ライフサイエンスコーパス: tumorigenic

1 es AT1 (mildly tumorigenic) and CA1d (highly tumorigenic).

2 (NF-kappaB) is generally believed to be pro-tumorigenic.

3 chanosensory touch dome epithelia are highly tumorigenic.

4 however, it has also been reported to be pro-tumorigenic.

5 mice, while parental HaCaT cells remain non-tumorigenic.

6 onstitutive TGF-beta signaling and were less tumorigenic.

7 at differ from one another in their relative tumorigenic abilities.

8 tive osteoblastic differentiation as well as tumorigenic ability.

9 tion in Nanog-expressing skin suppresses the tumorigenic activities of Nanog, which include the induc

10 te the cellular proliferation, invasion, and tumorigenic activity in a TWIST1-dependent manner in vit

11 rylation of TC21 and R-Ras potentiates their tumorigenic activity in immunodeficient mice.

12 rigenic signaling and suggest that EphA2 pro-tumorigenic activity is mediated by the EphA2 monomer.

13 -beta signaling has been associated with the tumorigenic activity of GIC.

14 e expression of Vps34 is correlated with the tumorigenic activity of human breast cancer cells.

15 g PTN expression in MLCs mitigated their pro-tumorigenic activity.

16 including significantly higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and

17 y different gene clusters that reflected the tumorigenic and angiogenic activities of the respective

18 degradation of IFN-gamma may block the anti-tumorigenic and anti-osteoclastogenic effects of IFN-gam

19 gamma and attenuates IFN-gamma-mediated anti-tumorigenic and anti-osteoclastogenic effects.

20 TAT3 as a key substrate of COP1 in promoting tumorigenic and cancer stem-like properties in prostate

21 ing cells that can self-renew and are highly tumorigenic and chemoresistant.

22 functional clonal profiling used to identify tumorigenic and drug-resistant tumor clones will lead to

23 more robust systemic effects, including both tumorigenic and immunogenic effects.

24 l potential because it is theoretically less tumorigenic and immunogenic than cell therapies.

25 Here, we discuss the tumorigenic and immunoregulatory effects of ER stress in

26 rcinoma (HNSCC) and has been shown to impart tumorigenic and invasive characteristics to these cancer

27 iate filament protein nestin correlates with tumorigenic and invasive melanoma growth.

28 FPR2 deletion also reduced the tumorigenic and metastatic capabilities of GC cells in v

29 stemness-high cancer cells, that are highly tumorigenic and metastatic have been isolated from cance

30 a hallmark of cancer and contributes to the tumorigenic and metastatic phenotypes of cancer cells.

31 pithelial-mesenchymal transition with highly tumorigenic and metastatic potential in vivo compared to

32 re depleting ILK significantly abrogated the tumorigenic and metastatic potential of invasive breast

33 MTD capecitabine-treated mice induced a more tumorigenic and metastatic profile in both breast and co

34 While the pro-tumorigenic and metastatic roles of MUC16 are ascribed t

35 (pIL6; (IL6) beta2SP(+/-) LSCs) were highly tumorigenic and metastatic, whereas those derived from W

36 r CD133(+)/CXCR4(+)/EpCAM(-) CICs are highly tumorigenic and metastatic.

37 In both tumorigenic and radioresistant cell populations, a pheno

38 s with foci of compacted chromatin, favoring tumorigenic and self-renewing properties.

39 CM protein constituents have distinguishable tumorigenic and tumor-repressive functions.

40 PHGDH-deficient cells were relatively weakly tumorigenic and tumors that did form were deficient in B

41 its Ras-transformed derivatives AT1 (mildly tumorigenic) and CA1d (highly tumorigenic).

42 ated substantial differences in physiologic, tumorigenic, and immunologic responses between the two a

43 on that shape host responses to physiologic, tumorigenic, and pathogenic conditions.

44 This was observed in tumorigenic as well as in normal organoids.

45 Cancer cells actively promote their tumorigenic behavior by reprogramming gene expression.

46 f PKCiota and NOTCH synergistically inhibits tumorigenic behavior in vitro and LADC growth in vivo de

47 e pro-angiogenic, immune suppressive and pro-tumorigenic behavior of these cells by upregulating the

48 pes are also mechanistically linked to their tumorigenic behaviors.

49 lls grew in vivo, forming tumors as large as tumorigenic CA1d cells.

