ライフサイエンスコーパス: tumor metastasis

1 olished increased neutrophil recruitment and tumor metastasis.

2 ganelles, is essential for platelet-mediated tumor metastasis.

3 ma tissues was significantly associated with tumor metastasis.

4 sembly to drive malignant transformation and tumor metastasis.

5 egulation of EC barrier function controlling tumor metastasis.

6 DNase I treatment was sufficient to suppress tumor metastasis.

7 and contributes to cancer cell invasion and tumor metastasis.

8 g miR-204 levels therapeutically to suppress tumor metastasis.

9 NX)-we showed that mtDNA could alter mammary tumor metastasis.

10 extracellular matrix degradation to promote tumor metastasis.

11 ation of HMGA2 and its effector functions in tumor metastasis.

12 ell migration and plays an important role in tumor metastasis.

13 critical process in normal morphogenesis and tumor metastasis.

14 indicating that host A2A receptors enhanced tumor metastasis.

15 latory loop plays important roles in EMT and tumor metastasis.

16 new actin-based mechanism that can suppress tumor metastasis.

17 ent may be an effective strategy to suppress tumor metastasis.

18 singly recognized for their contributions to tumor metastasis.

19 sm (EPLIN), a putative suppressor of EMT and tumor metastasis.

20 hat VEGFA induction of Sox2 promotes EMT and tumor metastasis.

21 helial plasticity implicated in fibrosis and tumor metastasis.

22 to specifically inhibit processes that drive tumor metastasis.

23 o establish a favorable microenvironment for tumor metastasis.

24 ng processes and also strongly implicated in tumor metastasis.

25 ion is available regarding their function in tumor metastasis.

26 inding proteins that is directly involved in tumor metastasis.

27 rrow-derived cells was necessary for optimal tumor metastasis.

28 l, suggesting the involvement of V-ATPase in tumor metastasis.

29 ssing SOX18 function is sufficient to impede tumor metastasis.

30 is commonly known as a central regulator of tumor metastasis.

31 ly decreased IL-6-meditated tumor growth and tumor metastasis.

32 signaling, cell adhesion, wound healing, and tumor metastasis.

33 at hijacks the Met signal pathway to promote tumor metastasis.

34 inase has been reported in human cancers and tumor metastasis.

35 a specific NK killer receptor in preventing tumor metastasis.

36 this interaction is involved in hematogenous tumor metastasis.

37 ence that these two genes are suppressors of tumor metastasis.

38 f understanding of the mechanisms leading to tumor metastasis.

39 lariasis, transplant rejection, obesity, and tumor metastasis.

40 bits ezrin protein as an approach to prevent tumor metastasis.

41 studies with respect to the role of SPDEF in tumor metastasis.

42 may contribute in part to hypoxia-stimulated tumor metastasis.

43 ent in the pathogenesis of lung fibrosis and tumor metastasis.

44 but also functionally involved in enhancing tumor metastasis.

45 s, a process essential for wound healing and tumor metastasis.

46 ould play a central role in TGFbeta-promoted tumor metastasis.

47 nto how miR-155 modulates the development of tumor metastasis.

48 giogenic switch during tumor development and tumor metastasis.

49 tion of C/EBP-delta in lymphangiogenesis and tumor metastasis.

50 nt issue given that EMT is an early event in tumor metastasis.

51 1 and Snail2 act together to promote EMT and tumor metastasis.

52 es to prevent ensuing tumor angiogenesis and tumor metastasis.

53 nce for a master regulatory role of FoxM1 in tumor metastasis.

54 (EMTs) during both embryonic development and tumor metastasis.

55 cells, reducing their number and inhibiting tumor metastasis.

56 flammation, angiogenesis, wound healing, and tumor metastasis.

57 small chemical compounds leads to a block of tumor metastasis.

58 RC-3Delta4 promotes MDA-MB231-induced breast tumor metastasis.

59 ption, and immune function and as a route of tumor metastasis.

60 proteins that can function as suppressors of tumor metastasis.

