ライフサイエンスコーパス: tubulogenesis

1 and tubules, two sequential intermediates in tubulogenesis.

2 he duct during de novo epithelialization and tubulogenesis.

3 and other p300-dependent genes required for tubulogenesis.

4 nt mitogenesis, migration, cell scatter, and tubulogenesis.

5 hesion, migration, and endothelial cell (EC) tubulogenesis.

6 eated with hepatocyte growth factor to model tubulogenesis.

7 it is functionally important in vivo during tubulogenesis.

8 al vulval lumen formation to complete vulval tubulogenesis.

9 spreading and migration necessary for normal tubulogenesis.

10 C4-null mouse embryos exhibit impaired renal tubulogenesis.

11 fate, the AC directly promotes dorsal vulval tubulogenesis.

12 y tubes through the process of intracellular tubulogenesis.

13 and actomyosin contractility during vascular tubulogenesis.

14 ormation and to the general process of early tubulogenesis.

15 gration, and tubulogenesis and Lys(1147) for tubulogenesis.

16 dothelial cell proliferation, migration, and tubulogenesis.

17 ndothelial cell proliferation, migration and tubulogenesis.

18 vements required for neural tube closure and tubulogenesis.

19 sis, mediating VEGF induction of endothelial tubulogenesis.

20 play an important role in the regulation of tubulogenesis.

21 moted endothelial cell proliferation but not tubulogenesis.

22 and dorsoventral patterning, and epithelial tubulogenesis.

23 glioma cells and prevented endothelial cell tubulogenesis.

24 e the expression of Lim1 for MM survival and tubulogenesis.

25 ystem that regulates vesicle dynamics during tubulogenesis.

26 g morphogenesis, and multicellular branching tubulogenesis.

27 brafish embryos specifically blocks vascular tubulogenesis.

28 GTPases are coordinated by Rasip1 to direct tubulogenesis.

29 s HGF-induced cell spreading, migration, and tubulogenesis.

30 iferation, migration, invasive capacity, and tubulogenesis.

31 implicating RGS4 as a potential regulator of tubulogenesis.

32 F coordinately regulate successive stages of tubulogenesis.

33 MCD, and UB cell culture models of branching tubulogenesis.

34 imulate endothelial cell differentiation and tubulogenesis.

35 B) and the transcription factor ETS1, during tubulogenesis.

36 enesis resembles aspects of mammalian kidney tubulogenesis.

37 ating the growth of the ureteric system with tubulogenesis.

38 yme-specific inducer, Wnt-4, and its role in tubulogenesis.

39 sms downstream of Rasip1 that drive vascular tubulogenesis.

40 nduced the nephrogenic mesenchyme to undergo tubulogenesis.

41 ureter in the presence of signals promoting tubulogenesis.

42 ot competent to respond to signals promoting tubulogenesis.

43 um, resulting in vasculogenesis and enhanced tubulogenesis.

44 th independently and in combination, inhibit tubulogenesis.

45 the hierarchy of molecular events mediating tubulogenesis.

46 a signaling cascade that may regulate renal tubulogenesis.

47 ng the importance of Wnt signaling for renal tubulogenesis.

48 iently lost and subsequently regained during tubulogenesis.

49 atenins in an MDCK epithelial cell model for tubulogenesis.

50 s characteristic of early in vitro branching tubulogenesis.

51 (Cad5KO)) at mid-gestation blocks angiogenic tubulogenesis.

52 mediated cell-cell adhesion is important for tubulogenesis.

53 regulating cell migration during epithelial tubulogenesis.

54 required for C. elegans excretory cell (EC) tubulogenesis.

55 rganizes F-actin and MT cytoskeletons during tubulogenesis.

56 wound healing, chemotaxis and invasion, and tubulogenesis.

57 lies frequently occur in organs that undergo tubulogenesis.

58 ial cell outputs, such as cell migration and tubulogenesis.

59 ated, but not Sema3e-mediated, inhibition of tubulogenesis.

