ライフサイエンスコーパス: tubulation

1 patients were observed (termed outer retinal tubulation).

2 ping, and in rare cases spontaneous membrane tubulation.

3 rminal BAR domain, which can induce membrane tubulation.

4 mpartments, reducing the frequency of LE/Lys tubulation.

5 ntiation factor 88, blocked T cell-dependent tubulation.

6 d CD2 are involved in induction of endosomal tubulation.

7 d from ARF1 activity in the control of Golgi tubulation.

8 ans-Golgi network (TGN) and caused extensive tubulation.

9 ion membrane and augments inclusion membrane tubulation.

10 kinase VPS34, results in prolonged lysosomal tubulation.

11 l components for the initiation of lysosomal tubulation.

12 Drp1 GTPase activity, as well as of membrane tubulation.

13 coupling as an additional driving force for tubulation.

14 spastin binds, also had increased endosomal tubulation.

15 ry and in occurring by membrane blebbing and tubulation.

16 degradation) proteins to regulate endosomal tubulation.

17 ns promote actin polymerization and membrane tubulation.

18 lations of WHAMM collaborate during membrane tubulation.

19 that contribute to membrane curvature and/or tubulation.

20 pin association, GTP hydrolysis and membrane tubulation.

21 moving to the OB surface through peroxisome tubulations.

22 al homology (ENTH) domain has potent vesicle tubulation activity despite a lack of intrinsic molecula

23 vitro and in vivo assays confirmed membrane-tubulation activity for muniscin EFC/F-BAR domains.

24 and is required for membrane penetration and tubulation activity of FAPP1, whereas the GTP-bound conf

25 The membrane tubulation activity of OPA1 is suppressed by GTPgammaS.

26 uniscins provide a combined adaptor/membrane-tubulation activity that is important for regulating end

27 a critical size is essential for its vesicle tubulation activity.

28 ENTH domain complexes abrogated the vesicle tubulation activity.

29 disrupted, the result of impaired lysosomal tubulation alongside ALR activation is massive cell deat

30 show that the function of SNX18 in membrane tubulation and autophagy is negatively regulated by phos

31 pendent mechanisms rescues aberrant retromer tubulation and cholesterol mistrafficking.

32 In vitro, calmodulin enhanced membrane tubulation and constriction by wild-type Rvs167 but not

33 phology of endosomal compartments, marked by tubulation and enlargement of endosomes containing trans

34 f-war mechanism, leading to MT1-MMP endosome tubulation and exocytosis.

35 mes then move by a dynamic process involving tubulation and fission, followed by rapid retrograde and

36 evering events, may play a role in endosomal tubulation and fission.

37 hat BIN1 plays an important role in membrane tubulation and may promote skeletal muscle weakness in C

38 f Parkin function led to decreased endosomal tubulation and membrane association of vesicle protein s

39 dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer

40 e STIM1-Orai1 coupling because of loss of ER tubulation and redistribution of STIM1 to ER sheets.

41 Extensive tubulation and relatively rapid Golgi resident redistrib

42 at mTOR is required for LPS-induced lysosome tubulation and secretion of major histocompatibility com

43 NTH-domain-induced membrane vesiculation and tubulation and the implications of the epsin's role in c

44 th the ability of RTNLB13 to induce membrane tubulation and to form low-mobility complexes within the

45 early endosomes undergo fusion, fission, and tubulation and transiently interact with one another, la

46 Pase dynamin, a protein involved in membrane tubulation and vesiculation, is essential for successful

47 used to characterize the process of liposome tubulation and vesiculation.

48 n preceded by the formation of outer retinal tubulations and choriocapillaris dropout.

49 h the size of the cargo (membrane budding or tubulation), and finally separation of the nascent carri

50 ubstantial reduction in binding affinity and tubulation, and simulations of the NAC-null protein sugg

51 at BFA stimulation of Golgi and TGN membrane tubulation, and the resultant retrograde transport of re

52 in biological processes such as endocytosis, tubulation, and vesiculation.

53 owed outer retinal layer loss, outer retinal tubulations at the margin of outer retinal loss, and inn

54 of these residues regulate lipid-binding and tubulation both in vitro and in cells.

55 h experimental observations of the degree of tubulation by amphipathic helices and variation of the f

56 ally dissimilar, the processes necessary for tubulation by epithelial and endothelial cells are very

57 icros provides a dynamic picture of membrane tubulation by lattices of F-BAR domains.

58 ion delayed and altered lung epithelial cell tubulation by selectively inhibiting G protein-mediated

59 It is found that tubulation can be generated by anisotropic N-BAR spontan

60 Endophilin's membrane tubulation capacity is well known.

61 of SNX18 depends on its membrane binding and tubulation capacity.

62 dly, deletion of Oma1 restored mitochondrial tubulation, cristae morphogenesis, and apoptotic resista

63 A tubulation-defective syt mutant was able to promote fusi

64 an N-BAR domain rescued the function of the tubulation-deficient syt mutant.

65 remodeling processes (e.g., vesiculation and tubulation) due to N-BAR domain interactions with the li

66 in nucleation activities to promote membrane tubulation during intracellular transport.

67 The tubulation effect is attributable to direct phospholipid

68 tein Syndapin (Synd) is involved in membrane tubulation, endocytosis, and, uniquely, in F-actin stabi

69 s failed to evoke T cell-polarized endosomal tubulation even though both conditions allowed T cell st

70 n widely implicated in facilitating membrane tubulation, fission, and in select cases, fusion.

