ライフサイエンスコーパス: tumoricidal

1 ecause neoepitope-specific T cells often are tumoricidal.

2 macrophages, which make arginase and are not tumoricidal.

3 ctive use of celecoxib enhances PDT-mediated tumoricidal action in an in vivo tumor model.

4 factor (TNF) alpha (Ad.Egr-TNF) enhances the tumoricidal action of ionizing radiation in a human epid

5 drug gene therapy to enhance selectively the tumoricidal action of ionizing radiation in human cancer

6 p to 70% of patients, and suggest a possible tumoricidal action.

7 tumor cell-derived GM-CSF in recruitment and tumoricidal activation of tissue macrophages.

8 In this study we examined the tumoricidal activities of the type I receptors for IgG (

9 nt enhancement of Kupffer cell (KC)-mediated tumoricidal activity (percentage of specific lysis, 55 +

10 wed with a uniquely potent MHC nonrestricted tumoricidal activity across several species.

11 hetic MMP inhibitor, Prinomastat, to enhance tumoricidal activity after PDT, using a mouse mammary tu

12 f the TNF superfamily that exhibits specific tumoricidal activity against a variety of tumors.

13 eosinophils exerted dose- and time-dependent tumoricidal activity against Colo-205 cells.

14 lls primed in this manner exhibited superior tumoricidal activity against target cells cultured in ei

15 ithin the ocular microenvironment limits CTL tumoricidal activity allowing ocular tumors to progress.

16 ed tumors in vivo by induction of macrophage tumoricidal activity and activation of antitumor activit

17 -DG potentiates the effect of (64)Cu-ATSM on tumoricidal activity and animal survival.

18 is-inducing ligand (TRAIL) exhibits specific tumoricidal activity and is under development for cancer

19 eripheral blood immature DCs mediate similar tumoricidal activity as their in vitro counterpart, indi

20 As OA lacks independent tumoricidal activity at concentrations equimolar to HAML

21 Moreover, these macrophages lose tumoricidal activity but become extremely proangiogenic,

22 iferation, intestinal microbiota effects, or tumoricidal activity by the adaptive immune system.

23 This tumoricidal activity depended strictly on tumor cell-sur

24 mma-dependent induction of antimicrobial and tumoricidal activity in macrophages.

25 We also observed enhanced tumoricidal activity in mice with TSA tumors containing

26 the latter markers associated with elevated tumoricidal activity in vitro.

27 These macrophages possess nonspecific tumoricidal activity in vivo as immune distinct MCA207 t

28 the present study, we demonstrate that this tumoricidal activity is mediated by multiple cytotoxic T

29 The released NO contributes to the tumoricidal activity of macrophages, whereas polyamines

30 However, the tumoricidal activity of TCR-modified T cells may be limi

31 vored generation of Th2 cells that had lower tumoricidal activity than Th1 cells.

32 r model system, M4N demonstrated substantial tumoricidal activity that correlated with a reduction in

33 s PA variant also displayed broad and potent tumoricidal activity to various human tumor cells, espec

34 nitric oxide (NO) in vascular function, host tumoricidal activity, and antiinflammatory effects is we

35 tes appeared to be primarily responsible for tumoricidal activity, because beta-glucan therapeutic re

36 umor-reactive lymphocytes and exerted direct tumoricidal activity, both in vivo and in situ.

37 ated with enhancement of splenocyte-mediated tumoricidal activity, whereas the effect of gammaIFN is

38 e pro-inflammatory and have microbicidal and tumoricidal activity, whereas the M2 macrophages are inv

39 xicity to normal tissue but broad and potent tumoricidal activity.

40 uced, but not of IFN-gamma-induced, monocyte tumoricidal activity.

41 -gamma, P < .01) but not lymphocyte-mediated tumoricidal activity.

42 ate and adaptive immunity contributes to the tumoricidal activity.

43 major factor responsible for Th-1-induced DC tumoricidal activity.

44 increased susceptibility to immune-mediated tumoricidal activity.

45 virus for tumor therapies due to its potent tumoricidal activity.

46 T cells, but this encounter opposes NK-cell tumoricidal activity.

47 thrax toxin from a highly lethal to a potent tumoricidal agent.

48 involved in the response of cancer cells to tumoricidal agents and found 4 genes required for the re

49 s and sensitizes cancer cells to traditional tumoricidal agents both and The potent and selective pro

50 In addition to new tumoricidal agents, parallel work is also being conducte

51 ide is an immunomodulatory agent with proven tumoricidal and antiproliferative activity in MCL.

