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1 nses to purified protein derivative (PPD) of tuberculin.
2 e of the broad antigenic cross-reactivity of tuberculin.
3 d as the new U.S. reference standard for PPD tuberculin.
4 an did PBMC from healthy persons reactive to tuberculin.
5 r induced skin test reactivity to commercial tuberculin.
6 t that measures an immunological response to tuberculin.
7 ically predisposed to react less strongly to tuberculin.
8 ced in the thigh by intradermal injection of tuberculin.
9 yed hypersensitivity response to intradermal tuberculin also demonstrates significant genetic varianc
10 n evaluation that included skin testing with tuberculin and at least two other antigens (mumps, tetan
13 esponse to purified protein derivative (PPD) tuberculin and mumps antigen, CD4 T-lymphocyte counts, a
14 f the IFN-gamma and IL-4 responses to bovine tuberculin and to ESAT-6 following experimental intratra
15 by the delayed hypersensitivity skin test to tuberculin, and antigen-induced lymphoproliferation in v
16 tuberculosis requires the development of new tuberculins consisting of antigens specific to M. tuberc
18 of pulmonary tuberculosis incidence based on tuberculin conversion rates may be invalid in such areas
19 on was significantly associated with risk of tuberculin conversion, while postal zone of residence wa
22 The rate of tuberculosis was highest among tuberculin converters (5.4 cases per 100 person-years [C
23 se in whole blood following stimulation with tuberculin has the potential to detect tuberculosis infe
24 ions as well as complex Ag mixtures, such as tuberculin, mycobacterial lysates, and culture supernata
28 e ability of healthy tuberculin-positive and tuberculin-negative individuals to restrict mycobacteria
31 iagnostic specificity due to the presence in tuberculin of antigens shared by many mycobacterial spec
32 trials to evaluate its potential to replace tuberculin, or purified protein derivative, as the rapid
34 ne production in 20 patients with PTB, in 20 tuberculin-positive asymptomatic subjects, and in 14 tub
37 was significantly lower in blood samples of tuberculin-positive individuals than in blood samples of
40 ) response to purified protein derivative of tuberculin (PPD), the expression of cellular IFN-gamma a
42 perienced paradoxical responses and received tuberculin purified protein derivative (PPD) in Group 1
44 we used a human experimental system whereby tuberculin purified protein derivative (PPD) was injecte
45 s incubated overnight in separate wells with tuberculin purified protein derivative (PPD), saline, an
48 were investigated by T cell proliferation to tuberculin purified protein derivative or allogeneic res
51 creted antigenic target 6 (ESAT6) protein or tuberculin (purified protein derivative) with interferon
57 feron production by lymphocytes from healthy tuberculin reactors and was recognized by monoclonal ant
59 Depletion of NK cells from PBMC of healthy tuberculin reactors reduced the frequency of M. tubercul
60 peripheral blood CD8(+) T cells from healthy tuberculin reactors that were cultured with Mycobacteriu
61 IFN-gamma production was highest in healthy tuberculin reactors, intermediate in human immunodeficie
62 ulated peripheral blood T cells from healthy tuberculin reactors, recombinant IL-10 and TGF-beta redu
70 , such as thymic atrophy, impaired cutaneous tuberculin responses, and reduced T cell mitogenesis in
73 test results, and 5% to 10% have a negative tuberculin result but have a positive reaction to anothe
74 ention Coalition conducted a community-based tuberculin screening and isoniazid preventive therapy pr
75 he major limitations of this community-based tuberculin screening and preventive therapy project were
78 the use of limited public health resources, tuberculin screening should target students at high risk
81 serum tumor necrosis factor alpha and causes tuberculin shock in infected guinea pigs characterized b
82 results point to the possible occurrence of tuberculin shock in sensitive individuals inoculated wit
84 aradoxical response associated with enhanced tuberculin skin reactivity may occur after the initiatio
85 erapy (ART)-naive HIV-infected patients with tuberculin skin test >/=5 mm were recruited from Khayeli
