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5 e have identified a BACE1 cleavage site that turns out be highly conserved among neuregulin-1 paralog
6 Herein, a structure-based lead optimization turned out into a small series of analogues, where 8 is
7 to choose a less familiar option that might turn out more advantageous (and thereby provide informat
10 is factors in pre-ribosomal particles, which turned out not to be pre-40S but 80S-like ribosomes.
14 the constructed maps from the forward model turned out statistically indistinguishable, thus providi
22 the translocon, however, in recent years it turned out that prolonged ER residence allows O-mannosyl
23 ted that SepF is membrane associated, and it turned out that purified SepF not only binds to lipid me
27 ated phosphatidylinositol monophosphates, it turned out that the relative stability of phosphatidylin
39 the CIN phenotype from stable cells, then it turns out that the emergence and growth of TSP(-/-) cell
47 and Gamma is an irreducible lattice of G it turns out that the subgroup growth of Gamma is independe
50 st separate for a Q(II) phase to form and it turns out that the work of their unbinding can be larger
58 th chairlike and boatlike conformations, yet turn out (theoretically) to have transition structures f
60 and the New York Post-Graduate were already turning out thousands of physicians who considered thems
61 wn as Lagrangian coherent structures (LCSs), turn out to admit highly attracting cores that lead to i
62 s; (3) What appears to be a single locus may turn out to be a cluster of loci; (4) Different loci fac
65 measured with fdOCT, RGC layer thickness may turn out to be a more direct and valid indicator of the
67 ia for the diagnosis of malignancy, yet they turn out to be benign, because they belong to a group of
69 Surprisingly, three-dimensional pseudopods turn out to be composed of thin (<0.75 microm), flat she
72 of an invariant diffuse layer effect, which turn out to be entirely analogous to those for a surface
75 ear electric quadrupolar coupling parameters turn out to be extremely sensitive experimental probes f
78 In fact, all the sequences we examine will turn out to be good averaging for Lp, p > 1; and even fo
79 the two areas for dealing with these issues turn out to be identical, opening ways for mutually bene
85 'receptive substance' by Langley, that would turn out to be nAChRs, and 'Vagusstoff' (acetylcholine)
86 at selectively target its enzymatic activity turn out to be potent only for lymphoma cells with EZH2-
87 a particular dynamical model, whereas others turn out to be quite robust across different models.
89 asurements to substantiate such a hypothesis turn out to be rather difficult and have rarely been per
94 t the C-termini of alpha-helices, and niches turn out to be the most common C-terminal features of al
99 ; while Al7Mg3(-), Al11Mg(-), and Al11Mg2(-) turn out to be unexpectedly stable at electron counts of
100 ost distance measures between binary vectors turn out to belong to a single parametric family, namely
101 ld such topological inter-module connections turn out to constitute a form of functional coordination
102 the smallest spectral gaps; such small gaps turn out to correspond to regimes where the low-frequenc
103 ESs) are examined more carefully, they often turn out to harbor cryptic promoters or splice sites.
104 e these new transitions or reaction channels turn out to have a transparent physical interpretation:
108 initially thought to be location-specifiers, turn out to respond promiscuously to a wide range of sti
109 heir 3'-end interaction sites in the 5'-UTRs turn out to simultaneously contain 5'-end interaction si
110 nces from genomic DNA, one of which (PtACO2) turned out to be >98% identical to PtACO1 in the nucleot
112 t B(6) auxotroph, but the pdxT (yaaE) mutant turned out to be a conditional auxotroph depending on th
113 with Arg(19) of PrRP20 led to D6.59R, which turned out to be a constitutively active receptor mutant
114 ST and microarray evidence for transcription turned out to be a duplicated pseudogene in the cat eye
115 cylglycerol O-Acyltransferase 1 (DGAT1) gene turned out to be a functional and positional candidate g
117 o maintain cellular memory of homeotic genes turned out to be a highly conserved and sophisticated ne
118 didate for optimization studies (compound 1) turned out to be a mixture containing two unknown specie
121 several compounds synthesized, derivative 55 turned out to be a potent, selective, and an orally acti
122 Terahertz (THz) absorption spectroscopy has turned out to be a powerful tool to study (bio)molecular
123 clodal, c[-Arg-d-Phe-d-Lys-d-Dmt-] (2), also turned out to be a selective MOR antagonist with 1 nM bi
128 VE-JAM/JAM 2 receptor, which, upon cloning, turned out to be a submitted sequence representing JAM 3
131 vity of the cinnamic anilide mPTP inhibitors turned out to be additive with that of CsA, suggesting f
132 greater rigidity of the ligand molecule and turned out to be advantageous, if not mandatory, for (cl
134 othiazol-2-yl)-4-propoxybenzamide (3), which turned out to be an analog of the drug nitazoxanide (1).
