ライフサイエンスコーパス: tryptamine

1 ketamine and phencyclidine-type substances, tryptamines).

2 lated (N-H)-indoles including derivatives of tryptamine.

3 involving the seven conformational minima of tryptamine.

4 versus acetyl-CoA and noncompetitive versus tryptamine.

5 of artificial seawater for acetylcholine and tryptamine.

6 uced priming explains the partial agonism of tryptamine.

7 5-HT and 2-Me-5HT but slightly different for tryptamine.

8 to form the beta-arylamine neurotransmitter tryptamine.

9 are significantly briefer in the presence of tryptamine.

10 ine were all synthesized in three steps from tryptamine.

11 on of serotonin and serotonin dimer, but not tryptamine.

12 ve in the synthesis of enantiomerically pure tryptamine.

13 e rearrangement of an unsymmetrical 2,2'-bis-tryptamine.

14 C-H-amination of the indole core of various tryptamines.

15 or involvement of the 5-HT(1A) receptor with tryptamines.

16 5-(Nonyloxy)tryptamine (10) represents a compound with optimal 5-HT1

17 chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine (11q) is a high affinity, potent full agonist

18 e alkyl chain, to 5-[(7,7-dimethylheptyl)oxy]tryptamine (15), results in an agent with somewhat lower

19 reoselective addition of 5-aminoindole (1a), tryptamine (1b), and histamine (1c) to alkynes 2a-s to s

20 w) whereas l-tryptophan (2.78mg/100g dw) and tryptamine (2.77mg/100g dw) were the only indole compoun

21 ith agonists including serotonin, histamine, tryptamine, 2-phenylethylamine, putrescine, and agmatine

22 One of the tryptamines, 4-fluoro-5-methoxy-DMT (6), displayed high

23 d to serotonin by a constitutively expressed tryptamine 5' hydroxylase (T5H) in rice plants.

24 ethyl)-1H-indole (CP-122,288), 5-carboxamido-tryptamine (5-CT), and dihydroergotamine.

25 5-hydroxy-tryptamine (5-HT) resulted in rapid activation of TACE,

26 platelet aggregation, secretion of 5-hydroxy tryptamine (5-HT), and an increase in cytosolic calcium.

27 Stimulation of 5-hydroxy-tryptamine (5-HT4 and 5-HT6 receptors causes an increase

28 -methoxy-tryptamine (6.1)>5-methoxy-dimethyl-tryptamine (5.4)> or =8-OH-DPAT (<5.0)=alpha-methyl-5-HT

29 one, butylone, 4-Me-PPP, and 4-MEC) and five tryptamines (5-EtO-DPT, 5-EtO-DALT, 5-EtO-MIPT, 5-EtO-AL

30 aneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryp

31 can acetylate the endogenous arylalkylamines tryptamine, 5-hydroxytryptamine (serotonin), and 5-metho

32 pEC50): 5-CT (7.4)>5-HT (6.5)> or =5-methoxy-tryptamine (6.1)>5-methoxy-dimethyl-tryptamine (5.4)> or

33 22 +/- 3; 5HT, 40 +/- 7; 5-methoxy-dimethyl tryptamine, 64 +/- 27; and BW-723C86, 1213 +/- 210.

34 s in mobilizing [Ca2+]i were (nM): 5-methoxy tryptamine, 8 +/- 4; (R)-DOI, 18 +/- 6; alpha-methyl-5HT

35 esis of regioisomeric spirocycles 87 and 90, tryptamines 88 and 91, Corey's aspidophytine tryptamine

36 tryptamines 88 and 91, Corey's aspidophytine tryptamine (97), and efavirenz (1) are also described.

37 this bottleneck by installing chlorine onto tryptamine, a downstream substrate.

