ライフサイエンスコーパス: turnover

1 riments of (13)C-labeled 2,4-D and ibuprofen turnover.

2 ety of genetic signals consistent with rapid turnover.

3 analysis to identify covariates of community turnover.

4 approximately 5-fold faster than the overall turnover.

5 ciated with internal Ca(2+) stores and their turnover.

6 gest parts of their cytoplasm for removal or turnover.

7 n that also inhibits MCV large T oncoprotein turnover.

8 nd recombination, and protein and nucleotide turnover.

9 vo evidence showing that p62 regulates Abeta turnover.

10 ites that modulate microtubule-activated ATP turnover.

11 idal, signaling an activation step, prior to turnover.

12 te, the C2 domain greatly enhances catalytic turnover.

13 osine adaptor protein ShcA regulates nephrin turnover.

14 to long bone regression and loss of skeletal turnover.

15 yanions, which ultimately inhibits catalytic turnover.

16 cers2b as a salvage pathway for sphingosine turnover.

17 nteraction that govern substrate binding and turnover.

18 plex and imparts an inhibitory effect on RPA turnover.

19 ress and inflammation driving cell death and turnover.

20 enriched with NMIIB because of faster NMIIA turnover.

21 depletion of cancer-relevant proteins after turnover.

22 stitute the rate-limiting step for catalytic turnover.

23 talk is a key determinant of the rate of ATP turnover.

24 rophy, hyperphosphatemia, and increased bone turnover.

25 e, to a degree that depends on the metabolic turnover.

26 mplexes or is ejected from RNAP by catalytic turnover.

27 he E46K mutation does not alter aSyn protein turnover.

28 a 5'-deoxyadenosyl radical, which initiates turnover.

29 pression, starvation responses, and ribosome turnover.

30 es during synthesis, folding, transport, and turnover.

31 inetochore substrates to promote microtubule turnover.

32 operties, rather than increased bone mineral turnover.

33 muCO ligand are likely involved in rapid H2 turnover.

34 xonal growth-cone dynamics and autophagosome turnover.

35 rather than cofactor exchange, for multiple turnover.

36 C through two S-adenosylmethionine-dependent turnovers.

37 m-scale biosynthesis, providing up to 15,300 turnovers, a turnover frequency of 6,100 h(-1), a 99:1 e

38 es the expression of genes involved in lipid turnover (ACADM) and insulin signalling (IRS2) in subcut

39 the context of a nucleosome, and its single-turnover activity is reduced approximately 500-fold, as

40 ctions and dispersal lags to plant community turnover along an elevational gradient following climate

41 regions, resulting in elevated sphingolipid turnover and an altered lipid composition of both MAM an

42 xes quantitatively reflect intracellular ATP turnover and cellular bioenergetics.

43 ish between changes in RNA synthesis and RNA turnover and did not address the role of enhancer elemen

44 zyme, while ensuring high rates of substrate turnover and electronic charge transfer with an electrod

45 Serotonin turnover and expression of 5-hydroxytryptamine (5-HT) 2A

46 is study was to evaluate the epithelial cell turnover and expression of proliferation and apoptosis-r

47 r mean that through oral administration, the turnover and flux through a number of different substrat

48 determine which processes limit steady-state turnover and how mutations that accumulated along the ev

49 Specifically, the mechanisms of TFEB turnover and how they might influence its activity remai

50 es comparative measurements during substrate turnover and in the resting state.

51 rat model characterizes the pattern of bone turnover and inflammation after extraction and bone graf

52 ell biological functions, including receptor turnover and maintenance of the immunological synapse.

53 with decreased nurse satisfaction, increased turnover and negative patient outcomes.

54 tress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth.

55 Taken together, our results show significant turnover and neurogenesis of adult enteric neurons and p

56 eractions were observed between lead or bone turnover and other prognostic indicators.

57 actors functionally interact to regulate the turnover and quality of mitochondria, by increasing both

58 Here, we investigated bone turnover and regeneration in mice lacking either C5aR1 o

59 naling dynamics, leading to aberrant nephrin turnover and slit diaphragm disassembly.