50 Here, we identify a highly tumorigenic cancer stem cell population in a mouse model

51 mary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to

52 und that roughly 1 out of 87 cells exhibited tumorigenic capability.

53 the molecular mechanisms underlying the pro-tumorigenic capacities of NQO1 have not been fully eluci

54 cancer reflects selection based on variable tumorigenic capacities, including the ability to activat

55 lencing of KANSL2 in GBM cells impairs their tumorigenic capacity in mouse xenograft models.

56 acity in normal mammary epithelial cells and tumorigenic capacity in TNBC is independent of expressio

57 l, high stem cell marker expression and high tumorigenic capacity in vivo.

58 sion, inhibit cell proliferation, and reduce tumorigenic capacity in vivo.

59 utgrowth, suggesting that age influences the tumorigenic capacity of BMCs in response to tumor-associ

60 We found that the tumorigenic capacity of human GC cell lines was dependen

61 ed p53 protein turnover, which blocked their tumorigenic capacity through cellular senescence and apo

62 and elucidate the mechanisms underlying its tumorigenic capacity.

63 The tumorigenic cell line BGC823 expressed high levels of HL

64 We identify a highly tumorigenic cell population within several independent s

65 e of the sensitive rather than the resistant tumorigenic cell population.

66 eam effector recruitment, MAPK-activity, and tumorigenic cell proliferation.

67 y contributes to transformation (stage a non-tumorigenic cell undergoes to become malignant) is unkno

68 or 53BP1-p53 cooperation in controlling anti-tumorigenic cell-fate decisions and reveal these activit

69 ected subpopulation of highly metastatic and tumorigenic cells (ALDH(high)) strongly affected the inv

70 asal cells but an increase of CK8(+) luminal tumorigenic cells and revealed a hierarchal lineage patt

71 dermal fibroblasts (NHDF) and to confine all tumorigenic cells from both the NHEK and NHDF.

72 We saw active 5' LTR use in tumorigenic cells only, suggesting that the cellular env

73 Deep metabolic characterization of these tumorigenic cells revealed their dependency on mitochond

74 ion pathogenicity was significantly lower in tumorigenic cells than normal stem cells.

75 drugs that specifically target the resistant tumorigenic cells that give rise to treatment failure.

76 ts of MCF7/SKBR3 breast cancer and MCF10 non-tumorigenic cells were used as a surrogate to support th

77 ng allows monitoring of the clonal output of tumorigenic cells without prospective isolation.

78 survive and outgrow neighbouring normal and tumorigenic cells, and potentially providing a new route

79 , LTR-driven transcription was restricted to tumorigenic cells, suggesting that LTR promoter activity

80 tem cells, immortal/preneoplastic cells, and tumorigenic cells.

81 umbers increased as normal stem cells become tumorigenic cells.

82 tself, but more selectively toxic toward the tumorigenic cells.

83 specifically stimulated in tumors and highly tumorigenic cells.

84 orm is associated with in vitro induction of tumorigenic characteristics in macrophages.

85 ory antibodies resulted in disruption of the tumorigenic collagen superstructure and in reduction of

86 rthermore, NT157 inhibited expression of pro-tumorigenic cytokines, chemokines and growth factors, in

87 strate that overexpressed IGF-2 is the major tumorigenic driver in a subset of CRCs and encourage tes

88 putational method, RegNetDriver, to identify tumorigenic drivers using the combined effects of coding

89 ablish the role of liver regeneration in the tumorigenic effect of RF ablation.

90 Enhanced secretion of tumorigenic effector proteins is a feature of malignant

91 ioid but not vice versa; and ZEB1 exerts its tumorigenic effects by promoting cell dedifferentiation,

92 Myc oncoproteins exert tumorigenic effects by regulating expression of target o

93 dentified mediator(s) to suppress off-target tumorigenic effects of hepatic RFA.

94 be limitations to this possibility, based on tumorigenic effects of Nrf2 in murine keratinocytes that

95 r microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors

96 bitor might attenuate or eliminate potential tumorigenic effects.

97 PAR-2 to elicit its pro-inflammatory and pro-tumorigenic effects.

98 vitamin D prevented these calcium-triggered tumorigenic effects.

99 l proteins contribute to the generation of a tumorigenic environment and are targets for drug and vac

100 LINCS cellular signatures such as their non-tumorigenic epithelial cell type, three-dimensional grow

101 donors stimulated growth in soft agar of non-tumorigenic epithelial cells.

