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1 ced in the thigh by intradermal injection of tuberculin.
2 nses to purified protein derivative (PPD) of tuberculin.
3 e of the broad antigenic cross-reactivity of tuberculin.
4 d as the new U.S. reference standard for PPD tuberculin.
5 an did PBMC from healthy persons reactive to tuberculin.
6 r induced skin test reactivity to commercial tuberculin.
7 t that measures an immunological response to tuberculin.
8 ically predisposed to react less strongly to tuberculin.
9 yed hypersensitivity response to intradermal tuberculin also demonstrates significant genetic varianc
10 n evaluation that included skin testing with tuberculin and at least two other antigens (mumps, tetan
13 esponse to purified protein derivative (PPD) tuberculin and mumps antigen, CD4 T-lymphocyte counts, a
14 f the IFN-gamma and IL-4 responses to bovine tuberculin and to ESAT-6 following experimental intratra
15 by the delayed hypersensitivity skin test to tuberculin, and antigen-induced lymphoproliferation in v
16 tuberculosis requires the development of new tuberculins consisting of antigens specific to M. tuberc
17 of pulmonary tuberculosis incidence based on tuberculin conversion rates may be invalid in such areas
19 The rate of tuberculosis was highest among tuberculin converters (5.4 cases per 100 person-years [C
20 se in whole blood following stimulation with tuberculin has the potential to detect tuberculosis infe
21 ions as well as complex Ag mixtures, such as tuberculin, mycobacterial lysates, and culture supernata
25 e ability of healthy tuberculin-positive and tuberculin-negative individuals to restrict mycobacteria
28 iagnostic specificity due to the presence in tuberculin of antigens shared by many mycobacterial spec
29 trials to evaluate its potential to replace tuberculin, or purified protein derivative, as the rapid
31 ne production in 20 patients with PTB, in 20 tuberculin-positive asymptomatic subjects, and in 14 tub
34 was significantly lower in blood samples of tuberculin-positive individuals than in blood samples of
37 ) response to purified protein derivative of tuberculin (PPD), the expression of cellular IFN-gamma a
39 perienced paradoxical responses and received tuberculin purified protein derivative (PPD) in Group 1
41 we used a human experimental system whereby tuberculin purified protein derivative (PPD) was injecte
44 were investigated by T cell proliferation to tuberculin purified protein derivative or allogeneic res
47 creted antigenic target 6 (ESAT6) protein or tuberculin (purified protein derivative) with interferon
50 feron production by lymphocytes from healthy tuberculin reactors and was recognized by monoclonal ant
52 Depletion of NK cells from PBMC of healthy tuberculin reactors reduced the frequency of M. tubercul
53 peripheral blood CD8(+) T cells from healthy tuberculin reactors that were cultured with Mycobacteriu
54 ulated peripheral blood T cells from healthy tuberculin reactors, recombinant IL-10 and TGF-beta redu
62 , such as thymic atrophy, impaired cutaneous tuberculin responses, and reduced T cell mitogenesis in
64 test results, and 5% to 10% have a negative tuberculin result but have a positive reaction to anothe
65 ention Coalition conducted a community-based tuberculin screening and isoniazid preventive therapy pr
66 he major limitations of this community-based tuberculin screening and preventive therapy project were
69 the use of limited public health resources, tuberculin screening should target students at high risk
72 serum tumor necrosis factor alpha and causes tuberculin shock in infected guinea pigs characterized b
73 results point to the possible occurrence of tuberculin shock in sensitive individuals inoculated wit
75 the single intradermal cervical comparative tuberculin (SICCT) test and that were identified from da
76 d by the Single Intradermal Comparative Skin Tuberculin (SICST), as a preliminary screen for the pres
77 aradoxical response associated with enhanced tuberculin skin reactivity may occur after the initiatio
78 erapy (ART)-naive HIV-infected patients with tuberculin skin test >/=5 mm were recruited from Khayeli
79 th latent tuberculosis infection by positive tuberculin skin test (>5 mm) were prospectively enrolled
80 om we tested, 56 (20 percent) had a positive tuberculin skin test (induration of at least 10 mm), inc
81 e tested for tuberculosis infection with the tuberculin skin test (n = 1389) and QuantiFERON assay (n
82 [OR], 7.90; P < .001), and baseline positive tuberculin skin test (OR, 2.21; P = .03); BCG vaccinatio
85 release assay was compared with the standard tuberculin skin test (TST) among 467 intravenous drug us
88 trimester and at delivery for LTBI using the tuberculin skin test (TST) and IFN-gamma release assay (
90 ld-in-tube (QGIT) antepartum and by QGIT and tuberculin skin test (TST) at delivery and postpartum.
