ライフサイエンスコーパス: truncation

1 lity, defining the mechanistic basis of axon truncation.

2 ative translation initiation, and C-terminal truncation.

3 eads to mRNA exon skipping and ABCA4 protein truncation.

4 or genetic knockdown with shRNA abated aSyn truncation.

5 nuates DNA charge transport, inhibits primer truncation.

6 of exon 33L causes frameshift and C-terminal truncation.

7 molecule velocities are not affected by this truncation.

8 Twitchin and projectin evolved later by truncation.

9 Cox regression analysis accounting for left truncation.

10 optosis is less prominent, resulted in canal truncation.

11 ducts, mixed disulfides, rearrangements, and truncations.

12 els of mutations, insertions, deletions, and truncations.

13 teoforms including various N- and C-terminal truncations.

14 to study a collection of gp120 mutations and truncations.

15 ing L1 ORF2p pausing in the generation of 5' truncations.

16 60 cell lines with CRISPR/Cas9-mediated CD38 truncations.

17 enza viruses had a high proportion of PB1-F2 truncations (15% since 2010; 61% of isolates in 2013) du

18 Functional in vitro studies revealed that truncation abrogated the NF-kappaB inhibition capacity o

19 ies, it is important to understand how these truncations affect the organization of alphaS into fibri

20 identified an average of 23-24 missense and truncation alleles per gene, with at least one truncatio

21 The SecA truncation also increased production of 30 different pro

22 ed in cells lacking O-glycans, with N-glycan truncation also increasing cell rolling velocity on L-se

23 Truncation analyses of the non-conserved regions showed

24 e in the level of the enzyme encoded by CHO1 Truncation analysis and site-directed mutagenesis of the

25 Site-directed mutagenesis and truncation analysis of ATR1 suggests that these homologs

26 APs targeted specifically to the LD surface, truncation analysis of LDAP3 revealed that essentially t

27 By mass spectrometry, truncation analysis, site-directed mutagenesis, phosphop

28 and animals is associated with small RNA 3' truncation and 3' uridylation and thus relies on exonucl

29 PIEZO1 (a splicing variant leading to early truncation and a non-synonymous missense variant) in a p

30 Truncation and alanine mutagenesis studies revealed that

31 was mapped in detail by NMR and confirmed by truncation and alanine mutagenesis.

32 ating F-actin amounts and rescued the axonal truncation and branching phenotype in Smn-depleted zebra

33 a structure-guided design strategy that, by truncation and computational reengineering, led to a sta

34 Using truncation and mutagenesis, we showed that inactivation

35 ation and nucleotide binding, and additional truncation and point mutants mapped the alterations of T

36 TRATA, the first web-based tool for microRNA Truncation and Tailing Analysis--the analysis of 3' modi

37 uniqueness as a webtool to perform microRNA truncation and tailing analysis.

38 was assessed using Cox regression with left-truncation and time-varying exposures.

39 -based LCA, which results in system boundary truncation and underestimation of the true impact.

40 In this study, we use a combination of truncations and artificial dimerization in budding yeast

41 We describe two truncations and four missense alterations, all of which

42 brinogen region susceptible to physiological truncations and mutation.

43 eports revealed widespread 3' modifications (truncations and non-templated tailing) of plant miRNAs w

44 hat question, sequential cytoplasmic TbetaRI truncations and point mutations identified a targeting m

45 Specifically designed BC200 truncations and RNase footprinting assays demonstrate th

46 ted repression was further confirmed by HRT2 truncations and siHRT2 treatments that rescued MLCK prom

47 ng voltage-gated sodium channel, lead to its truncations and, consequently, to the inactivation of th

48 cting on AGO1-bound miRNAs to cause their 3' truncation, and the truncated species are uridylated and

49 Recently, a C-terminal truncation (apoA-I(Delta185-243)) was crystallized as a

50 lectronic responses unfiltered by artificial truncation are then required to embody the terms that ti

51 mutations of ASXL1 that result in premature truncations are frequent in myeloid leukemias and Bohrin

52 pressing telomerase (e.g., bone marrow), the truncations are healed.