102 d at a high yield by serial extrusion of non-tumorigenic epithelial MCF-10A cells through filters wit

103 transition (EMT), generally considered a pro-tumorigenic event.

104 In the center of tumorigenic events caused by GERD is repeated damage of

105 The identification of key tumorigenic events in Sonic Hedgehog (SHH) subgroup medu

106 gain-of-function (GOF) activities to promote tumorigenic events.

107 l events are required to promote early-stage tumorigenic expansion of KRAS(G12D)-mutated cells.

108 tumor tissue, secrete pro-angiogenic and pro-tumorigenic factors and thereby increase tumor growth, t

109 (sh-a2) 4T-1 cells produce lower amounts of tumorigenic factors in vitro and have reduced ability to

110 Tumorigenic factors may act specifically on one of these

111 Some tumorigenic factors, such as activation of ErbB2 or loss

112 ontrol conditions and in response to various tumorigenic factors.

113 pigenetic programs are selected for enhanced tumorigenic fitness during the evolution of distant meta

114 efluor activity, were unable to discriminate tumorigenic from nontumorigenic cells in syngeneic trans

115 Consistent with this pro-tumorigenic function for NQO1, high NQO1 expression leve

116 K1 is known as a cytoskeleton regulator, its tumorigenic function in MPNSTs remains largely unknown.

117 b lacks a domain present in C9a, revealing a tumorigenic function that drives the phenotype of non-sm

118 a transcription factor, and many of its pro-tumorigenic functions have been attributed to its abilit

119 immune components that possess pro- and anti-tumorigenic functions in individual cancers remain large

120 more, we show that the pro-apoptotic and pro-tumorigenic functions of PKCdelta also segregate based o

121 hat, in addition to its cell-autonomous anti-tumorigenic functions, autophagy inhibits cancer develop

122 or-associated macrophages can have other pro-tumorigenic functions, including the induction of angiog

123 to mediate chromatin remodeling and regulate tumorigenic gene expression programs.

124 ription elongation, to inhibit elongation at tumorigenic genes.

125 nt (GRE), which drives the expression of pro-tumorigenic genes.

126 ave been proposed to be maintained by highly tumorigenic glioblastoma stem cells (GSCs) that are resi

127 ntains a population of self-renewing, highly tumorigenic glioma stem cells (GSCs), which contributes

128 Self-renewing, highly tumorigenic glioma-initiating cells (GIC) have been link

129 The depletion of KDM3 inhibits tumorigenic growth and chemoresistance of human colorect

130 ession promoted proliferation, migration and tumorigenic growth of human CRC cells in vitro and in vi

131 anges in the epigenetic landscape to support tumorigenic growth of LKB1-mutant cells, while resulting

132 cancers, and the PYCR1 knock-out suppresses tumorigenic growth, suggesting that PYCR1 is a potential

133 owed that cells of NSC-like origin were more tumorigenic, had a higher rate of self-renewal and proli

134 Comparisons with non-tumorigenic human breast epithelial MCF-10A and MCF7 cel

135 ructure and that this contributes to the pro-tumorigenic hypoxia-phenotype in breast cancer.

136 asmic localization of PELP1 up-regulates pro-tumorigenic IKK and secreted inflammatory signals, which

137 ute to tumor growth and to maintaining a pro-tumorigenic, immunosuppressed microenvironment.

138 cancer, changing its role from anti- to pro-tumorigenic in a context-dependent manner.

139 d form induced CAF-like cells, which are non-tumorigenic in animals, but promote tumor growth of huma

140 quiescent cells were very significantly more tumorigenic in forming bone metastases than fast-growing

141 Polyomaviruses (PyV) are potentially tumorigenic in humans.

142 MFD-1 was tumorigenic in SCID mouse and proliferative and invasive

143 lling can be both tumour suppressive and pro-tumorigenic in small-cell lung cancer.

144 e results indicate that MCPyV T antigens are tumorigenic in vivo, consistent with their suspected eti

145 sorted CK5+ compared to CK5- cells were more tumorigenic in vivo.

146 t express ER-alpha- and Her-2 and are highly tumorigenic in xenograft models.

147 ikely caused by diminished expression of pro-tumorigenic inflammatory cytokines.

148 acting as a cytotoxic cytokine or favoring a tumorigenic inflammatory microenvironment.