61 nal that mediates the microRNA regulation of tumor metastasis.

62 umor exosome-mediated expansion of MDSCs and tumor metastasis.

63 iogenesis, tumor growth, tumor invasion, and tumor metastasis.

64 n alpha4beta1 suppress lymphangiogenesis and tumor metastasis.

65 regulators of directional cell migration and tumor metastasis.

66 +)-binding proteins, is directly involved in tumor metastasis.

67 on guidance, angiogenesis, tumor growth, and tumor metastasis.

68 improve host immunosurveillance, and inhibit tumor metastasis.

69 any human diseases, including lymphedema and tumor metastasis.

70 genes controlling processes linked to breast tumor metastasis.

71 g renal tubular acidosis, osteopetrosis, and tumor metastasis.

72 anoikis--a critical physiologic barrier for tumor metastasis.

73 zation provides a selective advantage during tumor metastasis.

74 scriptional activity of RelA and facilitates tumor metastasis.

75 ventional wisdom about the role of Sema3s in tumor metastasis.

76 cancer cells suppresses tumor formation and tumor metastasis.

77 creased ovarian cancer cell invasiveness and tumor metastasis.

78 that plays crucial roles in inflammation and tumor metastasis.

79 enchymal transition (EMT) and correlate with tumor metastasis.

80 of FAK activity and, thereby, in Ras-related tumor metastasis.

81 Notch pathways, growth factor signaling, and tumor metastasis.

82 mouse model, SRC-1 strongly promotes mammary tumor metastasis.

83 ppresses cell migration, tumor invasion, and tumor metastasis.

84 nto mechanisms that govern cell adhesion and tumor metastasis.

85 e receptor tyrosine kinase HER2/neu enhances tumor metastasis.

86 repair, and pathological conditions such as tumor metastasis.

87 l resection of the tumors, by suppression of tumor metastasis.

88 ential drug target and prognostic marker for tumor metastasis.

89 at p90 ribosomal S6 kinase 2 (RSK2) promotes tumor metastasis.

90 al transition (EMT) occurs frequently during tumor metastasis.

91 in various human cancers and is involved in tumor metastasis.

92 upporting TNFalpha-activated MSCs to promote tumor metastasis.

93 tent microenvironmental factor that promotes tumor metastasis.

94 lates lung homeostasis, immune response, and tumor metastasis.

95 rocesses, including inflammatory disease and tumor metastasis.

96 l process for both embryonic development and tumor metastasis.

97 typically house primary breast carcinoma or tumor metastasis.

98 tial implication in cancer cell invasion and tumor metastasis.

99 s, identifying a crucial regulatory axis for tumor metastasis.

100 inases (TIMP)-1 has been thought to suppress tumor metastasis.

101 ascular invasion provides a direct route for tumor metastasis.

102 mor cells in vivo and inhibit development of tumor metastasis.

103 ymal transition (EMT) during development and tumor metastasis.

104 ism, liver homeostasis, immune response, and tumor metastasis.

105 CNL could be used to prevent and treat solid tumor metastasis.

106 g that TAMs may contribute to HOXB7-promoted tumor metastasis.

107 d iNKT cells effectively protected mice from tumor metastasis.

108 gical processes like cell differentiation or tumor metastasis.

109 back regulatory loop between anaphylaxis and tumor metastasis.

110 ch as lymphedema, inflammatory diseases, and tumor metastasis.

111 -C motif) receptor 4 (CXCR4) is critical for tumor metastasis.

112 and increased cell motility-all mediators of tumor metastasis.

113 t in cell migration, lymphatic invasion, and tumor metastasis.

114 eedback relationship between anaphylaxis and tumor metastasis.

115 talk between endocytic pathway, hypoxia, and tumor metastasis.

116 reover, TGF-beta blockade reduced postpartum tumor metastasis.

117 that postpartum involution increases mammary tumor metastasis.

