ライフサイエンスコーパス: trypanosomatid

1 nce against chemical and oxidative stress in trypanosomatids.

2 onserved among syntenic genes from different trypanosomatids.

3 rt, resulting in higher gene density than in trypanosomatids.

4 number and with protein expression level in trypanosomatids.

5 organellar C to U editing of tRNAs occurs in trypanosomatids.

6 on is available for monoxenous (single-host) trypanosomatids.

7 Splicing is essential for mRNA maturation in trypanosomatids.

8 efence against oxidative stress in parasitic trypanosomatids.

9 her PAB1 sequences, including those of other trypanosomatids.

10 trans splicing of polycistronic pre-mRNAs in trypanosomatids.

11 ual feature of these cysteine proteinases of trypanosomatids.

12 ll as other important metabolic processes in trypanosomatids.

13 wer range of amino donors than seen with the trypanosomatids.

14 y functional methionine-recycling pathway in trypanosomatids.

15 nization and segregation of kDNA networks in trypanosomatids.

16 genes within polycistronic gene clusters in trypanosomatids.

17 truction of evolutionary relationships among trypanosomatids.

18 s an important regulatory epigenetic mark in trypanosomatids.

19 land plants and excavate protists, including trypanosomatids.

20 othione, the major low mass thiol present in trypanosomatids.

21 by gene duplication and is found only in the trypanosomatids.

22 nent of key glycoproteins and glycolipids in trypanosomatids.

23 of the role of OPBs as virulence factors in trypanosomatids.

24 Ribosomes of trypanosomatids, a family of protozoan parasites causing

25 Uniquely, the genomes of trypanosomatids, a group of kinetoplastid protozoa of si

26 Trypanosomatids, a group of kinetoplastid protozoans, po

27 e in trypanosomatids and detailed studies of trypanosomatid adenylyl cyclases (ACs) and phosphodieste

28 We previously showed that trypanosomatid AdoMetDC differs from other eukaryotic en

29 In both tetrameric trypanosomatid aldolases, the PTS2s from two different s

30 Trypanosomatids also possess at least three variant hist

31 In trypanosomatids, alterations in gene expression in respo

32 in several unicellular eukaryotes, including trypanosomatid and apicomplexan parasites, algae, and sl

33 in several unicellular eukaryotes, including trypanosomatid and apicomplexan parasites, algae, and sl

34 storage compartments described initially in trypanosomatid and apicomplexan parasites.

35 o drugs that exploit polyamine metabolism of trypanosomatid and malaria parasites, and propose priori

36 Tyr210 is present in trypanosomatid and plant iPGAMs, but not in the enzymes

37 any thiol metabolism, has been elucidated in trypanosomatids and anaerobes.

38 arch linking cAMP signalling to virulence in trypanosomatids and detailed studies of trypanosomatid a

39 genome contains both sequences homologous to trypanosomatids and sequences never seen before.

40 system for studying the interactions between trypanosomatids and their hosts.

41 uctase (NTR) located in the mitochondrion of trypanosomatids and, at the same time, act as inhibitors

42 the closest known non-parasitic relative of trypanosomatids, and a second bodonid, Trypanoplasma bor

43 ion of either process leads to cell death in trypanosomatids, and genetic ablation of NMT compromises

44 tively with PTS1 motif binding or release in trypanosomatids, and would therefore disrupt glycosome b

45 operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling.

46 Gene expression in trypanosomatids appears to be regulated largely at the p

47 Trypanosomatids are causative agents of several devastat

48 ic analysis finds that Drosophila-associated trypanosomatids are closely related to taxa that are res

49 Trypanosomatids are flagellated protists that diverged e

50 Certain pathogenic trypanosomatids are highly dependent on glycolysis for A

51 The trypanosomatids are highly divergent organisms and posse

52 nt, suggesting that signalling mechanisms in trypanosomatids are highly unusual.