38 atalyzes hydroxylation of the amino group of tryptamine, a rate-limiting step in tryptophan-dependent

39 lase, the enzyme that converts tryptophan to tryptamine, accepts 7-chlorotryptophan at only 3% of the

40 Serotonin (but not tryptamine) acetylation varied according to hair cycle p

41 Tryptophan, indole, indole acetic acid, and tryptamine activated transcription in yeast coexpressing

42 int1, hHint3-1 and hHint3-2 prefer AIPA over tryptamine adenosine phosphoramidate by factors of 33- a

43 3-indolepropionic acyl-adenylate (AIPA) over tryptamine adenosine phosphoramidate monoester (TpAd).

44 ionic acyl-adenylate as a substrate, but not tryptamine adenosine phosphoramidate monoester.

45 Dietary amines such as tyramine and tryptamine also inhibited G34 cleavage.

46 lly exclusive interaction with serotonin and tryptamine also suggests a physiological rationale for t

47 ilent background, we introduced an unnatural tryptamine analog to the production media and demonstrat

48 er tetracyclic pyrroloindolines or tricyclic tryptamine analogues depending on the reaction condition

49 The initially reported tryptamine analogues displayed either poor solution stab

50 en-like behavioral properties of these rigid tryptamine analogues.

51 The reaction of tryptamine and (2-oxocyclohexyl)acetic acid can be catal

52 Starting from Boc-protected tryptamine and (S)-tetrahydro-5-oxo-2-furancarboxylic ac

53 r the derivatization of histamine, tyramine, tryptamine and 2-phenylethylamine, which eliminates the

54 of free radicals from two related compounds, tryptamine and 3-methylindole.

55 cturally complex alkaloids, in 10 steps from tryptamine and 6-methoxytryptamine.

56 sformation is successful for a wide range of tryptamine and alpha,beta-unsaturated aldehyde substrate

57 was a dead end competitive inhibitor versus tryptamine and an uncompetitive inhibitor versus acetyl-

58 f this reaction is broad with respect to the tryptamine and aniline components.

59 pling between two different indole moieties, tryptamine and aurantioclavine, to construct vicinal qua

60 munesin is biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks deri

61 Levels of tryptamine and beta-phenyl-ethylamine never exceeded 50

62 elated biogenic amines, tyramine, histamine, tryptamine and beta-phenylethylamine, were detected in p

63 thylamide (LSD), and a series of substituted tryptamine and phenethylamine 5-HT(2A) receptor agonists

64 Tryptamine and phenylethylamine were not detected in pre

65 , spermidine, spermine, histamine, tyramine, tryptamine and phenylethylamine) were determined.

66 , spermidine, spermine, histamine, tyramine, tryptamine and phenylethylamine) were determined.

67 he Strychnos alkaloid norfluorocurarine from tryptamine and pyridine.

68 oducts derived from two starting substrates, tryptamine and secologanin.

69 The levels of tryptamine and serotonin accumulation in these transgeni

70 a dominant effect on the recognition of both tryptamine and serotonin over mutations in TMD9-12.

71 Tryptamine and serotonin were weak inhibitors with K(I)

72 encoded protein catalyzed the methylation of tryptamine and structurally related compounds, and was i

73 ferase (INMT) catalyzes the N-methylation of tryptamine and structurally related compounds.

74 ferase (INMT) catalyzes the N-methylation of tryptamine and structurally related compounds.

75 that ZmYUC catalyzes the N-hydroxylation of tryptamine and that sugar levels regulate transcript lev

76 so applied to functionalized indoles such as tryptamine and tryptophan.

77 Only two biogenic amines (tryptamine and tyramine) and two polyamines (spermidine

78 oduct, was a noncompetitive inhibitor versus tryptamine and uncompetitive with respect to acetyl-CoA.

79 s C3-diazenated pyrroloindolines from simple tryptamines and aryldiazonium tetrafluoroborates.

