ライフサイエンスコーパス: tumor suppressor protein p53

1 repress the transcriptional activity of the tumor suppressor protein p53.

2 be a specific inhibitor of signaling by the tumor suppressor protein p53.

3 g homology to the proline-rich domain of the tumor suppressor protein p53.

4 to activation of a checkpoint involving the tumor suppressor protein p53.

5 lly deubiquitinates and hence stabilizes the tumor suppressor protein p53.

6 ant regulator of the proapoptotic BAX is the tumor suppressor protein p53.

7 at that this AR activity is repressed by the tumor suppressor protein p53.

8 Mdm2 is a critical negative regulator of the tumor suppressor protein p53.

9 oter DNA sequence in a complex stabilized by tumor suppressor protein p53.

10 ceptor is transcriptionally regulated by the tumor suppressor protein p53.

11 is through its interaction with the cellular tumor suppressor protein p53.

12 s also capable of complex formation with the tumor suppressor protein p53.

13 n regulating numerous proteins including the tumor suppressor protein p53.

14 of E2F97 resulted in down-regulation of the tumor suppressor protein p53.

15 n this report show that BKV TAg can bind the tumor suppressor protein p53.

16 dalton protein that inactivates the cellular tumor suppressor protein p53.

17 m that is dependent on the activation of the tumor suppressor protein p53.

18 factors such as PPARgamma, NFkappaB, and the tumor suppressor protein p53.

19 aration of reduced and oxidized forms of the tumor suppressor protein p53.

20 mor-associated HPV induce the degradation of tumor suppressor protein p53.

21 on of the tetramerization domain (TD) of the tumor suppressor protein p53.

22 gulating non-histone proteins, including the tumor suppressor protein p53.

23 ransferase enzyme SET8/PR-Set7 regulates the tumor suppressor protein p53.

24 derably the transcriptional network of human tumor suppressor protein p53.

25 ects, nucleophosmin is known to regulate the tumor suppressor protein p53.

26 into the intrinsically disordered tetrameric tumor suppressor protein p53.

27 tion is essential for the proper function of tumor suppressor protein p53.

28 could be partially rescued by removal of the tumor suppressor protein p53.

29 protein promotes apoptosis downstream of the tumor-suppressor protein p53.

30 ealed common signatures of activation of the tumor-suppressor protein p53.

31 ine mutations in TP53, the gene encoding the tumor-suppressor protein p53.

32 directly phosphorylating and activating the tumor-suppressor protein p53.

33 nit of S100B and target proteins such as the tumor suppressor protein, p53.

34 N1 gene product, interacts directly with the tumor suppressor protein, p53.

35 epresses the transcriptional activity of the tumor suppressor protein, p53.

36 of HCC through its ability to bind the human tumor suppressor protein, p53.

37 plasms were analysed for the presence of the tumor suppressor protein, p53.

38 to cancer progression by down-regulating the tumor suppressor protein, p53.

39 in has been shown to form a complex with the tumor suppressor protein p53, a known inducer of apoptos

40 ing is crucial to the protective role of the tumor suppressor protein p53, a nuclear phosphoprotein a

41 y regulate the activity and stability of the tumor suppressor protein p53--a cellular process initiat

42 Under influence of Myc, AMPK-stabilized tumor suppressor protein p53 accumulates in the mitochon

43 The tumor suppressor protein p53 activates transcription fro

44 The tumor suppressor protein p53 acts as a transcription fac

45 The tumor suppressor protein p53 acts as a transcriptional a

46 ection, E1B-55K binds to and inactivates the tumor suppressor protein p53, allowing efficient replica

47 phosphorylation and increased levels of the tumor suppressor protein p53 and a cell cycle inhibitor

48 y regulate the activity and stability of the tumor suppressor protein p53 and are important molecular

49 hich correlate with the up-regulation of the tumor suppressor protein p53 and concurrent up-regulatio

50 es cell survival by decreasing levels of the tumor suppressor protein p53 and downstream target genes

51 53BP1 binds to the tumor suppressor protein p53 and has a potential role in

52 Inhibition of the interaction between the tumor suppressor protein p53 and its negative regulators

53 ules selectively delivered recombinant human tumor suppressor protein p53 and its tumor-selective sup

54 molecular targets with the activators of the tumor suppressor protein p53 and NF-kappaB-p65, suggesti

55 zo(a)pyrene failed to significantly increase tumor suppressor protein p53 and p53-regulated growth-re

56 showed that EBNA3C can directly bind to the tumor suppressor protein p53 and repress its functions,

57 The tumor suppressor protein p53 and the adenoviral 12 S E1A

58 by nicotine results in the induction of the tumor suppressor protein p53 and the cdk inhibitor p21.