60 precise timing of these events in pronephros tubulogenesis.

61 ibition of Pak4, all blocks endothelial cell tubulogenesis.

62 rmation assays indicate that both can impede tubulogenesis.

63 and lumen formation/elongation during kidney tubulogenesis.

64 silencing of STIM1 or Orai1 did not prevent tubulogenesis.

65 inhibitor to activated PKA cultures rescued tubulogenesis.

66 ll surface, and defective cell migration and tubulogenesis.

67 ntify pathways regulating specific stages of tubulogenesis.

68 ith decreased cell viability, migration, and tubulogenesis.

69 ing pathway significantly reduced pronephric tubulogenesis.

70 of E-cadherin in epithelial polarization and tubulogenesis.

71 -STAT3 axis in epithelial sheet invasion and tubulogenesis.

72 s cysts in three-dimensional culture induces tubulogenesis [5, 6], which like most tubulogenic proces

73 excretory cell (EC) is a powerful model for tubulogenesis, a conserved process that requires precise

74 m1 and Wnt4 knockouts, which arrest in early tubulogenesis, a network of genes involving PKA, Wnt, Lh

75 central role in endothelial cell migration, tubulogenesis, adhesion, and permeability in response to

76 uding epithelial-mesenchymal conversions and tubulogenesis, although the mechanisms responsible for r

77 l patterning of both distal air and vascular tubulogenesis (alveolarization).

78 rofile associated with pancreatic epithelial tubulogenesis and a tissue architecture-specific signatu

79 ription factors implicated in wound healing, tubulogenesis and cancer.

80 ctor Atmin (Asciz) is required for both lung tubulogenesis and ciliogenesis.

81 ostulated to play an important role in renal tubulogenesis and compensatory hypertrophy.

82 is study tested the hypothesis that coronary tubulogenesis and coronary artery formation require VEGF

83 D), but its role in the molecular pathway of tubulogenesis and cystogenesis is not understood.

84 Nonetheless, the contribution of PCP to tubulogenesis and cystogenesis is uncertain, and two maj

85 ain insight into the role of polycystin-1 in tubulogenesis and cystogenesis using the well-characteri

86 we have utilized a 3D MDCK in vitro model of tubulogenesis and cystogenesis.

87 errantly, resulting in failure of epithelial tubulogenesis and ductal plexus formation.

88 le of influencing such cellular processes as tubulogenesis and endothelial cell migration, yet very l

89 opment but was responsible for postinductive tubulogenesis and epithelial integrity.

90 cell shape and cell rearrangements, de novo tubulogenesis and epithelial tubule remodeling.

91 enesis assay, activated G alpha 12 inhibited tubulogenesis and led to the formation of cyst-like stru

92 in cultured renal epithelial cells disrupted tubulogenesis and led to upregulation of Pkd1.

93 Tubulogenesis and lumen formation are critical to the de

94 tion; Lys(1146) for adhesion, migration, and tubulogenesis and Lys(1147) for tubulogenesis.

95 signaling at multiple steps, including IHBD tubulogenesis and maintenance, during hepatic developmen

96 e growth factor (HGF) plays central roles in tubulogenesis and metastasis [1-4].

97 ray analysis to further our understanding of tubulogenesis and observed a robust induction of regulat

98 e importance of Rho-kinase in normal nephron tubulogenesis and patterning.

99 ARF6 is transiently activated during tubulogenesis and perturbing the ARF6 GTP/GDP cycle by i

100 l epithelial cells was sufficient to disrupt tubulogenesis and produce cyst-like structures.

101 rving their in vivo angiogenic potential for tubulogenesis and sprouting.