80 The oxo-tryptamines and oxo-pyrroloethanamines are generated in

81 of two small basic molecules (serotonin and tryptamine) and two proteins (turkey and chicken lysozym

82 ed that 5-aminoindole was more reactive than tryptamine, and histamine was found to be the least reac

83 a variety of (Z)-enamines of 5-aminoindole, tryptamine, and histamine without affecting the 1 degree

84 s (aromatic and aliphatic) of 5-aminoindole, tryptamine, and histamine.

85 Tyramine, beta-phenylethylamine, tryptamine, and octopamine are biogenic amines present i

86 race amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine.

87 transfer potential, E1/2, of acetylcholine, tryptamine, and serotonin were found to be -0.11, -0.25,

88 proves the recognition of both serotonin and tryptamine, and these mutations show a dominant effect o

89 for C7-selective boronation of tryptophans, tryptamines, and 3-alkylindoles by way of a single-pot C

90 Tryptamine- and phenethylamine-derived imides were selec

91 r the construction of novel heterocycles and tryptamines are described.

92 With tryptamine as starting material, the entire sequence lea

93 The endogenous tryptamine-based agonist serotonin (5-HT; 1) and the ben

94 A focused library of tryptamine-based compounds was synthesized, characterize

95 he structure-activity relationships of these tryptamine-based inhibitors.

96 of (+/-)-subincanadine E was described from tryptamine-based maleimide.

97 Putrescine, cadaverine, tryptamine, beta-phenylethylamine spermidine, spermine w

98 S239A caused a 6- to 13-fold decrease in tryptamine-binding affinity and a 5-fold increase in aff

99 re, we show that RNA mediated suppression of tryptamine biosynthesis in Catharanthus roseus hairy roo

100 Suppression of tryptamine biosynthesis therefore did not appear to adve

101 Utilization of a brominated CoA-S-acetyl-tryptamine-bisubstrate analog inhibitor and the MAD meth

102 l 5-HT(1A)R agonists, 5-HT and 5-carboxamido-tryptamine, but not the partial agonist 8-OH-DPAT, trigg

103 from the production of trace amines (such as tryptamine) by pericytes that ectopically express the en

104 Up-regulation of TDC increased TDC activity, tryptamine concentration, and resistance to 4-methyl try

105 howed preferential stabilization of specific tryptamine conformers through hydrogen bonding.

106 ty of the aryldiazonium electrophile and the tryptamine core.

107 ial cholinesterase inhibitor and constrained tryptamine derivatives as selective inhibitors of the 5-

108 Examination of a series of 5-(alkyloxy)tryptamine derivatives demonstrated that compounds with

109 t general method for the direct synthesis of tryptamine derivatives from indoles and nitrogen-functio

110 new process for the union of anilines with tryptamine derivatives has been developed, furnishing C-

111 Tryptamine derivatives with substitutions at the 4 and 7

112 diastereoselective oxyamination reactions of tryptamine derivatives, a stereoselective sulfinimine al

113 e neurotransmitter and hormonal roles of the tryptamine derivatives.

114 convenient and sustainable access to several tryptamine derivatives.

115 ochlorides and ketones leads to formation of tryptamine derivatives.

116 (5-HT; 1) and the benzenesulfonyl-containing tryptamine-derived 5-HT6 receptor antagonist MS-245 (4a)

117 An efficient anionic bicyclization of tryptamine-derived Zincke aldehydes forms the basis for

118 se-mediated formal cycloaddition reaction of tryptamine-derived Zincke aldehydes has served as the ke

119 intramolecular Diels-Alder cycloadditions of tryptamine-derived Zincke aldehydes is described.

120 Tryptamines disubstituted at the beta-position with fluo

121 plants, this silenced line demonstrates that tryptamine does not play an essential role in growth or

122 ic drug classes, the phenethylamines and the tryptamines/ergolines.

