ライフサイエンスコーパス: tubercidin

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1 ducts such as toyocamycin, sangivamycin, and tubercidin.

2 dNT1 transport and consequently resistant to tubercidin.

3 ection to study the mechanism of toxicity of tubercidin (7-deazaadenosine) to procyclic Trypanosoma b

4 Analogous treatment of the antibiotic tubercidin [7-deazaadenosine; 4-amino-7-(beta-D-ribofura

5 ggested that glycolysis could be a target of tubercidin action and that RNAi silencing of glycolytic

6 Tubercidin, an inhibitor of SAHH, inhibits both chemotax

7 ensitivity to the cytotoxic adenosine analog tubercidin and concurrently restores the ability of this

8 antitrypanosomal agents adenine arabinoside, tubercidin, and cordycepin, or they need to be combined

9 ceding article we reported that analogues of tubercidin are potent adenosine kinase (AK) inhibitors w

10 Several tubercidin based AKIs, including the ribo- and lyxo-fura

11 s, including adenine, 2'-deoxyadenosine, and tubercidin, but not for any oxopurines.

12 Tubercidin does not inhibit starvation-induced expressio

13 Tubercidin has no effect on either capping of Con A rece

14 nd that transport the toxic adenosine analog tubercidin in addition to the natural substrates.

15 We conclude that 5 microm tubercidin kills trypanosomes by targeting glycolysis, e

16 cle, we demonstrate that substitution of the tubercidin molecule with aromatic rings at the N4- and t

17 structurally related to the natural product tubercidin, potently inhibited replication of poliovirus

18 1A mutation, Ser91Ala, and replacing A6 with tubercidin, purine, or 1-deazaadenine.

19 tion of glucose in the culture medium caused tubercidin resistance.

20 exokinase, a glycolytic enzyme, also yielded tubercidin-resistant parasites.

21 ic intermediates from parasites treated with tubercidin showed a dose-dependent increase in concentra

22 ression/selection using the toxic nucleoside tubercidin similarly yielded the TOR (toxic nucleoside r

23 RNAi-based genomic library, we used 5 microm tubercidin to select a drug-resistant cell line.

24 Furthermore, tubercidin triphosphate inhibited recombinant T. brucei

25 ed nucleosides, l-lyxofuranosyl analogues of tubercidin were tested as potential AKIs since the oppos

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