102 gnaling pathway that is necessary for normal tubulogenesis and that PKD1 may require the presence of

103 of several signaling pathways that regulate tubulogenesis and vascular branching, elongation, and pr

104 L rescued high glucose-induced impairment of tubulogenesis and vascular endothelial growth factor (VE

105 oxygen and prevention of low oxygen-induced tubulogenesis and vasculogenesis by anti-VEGF antibodies

106 These studies indicate that tubulogenesis and vasculogenesis can be partially recapi

107 cells, suggesting it may be involved in the tubulogenesis and/or maintenance of duct-lumen architect

108 g different stages of tubular morphogenesis (tubulogenesis) and of PANC-1 cells during spheroid forma

109 tputs such as cell migration, proliferation, tubulogenesis, and cell-cell interactions.

110 ssary for inhibition of p300, suppression of tubulogenesis, and interference with EMT.

111 1 and syndecan-4, inhibiting cell migration, tubulogenesis, and proliferation.

112 ein kinase C- and PI3K-dependent endothelial tubulogenesis, and stimulated angiogenesis in a mouse sp

113 that cause the cell shape changes that drive tubulogenesis are not well understood.

114 coordinating morphogenetic processes during tubulogenesis are poorly understood.

115 However, the mechanisms underlying vascular "tubulogenesis" are only beginning to be unraveled.

116 blood vessel morphogenesis using an in vitro tubulogenesis assay and three different culture systems:

117 Using the MDCK cell 3D-tubulogenesis assay, activated G alpha 12 inhibited tubu

118 In vitro tubulogenesis assays indicate that isolated BMPER(-/-) e

119 rformed using cell viability, migration, and tubulogenesis assays, as well as quantitative RT-PCR and

120 wth factor (SF/HGF) to initiate invasion and tubulogenesis atop either type I collagen or interstitia

121 nase expression and blunts proliferation and tubulogenesis, (b) in a PPARalpha-humanized mouse model,

122 hat TRPC channels are essential for in vitro tubulogenesis, both on endothelial cell line and on prim

123 oglycans and is only required for triggering tubulogenesis but not for later events.

124 One gene, ASPM, was down-regulated during tubulogenesis but up-regulated in human PDAC cell lines

125 in intercellular contacts at early steps of tubulogenesis, but assumes its basolateral localization

126 t an excellent model in which to investigate tubulogenesis, but the cell types and lineage relationsh

127 been previously implicated in intracellular tubulogenesis, but their specific role has not been defi

128 Thus, HNF-1beta regulates tubulogenesis by controlling the levels of SOCS-3 expres

129 creased levels of SOCS-3 inhibit HGF-induced tubulogenesis by decreasing phosphorylation of Erk and S

130 the proliferation of, chemoinvasion of, and tubulogenesis by endothelial cells in vitro, an effect m

131 Tubulogenesis by epithelial cells regulates kidney, lung

132 or (HGF/ SF)-stimulated MDCK cysts initiated tubulogenesis by forming many long cell extensions.

133 63 fine-tunes the rate of cyst formation and tubulogenesis by maintaining an appropriate expression l

134 that TAp63 is the major isoform required for tubulogenesis by maintaining an appropriate level of EMT

135 cell outgrowth and lumen formation during EC tubulogenesis by regulating F-actin at the tip of the gr

136 HNF-1beta rescues the defect in HGF-induced tubulogenesis by restoring phosphorylation of Erk and ST

137 soforms in cell proliferation, migration and tubulogenesis by using Madin-Darby Canine Kidney (MDCK)

138 ated from the floxed FAK mice led to reduced tubulogenesis, cell survival, proliferation, and migrati

139 Therefore, during tubulogenesis, cell-cell adhesive contacts are different

140 Finally a tubulogenesis defect phenotype was identified for the ge

141 Entrapped ECFCs underwent tubulogenesis dependent on the cellular interactions wit

142 helial cell apical junctions during vascular tubulogenesis depends on Rasip1, as well as the GTPase C

143 wn, and the role of membrane transporters in tubulogenesis during development has not been adequately

144 ) and metanephric mesenchyme are crucial for tubulogenesis during kidney development.

145 ch2 receptor is essential for normal biliary tubulogenesis during liver development.