59 We measured basal levels of the tumor suppressor protein p53 and the death effector prot

60 experimental approach was validated with the tumor suppressor protein p53 and the forkhead protein Fo

61 ell apoptosis in a pathway that involves the tumor suppressor protein p53 and the mitochondrial trans

62 not only suppresses apoptosis induced by the tumor suppressor protein p53 and the Myc oncoprotein but

63 sly unreported nuclear complexes between the tumor suppressor protein p53 and the pro-apoptotic prote

64 ing that there may be cross talk between the tumor suppressor protein p53 and WISP-1 signaling pathwa

65 eins involved in recombination and also with tumor suppressor proteins p53 and breast cancer suscepti

66 wth, was remarkably downregulated, while the tumor suppressor proteins p53 and p21 were substantially

67 , most likely due to the accumulation of the tumor suppressor proteins p53 and p21.

68 on in the levels of pyridine nucleotides and tumor suppressor proteins p53 and p73, and a decrease in

69 SV40 large T antigen (T) inactivates the tumor suppressor proteins p53 and pRb, and can induce ce

70 ue, at least in part, to inactivation of the tumor suppressor proteins p53 and pRB.

71 ciated tumor cells and was shown to bind the tumor suppressor proteins p53 and pRb.

72 ducts can associated with and inactivate the tumor suppressor proteins p53 and Rb (the retinoblastoma

73 ts interacting partners such as the cellular tumor suppressor proteins p53 and Rb, both in vitro and

74 proteins bind to and inactivate the cellular tumor suppressor proteins p53 and Rb, respectively.

75 illomaviruses (HPVs) bind and inactivate the tumor suppressor proteins p53 and Rb, respectively.

76 hat represses the functional activity of the tumor suppressor proteins p53 and RB.

77 is due in large part to perturbation of the tumor suppressor proteins p53 and the retinoblastoma (pR

78 The ability of both tumor suppressor proteins, p53 and BRCA1, to induce the

79 ell cycle regulatory proteins, including the tumor suppressor proteins, p53 and p105Rb, in order to i

80 ontrol of infected cells by inactivating the tumor suppressor proteins, p53 and Rb, respectively.

81 In addition, the tumor suppressor proteins, p53 and Rbp105, were detected

82 g to target proteins such as annexin A2, the tumor-suppressor protein p53 and myosin IIA.

83 tumor antigen (T-ag), which inactivates the tumor-suppressor proteins p53 and pRb family members.

84 periments showed that ORF-1 protein bound to tumor suppressor protein p53, and the ORF-1 binding doma

85 et for transcriptional downregulation by the tumor suppressor protein p53, and this repression can be

86 We found induction of tumor suppressor protein, p53, and apoptosis with suppre

87 0B(beta beta) was found to interact with the tumor suppressor protein, p53, and inhibit its PKC-depen

88 1 cell cycle arrest through induction of the tumor suppressor protein, p53, and the cyclin-dependent

89 xpression of Zta results in induction of the tumor suppressor protein, p53, and the cyclin-dependent

90 apoptosis and autophagy; not reliant on the tumor suppressor protein p53; and effective against mous

91 The levels of the tumor suppressor protein p53 are generally quite low in

92 Levels of the tumor suppressor protein p53 are normally quite low due

93 We also identified the tumor suppressor protein p53 as a mediator of podocyte a

94 The abrogation of function of the tumor-suppressor protein p53 as a result of mutation of

95 n Chk1, increased phosphorylation of the p53 tumor suppressor protein (p53) at serine 18, and increas

96 dc14A and hCdc14B proteins interact with the tumor suppressor protein p53 both in vitro and in vivo.

97 ates the binding of mtrII oncoprotein to the tumor suppressor protein p53 both in vivo using transien

98 n not only suppress apoptosis induced by the tumor suppressor protein p53, but also permit efficient

99 ily in melanoma cells harboring a functional tumor suppressor protein p53, but much less efficiently

100 itiate cell death are thought to involve the tumor suppressor protein p53, but the degree to which th

101 verexpressed in many cancers, stabilizes the tumor suppressor protein p53 by abrogating its MDM2-depe

102 Inactivation of the tumor suppressor protein p53 by mutagenesis, chemical mo

103 Tumor suppressor protein p53 can act as a transcription

104 Here we report that the tumor suppressor protein p53 can associate with PXR and

105 Like the tumor suppressor protein p53, components of this "RB pat

106 y regulate the activity and stability of the tumor suppressor protein p53, conferring tumor developme

107 Although the N-terminal BOX-I domain of the tumor suppressor protein p53 contains the primary dockin

108 The tumor suppressor protein p53 contributes to the control

109 Additionally, we show that Na and the tumor suppressor protein p53 cooperate to induce lytic g

110 Here we show that the tumor suppressor protein p53 cooperates with DNA methyla

111 The tumor suppressor protein p53 coordinates the cellular re

112 tion of the intrinsic apoptotic pathway in a tumor suppressor protein p53-dependent manner.

