ライフサイエンスコーパス: tryptophan

1 s directly from dietary amino acids (such as tryptophan).

2 , gamma-glutamyl amino acid, methionine, and tryptophan).

3 te-derived aromatic amino acids tyrosine and tryptophan.

4 forms a reverse WXXXH motif with the gating tryptophan.

5 additionally enrichment of motifs containing tryptophan.

6 nce and enantiomeric separation identified D-tryptophan.

7 l microbiota associated with serum levels of tryptophan.

8 icrobial diversity, which was increased by D-tryptophan.

9 formation of 3-methyl-2-indolic acid from l-tryptophan.

10 ionine, lysine, phenylalanine, tyrosine, and tryptophan.

11 esponsible for the specific recognition of l-tryptophan.

12 levels of interleukin 22 and serum levels of tryptophan.

13 most significant improvement observed for l-tryptophan.

14 ty profile in the synthesis of 5-substituted tryptophans.

15 xxC motifs that can be C-mannosylated on all tryptophans.

16 d the dietary supplement, composed of 2 g of tryptophan, 10 g of tyrosine, and blueberry juice with b

17 alpha-(11)C-methyl-l-tryptophan ((11)C-AMT) PET imaging demonstrated increase

18 [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP) positron emission tomography o

19 novel radiotracer 1-(2-(18)F-fluoroethyl)-l-tryptophan ((18)F-FETrp) may be useful to assess tryptop

20 inate targeting of the Trp catabolic enzymes tryptophan 2,3-dioxygenase (TDO) and IDO2 may also safel

21 Levels of messenger RNAs encoding tryptophan 2,3-dioxygenase-2 and solute carrier family 6

22 the tryptophan (Trp) analog probe 2,7-diaza-tryptophan ((2,7-aza)Trp), which exhibits unique water-c

23 netic tools, we show that the replacement of tryptophan 237 with phenylalanine imparts higher fidelit

24 by pi-stacking with a tryptophan side chain (tryptophan-253).

25 Tryptophan 7-halogenase catalyzes chlorination of free t

26 tic insights about the reaction mechanism of tryptophan 7-halogenase is vital and timely.

27 ion of tryptophan chlorination, performed by tryptophan 7-halogenase, by calculating potential energy

28 c pathogen Encephalitozoon cuniculi bound to tryptophan, a HisRS from Burkholderia thailandensis boun

29 color increased from 2 days to 6 days with l-tryptophan addition.

30 Herein, we show that a tryptophan analog, 4-cyanotryptophan, which differs from

31 In contrast, L-tryptophan and 11 other D-amino acids were inactive.

32 to carry out the simultaneous separation of tryptophan and 15 derivatives by Ultra Performance Liqui

33 ] carbazole (FICZ), is a UVB photoproduct of tryptophan and a powerful UVA chromophore.

34 an amide bond between the indole-nitrogen of tryptophan and an anthranilic acid residue, and a high y

35 e residues were replaced mainly by cysteine, tryptophan and arginine in a codon-specific manner.

36 Notably, both baseline levels of kynurenine:tryptophan and changes in the levels of kynurenine after

37 stigate associations between serum levels of tryptophan and composition of the fecal microbiota, anal

38 negative correlation between serum levels of tryptophan and disease activity or levels of C-reactive

39 negative correlation between serum levels of tryptophan and disease activity.

40 aled by studies of the intermolecular flavin-tryptophan and flavin-ascorbic acid photocycles and the

41 new method was applied to the determination tryptophan and its derivatives in black pigmented glutin

42 It allowed quantitation of low ppb levels of tryptophan and its derivatives in different fermented fo

43 n analytical method for the determination of tryptophan and its derivatives in kynurenine pathway usi

44 Tryptophan and its metabolites are involved in different

45 d to systematically evaluate serum levels of tryptophan and its metabolites in patients with inflamma

46 We measured cerebrospinal fluid (CSF) tryptophan and kynurenine metabolite concentrations in p

47 that the emission spectral profile levels of tryptophan and NADH were higher in AD samples than norma

48 ized redox cofactors in the late amino acids tryptophan and selenocysteine.