146 ic innervation coordinates multiple steps in tubulogenesis during organogenesis.

147 men signaling complexes, to control human EC tubulogenesis during vascular morphogenesis.

148 tes growth by cell proliferation and induces tubulogenesis, endothelial cell differentiation, and vas

149 rations, including proliferation, migration, tubulogenesis, enhanced vascular permeability, and endot

150 PGE(1)-OH and ONO-AE1-329 induced migration, tubulogenesis, ERK activation and cAMP production in con

151 regulated kinase 1/2 (ERK1/2) activation and tubulogenesis, even under conditions where tubulogenesis

152 Here, we describe a novel function during tubulogenesis for ZEN-4, the Caenorhabditis elegans orth

153 ulated during distinct stages of HGF-induced tubulogenesis from MDCK cysts.

154 on between glial ensheathment of neurons and tubulogenesis, have uncovered glial roles in neurite gro

155 does not block MDCK cell cyst formation and tubulogenesis in 3-D culture.

156 promote human endothelial cell survival and tubulogenesis in 3-D type I collagen gels, a response th

157 ta(1), which coassociate to control human EC tubulogenesis in 3D collagen matrices.

158 apical membrane surface during blood vessel tubulogenesis in 3D matrix environments.

159 -catenin dependent pathway) disrupted normal tubulogenesis in a manner similar to PKA-agonist treated

160 We show that during tubulogenesis in an in vitro model system the exocyst re

161 Although the process of tubulogenesis in culture specifically resembled early bi

162 Here we investigate epithelial tubulogenesis in Drosophila melanogaster by examining th

163 Sema4D potently induced chemotaxis and tubulogenesis in endothelial cells and enhanced blood ve

164 e might help us to find common principles of tubulogenesis in general.

165 ed IL-8-mediated cell migration and in vitro tubulogenesis in HMECs.

166 ess that occurs during the initial stages of tubulogenesis in intersegmental vessels (ISVs) in the em

167 This cell can undergo normal tubulogenesis in isolated cell culture.

168 r tubule formation, is sufficient to trigger tubulogenesis in isolated metanephric mesenchyme, wherea

169 tuned toward both the basic understanding of tubulogenesis in modular environments and as a clinicall

170 ll branching morphogenesis and multicellular tubulogenesis in mouse renal tubular epithelial cells an

171 the HGF/c-met signaling pathway of in vitro tubulogenesis in renal epithelial cells.

172 required for cystogenesis, but it suppressed tubulogenesis in response to hepatocyte growth factor.

173 Epithelial cells undergo tubulogenesis in response to morphogens such as hepatocy

174 a surprising player in directing epithelial tubulogenesis in salivary glands.

175 ependent induction of cell proliferation and tubulogenesis in the ASP and that homeotic selector gene

176 teractions regulating intermediate stages of tubulogenesis in the developing kidney have been difficu

177 nstrate that parasympathetic nerves regulate tubulogenesis in the developing salivary gland.

178 al calcium/Wnt pathway mediates Wnt4-induced tubulogenesis in the kidney.

179 In the absence of cv-c activity, tubulogenesis in the renal or Malpighian tubules fails a

180 The reduction of PC1 expression prevented tubulogenesis in three-dimensional collagen type I cultu

181 d from Clic4(-/-) mice demonstrated impaired tubulogenesis in three-dimensional fibrin gels compared

182 hibition of hepatocyte growth factor-induced tubulogenesis in Tuba knockdown Madin-Darby canine kidne

183 factor) that are known to induce kidney cell tubulogenesis in vitro and/or participate in renal regen

184 fects corresponded with impaired endothelial tubulogenesis in vitro following Notch1 activation and p

185 ll survival or invasion and serum-stimulated tubulogenesis in vitro, suggesting that this agent also

186 rp1(cyto) mutation also impaired endothelial tubulogenesis in vitro, which could be rescued by expres

187 rescue EC migration but not proliferation or tubulogenesis in vitro.