113 reasing intrinsic disorder-cytochrome c, the tumor suppressor protein p53 DNA binding domain (p53 DBD

114 The tumor suppressor protein p53 down-regulates a number of

115 ferentiation defect that is dependent on the tumor suppressor protein p53 (encoded by Trp53 in mice)

116 but not the oncoprotein Myc, or loss of the tumor suppressor protein p53 (encoded by Trp53 in mice)

117 Estrogen receptor alpha (ERalpha) and tumor suppressor protein p53 exert opposing effects on c

118 The tumor suppressor protein p53 exhibits high affinity to t

119 Under normal conditions, tumor suppressor protein p53 exists in the cell in its l

120 Despite previous assumptions that the tumor suppressor protein p53 exists primarily and functi

121 The tumor suppressor protein p53 functions as a transcriptio

122 Pifithrin-alpha, an inhibitor of the tumor suppressor protein p53, had no effect on ROS gener

123 The tumor suppressor protein p53 has a transcriptional activ

124 Since the tumor suppressor protein p53 has been implicated in apop

125 The tumor suppressor protein p53 has been implicated in the

126 The tumor suppressor protein p53 has been well documented as

127 The roles and actions of the tumor suppressor protein p53 have been extensively studi

128 roliferation of breast cancer cells, whereas tumor suppressor protein p53 impedes proliferation of ce

129 , we found that uPA alters expression of the tumor suppressor protein p53 in Beas2B airway epithelial

130 ay format was used to detect unlabeled human tumor suppressor protein p53 in crude lysates, without a

131 Lysine acetylation of the tumor suppressor protein p53 in response to a wide varie

132 14-3-3 sigma is induced by tumor suppressor protein p53 in response to DNA damage.

133 the dynamics of the tetramers formed by the tumor suppressor protein p53 in single living cells.

134 s multiple lines of evidence implicating the tumor suppressor protein p53 in terminal differentiation

135 protein, Parc, and its role in anchoring the tumor suppressor protein p53 in the cytoplasm reveals ye

136 ly to be a transcription target of the human tumor-suppressor protein p53 in signaling apoptosis and

137 The tumor suppressor protein p53 induces or represses the ex

138 ells, binding of E1B-55kDa and E4orf6 to the tumor suppressor protein p53 inhibits its transcriptiona

139 The multifunctional tumor suppressor protein, p53, inhibits cell growth and

140 te mechanism to ubiquitinate and degrade the tumor suppressor protein p53, involving interactions wit

141 Improper function of the tumor suppressor protein p53 is a contributing factor in

142 The major tumor suppressor protein p53 is a key cell regulator inv

143 The tumor suppressor protein p53 is a pivotal regulator of a

144 Tumor suppressor protein p53 is a tetrameric phosphoprot

145 The tumor suppressor protein p53 is a transcription factor t

146 The tumor suppressor protein p53 is a transcription factor t

147 The tumor suppressor protein p53 is a transcription factor t

148 The tumor suppressor protein p53 is a transcription factor t

149 Because tumor suppressor protein p53 is also a redox active tran

150 Antagonizing MDM2 and MDMX to activate the tumor suppressor protein p53 is an attractive therapeuti

151 The tumor suppressor protein p53 is an essential molecule in

152 The tumor suppressor protein p53 is emerging as a central re

153 In this study, we report that the tumor suppressor protein p53 is essential for the induct

154 The transcription factor and tumor suppressor protein p53 is frequently inactivated i

155 The tumor suppressor protein p53 is frequently inactivated i

156 The tumor suppressor protein p53 is inactivated by mutation

157 Under normal cellular conditions, the tumor suppressor protein p53 is kept at low levels in pa

158 The tumor suppressor protein p53 is known to be transported

159 The tumor suppressor protein p53 is known to induce either a

160 The function of the tumor suppressor protein p53 is modulated by post-transl

161 The tumor suppressor protein p53 is mutated in over half of

162 In unstressed cells, the tumor suppressor protein p53 is present in a latent stat

163 The C-terminal domain of the tumor suppressor protein p53 is the site of non-specific

164 In cancer cells, the function of the tumor suppressor protein p53 is usually blocked.

165 The tumor-suppressor protein p53 is tightly controlled in no

166 ial downstream effecter of this pathway, the tumor suppressor protein p53, is tightly regulated by co

