ライフサイエンスコーパス: tumor suppressor protein

1 fork recovery is mediated through the PALB2 tumor suppressor protein.

2 Tazarotene-induced gene 3 (TIG3) is a tumor suppressor protein.

3 of the human homologue of Mod5, TRIT1, as a tumor suppressor protein.

4 h SIRT2 may function, at least in part, as a tumor suppressor protein.

5 nt loss of function of the von Hippel-Lindau tumor suppressor protein.

6 and in cancer via interaction with the DAL-1 tumor suppressor protein.

7 gene doc-1 (deleted in oral cancer 1), is a tumor suppressor protein.

8 ubsequently stabilizes and activates the p53 tumor suppressor protein.

9 The transcription factor p53 is a key tumor suppressor protein.

10 of mutations in the von Hippel Lindau (VHL) tumor suppressor protein.

11 ied, including the c-JUN oncoprotein and p53 tumor suppressor protein.

12 ability of E7 to inhibit the retinoblastoma tumor suppressor protein.

13 the functionally critical UCH domain in this tumor suppressor protein.

14 istone acetyltransferase (HAT) complex and a tumor suppressor protein.

15 en shown to be identical to Nit2, a putative tumor suppressor protein.

16 ple, the transcriptional activity of the p53 tumor suppressor protein.

17 ed, suggesting that HBP1 may be an important tumor suppressor protein.

18 These data reveal the role of A20 as a tumor suppressor protein.

19 errant mitosis by directly regulating the Rb tumor suppressor protein.

20 by the expression of a chosen oncoprotein or tumor suppressor protein.

21 a significant role in the regulation of the tumor suppressor protein.

22 in the phosphatase and tensin homolog (PTEN) tumor suppressor protein.

23 s, and binding of inhibitors such as the p27 tumor suppressor protein.

24 lysis to demonstrate the role of MOAP-1 as a tumor suppressor protein.

25 development of small molecule activators of tumor suppressor proteins.

26 the cytoplasmic mislocalization of multiple tumor suppressor proteins.

27 ol systems in the degradative fate of mutant tumor suppressor proteins.

28 roteins inactivated the function of cellular tumor suppressor proteins.

29 program controlled by the p53 and p16(INK4a) tumor suppressor proteins.

30 gulate the expression of PTEN and p53-family tumor-suppressor proteins.

31 The expression of tumor suppressor protein 53 (p53) and its target genes:

32 Unlike in most adult tumors, tumor suppressor protein 53 (p53) mutations occur with a

33 The tumor suppressor protein 53BP1, a pivotal regulator of D

34 In contrast, CYLD (cylindromatosis tumor-suppressor protein), a K63-specific deubiquitinase

35 Many tumor suppressor proteins act to blunt the effects of mi

36 The ARF tumor suppressor protein activates p53 in response to on

37 The p53 tumor suppressor protein acts as a transcription factor

38 Here, we show that the tumor suppressor protein adenomatous polyposis coli (APC

39 In this study, the tumor suppressor protein adenomatous polyposis coli (APC

40 The tumor suppressor protein adenomatous polyposis coli (APC

41 The tumor suppressor protein adenomatous polyposis coli (APC

42 In one such pathway the tumor-suppressor protein adenomatous polyposis coli (APC

43 are expected for oncoproteins, we found that tumor suppressor proteins also exhibit strong biases tow

44 ased HIF-1alpha binding to von Hippel-Lindau tumor suppressor protein, an E3 ligase component and an

45 sis for understanding the role of menin as a tumor suppressor protein and as an oncogenic co-factor o

46 g TS and RR was enriched with retinoblastoma tumor suppressor protein and histone H3 tri-methylated a

47 cer include suppressing induction of the p53 tumor suppressor protein and maintaining metabolic funct

48 and tensin homolog deleted on chromosome 10) tumor suppressor protein and phosphate-depended kinase 1

49 sequence-specific DNA-binding domain of the tumor suppressor protein and preventing it from transcri

50 resents evidence that de-ph-S302-CUGBP1 is a tumor suppressor protein and that the Gank-UPS-mediated

51 15-PGDH is a tumor suppressor protein and the primary enzyme responsi

52 n homolog of the Drosophila polycomb L(3)MBT tumor suppressor protein and thus a candidate tumor supp

53 s the key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human

54 ) function, leads to nuclear accumulation of tumor suppressor proteins, and induces cancer cell death

55 gulated by the retinoblastoma (RB) family of tumor suppressor proteins, and virus-encoded oncogenes d

