ライフサイエンスコーパス: tumor suppressor activity

1 of DLC1 with focal adhesions and attenuates tumor suppressor activity.

2 x 1 (mTORC1) as a novel mediator of merlin's tumor suppressor activity.

3 ventional PcG complex can also have a potent tumor suppressor activity.

4 ing regulation by RBM5 may contribute to its tumor suppressor activity.

5 tic leukemia, implying that G0S2 may possess tumor suppressor activity.

6 en shown to regulate DNA methylation and has tumor suppressor activity.

7 ession of STAT1, a transcription factor with tumor suppressor activity.

8 dicate that TrkC is an inhibitor of TGF-beta tumor suppressor activity.

9 activity is required for full DLC-dependent tumor suppressor activity.

10 gulators of the circadian clock that display tumor suppressor activity.

11 ignancies in which ARF holds p53-independent tumor suppressor activity.

12 itional FOXP3 targets may be involved in its tumor suppressor activity.

13 otein phosphatase 2A (B56gamma-PP2A) and p53 tumor suppressor activity.

14 Conversely, PP2A has tumor suppressor activity.

15 tial gene regulation may contribute to IRF-1 tumor suppressor activity.

16 ncogenic tyrosine kinases can block TGF-beta tumor suppressor activity.

17 in mouse xenografts, confirming its in vivo tumor suppressor activity.

18 vin) is a multivalent anchoring protein with tumor suppressor activity.

19 ates 15-PGDH to have functional colon cancer tumor suppressor activity.

20 is likely to be an important feature of its tumor suppressor activity.

21 g whether tazarotene might activate putative tumor suppressor activity.

22 teresting possibility that hTID1 could exert tumor suppressor activity.

23 n by exerting a more general Env-independent tumor suppressor activity.

24 on of telomerase may contribute to the BRCA1 tumor suppressor activity.

25 nes in the contig had neither metastasis nor tumor suppressor activity.

26 pendent functions that may contribute to its tumor suppressor activity.

27 to how these mutations interfere with APC's tumor suppressor activity.

28 been studied primarily in the context of its tumor suppressor activity.

29 tant defective for TAF(II)250 interaction or tumor suppressor activity.

30 th regulatory functions and causes a loss of tumor suppressor activity.

31 on of tuberin is associated with loss of its tumor suppressor activity.

32 mors and thus represents a bona fide in vivo tumor suppressor activity.

33 KT/NF-kappaB pathway may be important to its tumor suppressor activity.

34 cogene that mainly functions to modulate p53 tumor suppressor activity.

35 e central third of APC is sufficient for its tumor suppressor activity.

36 nd cell - matrix interactions are due to its tumor suppressor activity.

37 Moreover, ACTN4 exhibits tumor suppressor activity.

38 ed by homozygous deletions and by functional tumor suppressor activity.

39 lacks Ap(3)A hydrolase activity but retains tumor suppressor activity.

40 inding protein, both of which have potential tumor suppressor activity.

41 he complex have been shown to have bona fide tumor suppressor activity.

42 on of Rap-1, a small G-protein that exhibits tumor suppressor activity.

43 anoma gene (INK4a/MTS1/CDKN2) encodes potent tumor suppressor activity.

44 tion domain of p53 is required for efficient tumor suppressor activity.

45 al and lower tumor grade consistent with its tumor suppressor activity.

46 neity, a function that may contribute to its tumor suppressor activity.

47 nidentified role for 53BP1 in regulating pRb tumor suppressor activity.

48 ranscription near DSBs may contribute to its tumor suppressor activity.

49 M2, a lysine methyltransferase with putative tumor suppressor activity.

50 pic changes, which may contribute to loss of tumor suppressor activity.

51 3-dependent translation, thus blocking their tumor suppressor activity.

52 ls, which may constitute the basis for their tumor suppressor activity.

53 cts of cancer-derived KLF6 mutants that lack tumor suppressor activity.

54 omes, which may confer autophagy-independent tumor suppressor activity.

55 is necessary but not sufficient for its full tumor suppressor activity.

56 mit aberrant self-renewal contributes to its tumor suppressor activity.