53 ncluding phosphorylation, ubiquitination and truncation, are characteristic features of tau present i

54 A truncation artifact in the spinal cord could be misinter

55 induced by kainic acid (KA) caused GSK-3beta truncation at C-terminus and hyperphosphorylation of tau

56 es were identified as light chain C-terminal truncation at Gly93 and oxidized heavy chains at Met40,

57 t neighbor (KNN) approach which accounts for truncation at the minimum value, i.e., KNN truncation (K

58 Left truncation bias was addressed by restricting analyses to

59 C-terminal truncation by the inflammatory protease caspase-1 has re

60 genetic impact, we evaluated whether histone truncation by tryptase could have an impact on epigeneti

61 Heterozygous BRCA2 truncations, by lowering pre-existing BRCA2 expression,

62 Age truncation can negatively affect population and communit

63 We analyzed a mouse model carrying a poly(A) truncation cassette inserted to prevent RNA transcripts

64 The sites of truncation coincide with stem-loop structures and SRP9/1

65 N- and C-terminal truncations comprised 73% and 30%, respectively, of the

66 Here we demonstrate that ASXL1 truncations confer enhanced activity on the ASXL1-BAP1 c

67 Truncation constructs lacking the acidic region or arm-l

68 also found that many strains expressing ede1 truncations could support a normal rate of site initiati

69 uipotent to the full-length peptide, further truncation decreases potency at the MC3R and MC4R.

70 Truncation, deletion, and mutation of this distal AP-1 s

71 in expression of the TP53 dominant negative truncations DeltaNTrp63 and DeltaNTrp73.

72 Mapping analysis with AKAP350A truncations demonstrated that AKAP350A contains discrete

73 These truncations demonstrated that SL3 is necessary for Pxr f

74 In mE7M-B6 mice, the exon 7-associated truncation diminished morphine tolerance and reward with

75 N-terminal truncations disrupt mVP24 dimerization, allowing monomer

76 Genetic analysis suggested that CTR truncation disrupts an interaction with the RELN recepto

77 This suggests that CTR-truncation disrupts an interaction with VLDLR (very low-

78 However, Siglec-1 protein truncation does not have a measurable impact on HIV-1 ac

79 This N-terminal truncation does not significantly affect Brr2's helicase

80 uppression of a stop codon can be limited by truncation due to competition with release factors.

81 is IVS7+2T>G, which causes premature protein truncation due to skipping of exon 7.

82 LSR truncations ectopically expressed in LSR knock-out cells

83 ix is required for association with actin as truncation eliminates binding.

84 through three mechanisms: MYB activation by truncation, enhancer translocation driving aberrant MYB-

85 on of Soluble Proteins by Random Incremental Truncation (ESPRIT) technique to identify discretely fol

86 on (14.2-21.4%) CRISPR/Cas9-induced specific truncation events, either from GhMYB25-like A DNA site o

87 iated by a truncated N-terminal tail, though truncations exceeding half of the tail length were no lo

88 Truncation experiments revealed that the cytoplasmic jux

89 Our data support the assessment of PB1-F2 truncations for genomic surveillance of influenza viruse

90 ther, the differential effects of C-terminal truncation illustrate the pharmacological importance of

91 Here, we quantified the extent of age truncation in 63 fished populations across five ocean re

92 ere, we investigate the effect of C-terminal truncation in GLP-1 and Ex-4 on the cAMP pathway.

93 Axon truncation in kbp(st23) mutants can be suppressed by SCG

94 A KIF3AC encoding a truncation in KIF3C loop L11 (KIF3ACDeltaL11) exhibited

95 al dependence, whereas the exon 4-associated truncation in mE4M-B6 mice facilitated morphine toleranc

96 Sequencing revealed a partial truncation in the C-terminal tail of Env that had emerge

97 ion, Hic binds specifically hTSP-1; however, truncation in the N-terminal part of Hic decreases the b

98 ass of exonucleases responsible for miRNA 3' truncation in vivo and uncovers a mechanism of specifici

99 We find that the frequency of rare germline truncations in 114 cancer-susceptibility-associated gene

100 analyses with RNA sequencing, we explain why truncations in the A-band domain of TTN cause DCM, where

101 dilated cardiomyopathy patients harbor Titin truncations in the C-terminal two-thirds of the protein,

102 the A-band domain of TTN cause DCM, whereas truncations in the I band are better tolerated.

