ライフサイエンスコーパス: tufted cell

1 nsient response profile, typical of external tufted cells.

2 s asynchronous glutamate release from mitral/tufted cells.

3 ation mainly reflects the activity of mitral/tufted cells.

4 with a feature-detecting function for mitral-tufted cells.

5 was not detected in the glutamatergic mitral/tufted cells.

6 , a small number of which are LOT-projecting tufted cells.

7 asts with the transient response in external tufted cells.

8 rons are similar between mitral and external tufted cells.

9 through feedforward excitation from external tufted cells.

10 ity of mitral cells but had little impact on tufted cells.

11 cortex but not in olfactory bulb mitral and tufted cells.

12 asing the spike output of presumptive mitral/tufted cells.

13 and intrinsic properties between mitral and tufted cells.

14 in 36-mediated gap junctions on MCs, but not tufted cells.

15 hemical features of superficial and external tufted cells.

16 s), sparing the other principal neurons, the tufted cells.

17 volving another glutamatergic cell type, the tufted cells.

18 ctive output onto interneurons and principal tufted cells.

19 Ng in maturation and dendritic remodeling of tufted cells.

20 weaker in mitral cells and less modulated in tufted cells.

21 ory inputs targeted onto excitatory external tufted cells.

22 nearly eliminated spiking in mitral, but not tufted, cells.

23 results suggest that disinhibition of mitral/tufted cells accounts for the observed enhancement in c-

24 ibuted to the differences between mitral and tufted cell activity.

25 om the dendritic tufts of other ET or mitral/tufted cells affiliated with the same glomerulus.

26 Surprisingly, mitral and tufted cells also showed firing mode differences.

27 7) was equivalent across mitral and external tufted cells and could be explained by a single pool of

28 Single-unit recordings from mitral/tufted cells and local field-potential recordings from b

29 ic and dendrodendritic circuitry in external tufted cells and mitral cells, respectively, tunes the p

30 l dendrites, whereas the dendrites of mitral/tufted cells and periglomerular interneurons form dendro

31 uts mediated by mitral, tufted, and external tufted cells, and, in turn, they indiscriminately releas

32 or neuron nerve terminals (input) and mitral/tufted cell apical dendrites (output).

33 stricted to the soma and proximal portion of tufted cell apical dendrites.

34 ncy responses in mitral cells, compared with tufted cells, are due to weaker excitation and stronger

35 lfactory bulb primary output neurons, mitral/tufted cells, are glutamatergic and excite inhibitory in

36 modulation adds an excitatory bias to mitral/tufted cells as opposed to increasing response gain or s

37 pendent on AMPA and NMDA receptors in mitral/tufted cells as well as on a previously undescribed meta

38 cell mediated feedback inhibition of mitral/tufted cells, as measured with field potential recording

39 ion of the raphe nuclei led to excitation of tufted cells at rest and potentiation of their odor resp

40 re first innervated by centrifugal or mitral/tufted cell axon collaterals in the GCL and that these i

41 ns in naive animals leads to an expansion of tufted cell axons that is identical to the changes cause

42 influence relatively large groups of MCs and tufted cells belonging to clusters of at least 15 glomer

43 (comprising the dendrites of both mitral and tufted cells) between E17 and E18.

44 Cs of the nerve layer, as well as mitral and tufted cells, but was excluded from GABAergic interneuro

45 ncreases the number of associated mitral and tufted cells by 40% and 100%, respectively.

46 ic excitability and more irregular firing in tufted cells can combine to drive distinct responses of

47 We suggest that sister mitral/tufted cells carry two different channels of information

48 By contrast, MOB external tufted cells contained two alpha subunit types (alpha1 a

49 sponse profiles in mitral cells and external tufted cells could be attributed to slow dendrodendritic

50 This stronger response of tufted cells could be partially attributed to synaptic d

51 lar stuttering of action potential clusters, tufted cells demonstrated a greater propensity to stutte

52 Neither mitral/tufted cell dendrites nor olfactory bulb astrocytes beca

53 temporal separation of the effects on mitral/tufted cell dendrites vs. somata were observed.

54 , attract postsynaptic innervation by mitral/tufted cell dendrites, and endow these cells with respon

55 mature olfactory receptor cell axons, mitral/tufted cell dendrites, and glial cells as well as a syna

56 lia (RG), astrocytes, ORNs, JG cells, mitral/tufted cell dendrites, and olfactory Schwann cells throu

57 The interactions between ORN axons, mitral/tufted cell dendrites, juxtaglomerular (JG) cells, and g

58 at both olfactory nerve terminals and mitral/tufted cell dendrites.

59 spines and dendrites, but negative in mitral/tufted cell dendrites.

