ライフサイエンスコーパス: tumorigenic potential

1 ve increased in vitro clonogenic and in vivo tumorigenic potential.

2 nitor cell differentiation, self-renewal and tumorigenic potential.

3 led that it is required for collagen-induced tumorigenic potential.

4 Card9 in VHL(-/-) cancer cells reduced their tumorigenic potential.

5 he kaposin A sequence has been shown to have tumorigenic potential.

6 ressed cell proliferation, cell survival and tumorigenic potential.

7 e regions of patient tumors retain selective tumorigenic potential.

8 of the HMGA2 transcript is required for its tumorigenic potential.

9 45 cells does not significantly affect their tumorigenic potential.

10 whereby altered expression of Bcl-3 leads to tumorigenic potential.

11 MCF-7 human breast cancer cells of differing tumorigenic potential.

12 y pro-HB-EGF did not exhibit any significant tumorigenic potential.

13 human and mouse cells in transformation and tumorigenic potential.

14 on cancer-initiating cells (CCIC), have high tumorigenic potential.

15 ve, and aneuploid, and had various levels of tumorigenic potential.

16 c T lymphocytes (CTL), contributing to their tumorigenic potential.

17 fferentiation properties along with a higher tumorigenic potential.

18 ntation into nude mice diminished the cells' tumorigenic potential.

19 microcolonies in soft agar without acquiring tumorigenic potential.

20 pesvirus 8, is a newly identified virus with tumorigenic potential.

21 expressed in NIH 3T3 cells, enhancing their tumorigenic potential.

22 hich facilitate oncogenic transformation and tumorigenic potential.

23 ogenes or creation of chimeric proteins with tumorigenic potential.

24 nt growth abilities and demonstrated similar tumorigenic potential.

25 grammed cell death, which could affect their tumorigenic potential.

26 l of metastasis is molecularly distinct from tumorigenic potential.

27 tablished and primary breast cancer cells on tumorigenic potential.

28 he sub-pool of cancer cells that retain high tumorigenic potential.

29 d osteoblastic differentiation and repressed tumorigenic potential.

30 tiated stem cell-like cancer cells with high tumorigenic potential.

31 , resulting in increased cancer stemness and tumorigenic potential.

32 rupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential.

33 e cells reduced invasion, although not their tumorigenic potential.

34 resulting in cellular senescence and reduced tumorigenic potential.

35 91Y) were assessed for cancer metabolism and tumorigenic potential.

36 wild-type hosts, reaffirming their inherent tumorigenic potential.

37 -renew, resulting in the abrogation of their tumorigenic potential.

38 ing CSC self-renewal, invasive capacity, and tumorigenic potential.

39 terruption of the MIF pathway also decreased tumorigenic potential.

40 and targeting Glut3 inhibits BTIC growth and tumorigenic potential.

41 genomic instability, immune reactivity, and tumorigenic potential.

42 cell stemness and increasing metastatic and tumorigenic potential.

43 levels, as well as to an attenuation of the tumorigenic potential.

44 transplantation, drastically reducing their tumorigenic potential.

45 rm tumours despite retaining their intrinsic tumorigenic potential.

46 ation of eIF4E at Ser209 is critical for its tumorigenic potential.

47 t cancer cell senescence, thereby increasing tumorigenic potential.

48 ion of p53-dependent senescence and enhanced tumorigenic potential.

49 ormation as well as increased clonogenic and tumorigenic potential.

50 NA knockdown of FoxO3a led to an increase in tumorigenic potential.

51 nes in GC B cells and counterbalance its own tumorigenic potential.

52 f DLK1 inhibits differentiation and enhances tumorigenic potentials.

53 radigm in oncology establishes a spectrum of tumorigenic potential across the heterogeneous phenotype

54 and METT-1) with differing developmental and tumorigenic potentials all were able to direct early emb

55 Decreased GABRP reduces in vitro tumorigenic potential and migration concurrent with alte

56 opulation of slow-cycling cells endowed with tumorigenic potential and multidrug resistance has been

57 erimental protocol also results in a loss of tumorigenic potential and profound changes in gene expre

58 tone demethylases plays an important role in tumorigenic potential and survival of human colorectal C

59 anoma cells growth arrest irreversibly, lose tumorigenic potential and terminally differentiate after

60 ers could lead to significant alterations in tumorigenic potential and/or progression.

61 le-targeting drugs, as well as the invasion, tumorigenic potential, and angiogenic potential.

