ライフサイエンスコーパス: tryptophanyl

1 which trypto-phan is transferred from TrpRS-tryptophanyl adenylate to tRNA.

2 l-tRNA synthetase is shown here to sequester tryptophanyl adenylate.

3 l-tRNA synthetase was solved at 2.1 A with a tryptophanyl-adenylate bound at the active site.

4 tRNA to bind the reaction intermediate TrpRS-tryptophanyl-adenylate, but predominantly affects the ra

5 diation of WT hSOD1 and bSOD1 that generated tryptophanyl and tyrosyl radicals.

6 o NH(2)-FMS can result in less tyrosinyl and tryptophanyl exposure OPAA molecules to aqueous environm

7 Changes in tryptophanyl fluorescence indicated that Ca2+ induced lo

8 ins (UFAC) induced concordant blue-shifts in tryptophanyl fluorescence spectra and a loss of beta-str

9 ace hydrophobicity and decrease in intrinsic tryptophanyl fluorescence.

10 een rho(C) and g(x) in other radicals, e.g., tryptophanyl, is discussed.

11 gal metabolite, apicidin [cyclo(N-O-methyl-L-tryptophanyl-L -isoleucinyl-D-pipecolinyl-L-2-amino-8-ox

12 to participate in biosynthetic nitration of tryptophanyl moieties in vivo.

13 ons; in Streptomyces, NOS proteins nitrate a tryptophanyl moiety in synthesis of a phytotoxin.

14 ts that the ribosomal A site occupied by the tryptophanyl moiety of the charged transfer RNA is the s

15 Moreover, the tryptophanyl radical detected by EPR spectroscopy of H2O

16 basis for the creation and maintenance of a tryptophanyl radical in a three-helix bundle protein maq

17 h species, and the deprotonated state of the tryptophanyl radical in the diiron(III,IV)-W* transient,

18 High field RFQ-EPR spectroscopy confirmed a tryptophanyl radical signal, and new analyses of X-band

19 This is followed by a mixture of tyrosyl and tryptophanyl radical species and finally to only a tyros

20 Both compound I and a compound II-associated tryptophanyl radical that resembles cytochrome c peroxid

21 pol, which recombines with the hSOD1-derived tryptophanyl radical, and did not occur in the absence o

22 oduct, characteristic of the generation of a tryptophanyl radical-cation (Trp(233*+)).

23 involving multiple tyrosyl (and perhaps one tryptophanyl) radical intermediates along a specific pat

24 Tryptophanyl radicals have been observed both in their p

25 xidized to a similar extent to hSOD1-derived tryptophanyl radicals.

26 The tryptophanyl residue at the 5'-terminus packs tightly ag

27 by gel-filtration chromatography, intrinsic tryptophanyl residue fluorescence changes, titration cal

28 A 33% quench of the intrinsic tryptophanyl residue fluorescence of HD(wt) by phosphate

29 calorimetry and by changes in the intrinsic tryptophanyl residue fluorescence.

30 Placement of a tryptophanyl residue near the serine binding site (W139F

31 xamined the fluorescence emission of the two tryptophanyl residues in the active site over the pH ran

32 lthough the quantum yield had decreased, the tryptophanyl residues remained largely buried.

33 vestigated: MPD-dependent C-mannosylation of tryptophanyl residues, and glucose-P-dolichol (GPD)-depe

34 f the synthetic peptide, which contained two tryptophanyl residues, shifted toward blue and increased

35 e near-UV circular dichroism (CD) spectra of tryptophanyl residues.

36 y be used as a "fingerprint" to identify the tryptophanyl side chains in situations where the benzene

37 An orthogonal tryptophanyl-transfer RNA (tRNA) synthetase (TrpRS)-muta

38 An auxiliary tryptophanyl tRNA synthetase (drTrpRS II) that interacts

39 iodurans (deiNOS) associates with an unusual tryptophanyl tRNA synthetase (TrpRS).

40 ted induction of the gene encoding the human tryptophanyl tRNA synthetase (WRS) results in the produc

41 netic codes, we have developed an orthogonal tryptophanyl tRNA synthetase and tRNA pair, derived from

42 aromatic amino acids; and cells harboring a tryptophanyl tRNA synthetase mutation conferring tempera

43 Kinetoplastids encode a single nuclear tryptophanyl tRNA that contains a CCA anticodon able to

44 an orthogonal promoter and to reengineer the tryptophanyl tRNA-synthetase:suppressor tRNA pair from S

45 nitial amber suppressor version of the yeast tryptophanyl tRNA.