60 rganisms (CUEh ) determines rates of biomass turnover and soil carbon sequestration.

61 ordinating an intricate balance between Fzo1 turnover and the status of fatty acids saturation.

62 Here, we demonstrate that TDP-43 turnover and toxicity depend in part upon the endocytosi

63 ning tissue homeostasis during physiological turnovers and injuries.

64 idually, on cross-link dynamics and filament turnover, and how these dependencies combine to determin

65 ubpopulations with highly divergent rates of turnover, and show that inflows of new cells sourced fro

66 tivity, as trait variation driven by species turnover appears to capture the effect of temperature.

67 llen, the perturbations in LD biogenesis and turnover are coupled to reduced germination in vitro and

68 onstrate that plant taxonomic and functional turnover are decoupled, which may allow these peat bogs

69 When relatively high rates of protein turnover are maintained despite advancing age, damaged p

70 al signals governing beta-cell mitochondrial turnover are unknown.

71 ularly those resident in tissues with little turnover, are largely quiescent and only activate in res

72 ng toward regulation of neuronal cholesterol turnover as a potential therapeutic avenue for PD.

73 subset of 553 patients, suppression of bone turnover (assessed by C-terminal telopeptide levels).

74 Moreover, Fft3 also precludes nucleosome turnover at several euchromatic loci to prevent R-loop f

75 RS2 in transcription termination-coupled RNA turnover at short transcription units like snRNA-, repli

76 of FVIIa by selectively optimizing substrate turnover at the membrane surface.

77 Nup62 and NPHP4 exhibit rapid turnover at the transition zone and thus define dynamic

78 ential electrolysis generated more than 1000 turnovers at eta = 550 mV.

79 of cytoplasmic IFs results from a continuous turnover based on the cooperation of an actin-dependent

80 tuations in which processes involved in cell turnover become uncoupled, including pharmacological tre

81 knockout mice by adoptive transfer, and bone turnover, bone mineral density, and indices of bone stru

82 involved in the constitutive pathway of Mei2 turnover, but rather plays a regulatory role to limit it

83 tiretrovirals (ARVs) affect bone density and turnover, but their effect on risk of fractures and oste

84 s been shown to participate in mitochondrial turnover, by targeting damaged mitochondria with low mem

85 mass in HSCs, we observed that mitochondrial turnover capacity is comparatively low in HSCs.

86 rimary driver in the productivity-allocation-turnover chain for the observed spatial differences in w

87 Under single-turnover conditions, the ratios of branched to linear ac

88 direction was detectable only under limited turnover conditions.

89 ds, e.g., uniquely patterned array and short turnover cycle, our data suggest that chicken gustatory

90 To avoid hyperplasia or atrophy, organ turnover demands strict equilibration of cell production

91 teps in the catalytic cycle were involved as turnover determining.

92 as shown by the impact of the mutation on FA turnover during day/night cycles.

93 lity regulated whether vinculin and paxillin turnover dynamics are correlated to each other at single

94 t allows transcription factor (TF) chromatin turnover dynamics to be measured across a genome.

95 elieve the first time that not only is DISC1 turnover elicited by the ubiquitin proteasome system (UP

96 ghout the SERCA transport cycle and multiple turnover events.

97 The biocatalyst is capable of up to 1,300 turnovers, exhibits excellent enantioselectivities, and

98 After breeding male turnover, fewer female pups were recruited in the new ma

99 veal that, on a molar basis, the circulatory turnover flux of lactate is the highest of all metabolit

100 ommon pattern of response was an increase in turnover, followed by an increase in abundance with no d

101 rylation in the P + 1 loop of PKD2 increases turnover for Syntide-2, while substrate specificity and

102 The turnover frequencies (TOF) of these Lewis pair catalyzed

103 ntermediates, consistently achieving maximum turnover frequencies (TOF) regardless of the quality of

104 Turnover frequencies (TOFs) from chemical reduction (66

105 Turnover frequencies of 0.88 and 0.89 s(-1) are achieved

106 By cyclic voltammetry, fast turnover frequencies of 3.2 and 4.8 s(-1) for isopropano

107 nctions performs best among the series, with turnover frequency >1000 s(-1).