135 hich upon treatment with Ag[CB(11)H(6)Cl(6)] turned out to be an excellent catalyst for the transform
136 mental agents or genetic defects, and IsoMut turned out to be an invaluable tool in the analysis of s
138 y current amplitudes of EAAT5 anion channels turned out to be approximately twice as high as single-c
139 uated in combination with flow cytometry and turned out to be around 25% (cells entering the ICP-MS f
140 tion, the 95% confidence interval would have turned out to be at least 40 times larger ( approximatel
141 -14PD (lacking 14 phosphoacceptor sites) and turned out to be based on a phosphorylation-independent
143 rst identified in CDK and Src kinases, which turned out to be central to understanding of how kinase
144 ents being less abundant in most tissues, it turned out to be challenging to enrich and identify GKAP
146 the existence of a second tiny RNA gene that turned out to be conserved in animals as diverse as flie
148 In both cases, Laplacian regularization turned out to be crucial for achieving a reasonable gene
149 of substrate conformers during the reaction turned out to be crucial in obtaining an accurate predic
151 eceptors, etc.), most of the over-responders turned out to be deleted of proteins functioning in the
152 rs with the dark homogeneous streaks pattern turned out to be different primary melanomas from the sa
153 arious stem and progenitor cells, Prominin-1 turned out to be dispensable for precursor cell prolifer
156 Many of the most informative predictions turned out to be either recovering existing knowledge ab
158 ing via gibberellic acid, on the other hand, turned out to be essential for the increase in APR mRNA
159 process of V(D)J recombination per se, CTCF turned out to be essential to control order, lineage spe
162 ADDOL-related diols with an acyclic backbone turned out to be excellent ligands for asymmetric gold c
163 However, development of such agents has turned out to be extremely challenging, with major hurdl
166 ic transcription factor binding (ASTF), have turned out to be far more pervasive-affecting many non-i
167 ed common ancestor of green and red proteins turned out to be green, indicating that in this case red
170 ied as the receptor-like kinase SR160, which turned out to be identical to the brassinosteroid recept
172 hoice of catalytic system as well as solvent turned out to be important in order to ensure a high che
173 ns used in nanomedicine and nanoformulations turned out to be inapplicable to clinical applications.
174 rocess of accumulation of damage, ageing has turned out to be influenced by mechanisms that show stro
178 in(-1) very sharp, pulled nanospray emitters turned out to be mandatory for the generation of a stabl
179 The corresponding 5-isopropylthiohydantoins turned out to be more prone to racemization at C-5 durin
180 d to T-Lite SF under low intensity UV, cells turned out to be more sensitive to cadmium, a priority p
183 Curiously, the obtained structural models turned out to be nearly indistinguishable from the model
186 ce its discovery in the late 1990s, Pten has turned out to be one of the most important tumor suppres
187 de Helm 15--where a simple military exercise turned out to be perceived as the beginning of a new civ
189 the emergence process and sub-lethal effects turned out to be potentially relevant model extensions.
190 ker residence time as a function of voltage, turned out to be practically the same for all six cases
192 ered a new polymerase, pol V, whose activity turned out to be regulated by bound molecules of RecA pr
199 oximal and distal phosphoacceptor sites both turned out to be sufficient to induce WT-like desensitiz
200 nts of the number of cases of disease, which turned out to be surprisingly low for an influenza pande
207 umentation, a modified Wilson cloud chamber, turned out to be the detector most suitable for their pu
213 tudies, the Aib-containing complexes 3 and 4 turned out to be the most effective toward all the human
214 d nucleophiles: the 1-dodecanethiolate anion turned out to be the most general and efficient reagent,
216 inating laboratory Escherichia coli strains, turned out to be the well-known lambdoid phage phi80.
217 s4B/PDEdelta complex formed in bulk solution turned out to be unstable in the presence of heterogeneo
220 rare earth amidinates and guanidinates have turned out to be very efficient homogeneous catalysts e.