91 (IFNG) rs1143627 (IL1B) as risk factors for tuberculin skin test (TST) conversion or development of
92 with a household member with TB or a recent tuberculin skin test (TST) conversion were included in t
94 QFT-GIT) is considered an alternative to the tuberculin skin test (TST) for the diagnosis of tubercul
96 of QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) has not been compared in a US
97 t clearly suggest that IGRAs are better than tuberculin skin test (TST) in identifying individuals wi
101 N Gold-in-Tube (QFT-GIT), T-SPOT.TB, and the tuberculin skin test (TST) might improve prediction of i
102 n-born individuals aged 12-50 years who were tuberculin skin test (TST) negative and eligible for BCG
103 ied in the same family sample, that controls tuberculin skin test (TST) negativity per se, that is, T
104 children and adults with LTBI have positive tuberculin skin test (TST) or interferon gamma release a
105 ium bovis bacillus Calmette-Guerin (BCG) nor tuberculin skin test (TST) positive (group A controls),
109 erican or other nonwhite ethnicity, positive tuberculin skin test (TST) results, age, and education;
110 ional health programs that switched from the tuberculin skin test (TST) to IFN-gamma release assays f
113 ients with tuberculosis who had a diagnostic tuberculin skin test (TST), only 18 (69%) were positive
114 esence of latent tuberculosis infection: the tuberculin skin test (TST), QuantiFERON-TB Gold (QFT-G),
115 ree commercially approved tests, namely, the tuberculin skin test (TST), the Quantiferon-TB Gold in-t
116 ma) assays are promising alternatives to the tuberculin skin test (TST), their serial testing perform
117 latent tuberculosis infection relies on the tuberculin skin test (TST), which has many drawbacks.
118 confirmed pulmonary tuberculosis (cases), 47 tuberculin skin test (TST)-positive controls, and 39 TST
123 agnostic test; 2) enroll based on a positive tuberculin skin test (TST); 3) enroll based on a positiv
124 over 3 consecutive periods: first, a 2-step tuberculin skin test (TST); second, a 2-step TST plus Qu
125 dentified as controlling the response to the tuberculin skin test (TST1 and TST2) and the production
126 ccording to their Mtb infection status using Tuberculin skin test (TST; cohort 1) or QuantiFERON (QFT
127 ding to their Mtb infection status using the tuberculin skin test (TST; cohort 1) or QuantiFERON (QFT
128 bacteriologies, TB infection (TBI) testing (tuberculin skin test [TST] and interferon gamma release
130 To determine the prevalence of a positive tuberculin skin test among economically disadvantaged yo
131 nt among persons with recent conversion of a tuberculin skin test and among most persons younger than
132 osis and history of tuberculosis then used a tuberculin skin test and an interferon-gamma release ass
133 tigated for latent tuberculosis infection by tuberculin skin test and at least one IFN-gamma release
134 ersons with induration of 10 mm or more on a tuberculin skin test and either human immunodeficiency v
135 e community-based study assessing use of the tuberculin skin test and IFN-gamma release assays among
136 is doses, suggesting that diagnostic assays (tuberculin skin test and IFN-gamma test) can detect catt
137 core predicted tuberculosis independently of tuberculin skin test and index-case drug sensitivity res
138 otifications in young children and trends in tuberculin skin test and interferon gamma-release assays
140 ersus low and high aerosols had differential tuberculin skin test and interferon-gamma release assay
141 were recruited; all participants underwent a tuberculin skin test and QuantiFERON-TB Gold assay.
