ライフサイエンスコーパス: tryptophan hydroxylase

1 tivity for the serotonin-synthesizing enzyme tryptophan hydroxylase.

2 anine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase.

3 ly using a monoclonal antibody (mAb) against tryptophan hydroxylase.

4 on in a small class of genes such as FAS and tryptophan hydroxylase.

5 n levels of tyrosine hydroxylase, but not of tryptophan hydroxylase.

6 te-limiting enzyme in the synthesis of 5-HT, tryptophan hydroxylase.

7 neurons in mice at any age did not stain for tryptophan hydroxylase.

8 is by the rate-limiting enzymes tyrosine and tryptophan hydroxylases.

9 ropulsion in isolated colons of mice lacking tryptophan hydroxylase 1 (Tph1(-/-) mice), which is the

10 In addition, 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase 1 (Tph1) expression were reduced

11 5-HT biosynthesis depends on tryptophan hydroxylase 1 (TPH1) in EC cells and on TPH2

12 antly in the central nervous system, whereas tryptophan hydroxylase 1 (TPH1) is expressed mostly in p

13 ZBP-89(DeltaInt) mice had reduced levels of tryptophan hydroxylase 1 (Tph1) messenger RNA, encoding

14 ed mice with mammary-specific disruptions of tryptophan hydroxylase 1 (Tph1) or low-density lipoprote

15 receptors (5-HTR), transporter (5-HTT), and tryptophan hydroxylase 1 (TPH1) was assessed in human OC

16 on factor Foxm1, both G1/S and G2/M cyclins, tryptophan hydroxylase 1 (Tph1), and islet serotonin pro

17 in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate p

18 stomach tissues of NeuroD1-cre;ROSA(tdTom), tryptophan hydroxylase 1 (Tph1)-cyan fluorescent protein

19 Specificity protein 2 (Sp2, rs3708840), tryptophan hydroxylase 1 (Tph1, rs262731280) and seroton

20 ically, there was an increased expression of tryptophan hydroxylase 1 and a suppression of monoamine

21 Mucosal 5-HT, tryptophan hydroxylase 1 messenger RNA, serotonin transp

22 mast cells, IL-33 enhanced the expression of tryptophan hydroxylase 1, serotonin synthesis, and stora

23 significantly increased colonic mRNAs Tph1 [(tryptophan hydroxylase) 1, rate limiting for mucosal 5-H

24 Peripheral serotonin, synthesized by tryptophan hydroxylase-1 (TPH(1)), has been shown to pla

25 used LP533401, a small molecule inhibitor of tryptophan hydroxylase-1 (Tph-1), the initial enzyme in

26 Expression of serotonin synthetic enzyme tryptophan hydroxylase-1 (Tph1) and serotonin production

27 ulates CD4(+) T-cell differentiation through tryptophan hydroxylase-1 (Tph1), independently of well-e

28 We also analyzed mice that lack tryptophan hydroxylase-1 (TPH1KO mice, which lack mucosa

29 5-MTP was synthesized from L-tryptophan via tryptophan hydroxylase-1 and hydroxyindole O-methyltrans

30 The former pointed to modulation of tryptophan hydroxylase-1 to enhance 5-HT synthesis, whil

31 Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses th

32 We have expressed human tryptophan hydroxylase 2 (hTPH2) and two deletion mutant

33 ain/pons of mice carrying a loxP-conditional tryptophan hydroxylase 2 (Tph2) allele.

34 Tryptophan hydroxylase 2 (TPH2) encodes the rate-limitin

35 was associated with significant decreases in tryptophan hydroxylase 2 (TPH2) expression and activity,

36 scription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitami

37 the two variants of tryptophan hydroxylase, tryptophan hydroxylase 2 (TPH2) is expressed predominant

38 a naturalistic model of 5-HT deficiency, the tryptophan hydroxylase 2 (Tph2) R439H knockin mouse, to

39 nt portions of medullary raphe serotonergic, tryptophan hydroxylase 2 (Tph2)(+) neurons by postnatal

40 rotonin (via a null mutation in the gene for tryptophan hydroxylase 2 (TPH2)) for behaviors that are

41 cause of a failure to activate expression of tryptophan hydroxylase 2 (Tph2), the key enzyme of serot

42 ant form of the brain 5-HT synthesis enzyme, tryptophan hydroxylase 2 (Tph2).