223 zed both in the solid state and in solution, turned out to exhibit a dual role, i.e., the oxidation o
225 tion, carbonyl cleavage, and redox reactions turned out to have a large impact on the diversity the M
227 ly normal neuroanatomical profiles, who also turned out to have the least abnormal cognitive and cere
228 2) were active, most of the anilides (n = 0) turned out to moderately or strongly inhibit 17beta-HSD2
229 widespread, conserved proteins many of which turned out to participate in translation, in particular
230 the types detected throughout the study, 24% turned out to persist in the parents and only 11% in the
232 with XO entrapped Ta2O5 nanofibers has been turned out to possess maximum sensitivity amongst the sy
234 the real maximum likelihood function, which turned out to provide us with significantly more accurat
236 ound 9c showed low eukaryotic cell toxicity, turning out to be an excellent lead candidate for precli
237 th platelet activation and aggregation, thus turning out to be more effective than the analogues quer
238 g efflux pump activity of mycobacteria, thus turning out to be promising multidrug-resistance-reversi
239 one genetic model species after another are turning out to have limited abilities to interbreed, as
240 iophages has at last been solved, the answer turning out to involve free-standing homologs of intron-
241 d size; the larger, overall place field size turns out to be a consequence of jitter across trials.
242 = 2.1478 compact galaxy, which-surprisingly-turns out to be a fast-spinning, rotationally supported
243 the spins, and the residual scalar coupling turns out to be a function of the chemical shift of spin
244 ures of analytes via Delta(f)H of ions which turns out to be a good quantitative structure-fragmentat
246 mal activation of the photocycle, melanopsin turns out to be a highly sensitive pigment consistent wi
249 Combined with multivariate data analysis, it turns out to be a powerful tool for profiling of many sa
251 most counterintuitive feature of the theory, turns out to be a useful resource for communication acro
255 articles as well as to model charge barriers turns out to be appropriate to approach an understanding
257 haracterized by dynamic heterogeneity, which turns out to be critical in reproducing the experimental
258 of molecular brightness to be handled which turns out to be critical to the fidelity of the final im
259 ies lend support to such a model, which also turns out to be crucial for a better understanding of th
260 ose a flexible notion of conservation, which turns out to be crucial for the quality of the resulting
262 adiponectin-based drug development approach turns out to be difficult due to extremely high serum le
263 couplings and short intermolecular distances turns out to be disadvantageous for efficient charge tra
264 th a wind flow, we show that the instability turns out to be driven by resonant grain trajectories, w
265 GTPase IFT27, a member of the IFT-B complex, turns out to be essential for retrograde cargo transport
266 l to match neural data, its top output layer turns out to be highly predictive of IT spiking response
269 tes to be connected just by a flexible chain turns out to be more a rough approximation than a good m
271 by mapping on a simple stochastic model and turns out to be of the order of gamma(HB) approximately
273 a differential screen of regenerating limbs turns out to be precisely such a cell surface component,
275 f these cargos required for spindle assembly turns out to be Rae1, previously known as an mRNA export
276 relevant figures: (1) the sensitivity, which turns out to be sample-dependent, as expected, (2) the p
277 objects (within a fixed homotopy class) that turns out to be similar to the Reidemeister-Singer theor
278 that, when account is taken of solvation, 2 turns out to be slightly more stable than 1 or 3 in pola
279 ing and Ca(2+) uncaging here reveal that CDF turns out to be strikingly faster, more Ca(2+) sensitive
281 ingle interaction of alpha-actinin and titin turns out to be surprisingly weak if force is applied.
282 ariance without sacrificing discriminability turns out to be that the learned and novel objects trans
284 er tradeoff between precision and recall and turns out to be the best one when incomplete annotation
285 solution of the biomass optimization problem turns out to be the dominant attractor of the metabolic
286 al silencing complex assembled by HPV E2 and turns out to be the long sought cellular corepressor tha
288 Particularly, the amino acid arginine (R) turns out to be the most favorable target of amino acid
292 the unfolded state of these proteins, which turns out to be unusually compact, strongly deviating fr
296 ional skew model, and the beta-pay sub-model turns out to have properties similar to the "restraint"
298 as a byproduct of the photochromic reaction turns out to prevent the desired high reversibility for
299 a class of closures we refer to as 'power-2' turns out to provide a good compromise between positivit
300 most stressed in a dominance hierarchy; this turns out to vary as a function of the social organizati
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