49 d preincubation experiments with 5-hydroxy-L-tryptophan and serotonin.

50 BACKGROUND & AIMS: Administration of tryptophan and some of its metabolites reduces the sever

51 succeeding chilled storage with more intense tryptophan and thiols depletion, higher protein carbonyl

52 d to extract information on contributions by tryptophan and tyrosine amino acid residues to the antio

53 Key ingredients (tryptophan and tyrosine) were shown not to affect their

54 L1 preferentially mannosylates the first two tryptophans and DPY19L3 prefers the third, whereas DPY19

55 amino acids (l-phenylalanine, l-tyrosine, l-tryptophan) and a polypeptide (epsilon-poly-l-lysine) in

56 rate), glutamate, fatty acid acylcarnitines, tryptophan, and polyamine metabolites and decreased leve

57 N-gamma)-mediated depletion of intracellular tryptophan, and some Ct strains utilize extracellular in

58 We found that leucine, cysteine and tryptophan are inserted during W1282X suppression.

59 red for quinolinic acid (QA) production from tryptophan are present.

60 with an effect of phosphorylation in burying tryptophans at the transmission interface.

61 serve as major sites of interaction with two tryptophan-binding pockets of CNOT9, previously found to

62 itical for GW182 docking into one of hAgo1's tryptophan-binding pockets.

63 rine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, ribosome biogenesis and glycoly

64 uctions, including loss of L-histidine and L-tryptophan biosynthesis.

65 enzyme catalyzing the formation of a lysine-tryptophan bond has been identified in Streptococcus the

66 5-hydroxy-l-tryptophan, but not 2-aminobicyclo-(2,2,1)-heptane-2-car

67 sumption of amino acids such as arginine and tryptophan by immunoregulatory macrophages is one pathwa

68 nalog, 4-cyanotryptophan, which differs from tryptophan by only two atoms, is the smallest fluorescen

69 din-4-like structure with its characteristic tryptophan-cage fold motif that is responsible for favor

70 presence of iron, large amounts of N-nitroso-tryptophan can be formed even at neutral pH, as in the i

71 renine to tryptophan was used as an index of tryptophan catabolic activity in this pathway.

72 ble genes included 3 transcripts involved in tryptophan catabolism (IDO1, KMO, KYNU) that play a pivo

73 suppression of Th cell growth by SF through tryptophan catabolism may play an important role in prev

74 2,3-dioxygenase (IDO), an enzyme involved in tryptophan catabolism, in macrophages and in the lungs o

75 HIV-1 infection is characterized by enhanced tryptophan catabolism, which contributes to immune suppr

76 Tumors use tryptophan-catabolizing enzymes such as indoleamine 2,3-

77 we examined a mechanism for the reaction of tryptophan chlorination, performed by tryptophan 7-halog

78 file, being hydroxybenzoic acid diglucoside, tryptophan, chrysoeriol-6,8-di-C-pentoside and isomers 4

79 atural product with an intramolecular lysine-tryptophan cross-link, which is installed by the radical

80 Tryptophan deficiency could contribute to development of

81 tes generated from the kynurenine pathway of tryptophan degradation have been implicated in several h

82 quinolinic acid-indicated a high activity of tryptophan degradation in patients with active IBD.

83 Quinolinic acid (QA) is a metabolite of tryptophan degradation obtained through kynurenine pathw

84 a single chain oxidoreductase that catalyzes tryptophan degradation to kynurenine.

85 ats and cultured astroglioma cells, shunting tryptophan degradation toward the production of neurotox

86 sociated with glutathione detoxification and tryptophan degradation were altered in HCA-positive CD4(

87 , acute phase response pathway, glutaryl-CoA/tryptophan degradations and EIF2/AMPK/mTOR signaling.