103 we generated six zebrafish lines with Titin truncations in the N-terminal and C-terminal regions.

104 iridophore shape and organisation caused by truncations in Tight Junction Protein 1a (ZO-1a).

105 res that reduce the impact of fishing on age truncation, including no-take areas, slot limits that pr

106 uR agonist, DHPG, did not result in B56alpha truncation, increased Arc synthesis and reduced levels o

107 The pervasiveness and intensity of age truncation indicates that fishing is likely reducing the

108 or their carboxy terminus as well as certain truncations induce active conformations of (beta-)arrest

109 The truncation-induced aggregation of aSyn is toxic to neuro

110 es DNA replication, by 85%, and that further truncation into the alpha-helical region compromises the

111 For some metrics, particularly when truncation is less frequent for a metabolite, mean cente

112 s frequently lost in these cancer-associated truncations is the SAMP repeats that mediate interaction

113 r truncation at the minimum value, i.e., KNN truncation (KNN-TN).

114 sulted in a premature stop codon and protein truncation leading to complete loss of function and loss

115 s or a melanoma-associated GbetaL(DeltaW297) truncation, leads to elevated mTORC2 formation, which fa

116 Serial truncation mapping identified the cleavage site as Leu(9

117 m defects in Mybphl mice support that MYBPHL truncations may increase risk for human arrhythmias and

118 orming activity of BRAF fusions results from truncation-mediated loss of inhibitory domains within th

119 studies of prevalent exposures involve left truncation (missingness on the left), studies of inciden

120 We found, using site-directed and truncation mutagenesis, surface plasmon resonance, nucle

121 4E, T269E, and S256E/T269E) and a C-terminal truncation mutant (DeltaP242) that lacked all phosphoryl

122 use kidney epithelial cells that PC1 and its truncation mutant comprising the last five transmembrane

123 of unbound TIS11d, the E220A mutant and the truncation mutant lacking the last two residues (D219/E2

124 A truncation mutant lacking the N terminus (DeltaN) was fo

125 rate that full-length CarO and a "loop-less" truncation mutant mediate small-molecule uptake at low l

126 ribe the isolation and characterization of a truncation mutant of pUL25.

127 t its familial adenomatous polyposis-related truncation mutant, prominently enhances HIV-1 production

128 Using truncation mutants and site-directed mutagenesis, we def

129 oprecipitation experiments we found that PC1 truncation mutants associate with PKR, or with PKR and i

130 rminal portion in the non-functional Orai1 N-truncation mutants formed new, inhibitory interactions w

131 Truncation mutants lacking the motor region failed to lo

132 cell HIV-1 infection, particularly for short-truncation mutants of </=43 amino acids or mutants with

133 A series of additional truncation mutants of Calkro_0111 revealed the essential

134 Here we made truncation mutants of Ede1 to better understand how diff

135 us (RSV) Gag protein and in parallel several truncation mutants of Gag and have studied their biophys

136 Using TALE truncation mutants, we further demonstrate that the N-te

137 By analyzing truncation mutants, we identified that the C-terminal 30

138 Using truncation mutants, we identified that the N-terminal BA

139 Using a series of truncation mutants, we mapped a C-terminal domain that i

140 The truncation mutants, which encompass the IP3-binding doma

141 of wild type drTRPM7 and multiple C-terminal truncation mutants.

142 erences are cell type dependent for large-CT-truncation mutants.

143 fferent, isoform-specific behavior of Orai N-truncation mutants.

144 Interestingly, a CSF3R cytoplasmic truncation mutation (W791X) found on the same allele as

145 DHSs and provide examples of high-resolution truncation mutation analysis for multiplex parsing of CR

146 From truncation mutation analysis, the capacity for XAB2 to p

147 We amassed Titin truncation mutation information from 1714 human dilated

148 eads to instability of its substrates and as truncation mutation of MRE11 lacking serines 688/689 lea

149 adult-onset cerebellar ataxia, and a de novo truncation mutation resulting in a dominant-negative eff

150 In addition, the truncation mutation was found to be a risk factor for th

151 substitution mutation, termed tel1-21, and a truncation mutation, called tel1-DeltaC, did not signifi

