ライフサイエンスコーパス: trypanothione

1 metry as N1,N8-bis-(glutathionyl)spermidine (trypanothione).

2 r than the parasite bisglutathione analogue, trypanothione.

3 ermidine and the spermidine-containing thiol trypanothione.

4 uction in catalytic efficiency compared with trypanothione.

5 njugate of glutathione and spermidine termed trypanothione.

6 thesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), a metabolite unique to trypanosomatids t

7 nzyme activity is linked to the reduction of trypanothione, a parasite-specific thiol, by glutathione

8 Concentrations of trypanothione, a spermidine conjugate, were also reduced

9 The trypanothione adduct of arsenite was effectively transpo

10 spermidine to form a unique cofactor termed trypanothione, an essential cofactor for the maintenance

11 t tetracycline induction resulted in loss of trypanothione and accumulation of glutathione, followed

12 red for synthesis of a novel cofactor called trypanothione and for deoxyhypusine modification of euka

13 sociated with an increase in reduced thiols (trypanothione and glutathione) or increased activity of

14 type H(+)-ATPases to pentamidine action, and trypanothione and several putative kinases to melarsopro

15 It includes trypanothione and trypanothione reductase (TryR) instead

16 cellularly to Sb(III)/As(III), conjugated to trypanothione, and extruded by the As-thiol pump.

17 the differential binding of glutathione and trypanothione-based substrates, and thus offer a route t

18 sis of both glutathionylspermidine (Gsp) and trypanothione (bis(glutathionyl)spermidine (T(SH)2)).

19 the reduction of the parasite-specific thiol trypanothione by ascorbate in a process that involves no

20 lso found to exhibit potent control on total trypanothione content but only when they were strongly i

21 ve more efficient inhibitory effect on total trypanothione content in comparison to other enzymes in

22 des in T. cruzi is catalyzed by two distinct trypanothione-dependent enzymes.

23 thylglyoxal detoxification is performed by a trypanothione-dependent glyoxalase I (GLO1) containing a

24 species is reflected in the multiplicity of trypanothione-dependent peroxidases.

25 ) catalyzes the NADPH-dependent reduction of trypanothione disulfide (1).

26 overall yield was exemplified by the case of trypanothione disulfide (TS2), a GSH-spermidine bioconju

27 oxidoreductases, catalyses the reduction of trypanothione disulfide [N1, N8-bis(glutathionyl)spermid

28 lity to regenerate dihydrotrypanothione from trypanothione disulfide following oxidation with diamide

29 are dependent on the parasite-specific thiol trypanothione for reducing equivalents.

30 zi, probably due to lower levels of TryR and trypanothione in T. brucei.

31 The role of trypanothione in the detoxification of reactive oxygen s

32 t curcumin, rapidly depleted glutathione and trypanothione in the wild-type line, although almost all

33 jugate of glutathione and spermidine, termed trypanothione, in place of glutathione to maintain cellu

34 the biosynthesis of glutathione and thereby trypanothione, is catalyzed by gamma-glutamylcysteine sy

35 the biosynthesis of glutathione, and thereby trypanothione, is catalyzed by the enzyme gamma-glutamyl

36 e considered to be ineffective inhibitors of trypanothione metabolism suggesting that these compounds

37 and amines, some of which are inhibitors of trypanothione metabolism.

38 ytic domains for synthesis and hydrolysis of trypanothione (N(1),N(8)-bis(glutathionyl)spermidine).

39 hione reductase enzyme targets in the unique trypanothione pathway of these parasites.

40 p substrates, so that increased synthesis of trypanothione produces resistance.

41 utational strategy was used to down-regulate trypanothione reductase (TR) activity levels in Leishman

42 Trypanothione reductase (TR) catalyzes the NADPH-depende

43 Trypanothione reductase (TR), a flavoprotein oxidoreduct

44 Trypanothione reductase (TR), a flavoprotein oxidoreduct

45 It includes trypanothione and trypanothione reductase (TryR) instead of the thioredoxi

46 ctase (merA), whereas goR is more related to trypanothione reductase (tryR) than to other members.

47 nhibit glutathionylspermidine synthetase and trypanothione reductase enzyme targets in the unique try

48 propyl]-dime thylammonium chloride inhibited trypanothione reductase from Trypanosoma cruzi with a li

49 gulation nor amplification of the endogenous trypanothione reductase gene (tryA) was observed.

50 A subset also inhibited trypanothione reductase in vitro and induced oxidase act

51 the functionally homologous glutathione and trypanothione reductase indicates conservation of the ca

52 e reductase, and therefore rely on the novel trypanothione reductase system to detoxify reactive oxyg

53 egulation of the terminal peroxidases of the trypanothione reductase system.

54 s showed that two compounds weakly inhibited trypanothione reductase, but none of them specifically i

55 Trypanothione reductase, one of the family of flavin-dep

56 e reductase, dihydrolipoamide dehydrogenase, trypanothione reductase, thioredoxin reductase, and merc

57 ascade composed of trypanothione (T(SH)(2)), trypanothione reductase, tryparedoxin (Tpx), and nonsele

58 w that TcGPXI activity can also be linked to trypanothione reduction by an alternative pathway involv

59 Trypanothione replaces glutathione in defence against ce

60 In trypanosomatids, trypanothione replaces the more common glutathione syste

61 The enzymes of trypanothione synthesis have recently been identified.

62 ine decarboxylase, which is rate-limiting in trypanothione synthesis.

63 In pathogenic trypanosomes, trypanothione synthetase (TryS) catalyzes the synthesis

64 The bifunctional trypanothione synthetase-amidase (TRYS) comprises two st

65 ltogether, EbS and EbS analogues disrupt the trypanothione system, hampering the defense against oxid

66 xides relies on a unique cascade composed of trypanothione (T(SH)(2)), trypanothione reductase, trypa

67 rypanosoma brucei utilizes a novel cofactor (trypanothione, T(SH)2), which is a conjugate of GSH and

68 r roles in addition to being a precursor for trypanothione, the major low mass thiol present in trypa

69 The system can be readily saturated by trypanothione, the rate-limiting step being the interact

70 dducts of AS-HK014 with both glutathione and trypanothione were identified in AS-HK014-exposed wild-t

71 erent, designed substrate analogues based on trypanothione were prepared by means of a solid-phase ap

72 and TSHSyn (the production catalyst of total trypanothione) were also found to exhibit potent control

73 rate-limiting step being the interaction of trypanothione with the tryparedoxin.