53 Trypanosomatids are important parasites and include the

54 Although trypanosomatids are known to rapidly transaminate exogen

55 Trypanosomatids are one of the earliest diverging eukary

56 Trypanosomatids are parasitic protozoa with a significan

57 Trypanosomatids are pathogenic protozoa that undergo a u

58 Interestingly, trypanosomatids are the only single-celled eukaryotes kn

59 g-specific spliced leader RNA, suggests that trypanosomatids assemble a highly divergent set of these

60 these appear to represent a small segment of trypanosomatid biodiversity, which still remains to be u

61 ped a method that takes advantage of unusual trypanosomatid biology and skews in nucleotide compositi

62 R), a flavoprotein oxidoreductase present in trypanosomatids but absent in human cells, is regarded a

63 terminal residues are fully conserved in the trypanosomatids but are absent from other eukaryotic hom

64 acterised recently as a flagellum protein in trypanosomatids, but associated with the conoid in apico

65 ee distinct enzyme families: (1) dUTPases in trypanosomatides, C.jejuni and several other Gram-negati

66 Parasitic trypanosomatids cause important diseases.

67 Trypanosomatid cells possess an extremely precise organi

68 tion is a target for the development of anti-trypanosomatid chemotherapeutics.

69 the emergence of viruses within an important trypanosomatid clade relevant to human disease.

70 WI-tryp in T. cruzi and other members of the trypanosomatid clade.

71 The trypanosomatid coiled-coil NUP-1 protein is a lamina com

72 DNA (kDNA), the form of mitochondrial DNA in trypanosomatids, consists of thousands of interlocked ci

73 toplast DNA (kDNA), the mitochondrial DNA of trypanosomatids, consists of thousands of minicircles an

74 RNA editing in Trypanosomatids creates functional mitochondrial mRNAs b

75 e mitochondrial DNA (kinetoplast DNA) of the trypanosomatid Crithidia fasciculata consists of minicir

76 e mitochondrial DNA (kinetoplast DNA) of the trypanosomatid Crithidia fasciculata has an unusual stru

77 ) encoding a mitochondrial DNA ligase in the trypanosomatid Crithidia fasciculata, and we show that a

78 The DNA polymerase beta from the trypanosomatid Crithidia fasciculata, however, was the f

79 te periodically during the cell cycle in the trypanosomatid Crithidia fasciculata.

80 primase from a mitochondrial fraction of the trypanosomatid Crithidia fasciculata.

81 des a metabolic bypass for inhibition of the trypanosomatid dihydrofolate reductase and therefore com

82 litation of nitro drugs for the treatment of trypanosomatid diseases and discuss the future prospects

83 s involved in disease phenotype in all three trypanosomatid diseases, with a particular focus on rece

84 Gene gain and loss continued during trypanosomatid diversification, resulting in the asymmet

85 lation, life cycle stage differentiation and trypanosomatid division in general.

86 cell cycle regulation of the mRNA levels of trypanosomatid DNA replication genes may be mediated by

87 These data suggest that trypanosomatids do not obey the general 5-bp rule for sn

88 anosoma brucei is a rational target for anti-trypanosomatid drug design because glycolysis provides v

89 uation of the structure-based design of anti-trypanosomatid drugs, parasite-selective adenosine analo

90 out the consequences of such modification in trypanosomatids, early branching protozoa of significant

91 rp1-3) have been identified in the parasitic trypanosomatids, early branching protozoa with no previo

92 In Trypanosomatids, endocytosis and exocytosis occur exclus

93 The related trypanosomatid Endotrypanum monterogeii also produced a

94 compounds that selectively inhibit all three trypanosomatid enzymes but not the human homologue.Adeno

95 In trypanosomatids, etiological agents of devastating disea

96 re associated with an extensive diversity of trypanosomatids (Euglenozoa, Kinetoplastea).

97 unction provide the principal innovations in trypanosomatid evolution.

98 es having large TR domains was unique to the trypanosomatids examined, including T. cruzi.

99 view the properties of histones in parasitic trypanosomatids, from gene organization and sequence to

100 or the high affinity of these inhibitors for trypanosomatid GAPDHs.

101 ng complementation of function between these trypanosomatid genes.

102 ngle tyrosyl-tRNA synthetase (TyrRS) gene in trypanosomatid genomes codes for a protein that is twice

103 Analysis of trypanosomatid genomes showed that the core cohesin and

104 ing the shared and derived features of known trypanosomatid genomes, but it will also identify those

105 We show that gene loss has "streamlined" trypanosomatid genomes, particularly with respect to mac

106 vidence defines the parasitic innovations of trypanosomatid genomes, revealing how a free-living phag

107 d innovation contributed to the character of trypanosomatid genomes.

108 se J-associated glucosyltransferase (JGT) in trypanosomatid genomes.

109 comparative analyses of existing and future trypanosomatid genomic resources.

