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1 ociated with a dramatic increase of NKG2D(+)-tumor infiltrating lymphocytes.
2 n association with elevated levels of Type-1 tumor-infiltrating lymphocytes.
3 or microenvironment that rapidly inactivates tumor-infiltrating lymphocytes.
4 ors in restricting TCR-mediated signaling in tumor-infiltrating lymphocytes.
5 H)2-skewed cytokine profile within blood and tumor-infiltrating lymphocytes.
6 Mechanisms were evaluated by analysis of tumor-infiltrating lymphocytes.
7 13 following adoptive transfer of autologous tumor-infiltrating lymphocytes.
8 carcinoma (RCC) tumors of the kidney and RCC tumor-infiltrating lymphocytes.
9 ated gene expression with protein status and tumor-infiltrating lymphocytes.
10 ls in the spleen and to generate E7-specific tumor-infiltrating lymphocytes.
11 8+ T cells and was associated with increased tumor-infiltrating lymphocytes.
12 n, especially tumor-induced angiogenesis and tumor-infiltrating lymphocytes.
13 fic CD8 responses detectable in PBMCs and in tumor-infiltrating lymphocytes.
14 haracterized chief cells, oxyphil cells, and tumor-infiltrating lymphocytes.
15 tory cells and decreased abundance of CD8(+) tumor-infiltrating lymphocytes.
16 ell line is efficiently lysed by the ex vivo tumor-infiltrating lymphocytes, all of the recurrent tum
17 IHC was used to determine the presence of tumor infiltrating lymphocytes and antigen-presenting ce
18 se the tumor uptake by approximately 40% for tumor-infiltrating lymphocytes and by approximately 60%
19 ing of freshly isolated CD8(+)/CD103(+) lung tumor-infiltrating lymphocytes and CD103(+) tumor-specif
20 ry CD8 T cells, as well as melanoma-reactive tumor-infiltrating lymphocytes and CD8 T cell clones.
21 sociated tumor cells increased the number of tumor-infiltrating lymphocytes and enhanced the survival
22 n of ex vivo-activated, melanoma Ag-specific tumor-infiltrating lymphocytes and high dose IL-2 result
23 137 mAbs and showed CD137 internalization in tumor-infiltrating lymphocytes and in activated human T
24 o ex vivo phenotypes of T and NK cells among tumor-infiltrating lymphocytes and in peripheral blood f
25 s corresponded with significant increases in tumor-infiltrating lymphocytes and increased expression
26 33 suggest its involvement in trafficking of tumor-infiltrating lymphocytes and indicate that STRL33
27 these DLBCLs include significant numbers of tumor-infiltrating lymphocytes and interdigitating dendr
28 umbers of morphologically distinct CD2+/CD3+ tumor-infiltrating lymphocytes and interdigitating S100+
30 ults suggest that IL-2 and -15 elaborated by tumor-infiltrating lymphocytes and macrophages may affec
31 gen MART-1/melan A is frequently observed in tumor-infiltrating lymphocytes and may be readily elicit
32 condary endpoints included the generation of tumor-infiltrating lymphocytes and modulation of immune
33 the presence of the Fas(CD95)-R molecule on tumor-infiltrating lymphocytes and on matched peripheral
34 e observed in the non-small cell lung cancer tumor-infiltrating lymphocytes and ovarian cancer tumor-
35 heckpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival afte
36 re, we detect neoepitope-specific T cells in tumor-infiltrating lymphocytes and peripheral blood from
37 nt exist based on the presence or absence of tumor-infiltrating lymphocytes and programmed death-liga
39 and activity, attenuated Foxp3 expression in tumor-infiltrating lymphocytes, and decreased tumor burd
40 X40 on CD4(+) FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, and increased the antitu
42 eg) that coexpress CD4 and CD25 in the PBLs, tumor-infiltrating lymphocytes, and regional lymph node
43 than 0, growth phase, thickness, ulceration, tumor-infiltrating lymphocytes, and sex were associated
49 gene product that was recognized by the bulk tumor-infiltrating lymphocytes as well as a dominant T c
51 g Ag104, these cells made up the majority of tumor-infiltrating lymphocytes at the late stage of tumo
52 leukin (IL)-2-based therapy (five patients), tumor-infiltrating lymphocyte-based therapy plus IL-2 (n
53 mor exhibit no gross defect in the number of tumor-infiltrating lymphocytes but have exaggerated angi
55 rity of melanoma patients analyzed and among tumor-infiltrating lymphocytes, but not in healthy donor
56 0: 331-340, respectively, were recognized by tumor-infiltrating lymphocyte clone M37 in an HLA-A2-res
58 ich were associated with increased levels of tumor-infiltrating lymphocytes compared with HPV-driven