108 lytic activity for ammonia synthesis, with a turnover frequency (0.1 s(-1) at 0.1 MPa, 400 degrees C)

109 e valuable but often show trade-offs between turnover frequency (TOF) and the effective overpotential

110 arly stoichiometric 3 % aqueous H2 O2 with a turnover frequency (TOF) of 16 000 h(-1) .

111 ysis of ammonia borane (H3 NBH3 , AB) with a turnover frequency (TOF) of 4896.8 h(-1) and an activati

112 mate at ambient temperature (3150 turnovers, turnover frequency = 9700 h(-1)), compared with prior ho

113 Ptiso species exhibited a 2-fold greater turnover frequency for CO oxidation than 1 nm Ptmetal cl

114 a turnover number of 9 x 10(9) cell(-1) and turnover frequency of 1.9 x 10(4) s(-1)cell(-1) without

115 the auto-oxidation reaction with an apparent turnover frequency of 440 s(-1), and continue to generat

116 nthesis, providing up to 15,300 turnovers, a turnover frequency of 6,100 h(-1), a 99:1 enantiomeric r

117 Early after SIV infection, the monocyte turnover further increased, and it remained high during

118 lude that morning fasting up-regulates lipid turnover genes in SCAT of lean individuals.

119 Breeder turnover had marked effects on the breeding opportunitie

120 ion, novel protein interactions, and protein turnover has progressed rapidly.

121 nce of protein/lipid interactions with lipid turnover impacting on vesicle trafficking and ultimately

122 enyltransferases, and we were able to detect turnover in >55% of the cases.

123 herefore sought to directly investigate GFAP turnover in a mouse model of AxD that is heterozygous fo

124 a lid-loop as general feature for substrate turnover in acyl-protein thioesterases and the described

125 Modulating protein turnover in ATM-depleted cells also has an adverse effec

126 dynamic regulation of mVEGFR1 stability and turnover in blood vessels impacts angiogenesis.

127 tal gradients, we find significant taxonomic turnover in both clusters.

128 ributions of different microbial groups to C turnover in different aggregates under various managemen

129 Assessment of their turnover in duodenal transplants revealed that all Mf su

130 ic community model to illustrate how species turnover in future communities might lag behind simple e

131 , we report a widespread increase in protein turnover in HGPS-derived cells compared to normal cells.

132 performed a cross-sectional study of matrix turnover in HIV type 1 (HIV-1)-infected and -uninfected

133 ind that Lin28a protein exhibits rapid basal turnover in neurons and that mitogen-activated protein k

134 ns is limited.We examined retinol uptake and turnover in nonhepatic organs, including skin, brain, an

135 ols is progressively lost during homeostatic turnover in several tissues, suggesting a decrease in th

136 ation and is the primary mediator of protein turnover in the cell.

137 NADH-binding pocket to facilitate substrate turnover in the DD-CoA binding region of the protein.

138 ety-signaling peptide YY 3-36 increased 5-HT turnover in the LH and ameliorated the ppDIO-induced sle

139 itions to accurately and reliably measure DA turnover in the mammalian retina.

140 numbers are replenished through homeostatic turnover in the mLNs.

141 om Central Europe, we do not observe a major turnover in the mtDNA record of the Iberian Late Chalcol

142 mixed population or a static network lacking turnover in the population and injecting partnerships.

143 bundle formation, as reducing protofilament turnover in WT is not sufficient to induce bundling.

144 , and Rcy1) work in parallel to promote Cse4 turnover in yeast.

145 e describe a method for measuring the single-turnover incorporation kinetics of non-fluorescent nativ

146 ol pyrophosphate signaling, regulating InsP8 turnover independently of 5-InsP7, in response to fluctu

147 Early suppression of adipocyte lipid turnover induces immunometabolic modulation in cancer ca

148 hondria in calcium handling, apoptosis, heme turnover, inflammation, and oxygen and nutrient sensing

149 30, tumor necrosis factor [TNF]), enterocyte turnover (intestinal fatty acid binding protein [I-FABP]

150 r theory and experiments suggest that starch turnover is controlled by the circadian clock acting as

151 Control of protein turnover is critical for meiotic progression.

152 A consequence of this reduced microtubule turnover is diminished recruitment and activity of Auror

153 ding of their maintenance, proliferation and turnover is essential.