60 by P6W, there was an overgrowth of mitral or tufted cells dendrites and a decreased number of active

61 f glomeruli is the penetration of the mitral/tufted cell dendritic zone by olfactory receptor cell ax

62 the Na beta 1 and Na alpha II signals within tufted cells disappeared almost completely.

63 IFICANCE STATEMENT Olfactory bulb mitral and tufted cells display different odor-evoked responses and

64 estin was experimentally induced in external tufted cells during regeneration of olfactory sensory ne

65 tions (IBPs) mediated by a class of external tufted cells (ET cells) specifically link isofunctional

66 SACs release both GABA and DA onto external tufted cells (ETCs) in other glomeruli.

67 both mitral/tufted cells (MTCs) and external tufted cells (ETCs), the two major excitatory neurons th

68 forebrain, which led to a mixture of mitral/tufted cell excitation and suppression.

69 ree antagonists significantly reduced mitral/tufted cell excitation of granule cells as measured with

70 el odorants, quantitative analysis of mitral-tufted cell excitatory ORFs revealed that the median ORF

71 OB projection neurons, mitral and tufted cells exhibit both spiking and subthreshold membr

72 sion of voltage-gated potassium currents, as tufted cells exhibited faster action potential repolariz

73 odor discrimination learning, mitral but not tufted cells exhibited improved pattern separation, alth

74 Compared to mitral cells, tufted cells exhibited twofold greater excitability and

75 sistent with previous studies, we found that tufted cells fire with higher probability and rates and

76 on of spontaneous and odor-driven mitral and tufted cells' firing activity.

77 cellularly recorded IPSP amplitude in mitral/tufted cells following LOT stimulation.

78 ges induces a strong increase in Ng-positive tufted cells from P10 to P20, whereas no changes have be

79 ptic processing at the reciprocal mitral and tufted cell-granule cell microcircuit, the most abundant

80 Although external tufted cells had a 4.1-fold larger peak EPSC amplitude,

81 esynaptic afferents onto mitral and external tufted cells had similar quantal amplitude and release p

82 lfactory system second-order neurons, mitral-tufted cells, have odorant receptive fields (ORFs) (mole

83 llular recordings from identified mitral and tufted cells in anesthetized rats demonstrate that nasal

84 SCs (mIPSCs) recorded in mitral and external tufted cells in rat olfactory bulb slices.

85 nnections with centrifugal inputs and mitral/tufted cells in the mouse olfactory bulb.

86 s VPAC2R is expressed in mitral and external tufted cells in the OB.

87 (OSNs) in the periphery project onto mitral/tufted cells in the olfactory bulb (OB) and these mitral

88 g pyramidal cells in the cerebral cortex and tufted cells in the olfactory bulb during development.

89 taining suggests that it receives input from tufted cells in the olfactory bulb in addition to mitral

90 ed precisely sniff-locked activity in mitral/tufted cells in the olfactory bulb of awake mouse.

91 ocust brain (the functional analog of mitral-tufted cells in the vertebrate olfactory bulb) to natura

92 in the olfactory bulb (OB) and these mitral/tufted cells in turn project to piriform cortex (PC).

93 r of their targets (glomeruli and mitral and tufted cells) in corresponding divisions of the MOB.

94 in relatively large cells, possibly external tufted cells, in the periglomerular region.

95 the time course of depolarization of mitral/tufted cells, indicating that K+ accumulation mainly ref

96 In individual mitral and tufted cells, inhibition was larger at specific respirat

97 ract with the apical dendrites of mitral and tufted cells inside glomeruli at the first stage of olfa

98 An OB circuit with tufted cells intermediate between OSNs and MCs suggests

99 Ng expression in developing tufted cells is also modulated at the cellular level: at

100 lfactory bulb projection neurons, mitral and tufted cells (M/T), is modulated by pairs of reciprocal

101 naptic targets of OSNs, including mitral and tufted cells (M/TCs) and juxtaglomerular cells, form glo

102 renaline (NA) increases excitation of mitral/tufted cells (M/TCs) by decreasing the release of GABA f

103 evoked responses has been reported in mitral/tufted cells (M/TCs).

104 ough the action potential activity of mitral/tufted cells (M/Ts), whose selectivity and tuning to odo

105 factory bulb (OB), principal neurons (mitral/tufted cells) make reciprocal connections with local inh

106 liable, short-latency firing consistent with tufted cell-mediated excitation.

107 Compared to external tufted cells, mitral cells have a prolonged afferent-evo

108 ation of nAChRs directly excites both mitral/tufted cells (MTCs) and external tufted cells (ETCs), th

109 tuning was heterogeneous in both mitral and tufted cells (MTCs) and GCs but relatively constant with

110 ically inhibits the OB output neurons mitral/tufted cells (MTCs) by GABA release from SACs: (2) gap j

111 reaching the cortex via inhibition of mitral/tufted cells (MTs).