56 diploid RPE-1 cells, either by depleting the tumor suppressor protein APC or the kinesin-13 protein M

57 asmic dynein, the adenomatous polyposis coli tumor suppressor protein (APC), and glycogen synthase ki

58 ctasia mutated (ATM) kinase and H2AX histone tumor suppressor proteins are each critical for maintena

59 Because many tumor suppressor proteins are wild-type in KS and PEL, d

60 Tumor-suppressor proteins are inactivated by many differ

61 BACKGROUND & AIMS: Tumor-suppressor proteins are inactivated by many differ

62 We show that the tumor suppressor protein ARF mediates this switch by inh

63 ell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to

64 study, we have examined the roles of the p53 tumor suppressor protein, as well as its downstream targ

65 The tumor suppressor protein ASPP (Apoptosis-Stimulating Pro

66 Mutation of the von Hippel-Lindau (VHL) tumor suppressor protein at codon 200 (R200W) is associa

67 s recognized multiple putative oncogenic and tumor suppressor protein binding sites in the AKR1B10 pr

68 show that DIM up-regulates expression of the tumor suppressor protein BRCA1 in carcinoma and normal c

69 The tumor suppressor protein BRCA1 is a constituent of sever

70 The tumor suppressor protein BRCA1 promotes homologous recom

71 air-mediated helicase unloading involves the tumor suppressor protein BRCA1, which acts upstream of M

72 The human tumor suppressor protein BRCA2 plays a key role in recom

73 otif is reminiscent of the FVPP motif in the tumor suppressor protein BRCA2 that mediates DMC1 intera

74 s as a crucial negative regulator of the p53 tumor suppressor protein by antagonizing p53 transactiva

75 rmore, we find that TRIB2 relieves the liver tumor suppressor protein C/EBPalpha-mediated inhibition

76 by mutations in the NF2 gene that encodes a tumor-suppressor protein called merlin.

77 oto-oncogenes can up-regulate Pol I, whereas tumor suppressor proteins can inhibit rRNA synthesis.

78 rticles containing the gene encoding the p53 tumor suppressor protein (chi-p53) and/or doxorubicin (D

79 rous transcription factors including the p53 tumor suppressor protein constitutes a vital early step

80 The ING3 tumor suppressor protein contains a plant homeodomain (P

81 g extracts and human cells, we show that the tumor suppressor protein CtIP plays a critical role in t

82 p53 is an important tumor-suppressor protein deactivation of which by mdm2 r

83 s revealed increased nuclear accumulation of tumor suppressor proteins, decreased cell proliferation,

84 e in the transcription and expression of the tumor suppressor protein E-cadherin (CDH1).

85 ads to microRNA-21 (miR-21) production and a tumor suppressor protein (e.g. PDCD4 (program cell death

86 y TGFbeta is dependent on the retinoblastoma tumor suppressor protein/E2 promoter binding factor (pRb

87 ike protein, also known as schwannomin) is a tumor suppressor protein encoded by the neurofibromatosi

88 The mouse p19(Arf) (human p14(ARF)) tumor suppressor protein, encoded in part from an altern

89 Members of the Myb oncoprotein and E2F-Rb tumor suppressor protein families are present within the

90 Fanconi anemia (FA) DNA repair pathway, the tumor suppressor proteins FANCI and FANCD2 (the ID compl

91 Argast et al. has shown that plexin B1 is a tumor-suppressor protein for melanoma metastasis in a mo

92 1, the Semaphorin 4D (Sema4D) receptor, is a tumor-suppressor protein for melanoma, which functions,

93 mplexes, leading to subsequent protection of tumor suppressor proteins from degradation.

94 analysis also demonstrated that recovery of tumor suppressor protein function is possible, indicatin

95 The p53 tumor suppressor protein has a well-established role in

96 suppressor protein, the role of MOAP-1 as a tumor suppressor protein has yet to be determined.

97 The BRCA1 tumor suppressor protein heterodimerizes with its partne

98 This process results in the reduction of a tumor suppressor protein (HOXD10), RhoA/RhoC up-regulati

99 roduction, leading to the down-regulation of tumor suppressor protein (HOXD10), RhoGTPase-ROK activat

100 Here, we report that loss of p53, a tumor suppressor protein, impaired repression of NF-kapp

101 r, which regulates the transcription of this tumor suppressor protein in a TSC2-dependent manner.

102 ssion, and decreased nuclear levels of BRCA1 tumor suppressor protein in invasive breast carcinomas.