62 NS4B has in vitro and in vivo tumorigenic potential, and the NS4B transforming activit

63 tion in cancer biology is whether cells with tumorigenic potential are common or rare within human ca

64 e highly proliferative and they retain their tumorigenic potential, as judged by their ability to for

65 expression changes reflective of attenuated tumorigenic potential, as marked by a nearly 10-fold ind

66 creased osteoblast maturation, and increased tumorigenic potential, as mice specifically deleted for

67 -transformed cells contributes to their high tumorigenic potential by enabling them to escape immune

68 of residual undifferentiated PSC, negligible tumorigenic potential by ISC-hpNSC and provide additiona

69 self-renewable and multipotent iNSCs without tumorigenic potential can be generated directly from fib

70 growth control mechanisms and an absence of tumorigenic potential can be readily screened and ensure

71 or there are multiple "stem-like" cells with tumorigenic potential casting some doubt on the hypothes

72 trend was observed for oxidative endurance, tumorigenic potential, cellular proliferation, and tumor

73 eatic cancer cells) had a 100-fold increased tumorigenic potential compared with nontumorigenic cance

74 or cells display increased proliferation and tumorigenic potential compared with progenitor cells fro

75 Akata cells restores tumorigenicity and that tumorigenic potential correlates with an increased resis

76 CSCs reduced their self-renewal and in vivo tumorigenic potential, defining DNMT1 as a candidate CSC

77 n kinase and then Lyn kinase, exhibit ranked tumorigenic potential during both paracrine-induced and

78 rative phase during which cells with limited tumorigenic potential expand is followed by a crisis per

79 neural crest stem cells, based on their high tumorigenic potential, expression of stem cell markers,

80 er cells can exhibit striking differences in tumorigenic potential following experimental transplanta

81 with our previous study showing an elevated tumorigenic potential for C-terminally truncated mutants

82 The tumorigenic potential has been linked to repair efficien

83 PCGEM1's tumorigenic potential has been recently shown to be in p

84 that the MPeM tumors contain stem cells with tumorigenic potential has important implications for und

85 hese data demonstrate that ACF with distinct tumorigenic potential have distinguishing molecular feat

86 F or wild-type HB-EGF significantly enhanced tumorigenic potential in athymic nude mice and exerted a

87 ith reduced anchorage-independent growth and tumorigenic potential in athymic nude mice.

88 ion in both anchorage-independent growth and tumorigenic potential in athymic nude mice.

89 of stem-like cancer cells and reduces their tumorigenic potential in both subcutaneous and orthotopi

90 These cultures had low tumorigenic potential in classical in vitro assays yet s

91 ght to determine whether CDX2 contributes to tumorigenic potential in established gastric cancer.

92 f HIP1 leads to such phenotypes, we analyzed tumorigenic potential in mice homozygous for a Hip1 muta

93 experimental framework to determine in vivo tumorigenic potential in mice, we found that NetSig cand

94 c-Met(high) cells had increased tumorigenic potential in mice; those that expressed c-Me

95 nescence in tumor cells and diminished their tumorigenic potential in mouse xenograft models.

96 ling properties, as well as reduction of the tumorigenic potential in nude mice.

97 unction to these cells greatly reduced their tumorigenic potential in nude mice.

98 nchorage-independent growth on soft agar and tumorigenic potential in nude mice.

99 tingly, ICAM-2 suppressed metastatic but not tumorigenic potential in preclinical models, supporting

100 provides a genetic platform for identifying tumorigenic potential in putative oncogenes and tumor su

101 omic instability preceded the acquisition of tumorigenic potential in rat liver epithelial cells subj

102 TPCs resist DNA damage and exhibit increased tumorigenic potential in response to chemotherapy, where

103 To examine tumorigenic potential in the eye and brain, we injected

104 Thus, CDX2 has tumorigenic potential in the human colon cancer cell lin

105 The results revealed a hierarchy in tumorigenic potential in the order of CD44(+)alpha2beta1

106 ls were highly tumorigenic in nude mice, the tumorigenic potential in vivo of shL5 cells was found to

107 ls showed a markedly higher repopulation and tumorigenic potential in vivo, which correlated with an

108 tumor cells reduces to the same degree their tumorigenic potential in vivo.

109 dothelial cells in vitro and inhibited their tumorigenic potential in vivo.

110 suppression of colony formation and reduced tumorigenic potential in vivo.

111 cells and a concurrent suppression of their tumorigenic potential in vivo.

112 ced granulocytic differentiation and reduced tumorigenic potential in vivo.

113 ll-like properties in vitro as well as their tumorigenic potential in vivo.

114 nd migration in vitro and a dramatic loss of tumorigenic potential in vivo.

115 al components of mir-17-92 by assaying their tumorigenic potential in vivo.

116 lar adaptation to hypoxia in vitro or confer tumorigenic potential in xenograft assays.