88 , transcription factors, and the tolerogenic tryptophan-degrading enzyme indoleamine 2,3-dioxygenase

89 Here we examined the impact of tryptophan depletion (TD) and adverse childhood experien

90 ytryptamine) neurotransmission using dietary tryptophan depletion (TD) in healthy volunteers on the p

91 ability to promote protein carbonylation and tryptophan depletion in myofibrillar proteins, ovalbumin

92 lavonoids, nutrients, amino acids (including tryptophan-derivatives that are uremic toxins), and lipi

93 postulated that: 1) malignant cells produce tryptophan-derived AHR ligand(s) through the kynurenine

94 and enzymes involved in the biosynthesis of tryptophan-derived metabolites, and the accumulation of

95 psis defense, a role previously dominated by tryptophan-derived small molecules.

96 The single tryptophan "doping" markedly increased the conductance o

97 cle involving the recently discovered fourth tryptophan electron donor.

98 that have a tetrad (rather than a triad) of tryptophan electron donors can still be expected to be v

99 d in both electrical and optical mode for of tryptophan enantiomers (D-/L-Trp).

100 enue for 2,6-diazatryptophan, an analogue of tryptophan exhibiting a similar ESTPT property with (2,6

101 A strong positional influence of tryptophans exists, with residues at the WR termini cont

102 tution of phenylalanine at position 327 with tryptophan (F327W).

103 s a likely UVB photoproduct of intracellular tryptophan, FICZ represents a de facto endogenous UVA ph

104 s using a laser-induced pH jump coupled with tryptophan fluorescence as a probe.

105 ahl value and ellipticity and an increase in tryptophan fluorescence at incremental fluences, as well

106 pectroscopy, equilibrium dialysis, intrinsic tryptophan fluorescence emission, and UV-vis spectroscop

107 exhibited significant changes in 2h: reduced tryptophan fluorescence intensity, carbonyl formation, a

108 y was developed that made use of the natural tryptophan fluorescence of proteins.

109 The tryptophan fluorescence of the GAC(F327W) mutant undergo

110 riments then demonstrated that the change in tryptophan fluorescence of the Y162W mutant is extremely

111 We assigned the tryptophan fluorescence signal from Y162W by removing tw

112 Using capillary assays and intrinsic tryptophan fluorescence spectra analysis, Mcp was confir

113 ce determination, and circular dichroism and tryptophan fluorescence spectroscopies for conformationa

114 Intrinsic tryptophan fluorescence studies of CFTR showed that phos

115 -vis spectrum, far-UV circular dichroism and tryptophan fluorescence, and the phase-diagram method.

116 ution of large residues such as histidine or tryptophan for serine 375 (S375H/W) in the gp120 Phe 43

117 everity of colitis in mice, whereas removing tryptophan from the diet increases susceptibility to col

118 ight act as flexible linker to rearrange the tryptophan gate.

119 arginine, cysteine, lysine, methionine, and tryptophan had the strongest antioxidant activities.

120 respectively, tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), and draw an evolutionary s

121 ed mice with mammary-specific disruptions of tryptophan hydroxylase 1 (Tph1) or low-density lipoprote

122 on factor Foxm1, both G1/S and G2/M cyclins, tryptophan hydroxylase 1 (Tph1), and islet serotonin pro

123 Specificity protein 2 (Sp2, rs3708840), tryptophan hydroxylase 1 (Tph1, rs262731280) and seroton

124 usly, we showed that daf-7 TGFbeta and tph-1 tryptophan hydroxylase expression in specific neurons en

125 studies suggested that telotristat ethyl, a tryptophan hydroxylase inhibitor, reduces bowel movement

126 ditionally, we checked for immunolabeling of tryptophan hydroxylase, an enzyme associated with the sy

127 interacts with phenylalanine, tyrosine, and tryptophan hydroxylases catalyzing the BH4-activated con

128 d for NOS efficacy and is synthesized from l-tryptophan in a series of reactions that have not been f

129 ivity of the modern amino acids tyrosine and tryptophan in oxidatively stressed cells.