57 wnregulated in breast cancer samples and has tumor suppressor activity.

58 as a loss-of-function mutation, lacking any tumor suppressor activity.

59 th eIF4G for binding to eIF4E and which have tumor-suppressor activity.

60 ich TrkC, a neuronal receptor, can block BMP tumor-suppressor activity.

61 rf locus, p16(INK4a) and p19(ARF), possesses tumor-suppressor activity.

62 and molecular partners necessary for merlin tumor-suppressor activity.

63 t growth inhibitory effect by modulating p53 tumor-suppressor activity.

64 estoration of p53ER(TAM) allele triggers p53-tumor-suppressor activity.

65 Such a trait has been hypothesized to confer tumor-suppressor activity.

66 ITGA7 lacking TIMP3 binding activity had no tumor-suppressor activity.

67 Mdm2 is the major negative regulator of p53 tumor-suppressor activity.

68 mammals that supports p53 function and other tumor suppressor activities.

69 s or, alternatively, they may have redundant tumor suppressor activities.

70 functioning as an apoptotic effector of p53 tumor suppressor activities.

71 diversity and determining why Rb has unique tumor suppressor activities.

72 y interact with Notch-mediated oncogenic and tumor-suppressor activities.

73 inhibitors, p16(INK4A) and p15(INK4B), have tumor suppressor activities and are inactivated in human

74 uence innate immune responses as part of its tumor suppressor activities and recent work suggests tha

75 ese mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help

76 ivation of HAI-2/SPINT2, causing loss of RCC tumor suppressor activity and implicate abnormalities of

77 These data suggest that BCSC-1 may exert a tumor suppressor activity and is a likely target of the

78 ata strongly suggest that wildtype Kras2 has tumor suppressor activity and is frequently lost during

79 tivation of Rap1, a protein known to exhibit tumor suppressor activity and mediate growth inhibitory

80 Loss of expression reduces tumor suppressor activity and promotes genomic instabili

81 ing of the PTEN mutants effectively restores tumor suppressor activity and represses excess PIP3 sign

82 d p53 proteins that have both lost wild-type tumor suppressor activity and show gain of functions tha

83 These results indicate that MTAP has tumor suppressor activity and suggest that its effects m

84 mutant p53 proteins that have lost wild-type tumor suppressor activity and, in many cases, have acqui

85 The loss of tumor-suppressor activity and gain of invasiveness from

86 ons in the TIP30 gene may abolish its native tumor-suppressor activity and gain oncogenic activities

87 our results show that IFIXalpha1 possesses a tumor-suppressor activity and suggest IFIXalpha1 may be

88 degrades prostaglandin E(2), appears to have tumor suppressor activity, and can be induced both by pe

89 gion 1A (E1A) has been shown to exhibit high tumor suppressor activity, and gene therapy using E1A ha

90 enforced expression of miR-19a overrides APC tumor suppressor activity, and knockdown of miR-19a in c

91 developmentally regulated gene with putative tumor suppressor activity, and loss of H19 expression ma

92 Lysyl oxidase in addition has tumor suppressor activity, and phenotypic reversion of t

93 induce apoptosis has been termed "intrinsic tumor suppressor activity," and reactivating this apopto

94 OXC6 regulates genes with both oncogenic and tumor suppressor activities as well as several genes suc

95 Dimerization has a direct impact on ING4 tumor suppressor activity because monomeric mutants lose

96 Consistent with its tumor-suppressor activity, BRCA2 plays an important role

97 and produce proteins that lack canonical p53 tumor suppressor activities but promote cancer cell prol

98 The p53 protein has not only important tumor suppressor activity but also additional immunologi

99 of a cancer cell not only by absence of p53 tumor suppressor activity but also by the presence of an

100 The protein kinases Mst1 and Mst2 have tumor suppressor activity, but their mode of regulation

101 248W and R273H), not only lose p53-dependent tumor-suppressor activities, but also acquire new oncoge

102 bers of this family are capable of potential tumor suppressor activity by gene dosage or other epigen

103 gest the possibility that Fhit may exert its tumor suppressor activity by interacting with microtubul

104 6gamma interaction and the modulation of p53 tumor suppressor activity by PP2A.