118 of PRL1 expression affects cell motility and tumor metastasis, although the biochemical pathways regu

119 CD73 also enhances tumor metastasis, although the nature of the immune subs

120 g the miR-23b/27b/24 cluster might influence tumor metastasis, although the precise nature of this re

121 As (miRNAs), but their roles in KSHV-induced tumor metastasis and angiogenesis remain largely unclear

122 To determine whether it has a role in breast tumor metastasis and angiogenesis, its levels were measu

123 Tumor-educated macrophages facilitate tumor metastasis and angiogenesis.

124 ctivity that has been implicated strongly in tumor metastasis and angiogenesis.

125 These discoveries suggest novel paradigms in tumor metastasis and identify new opportunities for ther

126 Reduced ASPP2 expression associates with tumor metastasis and increased p63 expression in human h

127 tasis, osteoclastogenesis, immune functions, tumor metastasis and infections such as osteonecrosis of

128 wound healing and plays an important role in tumor metastasis and inflammatory diseases.

129 hatic vasculature provides a major route for tumor metastasis and inhibiting neolymphangiogenesis ind

130 LRIG1 is acting as a critical suppressor of tumor metastasis and is an early clinical indicator of r

131 Tumor metastasis and lack of NKG2D ligand (NKG2DL) expre

132 vivo the requirement of "reversible EMT" in tumor metastasis and may resolve the controversy on the

133 Angiogenesis, a hallmark step in tumor metastasis and ocular neovascularization, is drive

134 Despite strong correlations with tumor metastasis and poor patient prognosis, there is ve

135 nd sarcomas, often associating with enhanced tumor metastasis and poor prognosis.

136 ted transcripts also strongly correlate with tumor metastasis and poor survival.

137 men, and increased collagen density promotes tumor metastasis and progression.

138 considered as a well-established marker for tumor metastasis and recurrence.

139 loid cell expression of EGFR associated with tumor metastasis and shorter patient survival time.

140 tor of ATF4-dependent anoikis resistance and tumor metastasis and suggest ATF4 and HO-1 as potential

141 show that beta1 integrin activation promotes tumor metastasis and that activated beta1 integrin may s

142 Furthermore, SOX9 knockdown suppressed tumor metastasis and the expression of the stem cell mar

143 inflammation and related diseases to prevent tumor metastasis and to increase tumor sensitivity to ch

144 ceptors, which play important roles in human tumor metastasis and tumor-induced angiogenesis.

145 2beta1 integrin functionally inhibits breast tumor metastasis, and alpha2 expression may serve as an

146 variety of human diseases such as arthritis, tumor metastasis, and atherosclerosis.

147 nflammation, bacterial and viral infections, tumor metastasis, and genetic disorders.

148 ntrols cell cycle, apoptosis, autophagy, and tumor metastasis, and its expression is frequently down-

149 promotes cancer cell migration/invasion and tumor metastasis, and its expression is upregulated in m

150 role in blood-lymphatic vessel development, tumor metastasis, and prevention of inflammatory bleedin

151 associated with increased expression of MET, tumor metastasis, and shorter patient survival times.

152 nhibit cell proliferation, angiogenesis, and tumor metastasis, and the biological activity of the HK

153 ssociated with advanced tumor stage, greater tumor metastasis, and worse survival.

154 biological processes, such as morphogenesis, tumor metastasis, and wound healing.

155 ing the stages of cancer progression-primary tumor, metastasis, and at the metastatic site.

156 em to be involved in initiation, growth, and tumor metastasis, as well as in radio- and chemotherapy

157 ymal transition, a critical step that drives tumor metastasis, as well as proliferation of carcinoma

158 ration, and invasion in vitro and orthotopic tumor metastasis assays in vivo.

159 MicroRNAs are well suited to regulate tumor metastasis because of their capacity to coordinate

160 TIAM1 is well known for its role in tumor metastasis, but it also possesses overlapping cell

161 he MET proto-oncogene is primarily linked to tumor metastasis, but MET is also involved in neurodevel

162 ic growth factors and later shown to promote tumor metastasis, but their effects on carcinogenesis ar

163 ha-driven remodeling of lymph nodes promotes tumor metastasis by activating integrin alpha4beta1 on l

164 umors, TG2 promotes EMT and enhances ovarian tumor metastasis by activating oncogenic signaling.