46 tion catalyzed by wild-type Escherichia coli tryptophanyl-tRNA synthe-tase (TrpRS) have now been inve

47 es the first step of protein synthesis-human tryptophanyl-tRNA synthetase (T2-TrpRS) has potent anti-

48 ccus radiodurans NOS (deiNOS) and an unusual tryptophanyl-tRNA synthetase (TrpRS II) catalyzes the re

49 al structures of Bacillus stearothermophilus tryptophanyl-tRNA synthetase (TrpRS) afford evidence tha

50 r example, an alternative splice fragment of tryptophanyl-tRNA synthetase (TrpRS) and a similar natur

51 Two forms of human tryptophanyl-tRNA synthetase (TrpRS) are produced in viv

52 that competes with tryptophan for binding to tryptophanyl-tRNA synthetase (TrpRS) enzymes.

53 c.770A > G (p.His257Arg), in the cytoplasmic tryptophanyl-tRNA synthetase (TrpRS) gene (WARS) that co

54 Binding ATP to tryptophanyl-tRNA synthetase (TrpRS) in a catalytically

55 Tryptophanyl-tRNA synthetase (TrpRS) is a close homologu

56 Human tryptophanyl-tRNA synthetase (TrpRS) is active in transl

57 by contemporary Bacillus stearothermophilus tryptophanyl-tRNA synthetase (TrpRS) over that of TrpRS

58 We have investigated the tryptophanyl-tRNA synthetase (TrpRS) purified from six a

59 Tryptophanyl-tRNA Synthetase (TrpRS) Urzyme (fragments A

60 As observed for the tryptophanyl-tRNA synthetase (TrpRS) Urzyme, these fragm

61 the aromatic amino acid permease (aroP) and tryptophanyl-tRNA synthetase (trpS) contained several am

62 Mitochondrial tryptophanyl-tRNA synthetase (Wars2), encoding an L53F p

63 Furthermore, we show that E. coli tryptophanyl-tRNA synthetase also displays tRNA-dependen

64 We deleted the anticodon binding domain from tryptophanyl-tRNA synthetase and fused the discontinuous

65 we report the co-crystal structure of human tryptophanyl-tRNA synthetase and tRNATrp.

66 an activation by Bacillus stearothermophilus tryptophanyl-tRNA synthetase falls asymptotically to a p

67 The crystal structure of a highly homologous tryptophanyl-tRNA synthetase from Bacillus stearothermop

68 ption of the auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene (trpRS1) in Streptomyc

69 RNATrp, and WRS-85D is likely to be the only tryptophanyl-tRNA synthetase gene in Drosophila.

70 la embryonic salivary gland, we identified a tryptophanyl-tRNA synthetase gene that maps to cytologic

71 uss the potential noncanonical activities of tryptophanyl-tRNA synthetase in immune response and regu

72 The bacterial tryptophanyl-tRNA synthetase inhibitor indolmycin featur

73 id activation by Bacillus stearothermophilus tryptophanyl-tRNA synthetase involves three allosteric s

74 A potential polymorphic variant of human tryptophanyl-tRNA synthetase is shown here to sequester

75 e our preliminary description of the class I tryptophanyl-tRNA synthetase minimal catalytic domain wi

76 subtilis containing a temperature-sensitive tryptophanyl-tRNA synthetase produce elevated levels of

77 While kinetic analysis of the tryptophanyl-tRNA synthetase suggests discrimination aga

78 A crystal structure of human tryptophanyl-tRNA synthetase was solved at 2.1 A with a

79 The structure of yeast tryptophanyl-tRNA synthetase was solved to 1.8 A by usin

80 ions were mapped to the trpS locus (encoding tryptophanyl-tRNA synthetase) have been previously isola

81 enzymes, tyrosyl-tRNA synthetase (TyrRS) and tryptophanyl-tRNA synthetase, connect protein synthesis

82 ining a temperature-sensitive mutant form of tryptophanyl-tRNA synthetase, encoded by the trpS1 allel

83 ese nucleotides for recognition by the plant tryptophanyl-tRNA synthetase.

84 Recent work suggests that human tyrosyl- and tryptophanyl-tRNA synthetases (TrpRS) link protein synth

85 he possibility that present day tyrosyl- and tryptophanyl-tRNA synthetases appeared after the separat

86 Ij particular, the eukaryotic tyrosyl- and tryptophanyl-tRNA synthetases are more related to each o

87 s shared by all tyrosyl-tRNA synthetases and tryptophanyl-tRNA synthetases for amino acid discriminat

88 ts of the closely related human tyrosyl- and tryptophanyl-tRNA synthetases were discovered to be acti

89 (another antibiotic that inhibits bacterial tryptophanyl-tRNA synthetases) and that its transcriptio

90 reptomyces coelicolor has two genes encoding tryptophanyl-tRNA synthetases, one of which (trpRS1) is

91 ycin, two antibiotics that inhibit bacterial tryptophanyl-tRNA synthetases.

92 at shows an unusual picture for tyrosyl- and tryptophanyl-tRNA synthetases.

93 Indoleamine-2,3-dioxygenase (IDO) and tryptophanyl-tRNA-synthetase (TTS) are interferon-gamma

94 The amino acid binding domains of the tryptophanyl (TrpRS)- and tyrosyl-tRNA synthetases (TyrR