103 earliest detectable epigenetically silenced tumor suppressor proteins in cancer, and we speculate th

104 xin B1 is predicted to function as a classic tumor-suppressor protein in melanoma, in part through su

105 Menin (MEN1) is a tumor-suppressor protein in neuroendocrine tissue.

106 it CRM-1 and promote nuclear accumulation of tumor-suppressor proteins in pancreatic cancer cells.

107 clude ARF and P16INK4A, both of which encode tumor suppressor proteins, in both human and mouse retin

108 ncogenic transformation by inhibition of key tumor suppressor proteins, including p53 and members of

109 oncogenic proteins, decreased expression of tumor suppressor protein, increased proliferation, decre

110 Herein, we identify a tumor suppressor protein, inhibitor of growth 4 (ING4),

111 The RASSF1A tumor suppressor protein interacts with the pro-apoptoti

112 p16(INK4a) is a tumor suppressor protein involved in several stress-rela

113 nterferon-regulated transcription factor and tumor suppressor protein IRF-1 is predicted to be largel

114 The BRCA1 tumor suppressor protein is a central constituent of sev

115 The p53 tumor suppressor protein is a major sensor of cellular s

116 The Rb1 tumor suppressor protein is a molecular adaptor that phy

117 lar senescence through activation of the p53 tumor suppressor protein is a new option for treating pr

118 The p53 tumor suppressor protein is a transcription factor that

119 special note is the observation that the p53 tumor suppressor protein is confined to the open chromat

120 g the interferon regulatory factor-1 (IRF-1) tumor suppressor protein is limited.

121 The p53 tumor suppressor protein is regulated by multiple post-t

122 The von Hippel-Lindau tumor suppressor protein is the substrate binding subuni

123 Our studies found that the p27(Kip1) tumor suppressor protein is upregulated and relocalized

124 ow that Beclin 1, an essential autophagy and tumor suppressor protein, is a target of the protein kin

125 In colorectal cancer cells, APC, a tumor suppressor protein, is commonly expressed in trunc

126 ic response element, in conjunction with the tumor suppressor protein Kruppel-like factor 6 functioni

127 One example is the conserved Drosophila tumor-suppressor protein Lethal giant larvae (Lgl).

128 r cells, and this is associated with reduced tumor suppressor protein level and enhanced cell surviva

129 elevation of p21(Cip1), p53, and p16(INK4A) tumor suppressor protein levels.

130 tal Cell, Jossin et al. (2017) show that the tumor suppressor protein Lgl1 interacts with N-cadherin

131 ical differences in mTORC1 regulation by the tumor suppressor proteins Lkb1 and Tsc1/Tsc2 may underli

132 The tumor suppressor protein Merlin inhibits cell proliferat

133 The tumor suppressor protein Merlin is proteasomally degrade

134 2 tumor suppressor gene that encodes for the tumor suppressor protein merlin.

135 The neurofibromatosis type 2 (NF2) tumor-suppressor protein Merlin is a member of the ERM f

136 antagonized by the neurofibromatosis type 2 tumor-suppressor protein merlin.

137 The neurofibromatosis type 2 tumor suppressor protein, merlin, is related to the ERM

138 Folliculin (FLCN) is a tumor-suppressor protein mutated in the Birt-Hogg-Dube (

139 The p53 tumor suppressor protein negatively regulates hypoxia-in

140 Cavin-3 is a tumor suppressor protein of unknown function.

141 ascade have been shown to function either as tumor suppressor proteins or as oncogenes in multiple hu

142 The tumor suppressor proteins p15(INK4B), p16(INK4A), and p1

143 INK4b-ARF-INK4a encodes 3 tumor-suppressor proteins, p15(INK4b), p14(ARF), and p16

144 arcinomas (CxCaRNA(+)), and the HPV-targeted tumor suppressor protein p16(INK4a) as markers for HPV i

145 sive breast cancer cells, down-regulates the tumor suppressor proteins p16(INK4A), p21(WAF1), and p53

146 Indeed, the binding of a human tumor suppressor protein, p21, to PCNA contributes to it

147 of cells incubated with KPT-185 accumulated tumor-suppressor proteins (p27, FOXO, p73, and prostate

148 ferentiation defect that is dependent on the tumor suppressor protein p53 (encoded by Trp53 in mice)

149 but not the oncoprotein Myc, or loss of the tumor suppressor protein p53 (encoded by Trp53 in mice)