167 This study provides evidence that the tumor suppressor protein, p53, is a transcriptional repr

168 Tumor suppressor protein, p53, is an intracellular prote

169 The tumor suppressor protein, p53, is either mutated or abse

170 The tumor suppressor protein p53 localizes to microtubules (

171 Because the tumor suppressor protein p53 may be involved in these ef

172 The tumor suppressor protein p53 may have other roles and fu

173 gh transcriptionally dependent inhibition of tumor suppressor protein p53, normalization of the pro-a

174 lium leads to marked hyperacetylation of the tumor suppressor protein p53 on lysine 370, 379 and 383;

175 The tumor suppressor protein p53, once activated, can cause

176 ition of c-Myc could be altered by depleting tumor suppressor protein p53 or its transcriptional targ

177 In cells deficient in either the tumor suppressor proteins p53 or Bax, apoptosis was leas

178 Moreover, knocking down tumor suppressor proteins p53 or pRB using small interfe

179 Tumor suppressor protein p53, our most critical defense

180 e acidic transactivation domain of the human tumor suppressor protein p53 (p53TAD) and the 70 kDa sub

181 The tumor suppressor protein p53 participates in DNA repair

182 t that two novel synthetic inhibitors of the tumor suppressor protein p53, pifithrin-alpha (PFT-alpha

183 The tumor suppressor protein p53 plays a central role in mod

184 The tumor suppressor protein p53 plays a central role in pro

185 The tumor suppressor protein p53 plays a central role in tum

186 Although tumor suppressor protein p53 plays a critical role in th

187 The tumor suppressor protein p53 plays a crucial role in coo

188 The tumor suppressor protein p53 plays a key role in maintai

189 The tumor suppressor protein p53 plays an important role in

190 The tumor suppressor protein, p53, plays a critical role as

191 The tumor suppressor protein, p53, plays a critical role in

192 The tumor suppressor protein p53 regulates numerous signalin

193 The tumor suppressor protein p53 regulates transcriptional p

194 The tumor suppressor protein p53 regulates various cellular

195 g the degree to which it cooperates with the tumor suppressor protein p53, remain poorly understood.

196 ition of certain types of DNA lesions by the tumor suppressor protein, p53, represents one of the sev

197 Rapid turnover of the tumor suppressor protein p53 requires the MDM2 ubiquitin

198 lls are exposed to stressful conditions, the tumor suppressor protein p53 restrains growth by promoti

199 Mutations within conserved regions of the tumor suppressor protein, p53, result in oncogenic forms

200 knockdown of NS increase the activity of the tumor suppressor protein p53, resulting in cell cycle ar

201 ction (p.i.), followed by phosphorylation of tumor suppressor protein p53 Ser 15 at 3 to 6 h p.i., st

202 shown previously that NPCs deficient in the tumor suppressor protein p53 show significantly less dea

203 ponse to a variety of stimuli, including the tumor suppressor protein p53, that can mediate cell cycl

204 The tumor suppressor protein p53, the "guardian of the genom

205 ressing temperature-sensitive mutants of the tumor suppressor protein p53, the viral oncogene protein

206 the mutant form seems to form a complex with tumor suppressor protein p53, thereby enhancing its intr

207 pansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechani

208 nges in small and large regions of the human tumor suppressor protein p53 to identify single amino-ac

209 cogenic human polyomavirus BK (BKV) with the tumor-suppressor protein p53 to understand the biology o

210 The ability of the tumor suppressor protein, p53, to recognize certain type

211 h inhibition of the expression of the mutant tumor suppressor protein p53 (Tp53).

212 R-132 on proliferating cell nuclear antigen, tumor suppressor protein p53, transcription factor NF-ka

213 o induce the accumulation and acetylation of tumor suppressor protein p53 upon the cell cycle entry o

214 nk between mitochondrial dysfunction and the tumor suppressor protein p53 using a set of respiration-

215 The tumor suppressor protein, p53, utilizes multiple mechani

216 dition, down-regulation of the pro-apoptotic tumor suppressor protein, p53, via PKB-mediated phosphor

217 eous shrinking: the intrinsically disordered tumor suppressor protein p53 was analyzed by using a com

218 We found that expression of the tumor suppressor protein p53 was higher in MCH(-/-) mice

219 Increased levels of the tumor suppressor protein p53 were observed in normal cel

220 M2 is an important negative regulator of the tumor suppressor protein p53 which regulates the express

221 and MDM4 are key negative regulators of the tumor suppressor protein p53, which are frequently upreg

222 In this highly malignant subset, the tumor suppressor protein p53, which can physically inter

223 rfamily trigger apoptosis independent of the tumor suppressor protein p53, which primarily affects DN

224 fection by human cytomegalovirus (HCMV), the tumor suppressor protein p53, which promotes efficient v

225 30-fold increase in the nuclear level of the tumor suppressor proteins p53 (wild type), pRb, and p130

226 zmB also induces a rapid accumulation of the tumor-suppressor protein p53 within target cells, which