130 A tryptophan in the additional ZF interacts with a conserv

131 All six tryptophan indole and eight glycine backbone (15)N-(1)H

132 We evaluated tryptophan, indole, and IFN-gamma levels in cervicovagin

133 In addition, F50, unlike JM22, uses a tryptophan instead of an arginine to fill a critical not

134 For tryptophan instead, it is theoretically predicted that a

135 e quenching measurements revealed that the l-tryptophan interacted with anthocyanins mainly through h

136 into L-dopa (the precursor of dopamine), and tryptophan into 5-hydroxytryptophan (the precursor of se

137 the enzyme that catalyzes the degradation of tryptophan into kynurenine.

138 D-tryptophan is a newly identified product from probiotic

139 of microbes to utilize mucins and metabolize tryptophan is diminished in IBD patients.

140 The main metabolism pathway of tryptophan is protein formation, but it can also be meta

141 preservation solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec on the ind

142 , livers were flushed in situ with histidine-tryptophan-ketoglutarate and subsequently preserved eith

143 tial COX-2 inhibitor Meloxicam via histidine-tryptophan-ketoglutarate showed the best graft-protectiv

144 ith 8-hour NEVKP or in 4 degrees C histidine-tryptophan-ketoglutarate solution (SCS), followed by kid

145 The plasma kynurenine/tryptophan (KT) ratio, a marker of adaptive immune defec

146 :0), dihydroxyacetone, ursodeoxycholic acid, tryptophan, L-valine, cycloserine, hypoxanthine, and 4-O

147 the stability of the structurally essential tryptophan ladder or to provide additional adhesion func

148 Decreased serum tryptophan level is associated with psychiatric problems

149 ho cleared infection had significantly lower tryptophan levels and trended toward lower IFN-gamma lev

150 Whether tryptophan levels are associated with Ct infection clear

151 ains utilize extracellular indole to restore tryptophan levels.

152 titration calorimetry data for binding of 11 tryptophan ligands to the homo-undecameric trp RNA-bindi

153 -like components was slower than that of the tryptophan-like component.

154 l humic-, terrestrial humic-, tyrosine-, and tryptophan-like fluorescent signatures.

155 strial humic-like, anthropogenic humic-like, tryptophan-like, and tyrosine-like components can be reg

156 that has relevance to human disease involves tryptophan limitation mediated by the host enzyme indole

157 Both systems promoted tryptophan loss and the formation of protein carbonyls a

158 Tryptophan lyase (NosL) is a radical S-adenosyl-l-methio

159 tidine, lysine, phenylalanine, tyrosine, and tryptophan) makes it a viable chemical assay for fingerp

160 The tryptophan metabolic enzyme kynureninase (KYNU) is mimic

161 emission tomography (PET) tracers addressing tryptophan metabolic pathways should allow the detection

162 ver, the causative link between dysregulated tryptophan metabolism and abdominal aortic aneurysm (AAA

163 on and potential immunologic function of the tryptophan metabolism enzyme KYNU in inflammatory skin d

164 e molecular imaging tool to examine abnormal tryptophan metabolism in human tumors.

165 SF to restrict Th cell proliferation through tryptophan metabolism may support the initiation and pro

166 < 0.01)), with significant downregulation of tryptophan metabolism metabolites (e.g., picolinic acid,

167 Abnormal tryptophan metabolism via the kynurenine pathway is invo

168 tophan ((18)F-FETrp) may be useful to assess tryptophan metabolism via the kynurenine pathway.

169 nic acid (KYNA, a neuroinhibitory product of tryptophan metabolism) counteracts the rewarding effects

170 sative role for 3-HAA, which is a product of tryptophan metabolism, in AAA formation.

171 ic acid metabolism, sphingolipid metabolism, tryptophan metabolism, phenylalanine metabolism, lysine

172 enase (KMO) is a key FAD-dependent enzyme of tryptophan metabolism.