110 i-fibrillarin antibodies indicated that this trypanosomatid has at least 30 fibrillarin-associated sn

111 Trypanosomatids have a large number of predicted RNA-bin

112 a major role in H(2)O(2)-detoxification, but trypanosomatids have been reported to lack this activity

113 Trypanosomatids have several remarkable and unique metab

114 was typically conserved for those genes with trypanosomatid homologs, strict colinearity was rarely o

115 eculiarities of the replication machinery in trypanosomatids, including how such divergence might aff

116 ncestral features, while evolution of extant trypanosomatids, including the human parasites, is assoc

117 TR, regarded as an ideal drug target against trypanosomatid infections, is a homodimeric flavoprotein

118 s a potential target for the chemotherapy of trypanosomatid infections.

119 rk underlines the importance of studying the trypanosomatid intracellular life cycle stages to gain a

120 As in trypanosomatids, introns were absent and %GC was elevate

121 However, our knowledge about this pathway in trypanosomatids is very limited.

122 kDNA, the mitochondrial genome of trypanosomatids, is a DNA network composed of several th

123 Trypanosomatids lack gene regulation at the level of tra

124 Leishmania and other trypanosomatids lack glutathione reductase, and therefor

125 Trypanosomatids lack Tom40, however, and use instead a p

126 To find additional trypanosomatid lamina components we identified NUP-1 int

127 I-glucoxylan) synthesized by the monogenetic trypanosomatid Leptomonas samueli has been determined.

128 to two of the three promoter elements in the trypanosomatid Leptomonas seymouri.

129 istent with the lack of heme biosynthesis in trypanosomatids, LHR1 and LABCG5, a protein involved in

130 y play distinct roles at some time points in trypanosomatid life cycles and collaborative or redundan

131 in the RNAi pathway during evolution of the trypanosomatid lineage.

132 nd the evolution of human parasitism in some trypanosomatid lineages.

133 The unique aspects of the biochemistry of trypanosomatids make rational drug design an attractive

134 The findings reveal how trypanosomatids may compensate for a paucity of canonica

135 s great importance for the regulation of the trypanosomatids' metabolism and can, dependent on enviro

136 nscriptomic surveys, which likely arise from trypanosomatid microbiota.

137 RNA ligase-containing complex (L-complex) in trypanosomatid mitochondria interacts by means of RNA li

138 Uridine insertion/deletion RNA editing in trypanosomatid mitochondria is a posttranscriptional RNA

139 Kinetoplast DNA (kDNA), from trypanosomatid mitochondria, is a network containing sev

140 Transcripts for key trypanosomatid mitochondrial proteins undergo extensive

141 In trypanosomatids, monoxeny is ancestral to dixeny, thus i

142 Thus, trypanosomatids must use post-transcriptional control me

143 A deep-branching clade of trypanosomatid narnaviruses was found, notable as Leptom

144 nt network and identifying NUP-2 as a second trypanosomatid nuclear lamina component.

145 Glycosome biogenesis in trypanosomatids occurs via a process that is homologous

146 This is the first example in trypanosomatids of the production of nuclear and mitocho

147 ulence, inhibition of TOR kinase function in trypanosomatids offers an attractive target for chemothe

148 p31 and its trypanosomatid orthologues were identified, but their am

149 A pol beta from the trypanosomatid parasite Crithidia fasciculata, however,

150 Species of the trypanosomatid parasite genera Trypanosoma and Leishmani

151 Trypanosomatid parasite infections have a devastating im

152 ase mining revealed three TOR kinases in the trypanosomatid parasite Leishmania major, as defined by

153 e-3-phosphate dehydrogenase (GAPDH) from the trypanosomatid parasite Leishmania mexicana in a new cry

154 the folate and biopterin transporters of the trypanosomatid parasite Leishmania.

155 TR plays a central role in the trypanosomatid parasite's defense against oxidative stre

156 Genetically, the populations of the trypanosomatid parasite, Crithidia bombi, sampled in 200

157 ing was unexpected since genome databases of trypanosomatid parasites appeared to lack general class

158 Kinetoplastea such as trypanosomatid parasites contain specialized peroxisomes

159 Trypanosomatid parasites infect over 21 million people w

160 Mitochondrial mRNA editing in trypanosomatid parasites involves several multiprotein a

161 Regulation of gene expression in trypanosomatid parasites is predominantly post-transcrip

162 Trypanosomatid parasites of the genus Leishmania synthes

163 Trypanosomatid parasites provide an extreme model for th

164 ease in a caspase-independent PCD pathway in trypanosomatid parasites since caspases have not been id

165 I or type II synthases to make fatty acids, trypanosomatid parasites such as Trypanosoma brucei are

166 GPI structures are particularly abundant in trypanosomatid parasites where they can be found attache

167 In trypanosomatid parasites, reduction of such oxidized pte

168 Like other trypanosomatid parasites, they are purine auxotrophs (i.

169 For trypanosomatid parasites, this is mediated by type I nit

170 of the globin family is still unknown in the trypanosomatid parasites, Trypanosome and Leishmania.