105 gene signature, suggesting that CUX1 exerts tumor suppressor activity by regulating proliferative ge

106 ty, which is required for full DLC-dependent tumor suppressor activity, can be inhibited by the Src h

107 atient-derived ATL lines demonstrated strong tumor-suppressor activity characterized by reduced proli

108 mplexing Fhit mutants show reduction of Fhit tumor suppressor activity, confirming that substrate bin

109 Alternatively, E-cadherin tumor suppressor activity could result from binding and

110 a chromatin remodelling-complex subunit with tumor suppressor activity, could be conditionally inacti

111 PTEN tumor-suppressor activity depends largely on its lipid p

112 lignant gliomas, 60%-80% show loss of P14ARF tumor suppressor activity due to somatic alterations of

113 r results indicate that wild-type N-ras has "tumor suppressor" activity, even in the absence of its o

114 nce has led to the suggestion of a potential tumor suppressor activity for IkappaBalpha, we have stud

115 des HDM2, which may define a p53-independent tumor suppressor activity for p14ARF.

116 y the Kruppel-like factor KLF2, suggesting a tumor suppressor activity for this factor.

117 PML, a RING finger protein with tumor suppressor activity, has been implicated in the pa

118 zation of a novel mitochondrial protein with tumor suppressor activity, henceforth designated MITOSTA

119 ble allele of Las2, resulting in the loss of tumor suppressor activities in both cell colony formatio

120 NOTCH has tumor suppressor activities in epithelial cells and is a

121 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer.

122 Mn-SOD has tumor suppressor activity in a wide variety of tumors an

123 SIRT2 is a protein deacetylase with tumor suppressor activity in breast and liver tumors whe

124 The maspin protein has tumor suppressor activity in breast and prostate cancers

125 of S100B to p53 down-regulates wild-type p53 tumor suppressor activity in cancer cells such as malign

126 stinal stem cell marker, is known to exhibit tumor suppressor activity in colon cancer, the mechanism

127 Thus, Dnmt1 has tumor suppressor activity in early-stage prostate cancer

128 The alpha 6 beta 4 integrin appears to have tumor suppressor activity in epithelial tumors.

129 3 and potentiates TGF-beta signaling and its tumor suppressor activity in gut epithelial cells.

130 ine (SCC22B) revealed its ability to provide tumor suppressor activity in HNSCC in vitro and in vivo.

131 the first time not only that C/EBPalpha has tumor suppressor activity in HNSCC, but also that it is

132 le arrest and adipocyte differentiation; has tumor suppressor activity in liposarcoma, lung, and pros

133 that p53 homologues do not contribute to p53 tumor suppressor activity in lymphoma development.

134 stages and lineages likely contribute to the tumor suppressor activity in MDS and AML.

135 to mitochondria exerts a significant in vivo tumor suppressor activity in p53-null lymphomas.

136 t the therapeutic relevance of rescuing PP2A tumor suppressor activity in Ph1 leukemias and strongly

137 first direct evidence that PKCalpha exhibits tumor suppressor activity in the lung in vivo.

138 show that the endogenous TGF-beta system has tumor suppressor activity in the mammary gland and lung.

139 ing growth factor-beta (TGF-beta) system has tumor suppressor activity in the mammary gland, we have

140 ro, the R175L mutant displayed an attenuated tumor suppressor activity in the regulation of transcrip

141 3p21.3 120-kb chromosomal region may exhibit tumor suppressor activity in vitro and in vivo.

142 ial downstream targets of PKCalpha-dependent tumor suppressor activity in vitro and in vivo.

143 have shown for the first time that BAP1 has tumor suppressor activity in vivo by showing that BAP1 c

144 t mitochondrial program exerts a significant tumor suppressor activity in vivo.

145 in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo.

146 rostaglandin dehydrogenase (PGDH), which has tumor-suppressor activity in lung, colon, breast, and ga

147 ng growth factor-beta (TGF-beta) pathway has tumor-suppressor activity in many epithelial tissues.