165 er, our results suggest that PELP1 regulates tumor metastasis by controlling the expression and funct

166 mmary, TGF-beta-induced TG2 enhances ovarian tumor metastasis by inducing EMT and a cancer stem cell

167 correlated with advanced cancer and promotes tumor metastasis by influencing tumor cell migration and

168 It is believed that fascin facilitates tumor metastasis by promoting the formation of invasive

169 ssociated platelets in the blood facilitates tumor metastasis by relaxing endothelial barrier functio

170 rectional cell migration, a critical step of tumor metastasis cascades.

171 TNFalpha-activated MSCs strikingly enhanced tumor metastasis compared with normal MSCs.

172 Tumor metastasis correlated significantly with an increa

173 In patients with distant tumor metastasis, deaths per 1000 person-years were 87.7

174 ZEB1 axis, defines a novel mechanism driving tumor metastasis, delineates collagen as a prognostic ma

175 cell lung cancer (NSCLC) and correlates with tumor metastasis, disease recurrence, and poor survival

176 s loss of cell-cell cohesion is prevalent in tumor metastasis, Dsg1 integrity was evaluated.

177 hesion molecule involved in angiogenesis and tumor metastasis formation.

178 lation between the parabiosed mice, to study tumor metastasis from one parabiont to another, or to in

179 angiogenic regulator stimulates MCF-7 breast tumor metastasis from their orthotopic sites to distant

180 and its potential involvement in controlling tumor metastasis has been lacking.

181 including breast cancer, and its role(s) in tumor metastasis has been studied on a very limited basi

182 ells, but their effects on cell motility and tumor metastasis have not been evaluated.

183 still poorly understood, and its effects on tumor metastasis have not yet been characterized.

184 ll migration, extracellular matrix assembly, tumor metastasis, hemostasis, and thrombosis.

185 on (EMT) is associated with increased breast tumor metastasis; however, the specific mechanisms by wh

186 herapy currently in phase II trials, reduced tumor metastasis in a murine model of prostate cancer.

187 argets to predict and inhibit, respectively, tumor metastasis in carcinoma patients.

188 major mediator of cancer cell migration and tumor metastasis in cell culture and in intact mice.

189 ignant cell proliferation, angiogenesis, and tumor metastasis in many cancers.

190 his study identifies a negative regulator of tumor metastasis in MDSCs, NGP, which is down-regulated

191 Tumor metastasis in mice was monitored for 30 d by biolu

192 of the epithelial isoform of Exo70 inhibits tumor metastasis in mice.

193 ared with control cells, but miR-28 promoted tumor metastasis in mice.

194 Targeting GDH1 with R162 attenuated tumor metastasis in patient-derived xenograft model and

195 LNs in axillary staging and to help evaluate tumor metastasis in patients with breast cancer.

196 ory mesenchymal state has been implicated in tumor metastasis in preclinical models.

197 have shown that AZD0530 profoundly inhibits tumor metastasis in severe combined immunodeficient mice

198 r exosomes had a significant acceleration of tumor metastasis in the lung.

199 ed evidence that IL-37 inhibited effectively tumor metastasis in vitro and in vivo.

200 show that vimentin has an important role in tumor metastasis in vivo in the setting of pre-diabetes

201 cts as a potent tumor suppressor, inhibiting tumor metastasis in vivo when systemically delivered.

202 attenuated cancer cell invasion in vitro and tumor metastasis in vivo, whereas expression of Fascin-1

203 we further show that FoxA1 inhibits prostate tumor metastasis in vivo.

204 cer cell migration and invasion in vitro and tumor metastasis in vivo.

205 function in vitro and hamper CXCR4-dependent tumor metastasis in vivo.

206 or cells in vitro, and effectively prevented tumor metastasis in vivo.