149 d primary human HNSCC samples contain highly tumorigenic, invasive, and cisplatin-resistant BMI1(+) C

150 ecific and cell-autonomous activation of the tumorigenic JNK stress-activated pathway drives the expr

151 The siRNA internalization into non-tumorigenic kidney cells was negligible with all fatty a

152 All eight tumorigenic KRAS mutations were associated with downstre

153 ilities may occur downstream of the same pro-tumorigenic lesions, depending on environmental factors

154 Pro-tumorigenic M2 macrophage activation was diminished in m

155 e of the stem cell-like populations from non-tumorigenic mammary epithelial cells and non-aggressive

156 Treatment of non-tumorigenic mammary epithelial cells with exosomes deriv

157 show that, in cultured breast tumor and non-tumorigenic mammary epithelial cells, TRIM29 is up-regul

158 Compounds 8b, 11a, and 11b were tested on tumorigenic MCF-7 and A2058 cells expressing high levels

159 Hence, non-tumorigenic MCF10-2A cells with reduced SENP7S exhibit g

160 Stable clones of non-tumorigenic MCF10A cells lacking giant obscurins fail to

161 ications and DNA methylation is an important tumorigenic mechanism.

162 ng that loss of enzyme function is a primary tumorigenic mechanism.

163 sensors endows malignant cells with greater tumorigenic, metastatic, and drug-resistant capacity.

164 -like cells (CSC) are thought to be the most tumorigenic, metastatic, and therapy-resistant cell subp

165 Here we demonstrate that the pro-tumorigenic/metastatic Six1 homeoprotein decreases p53 l

166 One highly tumorigenic MI line harbored membrane-bound, constitutiv

167 ulated in NFATc1-induced PCa, establishing a tumorigenic microenvironment involving both NFATc1 posit

168 ed AKT phosphorylation and expression of pro-tumorigenic molecules, including IL-6, IL-8, and BCL-2.

169 types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integ

170 lation of low-density neutrophils with a pro-tumorigenic N2 phenotype and unprompted neutrophil extra

171 hierarchically organized according to their tumorigenic nature.

172 Tumorigenic neutrophils promote disease progression, pro

173 on tumor necrosis factor-alpha (TNFalpha), a tumorigenic, NF-kappaB-mediated signaling pathway that w

174 se, that is, developing the understanding of tumorigenic or inflammatory pathways.

175 TGF-beta signaling can be pro-tumorigenic or tumor suppressive.

176 thogenesis by altering the expression of key tumorigenic or tumor-suppressive genes.

177 the apical side of the epithelium and begin tumorigenic overgrowth by exploiting endogenous Janus ki

178 tional studies show a strikingly constrained tumorigenic pathway underlying heterogeneous genetic var

179 s a distinct premalignant state and multiple tumorigenic pathways caused by loss of function of Id2 a

180 ed by either viral-dependent or UV-dependent tumorigenic pathways.

181 TGFBR3-PLAG1 promotes a tumorigenic phenotype in vitro, and is absent in 723 oth

182 t or activate PP2A and failed to reverse the tumorigenic phenotype induced by PTPA suppression, indic

183 (shR-SOCS1) led to partial reversion of the tumorigenic phenotype of B16F10-Nex2 melanoma cells.

184 division but also significantly delayed the tumorigenic phenotype of cancer cells in vivo, even in t

185 ation of downstream effectors that promote a tumorigenic phenotype.

186 nvironment is able to reprogram MPhis into a tumorigenic phenotype; inducing blood vessel formation a

187 c switching, whereas at late stages, several tumorigenic phenotypes are unexpectedly restored to wild

188 s, this stress signaling was shown to induce tumorigenic phenotypes in immortalized cells.

189 ly, we show that Dek overexpression promotes tumorigenic phenotypes in immortalized human mammary epi

190 ncer progression in vivo and S100A4 promotes tumorigenic phenotypes of pancreatic cancer cells throug

191 termine whether MLK4 is required to maintain tumorigenic phenotypes, we reconstituted its signaling a

192 reased proliferative capacity and aggressive tumorigenic phenotypes.

193 mbryos and investigate the developmental and tumorigenic phenotypes.