43 nced MS15 or MS180 demonstrated decreases in tryptophan hydroxylase 2 and serotonin transporter mRNA

44 Genetic deletion of NET almost eliminated tryptophan hydroxylase 2 expression and significantly re

45 Expression of tryptophan hydroxylase 2 in the dorsal raphe was normal.

46 pic and scotopic ERGs were recorded in R439H tryptophan hydroxylase 2 knockin (Tph2-KI) mice that hav

47 lity and antidepressant-like responses using tryptophan hydroxylase 2 knockin (Tph2KI) mice, which di

48 tial for serotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiol

49 eptide galanin and its receptors (GalR1-R3), tryptophan hydroxylase 2, tyrosine hydroxylase, and nitr

50 serotonin is synthesized from tryptophan by tryptophan hydroxylase 2, which is transcriptionally act

51 ant form of the brain 5-HT synthesis enzyme, tryptophan hydroxylase 2.

52 nzyme of neuronal serotonin synthesis, human tryptophan hydroxylase-2 (hTPH2).

53 s with regional shRNA interference (RNAi) of tryptophan hydroxylase-2 (Tph-2), the rate-limiting enzy

54 Tryptophan hydroxylase-2 (TPH2) catalyzes the synthesis

55 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enz

56 Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is pr

57 emical detection of the N-terminal region of tryptophan hydroxylase-2 (TPH2), the brain-specific isof

58 ly mapped gene expression in DRN and MRN for tryptophan hydroxylase-2 (Tph2), the serotonin transport

59 but not neuronal 5-HT) and mice deficient in tryptophan hydroxylase-2 (TPH2KO mice, which lack neuron

60 tic of control mice, including elevations in tryptophan hydroxylase-2 and CRF receptor-1 expression a

61 phe neurones with an immunocytochemistry for tryptophan hydroxylase (a marker of serotonergic neurone

62 A continuous fluorometric assay for tryptophan hydroxylase activity based on the different s

63 d 3.3 nmol) blocked the increase in cortical tryptophan hydroxylase activity, ex vivo, in response to

64 esidues with N-acetylimidazole did not alter tryptophan hydroxylase activity.

65 ound stress, was used as an index of in vivo tryptophan hydroxylase activity.

66 ditionally, we checked for immunolabeling of tryptophan hydroxylase, an enzyme associated with the sy

67 were immunostained for tyrosine hydroxylase, tryptophan hydroxylase and alpha-synuclein.

68 BH4, which is an essential cofactor for TH, tryptophan hydroxylase and nitric oxide synthase.

69 verlap of expression of the serotonin marker tryptophan hydroxylase and the alpha4 nAChR subunit in t

70 h isoforms of the serotonin synthetic enzyme tryptophan hydroxylase and the archetypal serotonergic t

71 bility, a homologue for aromatic amino acid (tryptophan) hydroxylase and the loss of tryptophan biosy

72 ouse 5-HT1a receptor, serotonin transporter, tryptophan hydroxylase, and aromatic L-amino acid decarb

73 which encodes the serotonin synthetic enzyme tryptophan hydroxylase, and cat-1, which encodes a vesic

74 ase, phenylethanolamine-N-methyltransferase, tryptophan hydroxylase, and histidine decarboxylase immu

75 wed simultaneous expression of the genes for tryptophan hydroxylase, arylalkylamine N-acetyltransfera

76 In contrast, the expression of tryptophan hydroxylase, as well as, the alpha7 nAChR sub

77 ERT -/- bowel, which contained mRNA encoding tryptophan hydroxylase, but no 5-HT was present in the b

78 a relatively minor role in the inhibition of tryptophan hydroxylase catalytic activity.

79 anine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase catalyze the hydroxylation of the

80 interacts with phenylalanine, tyrosine, and tryptophan hydroxylases catalyzing the BH4-activated con

81 anine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase constitute a small family of mono

82 turnover as well as the ex vivo activity of tryptophan hydroxylase (EC 1.14.16.4), the rate-limiting

83 tes tyrosyl residues at pH 8 only, inhibited tryptophan hydroxylase equally at either pH.

84 linesterase-, choline acetyltransferase-, or tryptophan hydroxylase-expressing, small bowel myenteric

85 usly, we showed that daf-7 TGFbeta and tph-1 tryptophan hydroxylase expression in specific neurons en

86 DAF-16 and serotonin-dependent inhibition of tryptophan hydroxylase expression.

87 Sodium bicarbonate protected tryptophan hydroxylase from peroxynitrite-induced inacti

88 enome sequence showed that there is a single tryptophan hydroxylase gene (tph-1)-the key enzyme for s

89 We showed expression of the tryptophan hydroxylase gene and of tryptophan hydroxylas

90 had opposing effects on transcription of the tryptophan hydroxylase gene tph-1, which encodes the rat