59 nt increase in the Fas(CD95)-R expression on tumor-infiltrating lymphocytes compared with matched pat
61 imilar to those found in human melanoma, and tumor-infiltrating lymphocytes could be cultured from th
62 s are currently testing strategies to infuse tumor-infiltrating lymphocytes, CTLs, Th cells, and Treg
63 ty for tumor antigens that were derived from tumor-infiltrating lymphocytes cultured for limited time
64 autologous tumor-reactive, rapidly expanded tumor infiltrating lymphocyte cultures and high-dose IL-
68 noma lines (F001TU-3 and -4) and 20 separate tumor-infiltrating lymphocyte cultures were generated fr
70 ication of Tax+ tumor cells and nonmalignant tumor-infiltrating lymphocytes demonstrated that each of
71 patient subsequently received treatment with tumor-infiltrating lymphocytes derived from gene-modifie
72 tion, FACS-based enumeration of intracranial tumor-infiltrating lymphocytes directly correlated with
73 r immunity was accompanied by an increase of tumor-infiltrating lymphocytes displaying low PD-1 expre
75 phocyte fronts, whereas the majority of CD8+ tumor-infiltrating lymphocytes express high levels of PD
78 umor-specific CTL clone was established from tumor-infiltrating lymphocytes from a regressing pulmona
80 we show that CD8+ T cells, isolated from the tumor-infiltrating lymphocytes from human melanoma, synt
81 study, we show that engagement of CTLA-4 on tumor-infiltrating lymphocytes from low-dose melphalan (
82 termined on CD4+CD25high T cells in PBMC and tumor-infiltrating lymphocytes from melanoma patients (n
83 4(+) cells that are otherwise observed among tumor-infiltrating lymphocytes from mice treated with IL
84 L-PAM-induced acquisition of the ability of tumor-infiltrating lymphocytes from MOPC-315 tumor beare
85 biomarkers in circulating blood cells and in tumor-infiltrating lymphocytes from patients with resect
86 taneous T cell lymphoma and the isolation of tumor-infiltrating lymphocytes from primary squamous cel
87 from peripheral blood mononuclear cells and tumor-infiltrating lymphocytes from stage I-IV HLA-A(*)0
89 h lymphocytes harvested from treated tumors (tumor-infiltrating lymphocytes) generated significant in
91 ressed in splenocytes, activated PBL, CD8(+) tumor infiltrating lymphocytes, granulocytes, and monocy
92 her T-cell receptor (TCR)-CD3 components, in tumor-infiltrating lymphocytes, human immunodeficiency v
93 cognized by tumor reactive CTLs derived from tumor infiltrating lymphocytes in the context of HLA-A31
95 hocytes in rats; (b) interleukin 2-activated tumor-infiltrating lymphocytes in humans; (c) nonactivat
98 hanges were correlated with Ki-67 and CD8(+) tumor-infiltrating lymphocytes in the tumor biopsies tak
99 urther validation of the clinical utility of tumor-infiltrating lymphocytes in this context is warran
101 ssociated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast
102 Recent clinical trials of ex vivo-expanded tumor-infiltrating lymphocytes indicated that differenti
103 + T cells and natural killer (NK) cells from tumor-infiltrating lymphocytes indicated that NK cells w
105 cal responses to adoptive immunotherapy with tumor-infiltrating lymphocytes isolated from human melan
106 tumorigenic than the parental cell line, and tumor-infiltrating lymphocytes isolated from these tumor
108 ocking anti-CTLA-4 mAb) resulted in enhanced tumor-infiltrating lymphocyte-mediated anti-MOPC-315 cyt
109 al suppressive activity that may account for tumor-infiltrating lymphocyte-mediated immune evasion by
110 gainst the transcription factor SOX10, using tumor-infiltrating lymphocytes obtained from a patient w
111 T-cell response against mutant KRAS G12D in tumor-infiltrating lymphocytes obtained from a patient w
112 variation in a clinical setting, we screened tumor-infiltrating lymphocytes of an HLA-A*02:06 melanom
113 ope of CD8+ T cells, commonly recovered from tumor-infiltrating lymphocytes of HLA-A2.1+ melanoma pat
114 lls were present in the peripheral blood and tumor-infiltrating lymphocytes of lymphoma patients, cou
115 s also found in the draining lymph nodes and tumor-infiltrating lymphocytes of OSCC patients with ear
116 Moreover, CCR6(+) Treg cells isolated from tumor-infiltrating lymphocytes or draining lymph nodes m
117 le CD4(+) T-cell clones isolated either from tumor-infiltrating lymphocytes or peripheral blood monon
118 01) but not with cell type, mitotic figures, tumor-infiltrating lymphocytes, or PAS-positive patterns
119 munogenic response consistent with increased tumor infiltrating lymphocytes, particularly within meta