194 n homolog (PTEN), which negatively regulates tumorigenic phosphatidylinositol (3,4,5)-trisphosphate (

195 pha positive and epithelial type with little tumorigenic potency, while SP cells are very similar to

196 radigm in oncology establishes a spectrum of tumorigenic potential across the heterogeneous phenotype

197 opulation of slow-cycling cells endowed with tumorigenic potential and multidrug resistance has been

198 tone demethylases plays an important role in tumorigenic potential and survival of human colorectal C

199 of residual undifferentiated PSC, negligible tumorigenic potential by ISC-hpNSC and provide additiona

200 of stem-like cancer cells and reduces their tumorigenic potential in both subcutaneous and orthotopi

201 experimental framework to determine in vivo tumorigenic potential in mice, we found that NetSig cand

202 nescence in tumor cells and diminished their tumorigenic potential in mouse xenograft models.

203 tingly, ICAM-2 suppressed metastatic but not tumorigenic potential in preclinical models, supporting

204 TPCs resist DNA damage and exhibit increased tumorigenic potential in response to chemotherapy, where

205 Notably, we found the tumorigenic potential of BVE(Cyp24a1-null)-derived tumor

206 ion of the aforementioned genes and with the tumorigenic potential of cell lines.

207 portantly, loss of DBC1 inhibited growth and tumorigenic potential of colon cancer cells, and DBC1 ex

208 h kinases is required to maximally block the tumorigenic potential of pancreatic cancer cells.

209 Loss of myristoylation abolished the tumorigenic potential of Src and its synergy with androg

210 cells without toxic effects and limited the tumorigenic potential of these cells.

211 The tumorigenic potential of USP6 was attenuated significant

212 Tumorigenic potential was evaluated in vitro or in xenog

213 CSCs reduced their self-renewal and in vivo tumorigenic potential, defining DNMT1 as a candidate CSC

214 ived HSCs express normal HBB in mice without tumorigenic potential, suggesting a safe strategy for pe

215 led that it is required for collagen-induced tumorigenic potential.

216 ressed cell proliferation, cell survival and tumorigenic potential.

217 e regions of patient tumors retain selective tumorigenic potential.

218 on cancer-initiating cells (CCIC), have high tumorigenic potential.

219 fferentiation properties along with a higher tumorigenic potential.

220 hich facilitate oncogenic transformation and tumorigenic potential.

221 tablished and primary breast cancer cells on tumorigenic potential.

222 he sub-pool of cancer cells that retain high tumorigenic potential.

223 rupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential.

224 wild-type hosts, reaffirming their inherent tumorigenic potential.

225 genomic instability, immune reactivity, and tumorigenic potential.

226 rm tumours despite retaining their intrinsic tumorigenic potential.

227 ver, KDM3A knockdown also potently inhibited tumorigenic potentials of breast cancer stem-like cells

228 ve zebrafish, and characterize the different tumorigenic probabilities when kRASG12V is expressed tra

229 t of mRNAs encoding proteins involved in the tumorigenic process and increased the ability of C6 cell

230 role of CAF-like cells and podoplanin in CNT tumorigenic process.

231 hether it is a cause or a consequence of the tumorigenic process.

232 n humans, implying their crucial role in the tumorigenic process.

233 ll selectively proliferate to facilitate the tumorigenic process.

234 of etiology, and remained modified along the tumorigenic process.

235 mation to a functional target fundamental to tumorigenic processes but expressed at significantly low

236 TERT) genes contribute to distinct aging and tumorigenic processes in humans and mice.

237 teases are important for regulating multiple tumorigenic processes, including angiogenesis, tumor gro

238 a significant role in the impact of Icmt on tumorigenic processes.

239 markedly improved in vivo optical imaging of tumorigenic processes.

240 s have been implicated in multiple stages of tumorigenic processes.

241 g enzyme, Usp9x, and has major impact on the tumorigenic program of metastatic melanoma.

242 molecular profile that facilitates the full tumorigenic program; furthermore, our outcomes uncover n

243 endent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreati

244 here PDHK4 regulates KRAS signalling and its tumorigenic properties and suggest that inhibition of PD

245 y of DCH, combined with its genotoxicity and tumorigenic properties make it an important potential co

246 IF levels and abolished the self-renewal and tumorigenic properties of CSCs induced by acidosis.

247 Deletion of either Egfr or Axl decreased the tumorigenic properties of HBEGF-transformed cells; howev

248 SENP7S depletion directly potentiates tumorigenic properties of MCF10-2A cells with induction

249 C, and where examined profoundly enhance the tumorigenic properties of MYC in vitro and in vivo.

250 ptide from a2V (a2NTD) that promotes the pro-tumorigenic properties of neutrophils.