152 Ten mutations were missense and one was a truncation mutation; de novo occurrence could be shown i

153 Truncation mutations and site-directed mutagenesis confi

154 rdiac disorders indicated that subjects with truncation mutations had an earlier occurrence of cardia

155 Three independent truncation mutations identified in each of these genes d

156 Genetic analysis showed truncation mutations in 58 patients from 31 families and

157 that other methods did not detect, including truncation mutations in known tumor suppressors and the

158 We also identified activating truncation mutations in other tumor types that were sens

159 The truncation mutations were associated with manifestation

160 Oncogenic surface antigen truncation mutations were detected in entecavir-treated

161 Furthermore, using truncation mutations, we show that the coiled-coil domai

162 omain of Tel1 by introducing substitution or truncation mutations.

163 Truncations, N-terminal methionine excision, signal pept

164 Truncation of a known PAR4 antagonist and identification

165 calcium channel opening, and resulted in the truncation of a regulatory subunit of PP2A, B56alpha.

166 F-actin across Sertoli cell cytosol, causing truncation of actin microfilament, thereby failing to su

167 fic trait variation by, for example, causing truncation of age and size structure of populations, whe

168 of a hypomorphic desmoglein 3 protein with a truncation of an extracellular cadherin domain.

169 The major catabolite [3-285] was formed by truncation of AP at the N-terminus and the minor catabol

170 return, regulates the nonlocal transport by truncation of avalanches by local sheared toroidal flows

171 In CRC cell lines, truncation of DATE activated expression of HGF, resultin

172 Truncation of DYRK1A in patients with developmental dela

173 tease generates a high-affinity IRES binding truncation of eIF4G that stimulates eIF4A duplex unwindi

174 b and GPER/GPR30 is substantially reduced by truncation of either or both of their C-terminal PDZ-bin

175 dition zone is likely to have contributed to truncation of eve(RNAi) embryos.

176 Given that N-terminal truncation of G1 and other adhesion G protein-coupled re

177 e of the patients with homozygous C-terminal truncation of GLI1 demonstrated that the corresponding m

178 of PMCA activity is significantly reduced by truncation of GPER/GPR30's C-terminal PDZ-binding motif.

179 These findings suggest that truncation of GSK-3beta by Ca(2+)/calpain I markedly inc

180 Truncation of HDC1 to the ancestral core sequence narrow

181 modulate WNT signalling both resulted in the truncation of head structures.

182 Similar truncation of HORMAD1 in mouse spermatocytes compromises

183 , notably, failure to address batch-specific truncation of low abundance compounds.

184 nfold MAD2 in the presence of ATP N-terminal truncation of MAD2 renders it refractory to TRIP13 actio

185 at the mutation in aura is associated with a truncation of Mid1 interacting protein 1 like (Mid1ip1l)

186 Truncation of PB1-F2 has been proposed to act as an adap

187 dimerization affinities, results in a severe truncation of proximal-anterior limb elements.

188 Conditional truncation of RhopH3 substantially reduces invasive capa

189 cell-based experiments demonstrate that the truncation of segments of the HIV-1 5'-untranslated regi

190 n pressure, resulting in progressive loss or truncation of tas3 and chp1 genes in S. octosporus and S

191 and three peptide antagonists obtained by N-truncation of the agonists.

192 In contrast, truncation of the C-terminal 40 residues in NavAb/1-226

193 ariants identified in our study suggest that truncation of the C-terminal domain of DVL1, a protein h

194 A new Reln mutant with a truncation of the C-terminal region (CTR) domain shows t

195 Employing structure-based design, truncation of the cyanophenyl group of 6 that binds in t

196 All of these rearrangements result in truncation of the cytoplasmic tail of EPOR at residues s

197 Truncation of the DHX34 CTD does not affect binding to U

198 h a DIAPH1 R1213* variant predicting partial truncation of the DIAPH1 diaphanous autoregulatory domai

199 nstrate that beta2A/B-tubulin is modified by truncation of the four C-terminal residues (EDEA).

200 a greater specificity increase in vivo with truncation of the gRNA homology regions.