188 and activator of transcription-1, and induce tubulogenesis in vitro.

189 nd present evidence for a multistep model of tubulogenesis in which cells rearrange without loss of c

190 In vivo, Egfl7 is important for regulating tubulogenesis in zebrafish and for controlling vascular

191 domain 7 (Egfl7) is important for regulating tubulogenesis in zebrafish, but its role in mammals rema

192 Epithelial tubulogenesis involves complex cell rearrangements that

193 ile ducts arise through a novel mechanism of tubulogenesis involving sequential radial differentiatio

194 Endothelial tubulogenesis is a crucial step in the formation of func

195 In glandular organs, tubulogenesis is a multistep process requiring coordinat

196 The formation of a single lumen during tubulogenesis is crucial for the development and functio

197 that hepatocyte growth factor (HGF)-induced tubulogenesis is dependent on functional beta1 integrins

198 Vascular tubulogenesis is essential to cardiovascular development

199 nsion is coordinated with other processes of tubulogenesis is not well known, and the role of membran

200 ar processes and physical forces involved in tubulogenesis is presented in this review and the accomp

201 But little is known about how tubulogenesis is regulated in vivo.

202 e molecular and cellular events coordinating tubulogenesis is relatively limited.

203 Our data document that tubulogenesis is temporally dependent on multiple VEGF f

204 directly modulate the actin cytoskeleton in tubulogenesis is unknown.

205 ng the role of several secreted molecules in tubulogenesis, it has become necessary to revise the cla

206 itory up-regulated during the p-EMT phase of tubulogenesis, it is not a repressor of E-cadherin durin

207 y alter critical pathways controlling normal tubulogenesis leading to cystic transformation.

208 the cell or in the apical cell migration and tubulogenesis machinery.

209 s even more distinct from typical epithelial tubulogenesis mechanisms because the heart lumen is boun

210 sandwich culture system, we could segregate tubulogenesis of bile ducts into distinct steps and foun

211 ion and Id-1 expression, cell spreading, and tubulogenesis of endothelial cells (EC).

212 Furthermore, IL-17A promoted tubulogenesis of HUVECs plated on Matrigel in a dose-dep

213 nditioned medium increased the migration and tubulogenesis of liver ECs as well as human umbilical ve

214 MP in a tissue remodeling system: growth and tubulogenesis of Madin-Darby canine kidney (MDCK) cells

215 Here we investigated the role of GRHL2 in tubulogenesis of Madin-Darby canine kidney cells, a proc

216 HKD(2) and HKE(2) stimulated migration and tubulogenesis of microvascular endothelial cells, implic

217 Tubulogenesis of the Drosophila dorsal eggshell structur

218 d super-resolution microscopy to analyze the tubulogenesis of the Drosophila salivary glands, I find

219 del to study renal-related issues, including tubulogenesis of the excretory canal, membrane transport

220 Here, we show that during tubulogenesis of the salivary glands in the fly embryo,

221 Furthermore, we found that tubulogenesis of wild-type cells in culture was inhibite

222 red for partial or complete EMT occurring in tubulogenesis or tumor progression and that GRHL2 suppre

223 s require MMP activities for both growth and tubulogenesis, over-expression of wild-type MT3-MMP, but

224 effects of Notch1 activation on endothelial tubulogenesis, paracrine regulation of smooth muscle cel

225 e showed that vacuoles along the endothelial tubulogenesis pathway are acidic in wild-type cells, and

226 We describe a unique tracheal tubulogenesis phenotype caused by loss of both Drosophil

227 phogenesis results in dramatically different tubulogenesis phenotypes, suggesting time-dependent role

228 ings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regu

229 These results demonstrate that urethral tubulogenesis, prepuce morphogenesis, and sexually dimor

230 of floating 3D collagen gels also disrupted tubulogenesis, promoted FAK phosphorylation, and sustain