251 r cell viability and are sufficient to drive tumorigenic properties of non-cancerous cells.

252 6 phosphorylation may contribute to the anti-tumorigenic properties of the MCV LT C-terminal domain.

253 a consequence that could conceivably confer tumorigenic properties to WWP1.

254 -knockout (KO) embryonic fibroblasts exhibit tumorigenic properties, including abnormally rapid conta

255 together with its known prosurvival and anti-tumorigenic properties, make it a good candidate for the

256 had significantly less proliferation and no tumorigenic properties.

257 m neurotrophic to anti-inflammatory and anti-tumorigenic properties.

258 creatic tumors harboring distinct cells with tumorigenic properties.

259 , an effect that contributes strongly to its tumorigenic properties.

260 rating MDM2-ALT1, an isoform attributed with tumorigenic properties.

261 c have additional anti-inflammatory and anti-tumorigenic properties.

262 ecule with potent anti-inflammatory and anti-tumorigenic properties; yet the molecular targets of HNK

263 features of migratory cancer stem cells with tumorigenic property is important to predict patient pro

264 Cancer cells require both migratory and tumorigenic property to establish metastatic tumors outs

265 a cells, but not in normal prostates and non-tumorigenic prostate cells.

266 us, our findings reveal a novel mechanism of tumorigenic PTEN deficiency.

267 the broadened proliferation zone induced by tumorigenic radiation can be attributed to cells respond

268 that Nrf2 silencing inhibited the ability of tumorigenic rat cells to grow in soft agar and to form t

269 s from each of seven patients were similarly tumorigenic, regardless of assay variations.

270 on of stromal ECM fibrils is associated with tumorigenic responses.

271 teration in gene expression also causes anti-tumorigenic RNAs to bind to and be stabilized by HEXIM1.

272 y oncogenic Ras, suggesting an important pro-tumorigenic role for CIB1.

273 This broad pro-tumorigenic role makes Cdk5 a promising drug target for

274 These experiments further highlight the tumorigenic role of gene fusions in the etiology of pedi

275 However, the tumorigenic role of individual Notch receptors in vivo r

276 ng MTSS1 expression, which impinges on a pro-tumorigenic role of MTSS1 in breast tumors.

277 Collectively, these results show a tumorigenic role of SPRY2 in colon cancer that is based

278 ndocrine tumour cells, consistent with a pro-tumorigenic role.

279 Overall, we have identified two novel pro-tumorigenic roles (promoting cell survival and altering

280 However, the tumorigenic roles of Nanog remain unclear.

281 el insight into the regulation of p53beta in tumorigenic settings.

282 relation between unliganded dimerization and tumorigenic signaling and suggest that EphA2 pro-tumorig

283 tial of matriptase and may contribute to pro-tumorigenic signaling in human epithelial carcinogenesis

284 of STAT3/NFkappaB-mediated inflammatory and tumorigenic signaling pathways can explain the absence o

285 many of the observed anti-inflammatory/anti-tumorigenic signaling pathways.

286 g implicates a new role of NPM1 in conveying tumorigenic signals from the BCR-ABL oncoprotein to ribo

287 sis contributes to the tRNAi(Met)-driven pro-tumorigenic stroma in vivo.

288 at tumor-repopulating cells (TRCs), a highly tumorigenic subpopulation of mouse melanoma cells, can b

289 tudying cancer metabolism gives insight into tumorigenic survival mechanisms and susceptibilities.

290 n-coupled receptor (PSGR), but the potential tumorigenic synergy between these lesions is unknown.

291 racteristics and were not significantly more tumorigenic than cells cultured as monolayers.

292 ore enriched with stem cell markers and more tumorigenic than the freshly isolated Aldefluor-positive

293 ication to activate transcription of the pro-tumorigenic TNF-NF-kappaB gene network.

294 xpression represents epiphenomena or confers tumorigenic traits is unknown.

295 Furthermore, FOSL1 re-enforced pro-tumorigenic transcription factors MYC, E2F3 and AP-1.

296 enting DNA damage and decreasing the risk of tumorigenic transformation caused by GERD.

297 However, random integration and potential tumorigenic transformation caused by viral transduction

298 s sufficient to induce dedifferentiation and tumorigenic transformation of mature adipocytes in mouse

299 ns on high-energy particle radiation-induced tumorigenic transformation of normal tissue in astronaut

300 abolic reprogramming and protects cells from tumorigenic transformation.