142 Among children with no documented contact, tuberculin skin test and QuantiFERON-TB Gold In-Tube pos
143 tionship between the intradermal comparative tuberculin skin test and serum immunoglobulin G [IgG] re
146 umber of contacts undergoing evaluation (ie, tuberculin skin test and/or chest radiograph) per preval
150 monkeys were successfully infected, based on tuberculin skin test conversion and peripheral immune re
153 fined as the propensity of isolates to cause tuberculin skin test conversions among named contacts, a
155 that either IGRA was more sensitive than the tuberculin skin test for active tuberculosis diagnosis.
156 they may offer advantages compared with the tuberculin skin test for identifying TB infection, and i
157 terferon release assays are preferred to the tuberculin skin test for screening certain at-risk popul
158 ly used as an alternative to the traditional tuberculin skin test for the diagnosis of latent Mycobac
159 period, 18 liver transplant candidates with tuberculin skin test greater than 5 mm or recent convers
162 s that are most likely to predict a positive tuberculin skin test in contacts of tuberculosis cases.
163 ailable data, IGRAs have advantages over the tuberculin skin test in specific patient populations and
164 999-2000, NHANES assessed LTBI (defined as a tuberculin skin test measurement >/=10 mm) in participan
165 findings showing that the performance of the tuberculin skin test might be affected by various factor
166 ow- and middle-income countries, neither the tuberculin skin test nor IGRAs have value for active tub
167 system was developed, including reaction to tuberculin skin test of the contacts, as well as smear-p
169 etween 5 and 17 years with either a positive tuberculin skin test or an immunocompromising condition,
170 restricted to patients who were positive on tuberculin skin test or interferon gamma release assay (
171 rate or high incidence areas irrespective of tuberculin skin test or interferon gamma release assay s
172 baseline and follow-up visits, (2) positive tuberculin skin test or QuantiFERON-TB Gold (Cellestis I
173 bservational studies that applied either the tuberculin skin test or the interferon gamma release ass
177 lowed 6 weeks later by a late-winter peak in tuberculin skin test positivity and 12 weeks after that
178 0.35-0.7 IU/ml, and greater than 0.7 IU/ml, tuberculin skin test positivity results were 15%, 53%, 6
180 prevalence of latent tuberculosis infection (tuberculin skin test reactivity >/=10 mm), human immunod
181 Children younger than 6 yr of age who had a tuberculin skin test read at public health clinics in ar
184 re found to significantly predict a positive tuberculin skin test result among contacts of an active
185 labeling change, 34 patients with a negative tuberculin skin test result before initiation of inflixi
187 result was shown by 5.5% of children with a tuberculin skin test result less than 5 mm, by 14.8% if
189 is commonly used to help interpret negative tuberculin skin test results, the validity of this appro
190 puses has prompted some schools to institute tuberculin skin test screening of students, but this scr
191 between sarcoidosis and tuberculosis include tuberculin skin test status, the presence of ocular surf
193 ollowing M. bovis infection, the comparative tuberculin skin test strongly boosted IgG, IgG1, and IgG
194 cial for effective tuberculosis control, but tuberculin skin test surveys have major limitations, inc
196 r than 5 mm or recent conversion to positive tuberculin skin test were identified and received isonia
197 can adults with HIV infection and a positive tuberculin skin test who were not taking antiretroviral
199 erformed in preference to T-SPOT.TB (and the tuberculin skin test) for diagnosing tuberculous uveitis
200 ative disease by IFN-gamma release assay and tuberculin skin test, 'resisting' development of classic
201 sted negative by IFN-gamma release assay and tuberculin skin test, 'resisting' development of classic
202 ative disease by IFN-gamma release assay and tuberculin skin test, 'resisting' development of classic
203 ning, 27% had an initial but no postexposure tuberculin skin test, 12% were not screened, and 6% had
204 B Gold In-Tube test, (2) T-SPOT.TB test, (3) tuberculin skin test, and (4) Battey skin test using pur
206 apy against tuberculosis without obtaining a tuberculin skin test, but duration of prophylaxis is res
207 ositivity rates were lower compared with the tuberculin skin test, likely reflecting the higher speci
208 ites located across the United States with a tuberculin skin test, QuantiFERON (R) Gold In-Tube test,
209 cyte sedimentation rate, C-reactive protein, tuberculin skin test, syphilis serology, and chest radio