171 astid and among the closest relatives of the trypanosomatid parasites, which cause such human disease

172 idants, xenobiotics and methylglyoxal in the trypanosomatid parasites, which cause trypanosomiasis an

173 are peroxisome-like organelles essential for trypanosomatid parasites.

174 x polypeptides that are conserved only among trypanosomatid parasites.

175 protein, AIR9, conserved in land plants and trypanosomatid parasites.

176 nt on glycolysis for ATP production, such as trypanosomatid parasites.

177 mals, it is obligatory in mRNA maturation of trypanosomatid parasites.

178 ase (3'-NT/NU) is a surface enzyme unique to trypanosomatid parasites.

179 the most fascinating and unusual features of trypanosomatids, parasites that cause disease in many tr

180 The primitive trypanosomatid pathogen of humans, Leishmania donovani,

181 y LmexCht1-chitinase gene from the primitive trypanosomatid pathogen of humans, Leishmania mexicana.

182 ells are asexual diploids, as are some other trypanosomatids, pathogenic fungi, and cultured mammalia

183 uated against the three most important human trypanosomatid pathogens (Trypanosoma brucei rhodesiense

184 uated against the three most important human trypanosomatid pathogens (Trypanosoma brucei rhodesiense

185 T. brucei and other trypanosomatid pathogens require a distinct form of post

186 It is found in bacteria, plants, and trypanosomatid pathogens, where it has been identified a

187 The trypanosomatids possess a single N-myristoyltransferase

188 However, trypanosomatid primary rRNA transcripts can first be pro

189 de novo assembly will be necessary, existing trypanosomatid projects will provide some guide to annot

190 ect genomes, including Drosophila, and three trypanosomatid protists.

191 escribed in the kinetoplast-mitochondrion of trypanosomatid protists.

192 , this structure appears to be common to all trypanosomatid protozoa and defines a novel class of cap

193 Gene expression in trypanosomatid protozoa is largely regulated posttranscr

194 mRNA cap formation in trypanosomatid protozoa is mediated through trans-splici

195 e of the unique aspects of RNA processing in trypanosomatid protozoa is the presence of a cap 4 struc

196 Among trypanosomatid protozoa the mechanism of RNA interferenc

197 In the mitochondria of trypanosomatid protozoa the precursors of messenger RNAs

198 Last, these studies call attention in trypanosomatid protozoa to the key metabolic intermediat

199 e unique thiol-redox system that operates in trypanosomatid protozoa, has been proposed as a potentia

200 Kinetoplast DNA, the mitochondrial DNA of trypanosomatid protozoa, is a network containing several

201 ional mechanisms remain poorly understood in trypanosomatid protozoa.

202 he mitochondrial, kinetoplast DNA network in trypanosomatid protozoa.

203 into the human parasite Leishmania major, a trypanosomatid protozoan belonging to one of the most an

204 The genome of the trypanosomatid protozoan genus Leishmania has been shown

205 The xenotransfection of this trypanosomatid protozoan led to their expression of the

206 However, mutants of the trypanosomatid protozoan Leishmania lacking serine palmi

207 sential roles in most eukaryotes, but in the trypanosomatid protozoan Leishmania major their function

208 lex IV) from kinetoplast mitochondria of the trypanosomatid protozoan Leishmania tarentolae.

209 To survive in its sand fly vector, the trypanosomatid protozoan parasite Leishmania first attac

210 dentification of drug resistance loci in the trypanosomatid protozoan parasite Leishmania major.

211 Trypanosomatid protozoans depend upon exogenous sources

212 ent short-chain reductase found in parasitic trypanosomatid protozoans.

213 Expression of a trypanosomatid pterin reductase (PTR1) enabled rescue of

214 we show that Crithidia luciliae, a primitive trypanosomatid, purine auxotroph, up-expressed its uniqu

215 While dixenous trypanosomatids represent one of the most dangerous path

216 rminal region, which is conserved only among trypanosomatid RET1 enzymes.