117 s: an EBER-dependent mechanism that enhances tumorigenic potential independent of a direct effect on

118 owed with unique self-renewal properties and tumorigenic potential is present in some, and perhaps al

119 miR-200b decreased the tumorigenic potential of a cancer cell line resistant to

120 RNA (hTR) antagonist, GRN163L, inhibited the tumorigenic potential of A549-luciferase (A549-luc) lung

121 levels of class I antigens contribute to the tumorigenic potential of Ad12 transformed cells by favor

122 capability for self-renewal and the highest tumorigenic potential of all cell populations studied.

123 the mechanism by which beta(1C) inhibits the tumorigenic potential of beta(1A), we analyzed changes i

124 Knockdown of SET or CIP2A reduces the tumorigenic potential of breast cancer cell lines both i

125 , a novel SET antagonist, also decreases the tumorigenic potential of breast cancer cells and induces

126 Here, we report that the tumorigenic potential of breast cancer cells is determin

127 ow a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells and ther

128 direct evidence that EBV contributes to the tumorigenic potential of Burkitt lymphoma and suggest a

129 Notably, we found the tumorigenic potential of BVE(Cyp24a1-null)-derived tumor

130 tissue against oxidative stress and suppress tumorigenic potential of c-myc oncogene.

131 gain of function and consequently reduce the tumorigenic potential of cancer cells.

132 ion of the aforementioned genes and with the tumorigenic potential of cell lines.

133 ced expression of this gene led to increased tumorigenic potential of cells implanted into nude mice

134 components Raptor and Rictor, abolished the tumorigenic potential of cells overexpressing SF2/ASF.

135 portantly, loss of DBC1 inhibited growth and tumorigenic potential of colon cancer cells, and DBC1 ex

136 docrine gastrins have been implicated in the tumorigenic potential of colon cancer cells.

137 ase signaling system in AR expression and in tumorigenic potential of colon cancer cells.

138 ely inhibits the proliferation, survival and tumorigenic potential of colorectal cancer cells with he

139 ocked activation of NF-kappaB caused loss of tumorigenic potential of CSMLO cells.

140 d an immunodeficient mouse model to test the tumorigenic potential of different populations of cancer

141 The tumorigenic potential of E4-ORF1, as well as its ability

142 V-positive cells, significantly enhanced the tumorigenic potential of EBV-negative BL cells in SCID m

143 electively inhibits growth, survival and the tumorigenic potential of ENO1-deleted GBM cells, and tha

144 pecially significant given the known greater tumorigenic potential of fjord region compared to bay re

145 These findings unravel a general and rapid tumorigenic potential of genomic instability, as opposed

146 We conclude that the increased tumorigenic potential of glioblastoma cells expressing t

147 ANXA7 haploinsufficiency doubles tumorigenic potential of glioblastoma cells, and combine

148 identified significantly contributes to the tumorigenic potential of glioblastoma stem cells.

149 mors, where it supports the self-renewal and tumorigenic potential of GSCs.

150 In vivo tumorigenic potential of heat-treated versus untreated H

151 ER-2/neu promoter activity, and suppress the tumorigenic potential of HER-2/neu-overexpressing ovaria

152 asiveness, anchorage-independent growth, and tumorigenic potential of highly invasive breast cancer c

153 e, we used xenotransplantation to assess the tumorigenic potential of human breast cancer cells follo

154 The gold standard for determining the tumorigenic potential of human cancer cells is a xenotra

155 odels may not properly reflect the long-term tumorigenic potential of human cells.

156 The tumorigenic potential of IGF-IR is mediated through its

157 attenuates the proliferation, migration, and tumorigenic potential of Ink4a/Arf(-/-) Pten(-/-) Egfr(v

158 cell death caused by PGE2 would enhance the tumorigenic potential of intestinal epithelial cells.

159 ceptibility involving a global change in the tumorigenic potential of keratinized epithelium in Atp2a

160 To determine how the tumorigenic potential of lineally related stem cells cha

161 xpression of repressed miRNAs diminishes the tumorigenic potential of lymphoma cells.

162 If amplified, the mdm2 gene can enhance the tumorigenic potential of murine cells.

163 To investigate the tumorigenic potential of mutant p53 when selectively exp

164 that silencing or loss of CDK4 augmented the tumorigenic potential of Myc-driven mouse and human B ce

165 Importantly, DPPIV suppressed the tumorigenic potential of NB cells in a xenotransplantati

166 antation-site microenvironment influence the tumorigenic potential of neoplastically transformed live

167 n, countering REST/NRSF function blocked the tumorigenic potential of NSC-M-R cells.