86 th latent tuberculosis infection by positive tuberculin skin test (>5 mm) were prospectively enrolled
87 om we tested, 56 (20 percent) had a positive tuberculin skin test (induration of at least 10 mm), inc
88 e tested for tuberculosis infection with the tuberculin skin test (n = 1389) and QuantiFERON assay (n
89 [OR], 7.90; P < .001), and baseline positive tuberculin skin test (OR, 2.21; P = .03); BCG vaccinatio
91 release assay was compared with the standard tuberculin skin test (TST) among 467 intravenous drug us
93 trimester and at delivery for LTBI using the tuberculin skin test (TST) and IFN-gamma release assay (
97 QFT-GIT) is considered an alternative to the tuberculin skin test (TST) for the diagnosis of tubercul
99 of QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) has not been compared in a US
100 t clearly suggest that IGRAs are better than tuberculin skin test (TST) in identifying individuals wi
104 n-born individuals aged 12-50 years who were tuberculin skin test (TST) negative and eligible for BCG
105 ied in the same family sample, that controls tuberculin skin test (TST) negativity per se, that is, T
106 children and adults with LTBI have positive tuberculin skin test (TST) or interferon gamma release a
107 ium bovis bacillus Calmette-Guerin (BCG) nor tuberculin skin test (TST) positive (group A controls),
110 erican or other nonwhite ethnicity, positive tuberculin skin test (TST) results, age, and education;
111 ional health programs that switched from the tuberculin skin test (TST) to IFN-gamma release assays f
114 ients with tuberculosis who had a diagnostic tuberculin skin test (TST), only 18 (69%) were positive
115 esence of latent tuberculosis infection: the tuberculin skin test (TST), QuantiFERON-TB Gold (QFT-G),
116 ree commercially approved tests, namely, the tuberculin skin test (TST), the Quantiferon-TB Gold in-t
117 ma) assays are promising alternatives to the tuberculin skin test (TST), their serial testing perform
118 latent tuberculosis infection relies on the tuberculin skin test (TST), which has many drawbacks.
119 confirmed pulmonary tuberculosis (cases), 47 tuberculin skin test (TST)-positive controls, and 39 TST
123 over 3 consecutive periods: first, a 2-step tuberculin skin test (TST); second, a 2-step TST plus Qu
124 dentified as controlling the response to the tuberculin skin test (TST1 and TST2) and the production
126 To determine the prevalence of a positive tuberculin skin test among economically disadvantaged yo
127 nt among persons with recent conversion of a tuberculin skin test and among most persons younger than
128 osis and history of tuberculosis then used a tuberculin skin test and an interferon-gamma release ass
129 tigated for latent tuberculosis infection by tuberculin skin test and at least one IFN-gamma release
130 ersons with induration of 10 mm or more on a tuberculin skin test and either human immunodeficiency v
131 e community-based study assessing use of the tuberculin skin test and IFN-gamma release assays among
132 is doses, suggesting that diagnostic assays (tuberculin skin test and IFN-gamma test) can detect catt
133 core predicted tuberculosis independently of tuberculin skin test and index-case drug sensitivity res
134 otifications in young children and trends in tuberculin skin test and interferon gamma-release assays
135 ersus low and high aerosols had differential tuberculin skin test and interferon-gamma release assay
136 were recruited; all participants underwent a tuberculin skin test and QuantiFERON-TB Gold assay.
137 Among children with no documented contact, tuberculin skin test and QuantiFERON-TB Gold In-Tube pos
138 tionship between the intradermal comparative tuberculin skin test and serum immunoglobulin G [IgG] re
141 f tuberculosis were screened by means of the tuberculin skin test and those with latent tuberculosis
142 umber of contacts undergoing evaluation (ie, tuberculin skin test and/or chest radiograph) per preval
144 monkeys were successfully infected, based on tuberculin skin test conversion and peripheral immune re
148 fined as the propensity of isolates to cause tuberculin skin test conversions among named contacts, a
150 that either IGRA was more sensitive than the tuberculin skin test for active tuberculosis diagnosis.