91 on analysis confirmed an association between tryptophan hydroxylase genotype and lifetime history of

92 e we show that developmental expression of a tryptophan hydroxylase: :GFP reporter construct is simil

93 ficity and hydroxylation regiospecificity of tryptophan hydroxylase have been investigated using tryp

94 Tyrosine hydroxylase (TH) or tryptophan hydroxylase immunohistochemistry was combined

95 etween CRF-immunoreactive varicose axons and tryptophan hydroxylase-immunoreactive neurons in the are

96 following post hoc immunohistochemistry were tryptophan hydroxylase-immunoreactive, indicating that t

97 coexpression of epsilon-sarcoglycan mRNA and tryptophan hydroxylase immunoreactivity was found in the

98 s, mouse Ucn 2 increased c-Fos expression in tryptophan hydroxylase immunostained neurons in the midd

99 rease in the expression of MAO-A, MAO-B, and tryptophan hydroxylase in the dorsal raphe nucleus of hi

100 l immunohistochemical staining for c-Fos and tryptophan hydroxylase in the DR or single immunohistoch

101 rolling serotonin biosynthesis, specifically tryptophan hydroxylase, in a light dark cycle (LD).

102 receptors and transporters and the levels of tryptophan hydroxylase, in rats with obesity induced by

103 HT levels by administration of the selective tryptophan hydroxylase inhibitor p-chlorophenylalanine o

104 tnatal days (PND) 10-20 by treating with the tryptophan hydroxylase inhibitor parachlorophenylalanine

105 natal stress and 5-HT depletion with pCPA, a tryptophan hydroxylase inhibitor, reduced the levels of

106 studies suggested that telotristat ethyl, a tryptophan hydroxylase inhibitor, reduces bowel movement

107 presence of p-chloro-phenylalanine (PCPA), a tryptophan hydroxylase inhibitor, the serotonin levels d

108 Tryptophan hydroxylase is a pterin-dependent amino acid

109 s and that the direction of the NIH shift in tryptophan hydroxylase is from carbon 5 to carbon 4.

110 reactions show that the regiospecificity of tryptophan hydroxylase is stringent.

111 enotyped for a biallelic polymorphism at the tryptophan hydroxylase locus.

112 This decreased expression of tryptophan hydroxylase observed in both the daf-2 and un

113 of serotonergic neurons identified by either tryptophan hydroxylase or serotonin immunostaining withi

114 Tryptophan hydroxylase oxidizes L-tryptophan to 5-hydrox

115 rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase plays an important role in modula

116 e serotonin [5-hydroxytryptamine (5-HT)] and tryptophan hydroxylase-positive clone was isolated, whic

117 Remarkably, Pet-1 RNA colocalizes with tryptophan hydroxylase-positive neurons in raphe nuclei

118 on of the tryptophan hydroxylase gene and of tryptophan hydroxylase protein immunoreactivity in mouse

119 quantitative autoradiography and determined tryptophan hydroxylase protein levels by Western blottin

120 Tryptophan hydroxylase protein levels in the raphe nucle

121 ve null alleles of a 5-HT2-like receptor and tryptophan hydroxylase, respectively, suggesting that se

122 Double immunostaining methods for c-Fos and tryptophan hydroxylase revealed that, consistent with pr

123 hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase--reveals important differences at

124 dy against TPH2, a brain-specific isoform of tryptophan hydroxylase (serotonin synthetic enzyme).

125 posite in phase to the circadian activity of tryptophan hydroxylase, the first enzyme in the melatoni

126 Tryptophan hydroxylase, the initial and rate-limiting en

127 F-beta-dependent developmental regulation of tryptophan hydroxylase, the rate-limiting enzyme in sero

128 sion responses of daf-7 (TGFbeta) and tph-1 (tryptophan hydroxylase) to food availability.

129 ulation of the serotonin-biosynthesis enzyme tryptophan hydroxylase tph-1 in the ADF neurons.

130 ntributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for

131 ved in anxiety behaviors, the mRNA levels of tryptophan hydroxylase (TPH) 1, TPH2 (both are involved

132 Using tryptophan hydroxylase (TPH) 2 deficient (Tph2-deficient

133 roscopy that the enzymes for 5-HT synthesis, tryptophan hydroxylase (TPH) and aromatic amino acid dec

134 nvestigation of the 5-HT-synthesizing enzyme tryptophan hydroxylase (TPH) and serotonin transporter (

135 rate-limiting serotonin biosynthetic enzyme tryptophan hydroxylase (TPH) are poorly understood.