168 confirm and extend previous findings on the tumorigenic potential of ORF74.

169 rotein kinase B (AKT) signaling, and reduced tumorigenic potential of ovarian cancer cells in a nude

170 Myc also serves to maintain robust tumorigenic potential of p53(-/-) Pten(-/-) TNSs.

171 h kinases is required to maximally block the tumorigenic potential of pancreatic cancer cells.

172 nisms that provide evidence for the emerging tumorigenic potential of PLD, the role of the microenvir

173 3/EHF inhibited the stem-like properties and tumorigenic potential of prostate cancer cells.

174 ithin EC nuclei define the developmental and tumorigenic potential of resulting NT ES cells.

175 The tumorigenic potential of s-HB-EGF has been studied exten

176 gr1 expression is to decrease the growth and tumorigenic potential of several tumor cell types.

177 The tumorigenic potential of spontaneously transformed cells

178 Loss of myristoylation abolished the tumorigenic potential of Src and its synergy with androg

179 We propose that the tumorigenic potential of SV40 Tag in some human mesothel

180 The proliferative and tumorigenic potential of the AS clones from the gastrin-

181 The tumorigenic potential of the Burkitt lymphoma (BL) cell

182 -2) expression and consequently suppress the tumorigenic potential of the HER2/neu-overexpressing ova

183 CD45 suppresses the tumorigenic potential of the kinase by dephosphorylation

184 which the resulting cell death increases the tumorigenic potential of the neighboring cells.

185 , the role of TGF-beta RII in regulating the tumorigenic potential of the SNU-638 human gastric cance

186 This combination affected the tumorigenic potential of these cancer cells to a signifi

187 However, the tumorigenic potential of these cells remains a great con

188 resulted in tumor development verifying the tumorigenic potential of these cells.

189 cells without toxic effects and limited the tumorigenic potential of these cells.

190 n D1, concomitantly with the loss or reduced tumorigenic potential of these cells.

191 treatment with 4-hydroxytamoxifen decreased tumorigenic potential of these MCF10A cells.

192 a cell cycle arrest, effectively abating the tumorigenic potential of these stimuli.

193 We have investigated the in vitro tumorigenic potential of these viruses using cultured no

194 RLTS1 reexpression significantly reduced the tumorigenic potential of TOV-112 in nude mice.

195 cell carcinoma formation, demonstrating the tumorigenic potential of transduced cells.

196 The tumorigenic potential of USP6 was attenuated significant

197 utation clusters examined contributed to the tumorigenic potential of v-Rel with the relative strengt

198 ver, KDM3A knockdown also potently inhibited tumorigenic potentials of breast cancer stem-like cells

199 he cellular factor DLG may contribute to the tumorigenic potentials of several different human virus

200 esults, we propose that the transforming and tumorigenic potentials of the adenovirus E4-ORF1 oncopro

201 proteins and, in addition, suggest that the tumorigenic potentials of these viral oncoproteins depen

202 Comparing the tumorigenic potentials of these viruses has allowed us t

203 cient to confer malignant transformation and tumorigenic potential on nontransformed (MCF-10A) mammar

204 ived HSCs express normal HBB in mice without tumorigenic potential, suggesting a safe strategy for pe

205 segregated with decreased transformation and tumorigenic potential, suggesting that an unrecognized t

206 l lineage relationship and display different tumorigenic potential, suggesting that effective therape

207 Wnt activity exhibited higher clonogenic and tumorigenic potential than pCCSCs with the lowest Wnt ac

208 with the FLI1 C-terminus confering a greater tumorigenic potential than the corresponding ETV1 domain

209 compound mezerein (MEZ) results in a loss of tumorigenic potential that correlates with an irreversib

210 cells within a variety of tumor types with a tumorigenic potential that is lacking in the rest of the

211 CtBP is a transcriptional corepressor with tumorigenic potential that targets the promoter of the t

212 enewing NSCLC stem-like cells with increased tumorigenic potential, that NSCLCs harboring tumor cells

213 ently isolated MSC populations exhibited low tumorigenic potential under syngeneic conditions, which

214 EBERs have been shown to impart significant tumorigenic potential upon EBV-negative Burkitt lymphoma

215 logous region on mouse chromosome 11 for its tumorigenic potential using segmental haploidy in combin

216 Tumorigenic potential was evaluated in vitro or in xenog

217 anced angiogenesis, but the most significant tumorigenic potential was realized by coexpression of bo

218 ssing some forms of mutant p53 show enhanced tumorigenic potential with increased resistance to chemo

219 tration of adult liver stem cells possessing tumorigenic potential without the use of a carcinogen or