211 s was reported among clients with a positive tuberculin skin test, thereby preventing as much as 95%
212 n (BCG) all interfere with the action of the tuberculin skin test, which is used to determine if anim
213 atent TB-infected subjects, TB patients, and tuberculin skin test-negative donors stimulated with the
214 heir tuberculin skin tests, and from healthy tuberculin skin test-negative individuals or individuals
215 on for tuberculous infection who were either tuberculin skin test-negative or positive, the specifici
216 0.80, p=0.02), whereas participants who were tuberculin skin test-negative received no significant be
218 h bacillus Calmette-Guerin (BCG) in healthy, tuberculin skin test-positive (>/=15-mm induration), HIV
219 Cell subsets from tuberculosis cases and tuberculin skin test-positive (TST(+)) and TST-negative
220 For this analysis we used naturally exposed tuberculin skin test-positive field reactor cattle, unin
221 smear and culture-positive tuberculosis and tuberculin skin test-positive healthy control individual
222 ompared between both M. tuberculosis-exposed tuberculin skin test-positive healthy household contacts
223 d by circulating CD8+ CTLs from both healthy tuberculin skin test-positive individuals and patients w
224 nts with active tuberculosis (TB) as well as tuberculin skin test-positive individuals who had no his
225 cer, and in peripheral blood of asymptomatic tuberculin skin test-positive individuals with recent (h
228 sponses toward IVE-TB Ags, albeit lower than tuberculin skin test-positive, ESAT6/CFP10-responsive in
229 roteins were recognized by immune cells from tuberculin skin test-positive, ESAT6/CFP10-responsive in
230 skin test reaction size were associated with tuberculin skin test-positive, IFN-gamma release assay-n
239 a release assays (IGRAs) are alternatives to tuberculin skin testing (TST) for diagnosis of latent tu
240 symptom-based screening as a replacement for tuberculin skin testing (TST) to simplify contact evalua
242 ntified, compared with $32,100 per case with tuberculin skin testing and $54,100 per case with sympto
243 eness of four strategies: no intervention or tuberculin skin testing followed by treatment with isoni
244 nce of tuberculous infection, measured using tuberculin skin testing in a cohort of schoolchildren, a
245 as a method of increasing the sensitivity of tuberculin skin testing in HIV-infected persons, a conse
249 workers, the 11 (15%) who had conversion on tuberculin skin testing were no more likely than those w
250 tuberculosis infection was measured through tuberculin skin testing, and relative risks were calcula
251 sis of tuberculosis (TB) in cattle relies on tuberculin skin testing, and when combined with the slau
256 fection, identified by persistently negative tuberculin skin tests (TST) and interferon-gamma release
257 ple living with HIV (PLWH) who have positive tuberculin skin tests (TST) benefit from isoniazid preve
258 ts screened using a TB risk assessment tool, tuberculin skin tests (TST) placed and read, TST results
263 erculosis in SOT candidates/recipients using tuberculin skin tests and interferon-gamma release assay
264 rotein derivative (PPD) in Group 1 had their tuberculin skin tests convert from negative to strongly
266 idence of previous tuberculosis and positive tuberculin skin tests who have not had prior treatment.
268 berculosis documented by conversion of their tuberculin skin tests, and from healthy tuberculin skin
273 the estimates derived from population-level tuberculin skin-test surveys using traditional cutoff me
274 ression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the ba
275 losis patients and healthy control subjects (tuberculin-skin test positive or general population) wer
276 y diagnosed pulmonary tuberculosis (TB), and tuberculin-skin-test-reactive healthy control subjects.
281 ctive tuberculosis, 10% to 20% have negative tuberculin test results, and 5% to 10% have a negative t
282 the single intradermal comparative cervical tuberculin test used to diagnose BTB is reduced in cattl
287 on appeared greatest in children stringently tuberculin tested, to try to exclude prior infection wit
289 ugh medical history regarding TB, as well as tuberculin testing and radiographic examination (if indi
290 nergy testing has been used as an adjunct to tuberculin testing for assessing M. tuberculosis (MTB) i
295 A total of 7,246 persons participated in tuberculin testing; 4,701 (65%) adhered with skin test r
297 tudy was to investigate the effect of repeat tuberculin tests at 1 wk in BCG-vaccinated healthy subje
298 s a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test
300 ersensitivity (DTH) responses to intradermal tuberculin were significantly lower, and peritoneal macr