231 provide clues of the underlying mechanism of tubulogenesis relevant to both normal and abnormal devel

232 ted by ERK activation, whereas migration and tubulogenesis require both p38 MAPK and PI3K/Akt activat

233 Tubulogenesis required the contraction of floating colla

234 Tubulogenesis requires coordinated movement of epithelia

235 These data indicate that pronephric tubulogenesis requires the Daam1/WGEF/Rho PCP pathway.

236 Blood vessel tubulogenesis requires the formation of stable cell-to-c

237 Renal tubulogenesis requires the presence of certain Wnt prote

238 We show that endothelial tubulogenesis requires the Ras interacting protein 1, Ra

239 carcinoma progression through an EMT versus tubulogenesis response.

240 Here, an unbiased RNAi-based tubulogenesis screen identifies a role of clathrin (CHC-

241 in vitro human endothelial cells undergoing tubulogenesis; some of which may well be effective as no

242 on this profile, we established a 6-28 gene tubulogenesis-specific signature that accurately determi

243 uggesting that PKA regulates a Wnt-dependent tubulogenesis step.

244 Here we developed a synchronous, efficient tubulogenesis system and used time-course transcriptiona

245 ctor (HGF)-induced Madin-Darby canine kidney tubulogenesis system, which provides a three-dimensional

246 ce ZO-1), were used to establish an in vitro tubulogenesis system.

247 ed a gene expression profile associated with tubulogenesis that resembled the profile of human pancre

248 ntagonist of epithelial and endothelial cell tubulogenesis that selectively antagonizes intracellular

249 We found that during tubulogenesis, the developing pronephric anlagen express

250 and sufficient to induce the first stage of tubulogenesis, the partial epithelial to mesenchymal tra

251 ; these genes sustain iterative UB branching tubulogenesis through minimal alterations in the network

252 lated human umbilical vein endothelial cells tubulogenesis through the paracrine secretion of HGF.

253 induced model system of MDCK epithelial cell tubulogenesis to analyze the mechanisms of cell rearrang

254 y collecting duct undergo in vitro branching tubulogenesis to both the c-met receptor ligand hepatocy

255 progenitors in the zebrafish embryo undergo tubulogenesis to form nephrons is poorly understood, but

256 Vascular cords then undergo tubulogenesis to form vessels with a central lumen.

257 on, which is necessary for breast epithelial tubulogenesis to occur.

258 In mammals, tubulogenesis underscores the development of several sys

259 the role of polycystin-1 in cystogenesis and tubulogenesis using the canine MDCK cell line.

260 family protein as an essential regulator of tubulogenesis using the notochord of the invertebrate ch

261 A classic model of tubulogenesis utilizes Madin-Darby canine kidney (MDCK)

262 induction of canonical Wnt signaling during tubulogenesis was confirmed genetically using MM from Ba

263 Some inhibition of tubulogenesis was documented when anti-FGF-2, but not an

264 F family members, because the early stage of tubulogenesis was markedly inhibited by VEGF-Trap and to

265 tterns the follicular epithelium prior to DA tubulogenesis, we show that Mirror has an independent, n

266 To examine if beta-catenin has a role in tubulogenesis, we tested the effect of expressing NH2-te

267 Aberrant branching morphogenesis and tubulogenesis were also observed.

268 that cadherin-6 functions as an inhibitor of tubulogenesis, whereas E-cadherin is required for lumen

269 ent membrane proteins, selectively regulates tubulogenesis, whereas glomerulogenesis is largely unaff

270 stablish the plane of polarization in kidney tubulogenesis, whether PCP effectors directly modulate t

271 gration known as branching morphogenesis, or tubulogenesis, which proceeds in mouse development conco

272 mented with estrogen-induced BM-EPC mediated tubulogenesis, which was an experimental in vivo represe

273 rofile associated with pancreatic epithelial tubulogenesis with that of PDAC samples from 27 patients

274 d tubulogenesis, even under conditions where tubulogenesis would otherwise not occur.