154 Turnover is found to depend cooperatively on two Mn(II)

155 Protein turnover is important for general health on cellular and

156 s readily available, but software to analyze turnover is lacking.

157 ation about cccDNA formation, stability, and turnover is lacking.

158 We show that the templated reaction turnover is limited by the duplex dissociation kinetics

159 within seconds, so the lamellipodial network turnover is local.

160 Our analysis predicts that filament turnover is required to maintain active stress against e

161 d from these regions of the membrane, so PSI turnover is sustained by long-distance diffusion of the

162 Actin turnover is the central driving force underlying lamelli

163 hould be preferred when the expected product turnover is within 30days.

164 generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary g

165 nickelacyclopentadiene intermediate prior to turnover-limiting formation of a catalytically active ni

166 Methanol elimination is predicted to be the turnover-limiting step for one substrate, and this is fa

167 The turnover-limiting step for the formation of a series of

168 The turnover-limiting step in the catalytic cycle for hydrob

169 identified the last redox event as being the turnover-limiting step of the overall process.

170 ition to form an intermediate oxetane as the turnover-limiting step.

171 exation of the arene by Ar-AuX2 becoming the turnover-limiting step.

172 h that Pd(II)-mediated C-H activation is the turnover-limiting step.

173 gands and variation can affect which step is turnover-limiting.

174 en shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women.

175 Bone turnover markers are not used for diagnosis of osteoporo

176 Bone turnover markers can be measured on several occasions in

177 Much remains to be learnt about how bone turnover markers can be used to monitor the effect of st

178 es are needed to investigate the use of bone turnover markers for assessment of the bone safety of ne

179 al, multi-subunit complex that catalyzes RNA turnover, maturation, and quality control processes.

180 proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-as

181 tivity-based protein profiling for enhancing turnover measurements of targeted, low-abundant proteins

182 a density-dependent formulation of microbial turnover, motivated by community-level interactions, tha

183 n the cellular environment and their protein turnover must be regulated via an alternate pathway.

184 of saturated N-heterocycles with the highest turnover number (TON) (1 mol% of 1, 12 h, TON = 62; 0.1

185 xtends catalyst lifetime to increase the Met turnover number (TON) 3-fold compared with H2O2, highlig

186 activity in propene self-metathesis at mild (turnover number = 90000 after 25 h).

187 ction proceeds at a low driving force with a turnover number of 9 x 10(9) cell(-1) and turnover frequ

188 t room temperature, representing the highest turnover number of any Fe-based N2 silylation catalyst t

189 iting reagent) and selectivity combined with turnover numbers >800.

190 creased coupling efficiency and higher total turnover numbers compared with TxtE.

191 completed within shorter reaction times, and turnover numbers of up to 100 could be achieved.

192 often feature high catalyst loading and low turnover numbers relative to non-oxidative cross-couplin

193 racter of the solid catalyst (at least 30000 turnover numbers without any loss of activity).

194 age to the protein, and produce higher total turnover numbers.

195 anabolic demand, necessitated by the diurnal turnover of a specialized membrane-rich organelle, the o

196 planta and promotes the proteasome-dependent turnover of ACD11 in cell-free degradation assays.

197 Neither is it explained by turnover of Aep3p, as evidenced by the failure of aep3 m

198 s also been reported to mediate heme-induced turnover of ALAS.

199 We found a high turnover of AMF with < 12% of VT present in all vegetati

200 ganelle (the vacuolar compartment or VAC) in turnover of autophagosomes and persistence during neural

201 autophagy on the proteolytic processing and turnover of C99.

202 ivity (e.g., by enhancing the processing and turnover of dead organic matter in soils of arid regions

203 e used as indicators of the biosynthesis and turnover of dopamine and serotonin in the brain.