52 crophage activation, which limits the cell's tumoricidal and bactericidal capacities.

53 Both the tumoricidal and growth-promoting activities from macroph

54 Lenalidomide has tumoricidal and immunomodulatory activity against multip

55 viral pathway in tumors can provoke parallel tumoricidal and immunostimulatory effects that bridge in

56 e being the evaluable outcome parameters for tumoricidal and survival studies, respectively.

57 is responsible in part for the proapoptotic, tumoricidal, and antiproliferative effects of statins in

58 crophages rapidly infiltrated tumors, became tumoricidal, and facilitated the depletion of tumor stro

59 We thus sought to evaluate the tumoricidal benefits of systemic decorin on a triple-neg

60 ent data apparently explain the mechanism of tumoricidal beta-glucans used for immunotherapy.

61 have a distinctive phenotype with increased tumoricidal capability and support the use of immune mod

62 and 3) differentiating into macrophages with tumoricidal capability.

63 targeting mAb, unmasking an underappreciated tumoricidal capacity of TAMs.

64 ome this suppression and thereby augment the tumoricidal capacity of tumor-reactive lymphocytes.

65 ocesses as this M1 phenotype correlates with tumoricidal capacity, whereas TAMs of M2 phenotype exert

66 r Ag-specific precursor frequency to reach a tumoricidal cell density.

67 eg numbers and a concomitant accumulation of tumoricidal cells such as CD8+NKG2D+ and NK cells.

68 lactalbumin made lethal to tumor cells) is a tumoricidal complex of partially unfolded alpha-lactalbu

69 Upon CTL transfer, tumoricidal concentrations of NO were only produced by s

70 lar in nature, composed of tumor-seeking and tumoricidal domains.

71 trials have been carried out to reach potent tumoricidal dose levels capable of eradicating tumors wi

72 s provides an innovative way to increase the tumoricidal dose of radiation to tumor sites, whereas sp

73 a phase II/III study using CatmAb revealed a tumoricidal effect associated with reduced VEGF levels,

74 The tumoricidal effect was also assessed ex vivo by immunohi

75 ith low-dose doxorubicin produced a profound tumoricidal effect, resulting in complete eradication of

76 nduced normal tissue injury without reducing tumoricidal effect, thereby increasing the therapeutic r

77 seen with MTX treatment while enhancing its tumoricidal effect.

78 cells, however, gelonin exerts only limited tumoricidal effect.

79 emonstrate a similar mutual potentiation and tumoricidal effect.

80 vation of innate immunity can lead to direct tumoricidal effect.

81 We also examined the tumoricidal effectiveness of combining PDT with the sele

82 signaling can further enhance recruitment of tumoricidal effector cells, in particular natural killer

83 CD8+ CTL are the predominant tumoricidal effector cells.

84 tumor-infiltrating T cells, which suppresses tumoricidal effector functions.

85 ave similar efficacy in remnant ablation and tumoricidal effects and is associated with improved pati

86 immunotherapeutic approach that shows strong tumoricidal effects in the gut, resulting in an almost t

87 and we explored its capacity to enhance the tumoricidal effects of doxorubicin.

88 Tumoricidal effects of lenalidomide are associated with

89 eclinical models its capacity to enhance the tumoricidal effects of paclitaxel and doxorubicin.

90 y acquire resistance to the proapoptotic and tumoricidal effects of TNF-alpha, a cytokine that is ele

91 erent tumor cell types led us to compare the tumoricidal effects of TRAIL to those of other TNF famil

92 sion and augment therapeutic benefits beyond tumoricidal effects to harness tumor-specific, durable,

93 -L and rG-L exhibited significantly improved tumoricidal effects, with IC50 values being 120-fold low

94 port rate constants along with having direct tumoricidal effects.

95 , but it has the potential to interfere with tumoricidal effects.

96 f chemotherapy to tumor sites, enhancing its tumoricidal effects.

97 ein expression levels, as well as remarkable tumoricidal effects.

98 ase (iNOS)-producing M1 macrophages that are tumoricidal for 4T1 tumor cells; (b) a rapid decrease in

99 ghest therapeutic efficacy, showing balanced tumoricidal function and increased T cell persistence ac

100 l costimulation induced CD4 T cell-dependent tumoricidal function in a mouse melanoma model.

101 effectively blocked both MAPK activation and tumoricidal function in NK cells.