123 s shows that the higher affinity of 5-HT and tryptamine for the 5-HT2C receptor than for the 5-HT2A r

124 Tryptophan decarboxylase (TDC) supplies tryptamine for the indole moiety of CPT and its derivati

125 By comparison to its close analogue tryptamine, for which firm assignments to seven low-ener

126 of)MS) to detect psychoactive cathinones and tryptamines from aqueous phase samples was evaluated.

127 ive effect of SEGA (3a), a newly synthesized tryptamine-gallic acid hybrid molecule against non-stero

128 indicate that fluorination of hallucinogenic tryptamines generally has little effect on 5-HT(2A/2C) r

129 2-Me-5HT and tryptamine have been defined as partial agonists of 5-HT

130 ructures of ligand complexes with serotonin, tryptamine, histamine, and norepinephrine.

131 of the sensor was demonstrated by analysing tryptamine in 10 different varieties of beers, obtaining

132 -6 mM for acetylcholine and of 0.5-10 mM for tryptamine in artificial seawater.

133 e two major problems of the determination of tryptamine in beer up to now: low sensitivity and matrix

134 direct determination of the concentration of tryptamine in beers.

135 a rapid synthesis of (+/-)-vindeburnol from tryptamine in only two steps.

136 ection, and identification of cathinones and tryptamines in less than 1 min.

137 trescine, spermine, spermidine, tyramine and tryptamine) in fish tissues.

138 CDD) and also microbiota-derived AhR ligands tryptamine, indole and 1,4-dihydroxy-2-naphthoic acid (D

139 Tryptamine is a direct precursor to many alkaloid natura

140 phosphorescence; the covalently immobilized tryptamine is quantified by SS-RTP, obtaining a detectio

141 Moreover, although tryptamine is widely found among plants, this silenced l

142 igands also seem to engage Ser5.46(242), but tryptamines lacking such a substituent may adopt an alte

143 -methyltryptamine and tryptophol in place of tryptamine led to the enzymatic synthesis of isocommunes

144 Polar ring-substituted tryptamine ligands also seem to engage Ser5.46(242), but

145 bstituents at either the 4- or 5-position of tryptamine ligands and the 5-position of phenylalkylamin

146 Irradiation of a tryptamine linked through its side-chain nitrogen to an

147 In guinea pig substantia nigra, 5-(nonyloxy)-tryptamine maximally stimulated [35S]GTPgammaS binding b

148 contained l-tryptophan, 5-methyltryptophan, tryptamine, melatonin, indoleacetonitrile and indole (1.

149 the remaining compounds, 5-methyltryptophan, tryptamine, melatonin, indoleacetonitrile and indole, va

150 h a longer tether between the acetyl-CoA and tryptamine moieties, demonstrates only the trans conform

151 wo radically different conformations for the tryptamine moiety in the catalytic site (cis and trans).

152 references of serotonin differ from those of tryptamine most notably in the selective stabilization o

153 fluorinated analogues of the hallucinogenic tryptamines N,N-diethyltryptamine (DET), 4-hydroxy-N,N-d

154 is hydrolysed by acetylcholine esterase and tryptamine neurotransmitters like serotonin are degraded

155 electrostatic interaction between K(+), the tryptamine NH(2) lone pair, and the indole ring in K(+)(

156 Neither tryptamine nor phenylethylamine was detected in the moni

157 ic Pictet-Spengler reaction of aldehydes and tryptamine nucleophiles.

158 late (AIPA) and with a series of fluorogenic tryptamine nucleoside phosphoramidates revealed that hHi

159 nm nanopipet electrode was 205 muM, and for tryptamine on a radius approximately 19 nm nanopipet ele

160 e detection of acetylcholine, serotonin, and tryptamine on nanopipet electrode probes with sizes rang

161 line- or quninoline-5,8-dione aldehydes with tryptamine or tryptophans yielded the lavendamycins.

162 we have identified the reaction pathway for tryptamine oxidation by aromatic amine dehydrogenase.

