ライフサイエンスコーパス: tumstatin

1 in binding site within 54-132 amino acids of tumstatin.

2 ng the two distinct anti-tumor properties of tumstatin.

3 essential for the antiangiogenic activity of tumstatin.

4 Tumstatin (alpha3(IV)NC1 domain) is one such novel molec

5 lpha(v)beta(3) integrin-mediated activity of tumstatin, although significant inhibition of endothelia

6 Tumstatin and endostatin are two inhibitors of angiogene

7 lectively, such distinct properties of human tumstatin and human endostatin provide the first insight

8 in is localized to a 25-amino acid region of tumstatin and it is independent of disulfide bond linkag

9 The collagen type IV cleavage fragment tumstatin and its active subfragments bind to integrin a

10 The peptides, similar to tumstatin and the tum-5 domain, bind and function via al

11 Deletion of tumstatin and thrombospondin-1 in mice lacking the p53 t

12 confirm that the anti-angiogenic activity of tumstatin and tum-5 is independent of disulfide bond req

13 Additionally, although human tumstatin binding to alpha v beta 3 integrin leads to th

14 We demonstrate that human tumstatin binds to alpha v beta 3 integrin in a vitronec

15 A fragment of tumstatin containing 54-132 amino acid (tum-2) binds bot

16 A similar experiment with fragment of tumstatin containing the 185-203 amino acid (tum-4) demo

17 suppressive action of TSP-1, endostatin, and tumstatin correlates with expression of CD36 receptor, a

18 rowth, whereas the absence of endostatin and tumstatin did not alter the effect of LDC.

19 three independent lines of mice deficient in tumstatin, endostatin, or thrombospondin-1 (TSP-1), to a

20 Here we show that tumstatin functions as an endothelial cell-specific inhi

21 isite interaction with alphaVbeta3 integrin, tumstatin inhibits activation of focal adhesion kinase (

22 model in which T3, while unable to alter the tumstatin-insensitive vasculature contributed by the alp

23 Tumstatin is a 28-kilodalton fragment of type IV collage

24 Tumstatin is an angiogenesis inhibitor that binds to alp

25 suggest that the anti-angiogenic activity of tumstatin is localized to a 25-amino acid region of tums

26 The activity of human tumstatin is mediated by alpha v beta 3 integrin, wherea

27 emonstrate that Tum-5, a domain derived from tumstatin, is an effective inhibitor of tumor-associated

28 ndostatin) or type IV collagen alpha3 chain (tumstatin) or TSP-1 to assess the contribution of these

29 uble-knockout mice, compared with either the tumstatin- or the TSP-1-deficient mice, strongly suggest

30 Collectively, our results demonstrate that tumstatin peptide binds specifically to the tumor endoth

31 The tumstatin peptide binds to alphavbeta3 integrin on proli

32 nstrate that systemic administration of this tumstatin peptide inhibits tumor growth and angiogenesis

33 Structural features and potency of the tumstatin peptide make it highly feasible as a potential

34 dentify a putative interaction interface for tumstatin peptide on alphavbeta3 integrin.

35 es identified a 25-aa fragment of tumstatin (tumstatin peptide) with in vitro antiangiogenic activity

36 The antitumor activity of the tumstatin peptide, in combination with bevacizumab (anti

37 Additionally, these studies show that tumstatin peptides can inhibit proliferation of endothel

38 tration of endostatin, thrombospondin-1, and tumstatin peptides, as well as deletion of their genes,

39 Human tumstatin prevents angiogenesis via inhibition of endoth

40 These results show that tumstatin, previously considered to be only an endogenou

41 thesis and suggest a potential mechanism for tumstatin's selective effects on endothelial cells.

42 wo distinct RGD-independent binding sites on tumstatin suggest unique alpha(v)beta(3) integrin-mediat

43 ffected by exposure to an active fragment of tumstatin (T3), whereas alpha(V)beta(3)-expressing gliom

44 Recently, we reported that tumstatin (the NC1 domain of alpha 3 chain of type IV co

45 Recently, tumstatin (the NC1 domain of alpha3 chain of type IV col

46 We hypothesized that the inability of tumstatin to directly suppress tumor cell growth might b

47 l cell apoptosis accounts for the ability of tumstatin to function as an endogenous inhibitor of angi

48 Moreover, tumors grow 2-fold faster in the tumstatin/TSP-1 double-knockout mice, compared with eith

49 nesis studies identified a 25-aa fragment of tumstatin (tumstatin peptide) with in vitro antiangiogen

50 esent study, the anti-angiogenic activity of tumstatin was localized to the putative 54-132-amino aci