150 Under influence of Myc, AMPK-stabilized tumor suppressor protein p53 accumulates in the mitochon

151 The tumor suppressor protein p53 acts as a transcription fac

152 phosphorylation and increased levels of the tumor suppressor protein p53 and a cell cycle inhibitor

153 es cell survival by decreasing levels of the tumor suppressor protein p53 and downstream target genes

154 Inhibition of the interaction between the tumor suppressor protein p53 and its negative regulators

155 ules selectively delivered recombinant human tumor suppressor protein p53 and its tumor-selective sup

156 showed that EBNA3C can directly bind to the tumor suppressor protein p53 and repress its functions,

157 We also identified the tumor suppressor protein p53 as a mediator of podocyte a

158 verexpressed in many cancers, stabilizes the tumor suppressor protein p53 by abrogating its MDM2-depe

159 Inactivation of the tumor suppressor protein p53 by mutagenesis, chemical mo

160 Here we report that the tumor suppressor protein p53 can associate with PXR and

161 Additionally, we show that Na and the tumor suppressor protein p53 cooperate to induce lytic g

162 Here we show that the tumor suppressor protein p53 cooperates with DNA methyla

163 The tumor suppressor protein p53 coordinates the cellular re

164 reasing intrinsic disorder-cytochrome c, the tumor suppressor protein p53 DNA binding domain (p53 DBD

165 The tumor suppressor protein p53 down-regulates a number of

166 The tumor suppressor protein p53 exhibits high affinity to t

167 The roles and actions of the tumor suppressor protein p53 have been extensively studi

168 ay format was used to detect unlabeled human tumor suppressor protein p53 in crude lysates, without a

169 the dynamics of the tetramers formed by the tumor suppressor protein p53 in single living cells.

170 The major tumor suppressor protein p53 is a key cell regulator inv

171 Because tumor suppressor protein p53 is also a redox active tran

172 Antagonizing MDM2 and MDMX to activate the tumor suppressor protein p53 is an attractive therapeuti

173 Under normal cellular conditions, the tumor suppressor protein p53 is kept at low levels in pa

174 lium leads to marked hyperacetylation of the tumor suppressor protein p53 on lysine 370, 379 and 383;

175 The tumor suppressor protein p53 plays a central role in tum

176 The tumor suppressor protein p53 plays a crucial role in coo

177 The tumor suppressor protein p53 plays an important role in

178 The tumor suppressor protein p53 regulates numerous signalin

179 ction (p.i.), followed by phosphorylation of tumor suppressor protein p53 Ser 15 at 3 to 6 h p.i., st

180 nges in small and large regions of the human tumor suppressor protein p53 to identify single amino-ac

181 o induce the accumulation and acetylation of tumor suppressor protein p53 upon the cell cycle entry o

182 nk between mitochondrial dysfunction and the tumor suppressor protein p53 using a set of respiration-

183 eous shrinking: the intrinsically disordered tumor suppressor protein p53 was analyzed by using a com

184 y regulate the activity and stability of the tumor suppressor protein p53, conferring tumor developme

185 te mechanism to ubiquitinate and degrade the tumor suppressor protein p53, involving interactions wit

186 Tumor suppressor protein p53, our most critical defense

187 knockdown of NS increase the activity of the tumor suppressor protein p53, resulting in cell cycle ar

188 The tumor suppressor protein p53, the "guardian of the genom

189 and MDM4 are key negative regulators of the tumor suppressor protein p53, which are frequently upreg

190 fection by human cytomegalovirus (HCMV), the tumor suppressor protein p53, which promotes efficient v

191 y regulate the activity and stability of the tumor suppressor protein p53--a cellular process initiat

192 tion of the intrinsic apoptotic pathway in a tumor suppressor protein p53-dependent manner.

193 factors such as PPARgamma, NFkappaB, and the tumor suppressor protein p53.

194 aration of reduced and oxidized forms of the tumor suppressor protein p53.

195 mor-associated HPV induce the degradation of tumor suppressor protein p53.

196 on of the tetramerization domain (TD) of the tumor suppressor protein p53.

197 into the intrinsically disordered tetrameric tumor suppressor protein p53.

198 Mdm2 is a critical negative regulator of the tumor suppressor protein p53.

199 is through its interaction with the cellular tumor suppressor protein p53.

200 n regulating numerous proteins including the tumor suppressor protein p53.