207 ghlight the critical role of nuclear MIIP in tumor metastasis.In colorectal cancer, EGFR signalling i

208 of genes critical for cell proliferation and tumor metastasis, including Cdc25b, Cyclin B1, Plk-1, Lo

209 identified upregulation of genes involved in tumor metastasis, including the G protein-coupled recept

210 2A(-/-) mice were strongly protected against tumor metastasis, indicating that host A2A receptors enh

211 During tumor metastasis, integrin-mediated cell adhesion to and

212 al analysis of several genes associated with tumor metastasis, invasion, and the epithelial-mesenchym

213 Organogenesis and tumor metastasis involve the transformation of epithelia

214 Solid tumor metastasis is a complex biology, impinged upon by

215 Tumor metastasis is a complex phenomenon that is the cul

216 Tumor metastasis is a highly complex, dynamic, and ineff

217 Tumor metastasis is a multi-step process with the last s

218 l role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood.

219 driving stromal activation and their role in tumor metastasis is critical to furthering research with

220 te a novel molecular mechanism through which tumor metastasis is endowed by the hnRNPM-mediated splic

221 Tumor metastasis is mainly caused by somatic genomic alt

222 tion factor FOXO3a in processes that promote tumor metastasis is poorly defined.

223 Epithelial tumor metastasis is preceded by an accumulation of colla

224 Tumor metastasis is the leading cause of death among bre

225 Tumor metastasis is the major cause of death among cance

226 Tumor metastasis is the primary cause of death due to ca

227 g receptors is involved in the prevention of tumor metastasis is unknown.

228 in addition to being an initiating event for tumor metastasis, is implicated in conferring several cl

229 ion and signaling, immune cell function, and tumor metastasis, it is of interest to determine how the

230 gulated in human cancers and correlates with tumor metastasis, its regulatory mechanism and related s

231 hological lymphangiogenesis, particularly in tumor metastasis, making it an attractive therapeutic ta

232 Here, by using an experimental tumor metastasis model and in vitro studies, we further

233 ely detected small disseminated lesions in a tumor metastasis model, complementing the current clinic

234 issemination in a syngeneic mouse 4T1 breast tumor metastasis model.

235 thermore, the results from a bioluminescence tumor/metastasis model showed that the overexpression of

236 OPN is associated with tumor metastasis of several tumors and is overexpressed

237 dundant functions that cooperatively promote tumor metastasis or limit EGFR-inhibitor response.

238 ke gene signature and were unable to control tumor metastasis or viral infection.

239 maging treatments and instead with different tumor metastasis potential.

240 Thus, our studies suggest a paradigm of tumor metastasis: primary epithelial carcinoma cells tha

241 Tumor metastasis refers to spread of a tumor from site o

242 te almost 200 years of study, the process of tumor metastasis remains controversial.

243 owever, the role of TNFalpha-treated MSCs in tumor metastasis remains elusive.

244 Tumor metastasis remains the major cause of cancer-relat

245 wever, the mechanism underlying Ras-promoted tumor metastasis remains unclear.

246 However, the role of this lipid kinase in tumor metastasis remains unclear.

247 ymph node microenvironment actively promotes tumor metastasis remains unknown.

248 eceptors RPTPbeta/zeta and Syndecan-3 during tumor metastasis remains unknown.

249 eseeding), and (iii) reseeding of metastatic tumors (metastasis reseeding).

250 Although the early stages of tumor metastasis result in the formation of clinically s

251 the PyMT mouse model, which enhances mammary tumor metastasis, results in selective inhibition of Akt

252 In 2 independent murine models of breast tumor metastasis, stable shRNA-based SRPK1 knockdown sup

253 ogical process that plays important roles in tumor metastasis, "stemness," and drug resistance.

254 plays critical roles in puberty regulation, tumor metastasis suppression, and vasoconstriction.

255 ethylation and transcriptional repression of tumor metastasis suppressor gene BRMS1, highlights a new

256 cer G-protein-coupled-receptor-1 (OGR1) is a tumor metastasis suppressor in prostate cancer (PCa).