201 20) precluded viral replication, whereas the truncation of the last 10 amino acids from the pUL33 C t

202 utational experiments disclosed that neither truncation of the MaLPMO10B family 2 carbohydrate-bindin

203 facial morphology in Vax1 mutants, including truncation of the midface associated with reduced cell p

204 ption of TACI-mTOR interaction by rapamycin, truncation of the MyD88-binding domain of TACI, or B-cel

205 Cambodian isolate varies only in C-terminal truncation of the p6 T cell epitope, raising the possibi

206 Intriguingly, the truncation of the PafE carboxyl-terminus resulted in the

207 These trends can be explained by demographic truncation of the population's age structure, phenotypic

208 nal cord regeneration in geckos represents a truncation of the restorative trajectory observed in som

209 Additionally, we demonstrated that truncation of the Rpn8 C-terminal disordered region does

210 Truncation of the S3 substituent of the biaryl aminothia

211 Thus, truncation of the S3 substituent represents a viable app

212 r/data system is saturated, causing clipping/truncation of the signal, or (c) the detector signal is

213 ic activities will soon precipitate a double truncation of the size distribution of the world's verte

214 lection who carry a TPM4 variant that causes truncation of the TPM4 protein and segregates with macro

215 Truncation of their cytoplasmic tail has little effect o

216 nt of chronic hepatitis C (HCV) includes the truncation of therapy from 12 to 8 weeks in treatment na

217 Truncation of these residues to alanine causes significa

218 Truncation of this domain renders the channel hyperactiv

219 Truncation of this EAP region impairs zorO translation,

220 C-terminal truncation of TREX1 by fs mutations dysregulated the OST

221 convertase were rate-limiting enzymes in the truncation of TSLP between residues 130 and 131 and gene

222 We sought to investigate the mechanisms of truncation of TSLP in NPs and the function of the trunca

223 Toxicity is suppressed by truncation of Uso1, a vesicle tether required for endopl

224 apped to the carboxyl acidic domain of TSPX, truncation of which renders TSPX to be stimulatory while

225 We found that small truncations of 28 to 43 amino acids (aa) or two LLP-3 po

226 Conversely, large truncations of 93 to 124 aa severely impaired cell-to-ce

227 erminus and the minor catabolite [29-270] by truncations of either side of the TN-ApoA1 sequence.

228 Additionally, C-terminal truncations of GASP-1 result in less potent myostatin in

229 tion of isolated domain A, and mutations and truncations of it, by methods including selective 2'OH a

230 C-terminal truncations of monomeric wild-type alpha-synuclein (henc

231 y catalyzes SUMOylation, we examined various truncations of PIASy for their ability to mediate SUMOyl

232 N-terminal truncations of the activated p12-I63-GFP indicated that

233 (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline significan

234 mutations have been described that result in truncations of the intracellular carboxyl terminus of hC

235 In this study, we used structure-guided truncations of the PB2 subunit to show that a PB2 subuni

236 ature stop codons that are expected to cause truncations of the protein, whereas avian IAVs usually e

237 A series of truncations of the tail region indicated that these 18 r

238 al/mol of kinetic barrier stabilization upon truncation, of which 4.4 kcal/mol was regained in the pr

239 s experimental results for the impact of CTD truncation on the nucleocapsid stability.

240 ntial role of RbpA, show the effects of RbpA truncations on transcription and cell physiology, and in

241 Strains harboring a truncation or a T28C substitution in erm(41) lose the in

242 llar assembly, some mutations that result in truncation or abolition of the glycan reduce bacterial m

243 uncation alleles per gene, with at least one truncation or deleterious missense mutation in more than

244 e most homogeneous preparations by construct truncation or intricate seeding protocols.

245 activity of the DYW deaminase domain through truncation or mutagenesis of the HXE motif.

246 ch a loop2 swap restored activation of the N-truncation Orai1 mutants.

247 low a truncated normal distribution with the truncation point at the detection limit (LOD).