163 spi1 is proposed to encode an enzyme in the tryptamine pathway for Trp-dependent auxin biosynthesis,

164 ryptamine (pEC50=7.0) and 5-methoxy-dimethyl-tryptamine (pEC50=5.7).

165 amidotryptamine (5-CT; pEC50=7.8), 5-methoxy-tryptamine (pEC50=7.0) and 5-methoxy-dimethyl-tryptamine

166 acterized by three stages: i) high levels of tryptamine, phenolics, and scavenging capacity; ii) high

167 Tryptamine, phenylethylamine and histamine (with the sin

168 The quantity of biogenic amines (tryptamine, phenylethylamine, putrescine, cadaverine, hi

169 The existing firm assignments for tryptamine play a decisive role in assignments in seroto

170 ines (histamine, tyramine, phenylethylamine, tryptamine, putrescine, and cadaverine) and two polyamin

171 ered to install chlorine preferentially onto tryptamine rather than the native substrate tryptophan.

172 utation in the 5-HT2A receptor for 5-hydroxy-tryptamine reduced its sensitivity to the inhibitor.

173 s a major determinant of the manner in which tryptamine-related agents bind at 5-HT6 serotonin recept

174 a series of endogenous indoles revealed that tryptamine, serotonin and 5-methoxytryptamine readily di

175 ngineered enzyme in vivo, we transformed the tryptamine-specific RebH mutant (Y455W) into the alkaloi

176 henylethylamine) or heterocyclic (histamine, tryptamine) structures.

177 lites were inactive, two metabolites, namely tryptamine (TA) and indole acetic acid (IAA), were shown

178 o found that VMAT1 has a higher affinity for tryptamine than VMAT2.

179 for the phenyl ring in the indole nucleus of tryptamines that bind to 5-HT2 receptor subtypes and pos

180 cation of the ethylamine side chain only for tryptamines that bind to the 5-HT2C receptor isoform.

181 From tryptamine, the sequence paralleling that leading to coe

182 2-Substituted tryptamines, then, might allow entry to a novel class of

183 cetylated serotonin to N-acetylserotonin and tryptamine to N-acetyltryptamine.

184 Tryptamine (TRM) content was significantly higher in age

185 emperature and charge on the conformation of tryptamine (Tryp) is examined in the gas phase by infrar

186 ecursors, and metabolites, such as tyrosine, tryptamine, tyramine, phenethylamine, dopamine, 3-methox

187 ically controlled covalent immobilisation of tryptamine via Michael type-reaction.

188 Tryptamine was not detected in any of the samples.

189 In this study, a series of N-substituted tryptamines was prepared to explore the structural requi

190 Tyramine and tryptamine were found in cheese from high SCC milk.

191 ies contained spermine; whereas tyramine and tryptamine were only detected in cheese from high SCC mi

192 permidine, spermine, histamine, tyramine and tryptamine) were determined.

193 ing step for the enzymatic transformation of tryptamine (which has similar kcat and kcat/Km compared

194 lase activities that converted tryptophan to tryptamine, which could be converted to serotonin by a c

195 This chemoselective coupling of a tryptamine with 1.2 equiv of 2-iodoaniline proceeds effi

196 ombinant enzyme catalyzed the methylation of tryptamine with an apparent K(m) value of 2.9 mM.

197 HCl gave amphimedine in 8 steps from tryptamine with an overall yield of 14%.

198 The addition-cyclization of tryptamines with alpha,beta-unsaturated aldehydes in the

199 phenylhydrazine hydrochloride gives branched tryptamines with aryl groups in the alpha-position to th

200 talyzed N-acyliminium cyclization cascade of tryptamines with enol lactones to form architecturally c

201 AT)) catalyzes the reaction of serotonin (or tryptamine) with acetyl-CoA to form N-acetylserotonin (o

202 ntermediates VI are effectively converted to tryptamines Xa and Xb under controlled protic acid condi