ライフサイエンスコーパス: tumor-infiltrating

1 -associated metastatic cervical cancer after tumor-infiltrating adoptive T cell therapy.

2 Interestingly, tumor-infiltrating and tumor-draining lymph node NK cell

3 The pathogenic impact of tumor-infiltrating B cells is unresolved at present, how

4 uce the growth factor FGF-2, which activates tumor-infiltrating B cells to produce the growth factor

5 cluded elevated immunoglobulin expression by tumor-infiltrating B cells, NF-kappaB activation, and in

6 In tumor-infiltrating B lymphocytes (TIL-B), both switched

7 The presence of tumor-infiltrating B lymphocytes has been linked to a fa

8 ultiple tumor types on both cancer cells and tumor-infiltrating blood vessels, making it a potentiall

9 d production of proinflammatory cytokines by tumor-infiltrating but not systemic Tregs and significan

10 FNgamma and the proliferation marker Ki67 in tumor-infiltrating CAR T cells when combined with alpha-

11 Tumor-infiltrating CCR5(+) MDSCs displayed higher immuno

12 kines optimally induced DC-HIL expression by tumor-infiltrating CD11b(+)Gr1(+) cells.

13 ' recruitment to tumors, which decreased the tumor-infiltrating CD11b(+)Jag2(+) cell population of in

14 CX3CL1 did not correlate with the density of tumor-infiltrating CD3(+) T cells or CD68(+) macrophages

15 en CXCL2 or MIF expression and the number of tumor-infiltrating CD33(+) MDSCs (P<0.01).

16 his corresponded to decreased frequencies of tumor-infiltrating CD4 helper T cells and CD8 memory cyt

17 this setting relied upon IFNgamma-expressing tumor-infiltrating CD4(+) and CD8(+) T cells and adminis

18 Tumor-infiltrating CD4(+) and CD8(+) T cells in patients

19 observed in C3aR-deficient mice and returned tumor-infiltrating CD4(+) T cells to control levels.

20 demonstrates that the modulation of AICD of tumor-infiltrating CD4(+) T cells using HDACIs can enhan

21 fficacy, and IL21 expression was enhanced in tumor-infiltrating CD4(+) T lymphocytes after anti-ErbB2

22 pment of Th17 cells from naive-, memory-, or tumor-infiltrating CD4+ T cells, driven by IL-1beta/IL-6

23 e tool for detecting changes in systemic and tumor-infiltrating CD8 expression in preclinical syngene

24 ng tumors and enhanced antigen reactivity of tumor-infiltrating CD8 T cells.

25 e activation and effector genes expressed by tumor-infiltrating CD8(+) and CD4(+) T cells, and tumor-

26 croenvironment, increasing the proportion of tumor-infiltrating CD8(+) T cells and sensitizing tumors

27 ociated with PD-L1 suppression, increases in tumor-infiltrating CD8(+) T cells and tumor cell killing

28 reveal a threshold for PD1 downregulation on tumor-infiltrating CD8(+) T cells below which the releas

29 The percentage of tumor-infiltrating CD8(+) T cells coexpressing PD-1 and

30 MEK inhibition protected tumor-infiltrating CD8(+) T cells from death driven by c

31 manner, likely limiting the accumulation of tumor-infiltrating CD8(+) T cells in TNF/TNF-R1-proficie

32 Here we describe a subset of tumor-infiltrating CD8(+) T cells marked by high express

33 ific immune responses, increase the ratio of tumor-infiltrating CD8(+) T cells to regulatory T cells

34 immunosurveillance relies on effector/memory tumor-infiltrating CD8(+) T cells with a T-helper cell 1

35 Tumor-infiltrating CD8(+) T cells with high CD39 express

36 mice, and this was associated with enhanced tumor-infiltrating CD8(+) T lymphocytes.