217 Genome comparison between trypanosomatids reveals that these parasites have evolve

218 study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug ta

219 To investigate the architecture of the trypanosomatid ribosomes, we determined the 2.5-A struct

220 Trypanosomatid RNA editing is a unique process and essen

221 These data indicate that trypanosomatid RNA editing is orchestrated by a variety

222 bic residues that are highly conserved among trypanosomatid RNA editing ligases which may play a role

223 Previously we showed that trypanosomatid S-adenosylmethionine decarboxylase (AdoMe

224 Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMe

225 nto the bodonid genome sequence, relative to trypanosomatid sequences.

226 nomes are available for dixenous (two hosts) trypanosomatid species of the genera Trypanosoma, Leishm

227 atty acid and sterol biosynthesis in several trypanosomatid species were investigated using 14C- and

228 re likely to be found in the >600 unsurveyed trypanosomatid species.

229 The latter motif is conserved in other trypanosomatid species.

230 pATOM36 is a trypanosomatid-specific essential mitochondrial outer me

231 he CAK sub-complex; instead it contained two trypanosomatid-specific subunits, which were indispensab

232 Previously, we showed that activity of a key trypanosomatid spermidine biosynthetic enzyme, S-adenosy

233 MSP homologues have been found in all other trypanosomatids studied to date including heteroxenous m

234 Trypanosomatids, such as the sleeping sickness parasite

235 ortholog suggests that SODA is essential for trypanosomatid survival.

236 e dehydrogenases (GAPDH) from the pathogenic trypanosomatids T. brucei, Trypanosoma cruzi and Leishma

237 Here we report the identification of a trypanosomatid TFIIB-like (TFIIB(like)) protein which ha

238 dine (trypanothione), a metabolite unique to trypanosomatids that may allow the parasites to overcome

239 ncoded by other eukaryotic parasites such as trypanosomatids (the RHS proteins) and the rhizarian Pla

240 In trypanosomatids, the adaptin-mediated sorting of protein

241 Trypanosomatids, the etiologic agents of sleeping sickne

242 In the mitochondria of trypanosomatids, the majority of mRNAs undergo massive u

243 f several pyrophosphate-utilizing enzymes in trypanosomatids, the presence of these inorganic polypho

244 free-living bodonid out-group taxa and other trypanosomatids, thereby overcoming some of the issues a

245 histone modification and variant histones in trypanosomatids therefore represents evidence for a netw

246 at this mechanism may be more widely used by trypanosomatids to control enzyme activity and ultimatel

247 wing that leucine can also be metabolized in trypanosomatids to generate acetyl-CoA.

248 The first comparison of parasitic trypanosomatids to their free-living relatives reveals t

249 In all trypanosomatids, trans splicing of the spliced leader (S

250 be possible to use PTP1B inhibitors to block trypanosomatid transmission.

251 In trypanosomatids, tRNAs undergo both cytidine-to-uridine

252 This paper demonstrates its presence in the trypanosomatid Trypanosoma cruzi.

253 shown that protein prenylation occurs in the Trypanosomatids Trypanosoma brucei (T. brucei), Trypanos

254 the survival, growth, and infectivity of the trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi,

255 In trypanosomatids, trypanothione replaces the more common

256 This insertion is present in all trypanosomatid TUTases.

257 The distinctive positioning of putative trypanosomatid U3 binding sites with respect to A" and A

258 Trypanosomatids, unicellular organisms responsible for s

259 Here, we show that trypanosomatids uniquely contain both a functional AdoMe

260 Trypanosomatids utilise polycistronic transcription for

261 A deep-branching trypanosomatid viral lineage showing strong affinities t

262 ed "Leishbunyaviridae" Numerous relatives of trypanosomatid viruses were found in insect metatranscri

263 bling studies probing the biological role of trypanosomatid viruses.

264 iodic expression of DNA replication genes in trypanosomatids, we have mapped splice acceptor sites in

265 This is not the case in trypanosomatids where most genes are transcribed at an e

266 Monoxenous trypanosomatids, which are usually regarded as benign dw

267 basal branch of the highly diverse parasitic trypanosomatids, which include human pathogens Trypanoso

268 ed, roughly 60% of all genes had homologs in trypanosomatids, while 28% were Bodo-specific.

269 This may provide the trypanosomatids with a manner to rapidly and efficiently

270 est that energy production can be blocked in trypanosomatids with a tight binding competitive inhibit

271 acidocalcisome is an acidic calcium store in trypanosomatids with a vacuolar-type proton-pumping pyro