173 ) has immunoregulatory roles associated with tryptophan metabolism.

174 limiting enzyme in the kynurenine pathway of tryptophan metabolism.

175 xpression of genes associated with the PG or tryptophan metabolism.

176 in a gene cluster enabling production of the tryptophan metabolite indoleacrylic acid (IA), which pro

177 Kynurenine is a tryptophan metabolite that plays a crucial role in cance

178 (kat), a gene involved in the production of tryptophan metabolite xanthurenic acid (XA), for its sur

179 PGs, bile acids, and tryptophan metabolites are important mediators regulatin

180 Analysis of tryptophan metabolites revealed activation of the kynure

181 biotics as well as natural compounds such as tryptophan metabolites, dietary components and microbiot

182 Increased levels of tryptophan metabolites-especially of quinolinic acid-ind

183 investigate the immunologic role of KYNU and tryptophan metabolites.

184 iated immunosuppression is the expression of tryptophan-metabolizing enzyme indoleamine 2,3-dioxygena

185 1F KatG produce the same methionine-tyrosine-tryptophan (MYW) cofactor radical intermediate at the ea

186 lyzed and the mechanisms and kinetic laws of tryptophan N-nitrosation were determined.

187 The chemical nature of the non-tryptophan (non-Trp) fluorescence of porcine and human e

188 duction in activity occurs upon reduction in tryptophan number below eight.

189 ther functional attrition follows subsequent tryptophan number reduction with substitution of all try

190 Additionally, other compounds derived from l-tryptophan occurred during fermentation.

191 (dumpy-19, DPY-19), modifying the first two tryptophans, occurs in Caenorhabditis elegans, but four

192 actobacillus strains capable of metabolizing tryptophan or by treatment with an AHR agonist.

193 lly involves spatially arranged redox-active tryptophan or tyrosine residues.

194 The association between tryptophan oxidation and CNS inflammatory responses as m

195 s of disease, with a progressive increase in tryptophan oxidation associated with stage progression.

196 The kynurenine pathway of tryptophan oxidation is associated with central nervous

197 67 peptides showing methionine, proline, and tryptophan oxidations were identified in common in all s

198 determine whether modification of intestinal tryptophan pathways affects the severity of IBD.

199 EEMs revealed two principal components (PC1-tryptophan, PC2-tyrosine) that captured significant vari

200 All three aromatic amino acids (tryptophan, phenylalanine and tyrosine) serve as substra

201 ect on several compounds (proline, cysteine, tryptophan, phenylalanine, alpha-terpineol and geraniol)

202 lating metabolites, including gut microbial, tryptophan, plant component, and gamma-glutamyl amino ac

203 uctural diversity of cyanobactins to include tryptophan-prenylated cyclic peptides.

204 yanthranilate 3,4-dioxygenase by 6-chloro-dl-tryptophan prevented both increased lactate production a

205 By using single tryptophan protein phosphorescence, we follow site-speci

206 nd the closely related intramolecular flavin-tryptophan radical pair in cryptochrome.

207 Tyrosine (TyrOH) and tryptophan radicals play important roles as intermediate

208 he form of the protein containing flavin and tryptophan radicals shows kinetics that differ markedly

209 er declines in the CD14 level and kynurenine-tryptophan ratio after 6 months of ART predicted a lower

210 production of kynurenine and the kynurenine:tryptophan ratio in patient blood serum were determined

211 On average, kynurenine:tryptophan ratios were reduced during RT but restored af

212 first time to determine spectral profiles of tryptophan, reduced nicotinamide adenine dinucleotide (N

213 ich every fifth residue is a tryptophan, the tryptophan repeat (WR).