37 that TNF-R1-dependent TNF signaling impairs tumor-infiltrating CD8(+) T-cell accumulation and may se

38 s and TCR repertoires of the circulating and tumor-infiltrating CD8(+)PD-1(+) cells appeared similar,

39 d of cancer immunology, including studies on tumor-infiltrating CD8+ cytotoxic T lymphocytes (CTLs),

40 ein 4 high (PD-1hiCTLA-4hi) cells within the tumor-infiltrating CD8+ T cell subset strongly correlate

41 stimulates the expansion and cytotoxicity of tumor-infiltrating CD8+ T cells and inhibits inflammator

42 he relative abundance of partially exhausted tumor-infiltrating CD8+ T cells predicts response to ant

43 ters and the functional immune reactivity of tumor-infiltrating cells after ex vivo exposure to ICB.

44 oach represents a novel means for protecting tumor-infiltrating cells from tumor-associated oxidative

45 ere we define the 'molecular fingerprint' of tumor-infiltrating CTLs and identify potentially new tar

46 We performed transcriptomic profiling of tumor-infiltrating CTLs from treatment-naive patients wi

47 d that Tregs induce a dysfunctional state in tumor-infiltrating CTLs that resembles T cell exhaustion

48 cancer patients, miR-23a was upregulated in tumor-infiltrating CTLs, and expression correlated with

49 PJ; and TAM, but not MTM, depletion restores tumor-infiltrating cytotoxic T cell responses and suppre

50 s immunotherapeutic regimen caused homing of tumor-infiltrating DC to draining lymph nodes and increa

51 4 lymphomas in parallel with an increment of tumor-infiltrating DCs in NOX2-sufficient mice but not i

52 s in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive

53 olic tumor-derived DNA within the cytosol of tumor-infiltrating DCs.

54 ubillos-Ruiz et al. demonstrate that XBP1 in tumor-infiltrating dendritic cells blunts anti-tumor imm

55 sting that type I IFN-mediated activation of tumor-infiltrating dendritic cells within a tumor will m

56 m absolute lymphocyte count, the presence of tumor-infiltrating dendritic cells, CD15 expression on t

57 , of type-1 IFN that can mature and activate tumor-infiltrating dendritic cells.

58 dominantly induces the expansion of specific tumor-infiltrating exhausted-like CD8 T cell subsets.

59 + breast cancers demonstrated high levels of tumor-infiltrating FOXP3+ cells (38%; range, 35%-41%).

60 reast cancer, we reinforced the concept that tumor-infiltrating gammadeltaT17 cells are endowed with

61 help tracked with an increased frequency of tumor-infiltrating granzyme B(+) effector CD8 T cells an

62 ouse lung carcinoma, the interaction between tumor-infiltrating hematopoietic cells and epithelial ca

63 and may therefore affect the composition of tumor-infiltrating hematopoietic cells and subsequent tu

64 This study highlights the importance of tumor-infiltrating hematopoietic cells in constraining c

65 Thus, we conclude that mBD14 expression by tumor-infiltrating host cells results in the chemoattrac

66 e based on PD-L1 staining on tumor cells and tumor-infiltrating immune cells (IC) with the SP142 assa

67 PD-L1 expression on tumor cells (TC) and tumor-infiltrating immune cells (IC), abundance of tumor

68 We develop a computational approach to study tumor-infiltrating immune cells and their interactions w

69 computational methods are needed to estimate tumor-infiltrating immune cells and understand tumor-imm

70 Tumor-infiltrating immune cells can be conditioned by mo

71 Tumor-infiltrating immune cells can promote chemoresista

72 elerated tumor onset and increased levels of tumor-infiltrating immune cells comprised of CD11b(+) ce

73 PD-L1-positive as >/= 25% of tumor cells or tumor-infiltrating immune cells expressing membrane PD-L

74 Tumor-infiltrating immune cells have been linked to prog

75 Mounting evidence suggests that tumor-infiltrating immune cells have prognostic value fo

76 and resistance and flow cytometry to assess tumor-infiltrating immune cells immediately after therap

77 e expression of a panel of ICPs on tumor and tumor-infiltrating immune cells in 305 patients with asy

78 We analyze tumor-infiltrating immune cells in over 10,000 RNA-seq s

79 se data suggest that, through recruitment of tumor-infiltrating immune cells, fusobacteria generate a

80 tionship between microsatellite instability, tumor-infiltrating immune cells, Immunoscore, and their

81 Among tumor-infiltrating immune cells, tumor-associated macrop

82 TLR4 is often overexpressed in malignant and tumor-infiltrating immune cells.

83 uced tumor fibrosis and decreased numbers of tumor-infiltrating immunosuppressive cells.