148 TFF2 has tumor-suppressor activity in the mouse pancreas and prev

149 by seven orders of magnitude, did not block tumor-suppressor activity in vivo, we determined whether

150 t that overexpression of MnSOD may exert its tumor suppressor activity, in part, by modulation of spe

151 pRb tumor suppressor activity is governed by a variety of po

152 However, IRF-4 tumor suppressor activity is lost in IRF association dom

153 These results indicate that pRB's tumor suppressor activity is not effectuated by active s

154 er, the mechanism by which merlin exerts its tumor suppressor activity is not well understood.

155 The mechanism of Fus1 tumor suppressor activity is unknown.

156 CKS, a major protein kinase C substrate with tumor suppressor activity, is likely the rodent ortholog

157 While the SWI/SNF complex displays potent tumor suppressor activity, it is unknown whether this ac

158 Unexpectedly, the tumor suppressor activity mapped to the LOX-PP domain, w

159 Modulation of tumor suppressor activities may provide new opportunitie

160 ient and control tumors suggests that TRIM14 tumor suppressor activity may depend on cell death signa

161 liver cancer, which is the neutralization of tumor suppressor activities of an RNA binding protein, C

162 nd Bard1/Brca1-mutant mice indicate that the tumor suppressor activities of both genes are mediated t

163 The tumor suppressor activities of RUNX1 and RUNX3 are media

164 High levels of Smad3 are required for the tumor suppressor activities of TGF-beta, whereas lower l

165 d a lack of in vitro but significant in vivo tumor suppressor activity of 15-PGDH via an antiangiogen

166 Thus, we conclude that the tumor suppressor activity of AP2alpha is mediated throug

167 Our findings suggest that the tumor suppressor activity of Bin1 reflects engagement of

168 The tumor suppressor activity of BRCA1 may require the parti

169 ntenance of genomic integrity as a principal tumor suppressor activity of BRCA1.

170 These observations suggest that the tumor suppressor activity of caspase-2 is linked to its

171 To show tumor suppressor activity of CYGB, we performed the foll

172 inds talin and FAK, is required for the full tumor suppressor activity of DLC1 and contributes to the

173 e Fhit-Ap(3)A complex, which may enhance the tumor suppressor activity of Fhit.

174 The tumor suppressor activity of GPx3 seems to relate to its

175 This effect could contribute to the tumor suppressor activity of HINT1.

176 Env proteins cause cancer by inhibiting the tumor suppressor activity of Hyal2.

177 provides a mechanism to explain in part the tumor suppressor activity of ICSBP, since ICSBP-deficien

178 In this issue of Blood, Song et al show that tumor suppressor activity of Ikaros is achieved though r

179 ork in the authors' laboratory has shown the tumor suppressor activity of IRF-1 expression and the on

180 in human and murine HCC and uncover a novel tumor suppressor activity of KLF6 in HCC by linking its

181 approach to investigate the mechanism of the tumor suppressor activity of lysyl oxidase.

182 These data suggest that the tumor suppressor activity of maspin may depend in large

183 indings reveal, for the first time, that the tumor suppressor activity of miR-124 could be partly due

184 portantly, this is the same region where the tumor suppressor activity of myopodin is located.

185 development, we systematically surveyed for tumor suppressor activity of Notch1 in vivo.

186 phorylation at conserved sites regulates the tumor suppressor activity of Numb.

187 The tumor suppressor activity of P14ARF is in part a result

188 rtant nongenotoxic stress that modulates the tumor suppressor activity of p53 during malignant progre

189 The tumor suppressor activity of p53 is regulated by interac

190 -dependent apoptosis and interferes with the tumor suppressor activity of p53.

191 proapoptotic functions are essential for the tumor suppressor activity of p53.

192 n of the G2 checkpoint may contribute to the tumor suppressor activity of p53.

193 Because of the ubiquitous expression and tumor suppressor activity of PP2A in cells, as well as t

194 ic Chk1 activity in cancer cells induced the tumor suppressor activity of protein phosphatase protein

195 of cyclin B1 and suggest a link between the tumor suppressor activity of ptc1 and the regulation of

196 e that Tag might not be fully inhibiting the tumor suppressor activity of Rb.