214 f Nanog encompassing the homeodomain and the tryptophan repeat can support LIF-independent colony for

215 nt FMDVs containing substitutions at 3D(pol) tryptophan residue 237 were genetically stable and displ

216 to create hydrophobic interactions with the tryptophan residue at position 316 and with other topolo

217 ky aromatic substituents at position 5 and a tryptophan residue at position N-3 of the rhodanine ring

218 Filling this cavity with a histidine or tryptophan residue in Env with a natural serine residue

219 ifications on four tyrosine residues and one tryptophan residue of hemopexin.

220 affect the catalytic activity, including one tryptophan residue W127 that likely acts through regulat

221 odynamic and kinetic description of a buried tryptophan residue.

222 nce signal from Y162W by removing two native tryptophan residues (W270A/W284A).

223 an number reduction with substitution of all tryptophan residues ablating dimerization and self-renew

224 ict specificity of the enzyme for lysine and tryptophan residues and the dependence of an eight-amino

225 n drug response, suggesting that the bulkier tryptophan residues directly block stimulator binding.

226 to Arabidopsis thaliana UVR8, has conserved tryptophan residues for UV-B photoreception, monomerizes

227 interface comprising the side chains of four tryptophan residues in a co-planar linear arrangement.

228 erferometry, we identified several conserved tryptophan residues in TTP that serve as major sites of

229 A reduction in the number of tryptophan residues leads initially to a gradual reducti

230 ne side chains, each one located between two tryptophan residues, are critical to insoluble and solub

231 tertiary structure and more solvent-exposed tryptophan residues.

232 ored via the anodic reaction of tyrosine and tryptophan residues.

233 valent reinsertion of the authentic residue (tryptophan), reverting the nonsense effects for the p.W2

234 ly, we have characterized a Plasmodium vivax tryptophan-rich antigen PvTRAg38, which is expressed by

235 odes a homologue of the yeast Get1 and human tryptophan-rich basic (WRB) proteins, which are receptor

236 We mutated the TRC40 receptor tryptophan-rich basic protein (Wrb) in hair cells of zeb

237 Thus, L. reuteri, together with a tryptophan-rich diet, can reprogram intraepithelial CD4(

238 r more transgenes by employing the bacterial tryptophan RNA-binding attenuation protein (TRAP), which

239 We employed a tryptophan scan to the protein surface one at a time and

240 tissues and plasma with disruptions also in tryptophan/serotonin, bile acid and lipid metabolism.

241 l cation is stabilized by pi-stacking with a tryptophan side chain (tryptophan-253).

242 ed conformational transitions of a conserved tryptophan side chain in the LBD that trigger reorganiza

243 the anisotropy dynamics of the corresponding tryptophan side chains and observed two distinct relaxat

244 the ability of tumor and T cells to adapt to tryptophan starvation and provide important insights int

245 ome transfers the colitogenic phenotype from tryptophan starved animals to normally nourished mice.

246 The tryptophan substitution (Y162W) appeared to be conservat

247 lity, we rationally engineered QUAD opsin by tryptophan substitution of four lipid-facing residues in

248 ed with continuum modeling revealed that the tryptophan substitutions lower the energetically unfavor

249 However, tryptophan substitutions were detrimental at two sites.

250 Over-expression studies confirmed tryptophan synthase as the biological target.

251 scovery of anti-tubercular agents inhibiting tryptophan synthase highlights the therapeutic potential

252 to a low-resolution crystal structure of Mtb tryptophan synthase showed they locate to the interface

253 to the essential alpha- and beta-subunits of tryptophan synthase.

254 unit active site of the PLP-requiring enzyme tryptophan synthase.

255 ted mechanisms are inspired by dimethylallyl tryptophan synthases, which direct biological electrophi

256 lly unstable in cells because its N-terminal tryptophan targets it for proteasomal degradation via th

257 pertoire but generated indole derivatives of tryptophan that activated the aryl-hydrocarbon receptor

258 By monitoring the fluorescence of tryptophans that were strategically introduced at variou

259 eat region in which every fifth residue is a tryptophan, the tryptophan repeat (WR).