84 Tumor-infiltrating inflammatory cells comprise a major p

85 c on malignant cells increased the number of tumor-infiltrating interferon gamma-producing natural ki

86 local p53 activation in TME comprising overt tumor-infiltrating leukocytes (TILeus) induces systemic

87 Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria

88 pression deconvolution approach for studying tumor-infiltrating leukocytes (TILs) in 23 cancer types

89 cancers with high levels of CCR4-expressing tumor-infiltrating leukocytes and abnormal plasma CCR4 l

90 CC that manipulates the activation status of tumor-infiltrating leukocytes and renders them immunocom

91 crease tumor immunogenicity, analysis of SM1 tumor-infiltrating leukocytes in PLX4720-treated mice de

92 ow cytometric analysis showed alterations in tumor-infiltrating leukocytes in the absence of C3aR.

93 ent reduced the migration and recruitment of tumor-infiltrating leukocytes into Matrigel plugs and po

94 Cellular analysis of tumor-infiltrating leukocytes revealed a significant inc

95 Analysis of tumor-infiltrating leukocytes revealed significant reduc

96 -II(hi) TAM, both of which were derived from tumor-infiltrating Ly6C(hi) monocytes.

97 or without 1,200 cGy TBI before transfer of tumor-infiltrating lymphcytes.

98 onstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting

99 h presence of mitoses (1.8 [1.0-3.3]), lower tumor-infiltrating lymphocyte (TIL) grade (nonbrisk, 0.5

100 mmune checkpoint, both of which can increase tumor-infiltrating lymphocyte (TIL) numbers.

101 he association of HHLA2 with the presence of tumor infiltrating lymphocytes (TILs) and five-year-even

102 Tumor infiltrating lymphocytes (TILs) have been associat

103 IHC was used to determine the presence of tumor infiltrating lymphocytes and antigen-presenting ce

104 Parathyroid tumor infiltrating lymphocytes are T cells by immunophen

105 Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a role for zinc

106 munogenic response consistent with increased tumor infiltrating lymphocytes, particularly within meta

107 ociated with a dramatic increase of NKG2D(+)-tumor infiltrating lymphocytes.

108 We isolated tumor-infiltrating lymphocytes (TIL) and intra-hepatic l

109 A, and CD4 mRNAs and their relationship with tumor-infiltrating lymphocytes (TIL) and PD-L1 IHC expre

110 combined treatment exhibited an increase in tumor-infiltrating lymphocytes (TIL) and T cells, as rev

111 Tumor-infiltrating lymphocytes (TIL) are potent mediator

112 naturally occurring and genetically modified tumor-infiltrating lymphocytes (TIL) by inhibitory recep

113 Adoptive T-cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) can induce tumor re

114 (+) T cells from melanoma patients' PBMC and tumor-infiltrating lymphocytes (TIL) capture melanoma Ag

115 Exhaustion of tumor-infiltrating lymphocytes (TIL) correlated with exp

116 Two thirds of CD8(+) tumor-infiltrating lymphocytes (TIL) expressed PD-1, whe

117 ere, we investigated the prognostic value of tumor-infiltrating lymphocytes (TIL) expressing CD3, Fox

118 Recent studies have found that tumor-infiltrating lymphocytes (TIL) expressing PD-1 can

119 equencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL) from a patient with

120 ic changes in the tumor microenvironment and tumor-infiltrating lymphocytes (TIL) in a B-RafV600E/Pte

121 ce of adding TBI to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a randomized fas

122 The presence of tumor-infiltrating lymphocytes (TIL) is a favorable prog

123 Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete

124 colorectal cancers have a higher density of tumor-infiltrating lymphocytes (TIL) than other colorect

125 sms of self-tolerance often result in CD8(+) tumor-infiltrating lymphocytes (TIL) with a hypofunction

126 ions and correspondingly expanded autologous tumor-infiltrating lymphocytes (TIL), we show how MHC cl