248 nd more insoluble aggregates with N-terminal truncations predominating in the insoluble material and

249 A progressive sequence truncation procedure is then used for editing the models

250 ferent methodological factors (size-effects, truncation procedures, long-range corrections and potent

251 The truncation product, Deltatau314, resists fibrillation an

252 cal modifications uses reverse transcriptase truncation products, which introduce biases and necessit

253 thway in which template-directed, endogenous truncation propagates aggregation through the core Tau b

254 We derive boundary-independent scaling and truncation properties, which are consistent with numeric

255 Importantly, two autism-associated truncations, R205X and E239X, were shown to be Dyrk1a lo

256 upported the conformational switch by serial truncation removing 22 (DeltaN22), 32 (DeltaN32), or 42

257 for the essential cofactor NADPH, while LBR truncations render the mutant protein metabolically unst

258 An EXO70 protein with a C-terminal truncation results in dominant ES2 resistance, uncoverin

259 Analysis of ectopically expressed MceA truncations revealed that the capacity to traffic to mit

260 ng in the insoluble material and C- terminal truncations segregating into the soluble aggregates.

261 A RELN-binding assay confirms that CTR truncation significantly decreases RELN binding to VLDLR

262 We found different levels of C-terminal truncation, soluble protein aggregates, and glycation th

263 er genes with significant enrichment of rare truncations, some associated with specific cancers (for

264 cosylation defect that results in N-terminal truncation stabilizes beta1ARs in a conformation that is

265 Herein, a truncation structure-activity relationship study of chim

266 say, CD analysis, melting curve analysis and truncation studies.

267 Our aptamer truncation study indicated that the hairpin-loop structu

268 ty in limbs undergoing PD duplication versus truncation, suggesting differences in patterning and ske

269 RHAU truncations support binding that is dependent upon a reg

270 65/6 is more susceptible to SDN1-mediated 3' truncation than AGO1-bound miR165/6.

271 isoforms, Orai3 tolerates larger N-terminal truncations than Orai1 in retaining store-operated activ

272 ral and dynamical changes resulting from the truncation that could lead to aggregation and toxicity,

273 pletion or expression of a dominant-negative truncation that models the chromosomal translocation of

274 xtended 3' overhangs and stochastic telomere truncations that could be healed by telomerase.

275 The majority of LKB1 mutations are truncations that disrupt its kinase activity and remove

276 vels or location of gm-hir1 expression while truncation to 370 bp resulted in a complete loss of expr

277 h throughput screening (HTS) hit followed by truncation to its minimal pharmacophore provided an inda

278 of glycine residues in collagen peptides and truncation to the smallest self-assembling collagen pept

279 of Pro-Hyp-Gly triplet repeats, allowing for truncation to the smallest self-assembling peptide syste

280 Here we generated a collection of PB2 truncations to identify a PB2 protein representative of

281 ding, insertions and deletions (indels), and truncations, to unmodified bases in the same contexts.

282 of dilated cardiomyopathy (DCM) due to titin truncation (TTNtv) may help guide patient stratification

283 py studies that indicate that the C-terminal truncation variant of alphaS, lacking residues 109-140 (

284 ture of the IFN-beta-IFNAR1 complex, we used truncation variants and site-directed mutagenesis to inv

285 del to explain the observed pattern of Titin truncation variants in patients with dilated cardiomyopa

286 rgeted (in keeping with the observation that truncation variants in this region escape nonsense-media

287 830+2_830+3insT mutations lead to C-terminal truncation variants of MECR.

288 Our investigation of N-terminal truncation variants shows this region is required for DN

289 Using truncation variants, crosslinking and translocation assa

290 table in 14% (11 of 78) of CRC samples; DATE truncation was also polymorphic and detected in 18% (13

291 ing of distal-associated genes, whereas limb truncation was associated with disrupted skeletal differ

292 Although N-terminal domain truncation was necessary for crystal formation, it resul

293 Through a series of truncations, we define a minimum recognition sequence (R

294 Using purified components, and Loqs-PD truncations, we provide a mechanistic basis for Loqs-PD

295 Using a series of C-terminal truncations, we show that the CSPG4-binding site on TcdB

296 transgenes expressing OTP84 with C-terminal truncations were capable of editing only one of the thre

297 These truncations were homeostatic but primate-specific events

298 d to wild-type levels but exhibited the same truncation, which resulted in the absence of the essenti

299 amycin provides salinisporamycin, which upon truncation with loss of the naphthoquinone ring leads to

300 Therefore, Disorder prediction-based truncation would be helpful to efficiently improve the e