112 However, mitral/tufted cell odorant receptive fields and behavioral odor

113 ly, bulbar cholinergic enhancement of mitral/tufted cell odorant responses was robust and occurred in

114 These results confirm that mitral/tufted cells of the anterior and posterior sub-regions o

115 Mitral/tufted cells of the olfactory bulb receive odorant infor

116 d the parallel pathways formed by mitral and tufted cells of the olfactory system in mice and charact

117 hypothesized that experience-induced mitral-tufted cell ORF changes reflect modulation of lateral an

118 The temporal specificity of mitral/tufted cell output provides a potentially rich source of

119 ruli and about 50% of the 160,000 mitral and tufted cells per bulb.

120 Stronger activation of mitral/tufted cells produced a low-threshold Ca2+ spike (LTS) t

121 s respiration-coupled activity in mitral and tufted cells produced by sensory synaptic inputs from na

122 Weak activation of mitral/tufted cells produced stochastic Ca2+ transients in indi

123 e, at P10, bulb and laminar sizes and mitral/tufted cell profile number had begun their decline, and

124 tive approach of retrogradely tracing mitral/tufted cell projections from different nuclei of the vom

125 In turn, mitral and tufted cells receive and relay this information to highe

126 Given that mitral-tufted cells receive exclusive excitatory input from olf

127 ially attributed to synaptic differences, as tufted cells received stronger afferent-evoked excitatio

128 External tufted cells receiving input from rI7 --> M71 glomeruli

129 namic center-surround organization of mitral/tufted cell receptive fields.

130 Individual olfactory bulb mitral/tufted cells respond preferentially to groups of molecul

131 ith sustained transmission, whereas external tufted cells responded transiently.

132 n with sustained responses, whereas external tufted cells responded transiently.

133 lar neurons mediates inhibition of principal tufted cells, retrograde inhibition of sensory input and

134 pulse LOT stimulation, suppression of mitral/tufted cell single-unit spontaneous activity following L

135 Cholinergic stimulation increased mitral/tufted cell spiking in the absence of inhalation-driven

136 f olfactory (OB) bulb mitral cells (MCs) and tufted cells (TCs) are known to depend on prior odor exp

137 use olfactory system, mitral cells (MCs) and tufted cells (TCs) comprise parallel pathways of olfacto

138 f olfactory bulb (OB) mitral cells (MCs) and tufted cells (TCs) is linked to a variety of computation

139 n olfactory bulb, the mitral cells (MCs) and tufted cells (TCs), differ markedly in physiological res

140 endent lateral inhibition between mitral and tufted cells that likely reflect newly described differe

141 l glomeruli with light, we identified mitral/tufted cells that receive common input (sister cells).

142 tains excitatory principal cells (mitral and tufted cells) that project to cortical targets as well a

143 amic, 2-D, optogenetic stimulation of mitral/tufted cells, that virtual odors that differ by as littl

144 enhance intraglomerular inhibition of mitral/tufted cells, the main output neurons in the olfactory b

145 impact of glomerular circuits on mitral and tufted cells, the output channels of the olfactory bulb.

146 The activity of mitral and tufted cells, the principal neurons of the olfactory bul

147 n and feedforward inhibition onto mitral and tufted cells, the principal neurons.

148 Mitral and tufted cells, the two classes of principal neurons in th

149 ne to drive distinct responses of mitral and tufted cells to afferent-evoked input.

150 e circuit-level differences allow mitral and tufted cells to best discriminate odors in separate conc

151 he distinct responses of mitral and external tufted cells to high frequency stimulation did not origi

152 ayers in the olfactory bulb (OB), mitral and tufted cells, using chronic two-photon calcium imaging i

153 esting that the larger peak EPSC in external tufted cells was the result of more synaptic contacts.

154 g the calcium indicator GCaMP2 in the mitral/tufted cells, we investigated the effect of ACh on the g

155 slices and glomerular stimulation of mitral/tufted cells, we observed two forms of action potential-

156 ow oscillations in mitral cells and external tufted cells were broader and had multiple peaks in OCAM

157 Tufted cells were devoid of Na beta 1 mRNA before P14, w

158 The RCMs indicated that mitral/tufted cells were excited by activation of a focal regio

159 d the superficial lamina Ia, labelled mitral/tufted cells were found distributed throughout the anter

160 naptic inputs that were targeted mainly onto tufted cells, which act as intermediaries in the excitat

161 rons in the mouse olfactory bulb, mitral and tufted cells, which send olfactory information to distin

162 ostsynaptic responses of mitral and external tufted cells within the glomerulus may involve both dire