127 ha- and interleukin (IL)-17-producing CD4(+) tumor-infiltrating lymphocytes (TILs) and aggressive dis

128 Adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) and high-dose inte

129 tive (TN) breast cancers (BCs), we evaluated tumor-infiltrating lymphocytes (TILs) and immunologicall

130 Evaluation of tumor-infiltrating lymphocytes (TILs) and PD-1 and PD-L1

131 ation and single-cell RNA profiles of CD8(+) tumor-infiltrating lymphocytes (TILs) and used genetic p

132 Recent studies suggest that tumor-infiltrating lymphocytes (TILs) are associated wit

133 Accumulating evidence indicates that tumor-infiltrating lymphocytes (TILs) are associated wit

134 It is well known that CD8(+) tumor-infiltrating lymphocytes (TILs) are correlated wit

135 Tumor-infiltrating lymphocytes (TILs) are important prog

136 umors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well under

137 Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) can mediate cancer

138 Adoptive transfer of tumor-infiltrating lymphocytes (TILs) can mediate regres

139 Long-term follow-up of patients receiving tumor-infiltrating lymphocytes (TILs) for metastatic mel

140 immunologic screening, we demonstrated that tumor-infiltrating lymphocytes (TILs) from 9 out of 10 p

141 tified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade se

142 ific (TA-specific) CD8(+) T cells and CD8(+) tumor-infiltrating lymphocytes (TILs) from patients with

143 Tregs represented a large proportion of the tumor-infiltrating lymphocytes (TILs) in claudin-low tum

144 o received adoptively transferred autologous tumor-infiltrating lymphocytes (TILs) in phase 2 clinica

145 Although the presence of tumor-infiltrating lymphocytes (TILs) indicates an endog

146 Importance: The presence of tumor-infiltrating lymphocytes (TILs) is a favorable pro

147 The presence of tumor-infiltrating lymphocytes (TILs) is associated with

148 flammation in which the effector function of tumor-infiltrating lymphocytes (TILs) is severely impair

149 Tumor-infiltrating lymphocytes (TILs) possessed higher V

150 studies suggest more favorable survival with tumor-infiltrating lymphocytes (TILs) present in primary

151 However, the evaluation of tumor-infiltrating lymphocytes (TILs) relies on histopat

152 Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) represents an effe

153 ession and chromatin accessibility in CD8(+) tumor-infiltrating lymphocytes (TILs) that recognize a m

154 Tumor-infiltrating lymphocytes (TILs) were scored in hem

155 Percentage of tumor cells and tumor-infiltrating lymphocytes (TILs) with PD-L1 express

156 ent survival, an immune response linked with tumor-infiltrating lymphocytes (TILs), and a repressed C

157 infiltrating immune cells (IC), abundance of tumor-infiltrating lymphocytes (TILs), and expression of

158 mphoid progenitor cells and cytotoxic CD8(+) tumor-infiltrating lymphocytes (TILs), leading to a majo

159 CRC for the presence of functionally active tumor-infiltrating lymphocytes (TILs), the tumor specifi

160 ing of freshly isolated CD8(+)/CD103(+) lung tumor-infiltrating lymphocytes and CD103(+) tumor-specif

161 137 mAbs and showed CD137 internalization in tumor-infiltrating lymphocytes and in activated human T

162 s corresponded with significant increases in tumor-infiltrating lymphocytes and increased expression

163 condary endpoints included the generation of tumor-infiltrating lymphocytes and modulation of immune

164 heckpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival afte

165 re, we detect neoepitope-specific T cells in tumor-infiltrating lymphocytes and peripheral blood from

166 nt exist based on the presence or absence of tumor-infiltrating lymphocytes and programmed death-liga

167 Stromal tumor-infiltrating lymphocytes and their association wit

168 Tumor-infiltrating lymphocytes appear to be a predictor

169 Tumor-infiltrating lymphocytes are key mediators of tumo

170 The presence of tumor-infiltrating lymphocytes at diagnosis is reported

171 Tumor-infiltrating lymphocytes coexpressed PD-1 with the

172 ich were associated with increased levels of tumor-infiltrating lymphocytes compared with HPV-driven