197 Reciprocating the anti-estrogenic tumor suppressor activity of RUNX proteins, inhibition o

198 but interactive pathways that inactivate the tumor suppressor activity of Schwannomin to allow prolif

199 Collectively, our findings suggest that the tumor suppressor activity of SIRT2 requires its ability

200 ired Mad activity in Drosophila or decreased tumor suppressor activity of Smad4/DPC4 in pancreas canc

201 We demonstrate that the tumor suppressor activity of Snf5 depends on its regulat

202 increased tumorigenicity in vivo indicating tumor suppressor activity of TGFbeta signaling in this m

203 Thus, tumor suppressor activity of the BMPs in skin epithelium

204 The tumor suppressor activity of the BRCA1 gene product is d

205 As a first step in evaluating the tumor suppressor activity of the manganese superoxide di

206 In the present study, we examined the tumor suppressor activity of the prohibitin 3'UTR in hum

207 ibited tumorigenesis, further supporting the tumor suppressor activity of this miRNA.

208 ntegrating metabolic effects of THs with the tumor suppressor activity of THRB, the effect of thyroid

209 These results suggest that the tumor suppressor activity of TMEFF2 requires the cytopla

210 e a possible mechanistic explanation for the tumor suppressor activity of WTX.

211 the view that p16INK4a and p19ARF exert the tumor-suppressor activities of this locus, although thei

212 s disrupted the subcellular localization and tumor-suppressor activity of PTEN.

213 The tumor-suppressor activity of the retinoblastoma protein

214 nscript map, important in the elucidation of tumor suppressor activity on chromosome 11p15.5.

215 cts of cancer-derived KLF6 mutants that lack tumor suppressor activity.Oncogene advance online public

216 However, the mechanism of myopodin tumor-suppressor activity or signaling that leads to act

217 tion, and that several NF2 mutants that lack tumor-suppressor activity present improper localization.

218 Factors that mediate p53 tumor suppressor activity remain largely unknown.

219 E7 oncoproteins that antagonize p53 and pRB tumor suppressor activity, respectively.

220 Besides losing tumor suppressor activity, some hotspot p53 mutants gain

221 repressed by Myc include several with potent tumor suppressor activity such as miR-15a/16-1, miR-34a,

222 as Ras and RhoA inhibit, whereas genes with tumor suppressor activity such as RhoB enhance NOS2 indu

223 n and deletion, including genes that exhibit tumor-suppressor activity, such as CISH1 (encoding SOCS1

224 ced ITGA7-TIMP3 signaling and the downstream tumor-suppressor activity, suggesting the existence of a

225 In addition, lysyl oxidase has tumor suppressor activity that has been shown to depend

226 tory subunit of ribonucleotide reductase has tumor suppressor activity that is mediated through effic

227 invasion of colon carcinoma cells indicating tumor suppressor activity that is unrelated to protease

228 Unc5c, encodes a pro-apoptotic receptor with tumor suppressor activity that we found is negatively re

229 we show that in addition to inactivating p53 tumor suppressor activities, the Tag-p53 complex has gro

230 ain a wild-type gene but exhibit reduced p53 tumor suppressor activity through overexpression of the

231 l, Kim et al. identify WTX modulation of p53 tumor-suppressor activity through regulation of p53 acet

232 ogether, our findings ascribe INK4a's potent tumor suppressor activity to the cooperative actions of

233 nvolved, at least in some cell types, in the tumor suppressor activity triggered after inappropriate

234 uppressor, but a mouse model for testing the tumor suppressor activity was missing.

235 lipid phosphatase-dependent and -independent tumor suppressor activities, we investigated the contrib

236 gate the molecular and cellular basis of BHD tumor suppressor activity, we generated mutant Bhd mice

237 The target genes mediating this tumor suppressor activity were unknown.

238 tide (LOX-PP) domain of secreted pro-LOX has tumor-suppressor activity, while the active enzyme promo

239 he two proteins (Adp14/p53) and compared its tumor suppressor activity with that of a single gene vec