151 they may offer advantages compared with the tuberculin skin test for identifying TB infection, and i
152 terferon release assays are preferred to the tuberculin skin test for screening certain at-risk popul
153 ly used as an alternative to the traditional tuberculin skin test for the diagnosis of latent Mycobac
154 period, 18 liver transplant candidates with tuberculin skin test greater than 5 mm or recent convers
158 s that are most likely to predict a positive tuberculin skin test in contacts of tuberculosis cases.
159 ailable data, IGRAs have advantages over the tuberculin skin test in specific patient populations and
160 999-2000, NHANES assessed LTBI (defined as a tuberculin skin test measurement >/=10 mm) in participan
161 findings showing that the performance of the tuberculin skin test might be affected by various factor
162 ow- and middle-income countries, neither the tuberculin skin test nor IGRAs have value for active tub
163 system was developed, including reaction to tuberculin skin test of the contacts, as well as smear-p
165 restricted to patients who were positive on tuberculin skin test or interferon gamma release assay (
166 rate or high incidence areas irrespective of tuberculin skin test or interferon gamma release assay s
167 baseline and follow-up visits, (2) positive tuberculin skin test or QuantiFERON-TB Gold (Cellestis I
168 bservational studies that applied either the tuberculin skin test or the interferon gamma release ass
172 lowed 6 weeks later by a late-winter peak in tuberculin skin test positivity and 12 weeks after that
173 0.35-0.7 IU/ml, and greater than 0.7 IU/ml, tuberculin skin test positivity results were 15%, 53%, 6
175 prevalence of latent tuberculosis infection (tuberculin skin test reactivity >/=10 mm), human immunod
176 Children younger than 6 yr of age who had a tuberculin skin test read at public health clinics in ar
179 re found to significantly predict a positive tuberculin skin test result among contacts of an active
180 labeling change, 34 patients with a negative tuberculin skin test result before initiation of inflixi
182 result was shown by 5.5% of children with a tuberculin skin test result less than 5 mm, by 14.8% if
185 is commonly used to help interpret negative tuberculin skin test results, the validity of this appro
186 puses has prompted some schools to institute tuberculin skin test screening of students, but this scr
187 between sarcoidosis and tuberculosis include tuberculin skin test status, the presence of ocular surf
189 ollowing M. bovis infection, the comparative tuberculin skin test strongly boosted IgG, IgG1, and IgG
190 cial for effective tuberculosis control, but tuberculin skin test surveys have major limitations, inc
192 r than 5 mm or recent conversion to positive tuberculin skin test were identified and received isonia
193 can adults with HIV infection and a positive tuberculin skin test who were not taking antiretroviral
195 erformed in preference to T-SPOT.TB (and the tuberculin skin test) for diagnosing tuberculous uveitis
196 ning, 27% had an initial but no postexposure tuberculin skin test, 12% were not screened, and 6% had
197 B Gold In-Tube test, (2) T-SPOT.TB test, (3) tuberculin skin test, and (4) Battey skin test using pur
199 apy against tuberculosis without obtaining a tuberculin skin test, but duration of prophylaxis is res
200 ositivity rates were lower compared with the tuberculin skin test, likely reflecting the higher speci
201 cyte sedimentation rate, C-reactive protein, tuberculin skin test, syphilis serology, and chest radio
203 s was reported among clients with a positive tuberculin skin test, thereby preventing as much as 95%
204 n (BCG) all interfere with the action of the tuberculin skin test, which is used to determine if anim
205 atent TB-infected subjects, TB patients, and tuberculin skin test-negative donors stimulated with the
206 heir tuberculin skin tests, and from healthy tuberculin skin test-negative individuals or individuals
207 on for tuberculous infection who were either tuberculin skin test-negative or positive, the specifici
208 0.80, p=0.02), whereas participants who were tuberculin skin test-negative received no significant be
210 h bacillus Calmette-Guerin (BCG) in healthy, tuberculin skin test-positive (>/=15-mm induration), HIV