173 Analysis of tumor-infiltrating lymphocytes demonstrated that CB T ce

174 tion, FACS-based enumeration of intracranial tumor-infiltrating lymphocytes directly correlated with

175 phocyte fronts, whereas the majority of CD8+ tumor-infiltrating lymphocytes express high levels of PD

176 We have further demonstrated that tumor-infiltrating lymphocytes expressed TIGIT and that

177 Analysis of tumor-infiltrating lymphocytes from Bach2-deficient mice

178 biomarkers in circulating blood cells and in tumor-infiltrating lymphocytes from patients with resect

179 Likewise, PD1 and CD137 were induced on tumor-infiltrating lymphocytes from surgically excised h

180 Patients with increased numbers of tumor-infiltrating lymphocytes in primary colon tumors a

181 Approaches to enhance tumor-infiltrating lymphocytes in the tumor bed may subs

182 hanges were correlated with Ki-67 and CD8(+) tumor-infiltrating lymphocytes in the tumor biopsies tak

183 urther validation of the clinical utility of tumor-infiltrating lymphocytes in this context is warran

184 ssociated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast

185 The presence of tumor-infiltrating lymphocytes in triple-negative breast

186 Recent clinical trials of ex vivo-expanded tumor-infiltrating lymphocytes indicated that differenti

187 Systematic interrogation of tumor-infiltrating lymphocytes is key to the development

188 T-cell response against mutant KRAS G12D in tumor-infiltrating lymphocytes obtained from a patient w

189 variation in a clinical setting, we screened tumor-infiltrating lymphocytes of an HLA-A*02:06 melanom

190 s also found in the draining lymph nodes and tumor-infiltrating lymphocytes of OSCC patients with ear

191 Moreover, CCR6(+) Treg cells isolated from tumor-infiltrating lymphocytes or draining lymph nodes m

192 CD8(+)tumor-infiltrating lymphocytes reactive to clonal neoant

193 alpha-beta paired T-cell receptors (TCRs) of tumor-infiltrating lymphocytes shared between multiple p

194 Expanded tumor-infiltrating lymphocytes showed TCR repertoire ske

195 Tumor-infiltrating lymphocytes that accomplish tumor rej

196 -1:28 engineering reinstated Th1 function in tumor-infiltrating lymphocytes that had been functionall

197 ls of chemotherapy or radiation can increase tumor-infiltrating lymphocytes that overcome resistance

198 oximately 1.11x10(11) HLA-C*08:02-restricted tumor-infiltrating lymphocytes that were composed of fou

199 le MEK inhibition can promote recruitment of tumor-infiltrating lymphocytes to the tumor, here we sho

200 The number of tumor-infiltrating lymphocytes was also reduced in LKB1-

201 The growth of large numbers of tumor-infiltrating lymphocytes with in vitro anti-cancer

202 X40 on CD4(+) FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, and increased the antitu

203 ll type, presence of melanin, nuclear grade, tumor-infiltrating lymphocytes, and necrosis.

204 Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functi

205 h model, GSK-3i inhibited PD-1 expression on tumor-infiltrating lymphocytes, while increasing Tbx21 (

206 haracterized chief cells, oxyphil cells, and tumor-infiltrating lymphocytes.

207 tory cells and decreased abundance of CD8(+) tumor-infiltrating lymphocytes.

208 ion of 2B4, LAG-3, and programmed death-1 on tumor-infiltrating MAA-specific CD8(+) T cells elicited

209 In this study, we show that targeting tumor-infiltrating macrophages (TAM) and inflammatory mo

210 Finally, NLRP3 expression in tumor-infiltrating macrophages correlated with survival,

211 In human melanoma tissues, tumor-infiltrating macrophages expressing CD7 are presen

212 Additionally, tumor-infiltrating macrophages from sh-a2 tumors showed

213 Additionally, AdMMP-9 activated tumor-infiltrating macrophages into a tumor-inhibiting p

214 were efficiently processed and presented by tumor-infiltrating macrophages to CD4+ T cells, complete