120 system resulting in more IFN-gamma-producing tumor-infiltrating lymphocytes per tumor when compared w
121 tor function on human memory CD8 T cells and tumor-infiltrating lymphocytes reactive against melanoma
123 ration into treated lesions was observed and tumor-infiltrating lymphocyte reactivity was enhanced in
125 melanoma-reactive T cell cloid derived from tumor infiltrating lymphocytes resulted in the isolation
126 ent in the in vitro-expanded and transferred tumor-infiltrating lymphocyte samples and certain T cell
127 alpha-beta paired T-cell receptors (TCRs) of tumor-infiltrating lymphocytes shared between multiple p
129 evels of cytokine release by MART-1-specific tumor-infiltrating lymphocytes than control DCs transduc
131 apy as evidenced by an active recruitment of tumor-infiltrating lymphocytes that are capable of lysin
132 -1:28 engineering reinstated Th1 function in tumor-infiltrating lymphocytes that had been functionall
133 ls of chemotherapy or radiation can increase tumor-infiltrating lymphocytes that overcome resistance
134 ly, irradiated mice had increased numbers of tumor-infiltrating lymphocytes that secreted IFN-gamma a
135 oximately 1.11x10(11) HLA-C*08:02-restricted tumor-infiltrating lymphocytes that were composed of fou
136 cytic lineage-specific antigen recognized by tumor-infiltrating lymphocytes, the adoptive transfer of
139 hat the same autologous tumor-cytolytic CD8+ tumor infiltrating lymphocyte (TIL) clone accumulated in
140 cells had corresponding effects on local DN tumor infiltrating lymphocyte (TIL) levels and inversely
142 es were screened with four CTLs derived from tumor infiltrating lymphocytes (TIL) that were able to r
143 ymphodepletion before infusion of autologous tumor infiltrating lymphocytes (TIL), objective response
144 ntigen tyrosinase was isolated from a CD4(+) tumor-infiltrating lymphocyte (TIL 1383I) and introduced
145 nin, which was shown to be recognized by the tumor-infiltrating lymphocyte (TIL) 1290, a HLA-A24 rest
146 4 MART-1:27-35 (MART-1) melanoma Ag-reactive tumor-infiltrating lymphocyte (TIL) clones from the tumo
147 onstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting
148 h presence of mitoses (1.8 [1.0-3.3]), lower tumor-infiltrating lymphocyte (TIL) grade (nonbrisk, 0.5
152 analyzing the pattern of gene expression of tumor-infiltrating lymphocyte (TIL), which can minimize
153 eukocyte antigen (HLA)-DR1-restricted CD4(+) tumor-infiltrating lymphocyte (TIL)1363 using a genetic
154 is of the recognition of melanoma Ags by the tumor-infiltrating lymphocytes (TIL) 1790, isolated from
157 A, and CD4 mRNAs and their relationship with tumor-infiltrating lymphocytes (TIL) and PD-L1 IHC expre
159 combined treatment exhibited an increase in tumor-infiltrating lymphocytes (TIL) and T cells, as rev
161 e TCR repertoires of Tregs and Tconvs within tumor-infiltrating lymphocytes (TIL) are largely distinc
165 naturally occurring and genetically modified tumor-infiltrating lymphocytes (TIL) by inhibitory recep
167 ternatively, adoptive transfer of autologous tumor-infiltrating lymphocytes (TIL) can mediate tumor r
168 (+) T cells from melanoma patients' PBMC and tumor-infiltrating lymphocytes (TIL) capture melanoma Ag
171 ere, we investigated the prognostic value of tumor-infiltrating lymphocytes (TIL) expressing CD3, Fox
172 results in the profound enhancement of CD4+ tumor-infiltrating lymphocytes (TIL) expressing FoxP3, I
175 equencing-based approach to demonstrate that tumor-infiltrating lymphocytes (TIL) from a patient with
176 The expansion of autologous tumor cells and tumor-infiltrating lymphocytes (TIL) from fine needle as
179 ic changes in the tumor microenvironment and tumor-infiltrating lymphocytes (TIL) in a B-RafV600E/Pte
180 ce of adding TBI to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a randomized fas
181 Recognition of the melanoma Ag gp100 by tumor-infiltrating lymphocytes (TIL) in vitro has been c
185 ss I-restricted CD4(+) T cells obtained from tumor-infiltrating lymphocytes (TIL) of a metastatic mel
186 Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete
187 colorectal cancers have a higher density of tumor-infiltrating lymphocytes (TIL) than other colorect
188 tumor, but it has been difficult to identify tumor-infiltrating lymphocytes (TIL) that show in vitro
190 sms of self-tolerance often result in CD8(+) tumor-infiltrating lymphocytes (TIL) with a hypofunction
191 icularly the adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TIL), is a very promisin
192 ions and correspondingly expanded autologous tumor-infiltrating lymphocytes (TIL), we show how MHC cl