136 Rabbit brain tryptophan hydroxylase (TPH) has been expressed in insec

137 The discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described.

138 e-limiting enzyme in serotonin biosynthesis, tryptophan hydroxylase (TPH) is a potential target for t

139 Tryptophan hydroxylase (TPH) is the initial and rate-lim

140 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme

141 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme

142 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme

143 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme

144 hieved through pharmacological inhibition of tryptophan hydroxylase (Tph) using p-chlorophenylalanine

145 The expression of mRNA for tryptophan hydroxylase (TPH) was examined in ovariectomi

146 We found that the 5-HT biosynthetic enzyme tryptophan hydroxylase (TPH) was expressed in nearly 10%

147 here looked at epidermal Trp metabolism via tryptophan hydroxylase (TPH) with its downstream cascade

148 respectively, tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), and draw an evolutionary s

149 mmunohistochemical analysis of CART and CART+tryptophan hydroxylase (TPH), CART+estrogen receptors (E

150 several loci of interest in neuropsychiatry-tryptophan hydroxylase (TPH), dopamine transporter prote

151 body to either the 5-HT-synthesizing enzyme, tryptophan hydroxylase (TPH), or to the astrocytic marke

152 Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the me

153 Exposure of tryptophan hydroxylase (TPH), the initial and rate-limit

154 Tryptophan hydroxylase (TPH), the initial and rate-limit

155 whereas other serotonergic markers, such as tryptophan hydroxylase (TPH)- or 5-HT-positive cells and

156 e and no change with ageing in the number of tryptophan hydroxylase (TPH)-positive neurons in the DR

157 alpha and the serotonin-synthesizing enzyme, tryptophan hydroxylase (TPH).

158 locally acting, small molecule inhibitor of tryptophan hydroxylase (TPH).

159 Tryptophan hydroxylase (Tph)1-deficient mice, lacking no

160 nsive elements (VDREs) at -7/-10 kb in human tryptophan hydroxylase (TPH)2 were probed.

161 f the gene encoding the 5HT synthesis enzyme tryptophan hydroxylase (tph-1) in the serotonergic chemo

162 genes essential for serotonin biosynthesis (tryptophan hydroxylase [TPH] and aromatic amine decarbox

163 nthesized through the actions of 2 different tryptophan hydroxylases, TpH1 and TpH2, which are found,

164 female colon from wild-type and mice lacking tryptophan hydroxylase (TPH1KO).

165 exception of serotonin transporter Sert and tryptophan hydroxylase TPH2, whose expression appears to

166 tyrosine hydroxylase (TH), and dorsal raphe tryptophan hydroxylase (TPH2) gene expression in male C5

167 -limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase (TPH2), we showed that quinine co

168 copy to show that neurons immunoreactive for tryptophan hydroxylase (TpOH) are tightly apposed to lar

169 -95, and a marker for 5-HT cells, the enzyme tryptophan hydroxylase (TPOH).

170 n the medullary raphe are immunoreactive for tryptophan hydroxylase (TpOH-ir).

171 le-labelling of NK1R-immunoreactive (ir) and tryptophan-hydroxylase (TPOH)-ir neurones.

172 Wild type rabbit tryptophan hydroxylase (TRH) and two truncated mutant pr

173 m the PFC and immunogold-silver labeling for tryptophan hydroxylase (TrH) or for GABA.

174 fly, Drosophila melanogaster, and identified tryptophan hydroxylase (Trh), serotonin receptor 2a (5HT

175 vesicular glutamate transporter-2 (VGLUT-2), tryptophan-hydroxylase (TrOH), glial fibrillary acid pro

176 Phenylalanine hydroxylase (PheH) and tryptophan hydroxylase (TrpH) catalyze the aromatic hydr

177 Tryptophan hydroxylase (TrpH) uses a non-heme mononuclea

178 ns by simultaneous histological detection of tryptophan hydroxylase (TrpOH) immunoreactivity with GAD

179 he DR, which were delineated on the basis of tryptophan hydroxylase (TrpOH) immunoreactivity.

180 Of the two variants of tryptophan hydroxylase, tryptophan hydroxylase 2 (TPH2)

181 The less common tryptophan hydroxylase U allele occurred with greater fr

182 data suggest that peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation.

183 Immunostaining for tryptophan hydroxylase was performed on serial 50 microm

184 Peroxynitrite-modified tryptophan hydroxylase was resistant to reduction by ars

185 K-3 with immunohistochemical localization of tryptophan hydroxylase, we found that a majority of sero

186 7 A) of a truncated functional form of human tryptophan hydroxylase with the bound cofactor analogue

187 caused the nitration of tyrosyl residues in tryptophan hydroxylase, with a maximal modification of 3