204 factors with pre-60S subunits, resulting in turnover of early preribosomes, before the ITS1 spacer c

205 The turnover of endoplasmic reticulum (ER) ensures the corre

206 ific receptors: FAM134B, responsible for the turnover of ER sheets and SEC62 that regulates ER recove

207 Because of the turnover of fdC and cadC during cell state transitions,

208 GTPase activity was essential only for turnover of FtsZ2 and FtsZA filaments.

209 reductase (N2OR) that is observed in single turnover of fully reduced N2OR with N2O.

210 re of local lysosomes, thereby impairing the turnover of gangliosides in myelin.

211 Week-to-week turnover of interactions (1) was high, (2) followed a co

212 By orchestrating the remodelling and turnover of K16, and uncoupling it from K6, iRHOM2 regul

213 at this misregulation is due to both delayed turnover of maternal transcripts and inappropriate trans

214 iversity driven by the apparently continuous turnover of minor alleles, which could serve as the sour

215 Nonetheless, we also report a continuous turnover of minor variants, which could give rise to the

216 We determined the kinetics of growth and turnover of nitric oxide (NO) and N2 O at low cell densi

217 ecies stoichiometry and proteasome-dependent turnover of nuclear MAF1.

218 Furthermore, PML promotes turnover of nuclear Stat3, and knockdown of PML mitigate

219 owledge gap by quantifying the within-season turnover of plant-pollinator interactions from weekly ce

220 isomerase nonsense mutant, which arrests the turnover of prolycopene.

221 nserved sorting nexin Snx4 in the autophagic turnover of proteasomes and several other large multisub

222 (PC), the methylation of PE facilitates the turnover of SAM for the synthesis of cysteine and glutat

223 Consequently, abnormal turnover of SGs has been implicated in the development o

224 ance (long-term) influences the phylogenetic turnover of soil microbial communities responding to pul

225 Wt1 deletion leads to rapid turnover of specific mRNAs.

226 ty and thus plays an instructive role in the turnover of synaptic membrane proteins.

227 d that LIS1 involvement in the formation and turnover of synaptic protrusions and synapses of young b

228 Turnover of the 26S proteasome by autophagy is an evolut

229 pithelial cell migration during homoeostatic turnover of the epithelium.

230 ow polarity signaling can affect the dynamic turnover of the IF network to promote the polarization o

231 of the photochemistry, arrestin binding and turnover of the visual pigments located in the various p

232 ow that Ubp2 also counteracts Mdm30-mediated turnover of the yeast mitofusin Fzo1 and that Mdm30 targ

233 duals, thus indicating recent activation and turnover of these cells in vivo.

234 e production of PtdIns(3)P, allowing for the turnover of this lipid by PIKfyve.

235 lutionary analyses confirmed the higher gene turnover of trans-membrane proteins in NK cells compared

236 Here we use the rapid turnover of venom genes in parasitoid wasps to study how

237 qualifications of its workforce, ageing and turnover of village doctors, fragmented health informati

238 e antifungal therapy is hampered by the slow turnovers of the conventional antimicrobial testing tech

239 rovide insights about the effects of breeder turnover on groups have generally been conducted on spec

240 e kinetically relevant step for dimerization turnovers on protons within TON (0.57 nm) and MOR (0.67

241 functional integrity during ordinary tissue turnover or following injury represents a central biolog

242 nge, host availability, salinity, diversity, turnover, or community structure.

243 ic insulin clamp with measurement of glucose turnover; oral glucose tolerance test; and a liver biops

244 es associated with catalyst illumination and turnover outweigh the touted advantages of replacing hea

245 a luciferase readout to evaluate the single-turnover PCSK9 proteolytic event.

246 mechanism in which suppression of nucleosome turnover prevents formation of structural barriers that

247 caused by estrogen deficiency, improved bone turnover, promoted a favorable estrogen metabolite profi

248 f E6APC820A on wild-type activity and single-turnover pulse-chase kinetics.