211 Cell subsets from tuberculosis cases and tuberculin skin test-positive (TST(+)) and TST-negative
212 For this analysis we used naturally exposed tuberculin skin test-positive field reactor cattle, unin
213 smear and culture-positive tuberculosis and tuberculin skin test-positive healthy control individual
214 ompared between both M. tuberculosis-exposed tuberculin skin test-positive healthy household contacts
215 ines (AL) and alveolar macrophages (AM) from tuberculin skin test-positive healthy subjects to serve
216 d by circulating CD8+ CTLs from both healthy tuberculin skin test-positive individuals and patients w
217 nts with active tuberculosis (TB) as well as tuberculin skin test-positive individuals who had no his
218 cer, and in peripheral blood of asymptomatic tuberculin skin test-positive individuals with recent (h
221 sponses toward IVE-TB Ags, albeit lower than tuberculin skin test-positive, ESAT6/CFP10-responsive in
222 roteins were recognized by immune cells from tuberculin skin test-positive, ESAT6/CFP10-responsive in
223 skin test reaction size were associated with tuberculin skin test-positive, IFN-gamma release assay-n
232 a release assays (IGRAs) are alternatives to tuberculin skin testing (TST) for diagnosis of latent tu
233 ratories to determine the status of existing tuberculin skin testing (TST) programs and to evaluate t
235 ntified, compared with $32,100 per case with tuberculin skin testing and $54,100 per case with sympto
236 eness of four strategies: no intervention or tuberculin skin testing followed by treatment with isoni
237 nce of tuberculous infection, measured using tuberculin skin testing in a cohort of schoolchildren, a
238 as a method of increasing the sensitivity of tuberculin skin testing in HIV-infected persons, a conse
243 workers, the 11 (15%) who had conversion on tuberculin skin testing were no more likely than those w
244 tuberculosis infection was measured through tuberculin skin testing, and relative risks were calcula
245 sis of tuberculosis (TB) in cattle relies on tuberculin skin testing, and when combined with the slau
250 ple living with HIV (PLWH) who have positive tuberculin skin tests (TST) benefit from isoniazid preve
251 ts screened using a TB risk assessment tool, tuberculin skin tests (TST) placed and read, TST results
256 erculosis in SOT candidates/recipients using tuberculin skin tests and interferon-gamma release assay
258 rotein derivative (PPD) in Group 1 had their tuberculin skin tests convert from negative to strongly
260 ex patient were more likely to have positive tuberculin skin tests than those in the rest of the sect
261 idence of previous tuberculosis and positive tuberculin skin tests who have not had prior treatment.
264 berculosis documented by conversion of their tuberculin skin tests, and from healthy tuberculin skin
270 the estimates derived from population-level tuberculin skin-test surveys using traditional cutoff me
271 ression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the ba
272 losis patients and healthy control subjects (tuberculin-skin test positive or general population) wer
273 y diagnosed pulmonary tuberculosis (TB), and tuberculin-skin-test-reactive healthy control subjects.
274 e United States was estimated from published tuberculin surveys and found to be related to tuberculos
280 ctive tuberculosis, 10% to 20% have negative tuberculin test results, and 5% to 10% have a negative t
281 the single intradermal comparative cervical tuberculin test used to diagnose BTB is reduced in cattl
282 antigen to aid in the interpretation of the tuberculin test will often lead to erroneous conclusions
287 on appeared greatest in children stringently tuberculin tested, to try to exclude prior infection wit
289 ugh medical history regarding TB, as well as tuberculin testing and radiographic examination (if indi
290 nergy testing has been used as an adjunct to tuberculin testing for assessing M. tuberculosis (MTB) i
295 A total of 7,246 persons participated in tuberculin testing; 4,701 (65%) adhered with skin test r
297 tudy was to investigate the effect of repeat tuberculin tests at 1 wk in BCG-vaccinated healthy subje
298 s a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test
300 ersensitivity (DTH) responses to intradermal tuberculin were significantly lower, and peritoneal macr
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