV-1 integrase, including both
264 otenoid in the absence of NTD, and name this truncated variant the C-terminal domain-like carotenoid
265 The spectroscopic characteristics of the truncated variant were not measurably different from tho
266 by homologous recombination (HR), and RAD51D truncating variant carriers have an increased risk for o
267 affected members, we identified a homozygous truncating variant in EML1, which we propose as a novel
269 iant, the only missense (rather than protein-truncating) variant in APOC3 reported to be TG lowering
271 mune responses, and the emergence in vivo of truncated variants in the major target of cellular immun
273 Examining associations involving protein-truncating variants (PTV), most at low population freque
275 ection coefficients for heterozygous protein-truncating variants (PTVs), we provide corresponding Bay
277 ic determinant in individuals with predicted truncating variants and deletions encompassing BMP2.
278 demonstrates that heterozygous RFX6 protein truncating variants are associated with MODY with reduce
281 three independent families having biallelic truncating variants in GLI1 and developmental defects ov
282 iogenesis in humans and mice and reveal that truncating variants in TPM4 cause a previously undescrib
283 e exome sequencing, we identified homozygous truncating variants in TRAK1 (NM_001042646:c.287-2A > C)
285 utively expressing full-length HWS-but not a truncated version lacking the F-box domain-display morph
286 as well as in Shigella boydii Furthermore, a truncated version of EspW, containing the first 206 resi
287 ection of mice with sporozoites expressing a truncated version of EXP-1 resulted in both a significan
290 h Delta49apolipoprotein A1 (Delta49ApoA1), a truncated version of mouse ApoA1 in which the N-terminal
292 A primase chimera, where PriX is fused to a truncated version of PriL lacking the Fe-S cluster domai
294 and C-terminal regions of SS4 by expressing truncated versions of SS4 and a fusion between the N-ter
296 porting EMSA studies with a series of DeltaC truncated versions show that a systematic deletion of th
298 portion, but not Gsalpha or an N-terminally truncated XLalphas mutant unable to interact with SNX9 o
300 This finding supports the existence of a truncated ZSWIM6 protein lacking the Sin3-like domain, w
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