215 Use of apoA1 to redirect in vivo elicited tumor-infiltrating macrophages toward tumor rejection ma

216 A high density of tumor-infiltrating mature dendritic cells (DC) and CD8(+

217 on of H2O2, and it increased the quantity of tumor-infiltrating MDSC by reducing their oxidative stre

218 mice because the decreased apoptotic rate of tumor-infiltrating MDSC was balanced by a decreased rate

219 Furthermore, tumor-infiltrating MDSCs in mice injected repeatedly wit

220 mulation and immunosuppressive activities of tumor-infiltrating MDSCs without alterations of the bone

221 on of several derepressed miR-155 targets in tumor-infiltrating, miR-155-deficient CD8(+) T cells, su

222 In response to conditioned media from tumor-infiltrating monocytes/macrophages, cancer cells u

223 a mechanism involving TNF-alpha release from tumor-infiltrating monocytes/macrophages.

224 ssion, evaluated by immunohistochemistry, on tumor infiltrating mononuclear cells (TIMCs) and tumor c

225 The presence of tumor-infiltrating MSCs is associated with tumor progres

226 sion was recently found to be upregulated on tumor-infiltrating murine (CD11c(+)CD11b(+)CD8(-)CD209a(

227 essed on and thereby impair the functions of tumor-infiltrating murine and human myeloid dendritic ce

228 h the complement C5a receptor 1 expressed on tumor infiltrating myeloid-derived suppressor cells.

229 Moreover, we identified changes in tumor-infiltrating myeloid cell (TIM) subsets that likel

230 Colony stimulating factor 1 (CSF-1) recruits tumor-infiltrating myeloid cells (TIM) that suppress tum

231 Tumor-infiltrating myeloid cells (TIM), including CD11b

232 Tumor-infiltrating myeloid cells (TIMs) are known to pro

233 Here we report that tumor-infiltrating myeloid cells and circulating monocyt

234 ved in the regulation of PD-L1 expression in tumor-infiltrating myeloid cells and, therefore, reprogr

235 d that local nitric oxide (NO) production by tumor-infiltrating myeloid cells is important for adopti

236 Tumor-infiltrating myeloid cells such as myeloid-derived

237 tumor multiplicity and selectively recruits tumor-infiltrating myeloid cells, which can promote tumo

238 In antibiotics-treated or germ-free mice, tumor-infiltrating myeloid-derived cells responded poorl

239 gistically reduced the local accumulation of tumor-infiltrating myeloid-derived suppressor cells (MDS

240 tic reduction in the numbers and function of tumor-infiltrating myeloid-derived suppressor cells (MDS

241 cumulation and immune inhibitory activity of tumor-infiltrating myeloid-derived suppressor cells (MDS

242 ess in the TME promotes immunosuppression by tumor-infiltrating myeloid-derived suppressor cells (MDS

243 Tumor-infiltrating neutrophils have been implicated in m

244 Tumor-infiltrating NK cells isolated from GBM patients f

245 that is required for the differentiation of tumor-infiltrating NK cells, and IL-15 deficiency, but n

246 tissues was different, with a trend toward a tumor-infiltrating NK population enriched in noncytotoxi

247 therapeutic approaches aiming at increasing tumor-infiltrating NKs (TINKs).

248 ed DNA-methylation programs were acquired in tumor-infiltrating PD-1hi CD8 T cells, and approaches to

249 Tumor-infiltrating PD-L1(+) cells isolated from tumor-be

250 metalloproteinase (MMP)-2 and MMP-9 release, tumor-infiltrating PMNs, and microvessel density.

251 ted macrophages, but also an accumulation of tumor-infiltrating polymorphonuclear mononuclear cells c

252 Elucidating the function of tumor-infiltrating regulatory T (Treg) cells has been di

253 sive mechanisms used by different subsets of tumor-infiltrating regulatory T (Treg) cells is critical

254 diation (IR) can lead to the accumulation of tumor-infiltrating regulatory T cells (Treg cells) and s

255 L) patients is suspected to be influenced by tumor-infiltrating regulatory T cells (Treg).

256 We investigated the influence of tumor-infiltrating regulatory T cells on tumor-specific

257 r by remotely supplying a distinct subset of tumor-infiltrating SiglecF(high) neutrophils, which exhi

258 -gamma and TNF-alpha released from activated tumor infiltrating T cells is likely responsible for the

259 These analyses reveal a spectrum of tumor-infiltrating T cell populations that are highly si

260 nt blockade targets only specific subsets of tumor-infiltrating T cell populations.