196 he association of HHLA2 with the presence of tumor infiltrating lymphocytes (TILs) and five-year-even
199 s I-restricted CD4+ T cell isolated from the tumor infiltrating lymphocytes (TILs) of a patient with
200 ha- and interleukin (IL)-17-producing CD4(+) tumor-infiltrating lymphocytes (TILs) and aggressive dis
201 autoimmune diseases, their prevalence among tumor-infiltrating lymphocytes (TILs) and function in hu
202 Adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) and high-dose inte
203 tive (TN) breast cancers (BCs), we evaluated tumor-infiltrating lymphocytes (TILs) and immunologicall
205 ation and single-cell RNA profiles of CD8(+) tumor-infiltrating lymphocytes (TILs) and used genetic p
211 umors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well under
215 tive immunotherapy with autologous antitumor tumor-infiltrating lymphocytes (TILs) following nonmyelo
216 Long-term follow-up of patients receiving tumor-infiltrating lymphocytes (TILs) for metastatic mel
217 immunologic screening, we demonstrated that tumor-infiltrating lymphocytes (TILs) from 9 out of 10 p
218 tified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade se
219 ific (TA-specific) CD8(+) T cells and CD8(+) tumor-infiltrating lymphocytes (TILs) from patients with
220 the T-cell receptor-associated zeta chain in tumor-infiltrating lymphocytes (TILs) has been proposed
221 ion of ex vivo cultured, naturally occurring tumor-infiltrating lymphocytes (TILs) has been shown to
222 lls (NK), T-cells, dendritic cells (DC), and tumor-infiltrating lymphocytes (TILs) have been document
223 uced immunity, the phenotype and function of tumor-infiltrating lymphocytes (TILs) in 9Lneo and 9LmIL
224 Tregs represented a large proportion of the tumor-infiltrating lymphocytes (TILs) in claudin-low tum
226 lobulin mucin (Tim) 3 is expressed on CD8(+) tumor-infiltrating lymphocytes (TILs) in mice bearing so
227 o received adoptively transferred autologous tumor-infiltrating lymphocytes (TILs) in phase 2 clinica
228 the role of different subsets of regulatory tumor-infiltrating lymphocytes (TILs) in the immunopatho
232 flammation in which the effector function of tumor-infiltrating lymphocytes (TILs) is severely impair
235 tumor-specific CD4(+) Treg cell clones from tumor-infiltrating lymphocytes (TILs) of cancer patients
236 c CD4(+) Treg cell clones generated from the tumor-infiltrating lymphocytes (TILs) of cancer patients
238 studies suggest more favorable survival with tumor-infiltrating lymphocytes (TILs) present in primary
241 ession and chromatin accessibility in CD8(+) tumor-infiltrating lymphocytes (TILs) that recognize a m
242 In a recent report,, the presence of CD3+ tumor-infiltrating lymphocytes (TILs) was found to corre
245 ent survival, an immune response linked with tumor-infiltrating lymphocytes (TILs), and a repressed C
246 infiltrating immune cells (IC), abundance of tumor-infiltrating lymphocytes (TILs), and expression of
247 transfer from melanoma to T cells, including tumor-infiltrating lymphocytes (TILs), and subsequently
248 ed from peripheral blood lymphocytes (PBLs), tumor-infiltrating lymphocytes (TILs), and tumor-associa
249 mphoid progenitor cells and cytotoxic CD8(+) tumor-infiltrating lymphocytes (TILs), leading to a majo
250 CRC for the presence of functionally active tumor-infiltrating lymphocytes (TILs), the tumor specifi
254 Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a role for zinc
255 ssel endothelial cells, and 2) acting on the tumor-infiltrating lymphocytes to indirectly alter endot
256 h AdVMART1 stimulated MART-1(27-35)-specific tumor-infiltrating lymphocytes to synthesize IFN-gamma.
257 le MEK inhibition can promote recruitment of tumor-infiltrating lymphocytes to the tumor, here we sho
258 was widespread RAR alpha immunoreactivity in tumor-infiltrating lymphocytes, vascular endothelial cel
260 ly, traditional histologic identification of tumor-infiltrating lymphocytes was not a significant ind
261 The upregulation of IL-17-secreting CD4(+) tumor-infiltrating lymphocytes was substantiated at the
263 To characterize the putative T-pro cells, tumor-infiltrating lymphocytes were isolated from normal
264 Finally, tumor-reactive in vitro expanded tumor infiltrating lymphocytes, which are used clinicall
265 The TCR alpha- and beta-chain genes from a tumor-infiltrating lymphocyte, which recognized the tyro
266 h model, GSK-3i inhibited PD-1 expression on tumor-infiltrating lymphocytes, while increasing Tbx21 (
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