257 me, in any system, that SPDEF functions as a tumor metastasis suppressor in vivo.

258 l migration and invasion in vitro and acts a tumor metastasis suppressor in vivo.

259 To determine how tetraspanin KAI1/CD82, a tumor metastasis suppressor, inhibits cell migration, we

260 n the RNA editing hotspot in miR-200b, a key tumor metastasis suppressor, we found that the miR-200b

261 Elucidating targets of physiological tumor metastasis suppressors can highlight key signaling

262 trolling the expression and functions of the tumor metastasis suppressors miR-200a and miR-141.

263 ta expression, and a reduction of postpartum tumor metastasis that was similar to the metastasis freq

264 al antibodies that inhibit cell invasion and tumor metastasis, the hallmark of heparanase activity.

265 at loss of E-cadherin is a central tenant in tumor metastasis, the results of our studies, by providi

266 cell migration, cytoskeletal remodeling and tumor metastasis, the tumor-derived mutants (L(71)P, L(9

267 ily controversial role of SH3BGRL in driving tumor metastasis through c-Src activation, and suggests

268 atency and size, but significantly decreased tumor metastasis through inhibition of tumor cell intrav

269 Our results thus revealed that CD73 promotes tumor metastasis through multiple mechanisms, including

270 of the MYC oncogene, which in turn regulates tumor metastasis through specific effects on cancer cell

271 t NGF blockade immediately upon detection of tumor metastasis to bone may help preserve the integrity

272 In a model of tumor metastasis to bone, bone tumor burden was decrease

273 the recruitment of molecules that facilitate tumor metastasis to integrin-based adhesions.

274 the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tu

275 vessels at the periphery of tumors promotes tumor metastasis to lymph nodes.

276 tumor-induced lymphangiogenesis, as well as tumor metastasis to lymph nodes.

277 MM is the most common solid tumor metastasis to the breast.

278 excised avian embryonic organs revealed that tumor metastasis to the liver was significantly reduced

279 in liver architecture significantly enhance tumor metastasis to the liver.

280 ll proliferation and migration in vitro, and tumor metastasis to the lung in vivo.

281 tatic potential in a setting of experimental tumor metastasis to the lung.

282 e (247 mg/m(3) TSP), P=0.02) and significant tumor metastasis to various distant organs in the CS-exp

283 ion, on generation of a primary subcutaneous tumor, metastasis to regional lymph nodes was clearly re

284 For many tumors, metastasis to the LNs is predictive of poor prog

285 nstrate that TNFalpha-activated MSCs promote tumor metastasis via CXCR2(+) neutrophil recruitment.

286 key hormone for puberty and an inhibitor for tumor metastasis via the activation of G protein-coupled

287 f GAS5-AS1 in NSCLC and subsequently promote tumor metastasis via upregulation of several key EMT mar

288 negative and IL-13Ralpha2-positive cells and tumor metastasis was assessed in murine model for human

289 Unexpectedly, tumor metastasis was observed in 77% of the subjects tre

290 ntribution of N-cadherin and HER2 in mammary tumor metastasis, we targeted N-cadherin expression in t

291 chanism through which pleiotrophin regulates tumor metastasis, we used two different prostate carcino

292 ression is of utmost importance for blocking tumor metastasis; we have identified that semaphorin 7a

293 omoting epithelial to mesenchymal transition/tumor metastasis were activated.

294 In addition, tumor growth and tumor metastasis were also impaired in a spontaneous mam

295 These effects on tumor metastasis were not a result of the effect of SPDE

296 We focus in particular on tumor metastasis, which is the greatest impediment to cl

297 essed the growth of CCA tumor xenografts and tumor metastasis while displaying low toxicity levels.

298 rapies targeting hematologic cancer or solid tumors metastasis with bone tropism.

299 5) can lead to heterotypic cell adhesion and tumor metastasis within the pleural and peritoneal cavit

300 Lymph nodes are initial sites of tumor metastasis, yet whether the lymph node microenviro