201 apoptosis and autophagy; not reliant on the tumor suppressor protein p53; and effective against mous

202 wth, was remarkably downregulated, while the tumor suppressor proteins p53 and p21 were substantially

203 ts interacting partners such as the cellular tumor suppressor proteins p53 and Rb, both in vitro and

204 hat represses the functional activity of the tumor suppressor proteins p53 and RB.

205 The tumor-suppressor protein p53 is tightly controlled in no

206 zmB also induces a rapid accumulation of the tumor-suppressor protein p53 within target cells, which

207 ine mutations in TP53, the gene encoding the tumor-suppressor protein p53.

208 ealed common signatures of activation of the tumor-suppressor protein p53.

209 n Chk1, increased phosphorylation of the p53 tumor suppressor protein (p53) at serine 18, and increas

210 We found induction of tumor suppressor protein, p53, and apoptosis with suppre

211 The tumor suppressor protein, p53, is either mutated or abse

212 to cancer progression by down-regulating the tumor suppressor protein, p53.

213 In summary, our phosphorylation analysis of tumor suppressor protein PALB2 uncovers new layers of re

214 e for the cyclin D1/Cdk4/pRb (retinoblastoma tumor suppressor protein) pathway in delayed neuronal de

215 The tumor suppressor protein Pdcd4 has been shown to inhibit

216 This process results in a decrease of a tumor suppressor protein (PDCD4), and an upregulation of

217 (human homolog of the Drosophila discs large tumor suppressor protein) PDZ (postsynaptic density/disc

218 A tumor suppressor protein, PHAPI, enhances caspase-9 acti

219 DA-MB-231) by increasing the activity of the tumor suppressor protein phoshatase 2A (PP2A).

220 ukemic HSCs in BM requires inhibition of the tumor suppressor protein phosphatase 2A (PP2A) and expre

221 we have demonstrated that activation of the tumor suppressor protein phosphatase 2A (PP2A), a negati

222 multiple cellular processes, inhibiting the tumor suppressor protein phosphatase 2A (PP2A), and inhi

223 In this study, we show that the tumor suppressor protein phosphatase 2A (PP2A), one of t

224 trocytes deficient in the major glioblastoma tumor suppressor protein phosphatase and tensin homolog

225 High glucose-induced reduction of the tumor suppressor protein phosphatase and tensin homolog

226 The p53 tumor suppressor protein plays a critical role in cellul

227 The p53 tumor suppressor protein plays a critical role in orches

228 ast cancer by showing how it upregulates the tumor suppressor protein PML.

229 The retinoblastoma tumor suppressor protein pRb is a key regulator of cell

230 The retinoblastoma tumor suppressor protein pRB is conventionally regarded

231 The retinoblastoma tumor suppressor protein pRb restricts cell growth throu

232 nding the cellular life span by sequestering tumor suppressor proteins pRB and p53 in virus-transform

233 tion, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites ordinarily phosp

234 of Cdc25A led to reduction in retinoblastoma tumor suppressor protein (pRb) phosphorylation.

235 key downstream target of the retinoblastoma tumor suppressor protein (pRB), which is frequently inac

236 that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions

237 nd hypophosphorylation of the retinoblastoma tumor suppressor protein (pRb), with no effect on cyclin

238 The retinoblastoma tumor-suppressor protein, pRb, is a member of the pocket

239 previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardia

240 MO, which in turn promotes expression of the tumor suppressor protein promyelocytic leukemia (PML).

241 The tumor-suppressor protein promyelocytic leukemia (PML) is

242 We present evidence that the tumor suppressor protein prostate apoptosis response-4 (

243 effect of C-terminal phosphorylation on the tumor suppressor protein PTEN.

244 d predictive markers, such as alterations of tumor suppressor proteins PTEN or p53, to augment curren

245 The von Hippel-Lindau (VHL) tumor suppressor protein pVHL is commonly mutated in cle

246 sing pathway including the von Hippel-Lindau tumor suppressor protein (pVHL) and the hypoxia inducibl

247 endent and -independent functions of the VHL tumor suppressor protein (pVHL) can contribute to tumor

248 tered metabolism in cancer cells related to: tumor suppressor protein (pVHL) function, the histone ac

249 Inactivation of von Hippel-Lindau tumor-suppressor protein (pVHL) is associated with von H

250 oded proteins with cell cycle regulators and tumor suppressor proteins, raising the possibility that

251 It is an integral partner to the tumor suppressor protein, Ras association domain family

252 iferation via proteasomal degradation of the tumor suppressor protein Rb.