260 s synthesize indole-3-acetic acid (IAA) from tryptophan through indole-3-pyruvic acid (3-IPA) in resp

261 nucleotide (NAD) is synthesized de novo from tryptophan through the kynurenine pathway.

262 7-halogenase catalyzes chlorination of free tryptophan to 7-chlorotryptophan, which is the first ste

263 Feeding D-tryptophan to mice before experimental asthma induction

264 ndoleamine 2,3-dioxygenase, which converts l-tryptophan to N-formylkynurenine.

265 The intensity ratio of tryptophan to NADH and the change rate of fluorescence i

266 ant endogenous amino acids, aminoadipate and tryptophan, to their respective N-acetylated products in

267 By use of the tryptophan (Trp) analog probe 2,7-diaza-tryptophan ((2,7

268 intramolecular cation-pi interaction between tryptophan (Trp) and an amine cation are shown to absorb

269 utilizing the intrinsic fluorescence of the tryptophan (Trp) and tyrosine (Tyr) amino acid residues

270 discuss how small-molecule inhibitors of the tryptophan (Trp) catabolic enzyme indoleamine 2,3-dioxyg

271 of kynurenine (Kyn) as a main catabolite of tryptophan (Trp) degradation is involved in the immuno-e

272 y tracking auto-fluorescent NAD(P)H, FAD and tryptophan (Trp) lifetimes and their enzyme-bound fracti

273 synthesized in the placenta from maternal l-tryptophan (TRP) reaches the fetal brain.

274 ic cleavage C-terminal to tyrosine (Tyr) and tryptophan (Trp) residues provides a potential alternati

275 Derivatives of the amino acid tryptophan (Trp) serve as precursors for the chemical an

276 eamine 2,3-dioxygenase (IDO), which degrades tryptophan (Trp) to kynurenine (Kyn), has been demonstra

277 an immunoregulatory enzyme that breaks down tryptophan (Trp) to metabolites known as kynurenines (Ky

278 is protocol describes the preparation of the tryptophan (Trp)-based fluorogenic amino acid Fmoc-Trp(C

279 terferon gamma (IFN-gamma), which leads to a tryptophan (Trp)-limiting environment via induction of t

280 TsrM catalyzes the methylation of C2 in l-tryptophan (Trp).

281 We also show that an active-site tryptophan, Trp-321, participates in off-pathway electro

282 All other enzymes containing CTQ or tryptophan tryptophylquinone (TTQ) cofactors are dehydro

283 ntification and quantification of individual tryptophan-, tyrosine- and phenylalanine-containing dipe

284 reporters, each incorporating a bimane and a tryptophan/tyrosine, whose close distance causes fluores

285 11)C-AMT) PET imaging demonstrated increased tryptophan uptake and trapping in epileptic foci and bra

286 Ca and P, and essential amino acids, such as tryptophan, valine, and threonine, were determined in ya

287 de novo biosynthesis pathway for NAD(+) from tryptophan via QA, highlighting the functional conservat

288 We identify an exceptional tryptophan (W583) at the terminus of the intracellular p

289 A conserved tryptophan (W972) in the C-terminal alpha-helix is widel

290 In cocultures of SF and Th cells, tryptophan was completely depleted within a few days, re

291 A W321F variant in which the proximal tryptophan was replaced with a non-oxidizable phenylalan

292 After treatment, tryptophan was the only amino acid that exhibited specif

293 The ratio of kynurenine to tryptophan was used as an index of tryptophan catabolic

294 eurotransmitter precursors phenylalanine and tryptophan were decreased.

295 Metabolites of tryptophan were measured in serum from 148 patients and

296 ndividuals without IBD (controls); levels of tryptophan were measured using high-performance liquid c

297 Serum levels of tryptophan were significantly lower in patients with IBD

298 e found for zinc, folic acid, vitamin C, and tryptophan, with nonsignificant results for inositol.

299 The binding interface comprises a central tryptophan within SST14 and the N-terminus of Abeta1-42.

300 merization assays to show that the number of tryptophans within the WR is linked to the strength of h