261 tigate the molecular mechanisms during which tumor-infiltrating T cells (TILs) are altered in the FL

262 nduced phosphorylation of STAT6 and STAT3 in tumor-infiltrating T cells (TILs) in follicular lymphoma

263 In this study, we tested the hypothesis that tumor-infiltrating T cells could be more effectively act

264 ith upregulation of Notch and its ligands in tumor-infiltrating T cells enhanced expression of T-bet

265 ity-determining region 3 (CDR3) sequences of tumor-infiltrating T cells in 9,142 RNA-seq samples acro

266 iferation (Ki-67) and increases in cytotoxic tumor-infiltrating T cells in corresponding tumor biopsi

267 tion, which constituted approximately 40% of tumor-infiltrating T cells in human pancreatic ductal ad

268 ncreased the persistence and accumulation of tumor-infiltrating T cells in vivo, compared with the pa

269 Approximately 50% of PD-1(+) tumor-infiltrating T cells lacked Tim-3 expression and m

270 r reprogramming of the altered metabolism of tumor-infiltrating T cells might represent a potential s

271 Tumor-infiltrating T cells play an important role in man

272 Dysregulation of this pathway in tumor-infiltrating T cells results in diminished anti-tu

273 Analysis of tumor-infiltrating T cells revealed exhaustion programs,

274 ients were treated with a single infusion of tumor-infiltrating T cells selected when possible for hu

275 Tumor-infiltrating T cells showed a progressive loss of

276 Transcriptional signatures of tumor-infiltrating T cells were indicative of reduced pr

277 1 antibody decreased tumor growth, increased tumor-infiltrating T cells, and decreased regulatory T c

278 IGIT is highly expressed on human and murine tumor-infiltrating T cells, and, in models of both cance

279 Tumor-infiltrating T cells, particularly CD45RO(+)CD8(+)

280 icroenvironment limits aerobic glycolysis in tumor-infiltrating T cells, which suppresses tumoricidal

281 Tumor-infiltrating T helper type 17 (T(H)17) cells and i

282 ts with DCB displayed a higher proportion of tumor-infiltrating T lymphocytes (TIL) (n = 24, Mann-Whi

283 ht to understand the molecular correlates of tumor-infiltrating T lymphocytes (TIL) in squamous cell

284 enhances the proliferation of both naive and tumor-infiltrating T lymphocytes (TIL).

285 How tumor-infiltrating T lymphocytes (TILs) adapt to the met

286 Adoptively transferred tumor-infiltrating T lymphocytes (TILs) that mediate com

287 blockade increases IFNgamma-producing CD8(+) tumor-infiltrating T lymphocytes and results in a profou

288 thogenesis, we found that metastatic primary tumor-infiltrating T lymphocytes produced elevated level

289 with higher ratios of IFN-gamma(+)/IL-10(+) tumor-infiltrating T lymphocytes, as well as induction o

290 egrin alphaE(CD103)beta7, often expressed on tumor-infiltrating T lymphocytes, with its cognate ligan

291 to off-target suppression of the activity of tumor-infiltrating T lymphocytes.

292 eckpoint molecules PDL1 and CTLA4, increased tumor-infiltrating T regulatory cells, and decreased nat

293 nd CDK4/6 inhibition significantly increased tumor-infiltrating T-cell activation and cytotoxicity an

294 tanding regarding the antigens recognized by tumor-infiltrating T-cell populations, the mechanisms th

295 hat CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans.

296 ting FcgammaRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Tre

297 e, MK-4166 downregulated FOXP3 mRNA in human tumor infiltrating Tregs, suggesting that, in addition t

298 in the suppression mediated by the activated tumor-infiltrating Tregs and restores the proliferative

299 TR was comparable with that of mouse GITR in tumor-infiltrating Tregs despite being drastically lower

300 A-4 and anti-OX40 together with CpG depleted tumor-infiltrating Tregs.