249 exhibits an approximately 1,000-fold slower turnover rate (0.06-0.17 s(-1)), suggesting a potential

250 e APT2, that each species varies in terms of turnover rate and activity, altogether allowing the cell

251 is (mPDE), that resulted in decreased enzyme turnover rate compared with its unphosphorylated counter

252 erary of the cadherin, resulting in a higher turnover rate due to decreased recycling and increased d

253 K(+)-ATPase retained a wild-type-like enzyme turnover rate for ATP hydrolysis and rate of cellular K(

254 absolute (molar) abundance and determine the turnover rate of glycerophospholipids and sphingolipids

255 ted a higher physiological baseline monocyte turnover rate than adults.

256 apparent Ca(2+) affinity and a lower maximal turnover rate than the purified sarco(endo)plasmic retic

257 iously that a high peripheral blood monocyte turnover rate was predictive for the onset of disease pr

258 by the complexity of water currents or slow turnover rate.

259 on the reaction, catalyst resting state, and turnover-rate limiting step has been examined.

260 ly 70 most abundant proteins, variability in turnover rates among rats was low (median coefficient of

261 eptidoglycan decomposition exhibited similar turnover rates as their l-enantiomers.

262 This enrichment resulted in turnover rates for an additional 17 proteins.

263 Turnover rates for mixed alkenes give relative alkoxide

264 rats in vivo, measure variability of protein turnover rates in any animal model, and utilize activity

265 s the first to measure global plasma protein turnover rates in rats in vivo, measure variability of p

266 Because increased turnover rates of new soil C limit the potential for add

267 and suggest that elevated CO2 might increase turnover rates of new soil C.

268 Here, turnover rates of plasma proteins in rats were measured

269 Production and turnover rates suggest that day/night Abeta patterns are

270 tial equations was used to calculate protein turnover rates.

271 ospinal fluid Abeta concentrations and Abeta turnover rates.

272 ses of the products from single and multiple turnover reactions demonstrated that HadA prefers 4-CP a

273 Increased protein turnover renders mesenchymal sub-populations highly susc

274 nd lung clearance index based on lung volume turnover required to reach 2.5% of starting N2 concentra

275 ncover an inherent problem with side-by-side turnover/resting state measurements, i.e., the difficult

276 ransport obstruction and defective lysosomal turnover resulting from NPC1 deficiency.

277 s been used to image and characterize single turnover sites at catalytic surfaces, but is restricted

278 ding back Kapbeta1 rescues it while Kapbeta1 turnover softens it.

279 hibited higher physiologic baseline monocyte turnover than adults.

280 the precursor peptide is often required for turnover, the exact mode of recognition by the modifying

281 timulating both mitochondrial biogenesis and turnover through BNIP3 induction.

282 OSNs undergo continuous turnover throughout life, causing the constant replaceme

283 Taste cells undergo constant turnover throughout life; however, the molecular mechani

284 se cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates.

285 mF is prone to inactivation during catalytic turnover, thus setting up its dependence on a cofactor r

286 heptyl bromide electrophile over the average turnover time of catalysis, the in situ formed neutral m

287 ved distribution of DOS, concluding that the turnover time of refractory DOS that Ksionzek et al pres

288 The decomposition of SOC components with turnover times of years and decades, which contributed t

289 ing, causing defects most pronounced in high-turnover tissues including intestinal epithelium.

290 us to associate broad patterns of community turnover to local, species-level effects, ultimately imp

291 CO2 to formate at ambient temperature (3150 turnovers, turnover frequency = 9700 h(-1)), compared wi

292 O2, rendering standard assays of Krebs cycle turnover unusable.

293 merically identical in both groups, but bone turnover was greater (C-terminal telopeptide levels were

294 was identified as a Parkin substrate and its turnover was Parkin-dose and proteasome-dependent.

295 l density, and indices of bone structure and turnover were quantified.

296 ated reactions is a function of the template turnover, wherein the template acts as the catalyst.

297 of CDK inhibitors and decreased p53 protein turnover, which blocked their tumorigenic capacity throu

298 duction of neuronal autophagy enhances BACE1 turnover, which is suppressed by lysosomal inhibition.

299 p1-Nrf2 PPI inhibitors promote mitochondrial turnover, while covalent Keap1 modifiers, including sulf

300 low packed-bed reactor achieved nearly 60000 turnovers with no apparent loss of catalytic activity.