102 ogression and invasion while still retaining tumoricidal function in the presence of tumor-targeting

103 Thus, the tumoricidal function of CR3-binding polysaccharides such

104 enhances antitumor therapy by improving the tumoricidal function of E7-specific CD8(+) T cells but m

105 difference in their efficiency in mediating tumoricidal functions was seen in response to specific c

106 and nonspecific IgG4 inhibited IgG1-mediated tumoricidal functions.

107 ests that dendritic cells may mediate direct tumoricidal functions.

108 the full-length hTERT, effectively stimulate tumoricidal, hTERT-specific CTLs.

109 , IgG4 significantly impaired the potency of tumoricidal IgG1 in a human melanoma xenograft mouse mod

110 ting gene-transduced cancer vaccines induces tumoricidal immune responses.

111 he present study show the potential of using tumoricidal/immunostimulatory CpG-siRNA oligonucleotides

112 It is most practical, tolerable, and tumoricidal in its most potent form treating tumors in t

113 NKG2D(+) but not NKG2D(-) NK cells are tumoricidal in vitro, and in vivo they selectively traff

114 hibited reduced toxicity and was effectively tumoricidal in vivo in a murine colon carcinoma model.

115 e of intraperitoneal instillation of various tumoricidals in order to reduce the risk of port site se

116 thin the tumour immune microenvironment with tumoricidal M1 and tumour-protective M2 phenotypes could

117 lated by IL-13 and requires the induction of tumoricidal M1 macrophages and lymphocytes combined with

118 notype, thereby inhibiting the generation of tumoricidal M1 macrophages.

119 ich induce human mMDSC to differentiate into tumoricidal M1-like macrophages.

120 Although tumoricidal macrophages are a necessary component of imm

121 Thus, this study further defines the tumoricidal mechanism of the mAbs and provides strong ev

122 Granulysin is an antimicrobial and tumoricidal molecule expressed in granules of CTL and NK

123 roduction of IFN-gamma capable of activating tumoricidal Mphi.

124 ed macrophages have the potential to develop tumoricidal NK cell-like functions that may be exploited

125 Tumoricidal penetration depth of temoporfin-PDT (T-PDT)

126 n create a potentially valuable new class of tumoricidal peptides.

127 of the present study was to investigate the tumoricidal potential of combining the apoptosis-inducin

128 Only R24 augmented the tumoricidal potential of fresh canine peripheral blood m

129 ic radiosurgery (SSRS), allowing delivery of tumoricidal radiation doses with sparing of nearby organ

130 omise, but as yet has been unable to deliver tumoricidal radiation doses without unacceptable toxicit

131 hytherapy (HDR) was used to deliver adequate tumoricidal radiation while preserving bone and organ gr

132 perimental treatment approach that elicits a tumoricidal response against diffuse, solid i.p. disease

133 beta-Glucan enhancement of the mAb tumoricidal response did not occur in mice deficient in

134 model, resulting in a significantly enhanced tumoricidal response to CPT-11 via increased induction o

135 the control group and significantly improved tumoricidal response to treatment compared with all trea

136 t zinc protoporphyrin (ZnPP) induce a potent tumoricidal response via a mutual potentiating mechanism

137 rapy (IM862 or EMAP-II) and PDT had improved tumoricidal responses compared with individual treatment

138 ction and promote the engagement of adaptive tumoricidal responses is likely to lead to the developme

139 indicate that monocytes can be activated for tumoricidal responses through a membrane structure assoc

140 nistration of ganciclovir, could enhance the tumoricidal responsiveness of PDT.

141 croenvironments that inhibit the activity of tumoricidal T and NK cells.

142 However, WT-1 peptides known to induce tumoricidal T cells are few.

143 DC vaccines in stimulating the production of tumoricidal T cells, with broad implications for many of

144 tion of NO-producing M1 macrophages that are tumoricidal, the reduction in MSC levels to baseline aft

145 study demonstrates that unlike conventional tumoricidal therapies, which rely on effective p53 targe

146 as well as in the assessment of response to tumoricidal therapies.

147 sic cell death program of ICE as a means for tumoricidal therapy in a rat brain tumor model.

148 Local application of heat is tumoricidal; therefore, the authors investigated a novel

149 lated radiation therapy (IG-IMRT) allows for tumoricidal treatment of traditionally radioresistant ca

150 ges, which contain high levels of NO and are tumoricidal, whereas BALB/c mice produce M2 macrophages,