71 a vertebrate protein functioning in membrane tubulation for intracellular membrane trafficking and sp

72 the patients and carriers had outer retinal tubulations forming pseudopod-like extensions from islan

73 epithelium, and choroid, with outer retinal tubulations frequently observed.

74 ssion of RTNLB13 was sufficient to induce ER tubulation in an Arabidopsis mutant (pah1 pah2) whose ER

75 hology, but is dispensable for peripheral ER tubulation in an endogenous context, and that its activi

76 FlnA-PACSIN2 interaction regulates membrane tubulation in MKs and platelets and likely contributes t

77 ells that allow Ag-specific T cells to evoke tubulation in the dendritic cell.

78 no acid segment required for trafficking and tubulation in the endolysosomal pathway.

79 D) is required for trafficking and organelle tubulation in the endolysosome system.

80 n and enhanced PACSIN2 F-BAR domain membrane tubulation in vitro.

81 of calmodulin with endophilin A2 potentiated tubulation in vivo.

82 There were outer retinal tubulations in degenerated, nonatrophic retina in the ma

83 le loss of the ER cisternae and extensive ER tubulation, including formation of ER patches comprising

84 aling pathway regulates LPS-induced lysosome tubulation independently of IRAK1/4 and TBK.

85 Similarly, we found that Golgi tubulation induced by brefeldin A, a known microtubule-d

86 thick in early stages of disease and retinal tubulation is present in advanced disease.

87 increasing membrane surface area by endosome tubulation is the main mechanism to ensure efficient rec

88 ion reduction initiates membrane budding and tubulation mediated by endocytic proteins, such as endop

89 ndosomal/lysosomal trafficking and organelle tubulation observed for the intact molecule, whereas del

90 s was 183.0 mum (n = 33), with outer retinal tubulation observed in 15 (45%).

91 zed cell system, consistent with the lack of tubulation observed upon EHD3 depletion.

92 qualities, such as helical self-assembly and tubulation of a lipid bilayer.

93 he MT-severing protein spastin had increased tubulation of and defective receptor sorting through end

94 in the intermediate compartment (IC) and the tubulation of cis-Golgi and IC membranes.

95 ber that participates in the trafficking and tubulation of early endosomes along microtubules.

96 Surprisingly, the addition of EHD3 causes tubulation of endocytic membranes in our semipermeabiliz

97 oplasmic huntingtin also exhibited increased tubulation of endosomal membranes.

98 Tubulation of ERCs within human DCs requires antigen-spe

99 We conclude from these observations that tubulation of Golgi complex and TGN membranes requires a

100 ine acyltransferase (LPAT) induces the rapid tubulation of Golgi membranes, leading in their retrogra

101 opsis CURT1A proteins oligomerize and induce tubulation of liposomes, implying that CURT1 proteins su

102 udies have shown that IMDs can induce inward tubulation of liposomes.

103 e that is activated by RhoA, SifA can induce tubulation of mammalian endosomes.

104 uorescence and a significant aggregation and tubulation of mitochondria by immunofluorescence microsc

105 , and loss of Rab11 prevents TBC1D14-induced tubulation of REs.

106 omain, the RCB domain/IMD did not cause long tubulation of the artificial liposomes; however, the Rac

107 Fenestration and tubulation of the ER correlates with a reduced number of

108 med by a dynamic process of congregation and tubulation of the newly inherited Golgi fragments.

109 s authentic dynamins) function in fission or tubulation of the plasma membrane, trans-Golgi network,

110 ctor protein SifA regulates the assembly and tubulation of the Salmonella phagosome.

111 utrient deprivation stimulated the excessive tubulation of these autolysosomal compartments.

112 TLR triggering was insufficient for induced tubulation of transferrin-positive endosomal recycling c

113 To document outer retinal tubulation (ORT) formation in advanced retinal disorders

114 is also maintained by proteins acting in the tubulation pathway.

115 Rather, tubulation promotes MHC-II presentation by enabling maxi

116 This tubulation requires mTOR activity, and we identified two

117 their differential roles in vesiculation and tubulation, respectively.

118 We propose that such tubulation serves to facilitate the ensuing T-cell respo

119 spastin or IST1 also had abnormal endosomal tubulation, so we propose this phenotype is important fo

120 iated Arl8b, a lysosomal GTPase required for tubulation that promotes kinesin-dependent lysosome move

121 We also found that Drp1 induced membrane tubulation that was stimulated by cardiolipin.

122 required to support Sar1p-dependent membrane tubulation, the subsequent Sar1p-dependent recruitment o

123 induction is different for vesiculation and tubulation, these data also explain why previous studies

124 in lysosome identity by initiating lysosomal tubulation through a process termed autophagosome-lysoso

125 t links phospholipid remodeling and membrane tubulation to dynein-dependent transport.

126 Finally, we establish that mitochondrial tubulation upon nutrient deprivation protects mitochondr

127 Significantly, without WASH, retromer tubulation was exaggerated, supporting a model wherein W

128 Tubulation was suppressed in the context of the full-len

129 bution of the same markers, without apparent tubulation, was observed under hyperosmotic conditions.

130 Outer retinal tubulations were associated with absence of underlying r

131 pigment epithelium detachment, outer retinal tubulation) were identified in the retinae of the GA pat

132 roliferation involving membrane blebbing and tubulation, which is dependent on an altered rate of mem

133 t with microtubules plays a role in membrane tubulation, while its capacity to induce actin assembly