253 pment of liver cancer is a neutralization of tumor suppressor proteins Rb, p53, hepatocyte nuclear fa

254 Disruption of murine retinoblastoma tumor suppressor protein (Rb) in mature pancreatic beta-

255 The retinoblastoma tumor suppressor protein (RB) plays a critical role in c

256 virus (HCV) downregulates the retinoblastoma tumor suppressor protein (Rb), a central cell cycle regu

257 lid tumor cells, requires the retinoblastoma tumor suppressor protein (Rb).

258 N-terminal domain of the retinoblastoma (Rb) tumor suppressor protein (RbN) harbors in-frame exon del

259 biopsies showed nuclear accumulation of key tumor-suppressor proteins, reduction of cell proliferati

260 The Von Hippel-Lindau (VHL) tumor suppressor protein regulates VEGF gene expression

261 The tumor suppressor protein retinoblastoma (RB) is mechanis

262 The latter inactivates the tumor suppressor protein retinoblastoma (Rb), which lead

263 was further ratified by the upregulation of tumor suppressor protein retinoblastoma, which repressed

264 ell division and cell differentiation is the tumor suppressor protein RETINOBLASTOMA.

265 C-terminal domain (RbC) is necessary for the tumor suppressor protein's activities in growth suppress

266 The tumor suppressor protein Scribble (SCRIB) plays an evolu

267 motes a variety of human tumors by degrading tumor suppressor proteins such as p53.

268 The tumor suppressor protein Suppressor of fused (Sufu) play

269 IRF-1 is a tumor suppressor protein that activates gene expression

270 p53 is a tumor suppressor protein that acts as a transcription fa

271 st cancer susceptibility gene 1 (BRCA1) is a tumor suppressor protein that functions to maintain geno

272 Tazarotene-induced gene 3 (TIG3) is a tumor suppressor protein that has a key role in controll

273 p53 is a key tumor suppressor protein that has numerous functions.

274 on-associated miRNA-mediated regulation of a tumor suppressor protein that has the ability to influen

275 Menin is a tumor suppressor protein that is encoded by the MEN1 (mu

276 WTX is a tumor suppressor protein that is lost or mutated in up t

277 bunit of an SCF ubiquitin ligase and a major tumor-suppressor protein that is altered in several huma

278 homolog deleted on chromosome 10 (PTEN) is a tumor-suppressor protein that regulates phosphatidylinos

279 though RASSF1A is now considered a bona fide tumor suppressor protein, the role of MOAP-1 as a tumor

280 proteins and host cell cycle regulators and tumor suppressor proteins, the relevance of these observ

281 Small molecule mediated stabilization of p53 tumor suppressor protein through sumoylation is a promis

282 method showed that translocation of the p53 tumor-suppressor protein to the perinucleus in immortali

283 By providing a means to restore a functional tumor-suppressor protein to tumor cells, PTEN-Long may h

284 Telomeres and tumor suppressor protein TP53 (p53) function in genome p

285 ntranslated region (3'UTR) of the mRNA for a tumor suppressor protein, tumor protein 53-induced nucle

286 The Ras-assocation domain family (RASSF) of tumor suppressor proteins until recently contained six p

287 Here, we use the von Hippel-Lindau tumor suppressor protein VHL as a model substrate for st

288 specific disruption of the von Hippel-Lindau tumor suppressor protein (VHL) resulted in constitutive

289 tion of genes encoding the von Hippel-Lindau tumor suppressor protein (Vhl), hypoxia-inducible factor

290 ter for degradation by the von Hippel-Lindau tumor-suppressor protein (VHL).

291 The levels of p53 (TRP53) tumor suppressor protein were also increased in the same

292 residues creates binding sites for the COP1 tumor suppressor protein, which is an ubiquitin ligase c

293 f cancers with defects in the BRCA1 or BRCA2 tumor suppressor proteins, which are involved in the rep

294 DLC1 is a tumor suppressor protein whose full activity depends on

295 p53 is a tumor suppressor protein whose function is frequently lo

296 LKB1 is a tumor suppressor protein whose loss leads to HIF1alpha-m

297 ated, pro-apoptotic peptide derived from p53 tumor suppressor protein with a human cancer cell line.

298 ortance of FAK following deletion of the Apc tumor suppressor protein within the intestinal epitheliu

299 9 locus harbors an imprinted gene encoding a tumor suppressor protein within the long-sought WT2 locu

300 The Wilms' tumor suppressor protein WT1 functions as a transcriptio