ライフサイエンスコーパス: twitching

1 in vitro would be associated with AS-related twitching.

2 sulting in myotube formation and spontaneous twitching.

3 ally decreased sleep durations and inhibited twitching.

4 ly during transitions from awake behavior to twitching.

5 dent form of multicellular motility known as twitching.

6 ements, and continued throughout the whisker twitching.

7 ons of corollary discharge are absent during twitching.

8 in transections had no significant effect on twitching.

9 temperature and decreased rates of myoclonic twitching.

10 specific cortical activity during periods of twitching.

11 swarming motility, and type IV pilus-driven twitching.

12 ly during periods of sleep-related myoclonic twitching.

13 ts that spinal reflexes are inhibited during twitching [9-11], this finding suggests that twitches tr

14 and maintained baseline levels of myoclonic twitching, a behavior commonly associated with active sl

15 ese findings, we propose that during whisker twitching, a descending signal from SI triggers thalamic

16 By chelating iron, lactoferrin stimulates twitching, a specialized form of surface motility, causi

17 py) of more-complex, multi-joint patterns of twitching; again, wild-types/heterozygotes exhibited dev

18 accompanied by sharp decreases in myoclonic twitching and equally sharp increases in spontaneous SBs

19 vity in muscle bundles was linked with early twitching and eventual coordinated movement.

20 esults show that the forces generated during twitching and gliding have complementary characters, and

21 es the basic mechanochemistry of single cell twitching and gliding movements, so cell-to-cell signall

22 ing swimming in aqueous media, and swarming, twitching and gliding on solid and semi-solid surfaces.

23 ty mechanisms of Myxococcus xanthus, namely, twitching and gliding.

24 Twitching and social gliding motility allow many gram ne

25 Type IV pili (Tfp) are required for twitching and social gliding, but the mechanism by which

26 e IV pili, cellular appendages implicated in twitching and social motility in a range of bacteria.

27 and btaR3 genes altered colony morphology on twitching and swarming motility plates and induced pigme

28 crocolonies despite being proficient in both twitching and swimming motility.

29 Neurons in the RN fired phasically before twitching and wake movements of the contralateral foreli

30 llowed by a marked and prolonged decrease in twitching and wake movements.

31 enerating muscle fibers of the type II (fast-twitching) and were in part associated with overexpressi

32 ing brain and spinal mechanisms that produce twitching, and the role that sensory feedback from twitc

33 cells utilize endogenous factors to organize twitching, and we purified from wild-type cells a lipid

34 echanisms, including swimming, swarming, and twitching, are known to have important roles in biofilm

35 results also highlight the potential use of twitching as a uniquely informative diagnostic tool for

36 dentified the neural mechanisms that produce twitching as well as those that convey sensory feedback

37 ng to assess the spatiotemporal structure of twitching at forelimb joints in 2- and 8-day-old rats.

38 Twitching bacterial groups also produce traction hotspot

39 arming bacteria and the pilGHIJ genes of the twitching bacterium Pseudomonas aeruginosa, the M. xanth

40 enhanced signal detection during the whisker twitching behavior.

41 many phenotypes tested, mucoidy and reduced twitching best predicted subsequent PE.

42 ion eliminated PFCN stimulation-induced anal twitching but did not change the stimulation-induced bla

43 76%, rostral pontine decerebrations reduced twitching by 40%, and midbrain transections had no signi

44 dal pontine decerebrations reduced myoclonic twitching by 76%, rostral pontine decerebrations reduced

45 In this article we track individual twitching cells and observe that their trajectories cons

46 lly structured, or whether the patterning of twitching changes with age; such information is critical

47 xpectedly revealed a category of reflex-like twitching-comprising an agonist twitch followed immediat

48 arvae exhibited abnormal swimming, increased twitching, defective eye movement and pectoral fin contr

49 development of local and global features of twitching, demonstrating that twitching is shaped by sen

50 is helps to maintain high rates of myoclonic twitching during cold exposure in infant rats.

51 0-min deprivation period, leading to rebound twitching during recovery sleep.

52 altered the temporal patterning of myoclonic twitching, extreme cooling substantially decreased sleep

53 of motility, from paralysis with flaccid or twitching flagella as other spoke mutants to wildtype-li

54 strain PAO1 to assess the roles of motility, twitching, growth rate, and overproduction of a capsular

55 line or amphetamine treatment, produced mild twitching in 61% of rats but did not affect amphetamine

56 N is also a major source of motor output for twitching in early infancy, a period when twitching is a

57 tagonist ketanserin reduces DOI-induced head twitching in MIA offspring.

58 gated the contributions of proprioception to twitching in newborn ErbB2 conditional knockout mice tha

59 as social gliding in Myxococcus xanthus and twitching in organisms such as Pseudomonas aeruginosa an

60 adient in comparison to transcription during twitching in the absence of any externally applied phosp

61 with 2 months of diffuse, involuntary muscle twitching in the absence of myasthenic symptoms, electro

62 er, analysis of the temporal organization of twitching indicated that pontine decerebrations predomin

63 atonia (with or without concurrent myoclonic twitching), indicative of REM sleep.

64 Myoclonic twitching is a ubiquitous feature of infant behavior tha

65 or twitching in early infancy, a period when twitching is an especially abundant motor behavior.

66 esults support the hypothesis that myoclonic twitching is sensitive to the prevailing air temperature

67 al features of twitching, demonstrating that twitching is shaped by sensory experience.

68 ted by the observation that reafference from twitching limbs reliably and substantially triggers brai

69 l as those that convey sensory feedback from twitching limbs to the spinal cord and brain.

70 The sensorimotor circuits activated by twitching limbs, and the developmental context in which

71 asic motor activity in the form of myoclonic twitching, may provide conditions that are conducive to

72 t was discovered that P. aeruginosa exhibits twitching-mediated chemotaxis toward unsaturated LCFAs (

73 r twitching motility per se, is required for twitching-mediated migration up a gradient of PE or phos

74 re new ideas about the functional roles that twitching might play in the self-organization of spinal

75 omain, pilF, involved in pilus formation and twitching mobility.

76 confidence interval, 1.19-2.57) and reduced twitching motility (odds ratio, 1.43; 95% confidence int

77 their resistance to phage PO4 and/or loss of twitching motility (twt-).

78 stic pathogen Pseudomonas aeruginosa mediate twitching motility and act as receptors for bacteriophag

79 showed that the PilC1 site is necessary for twitching motility and adherence to Chang epithelial cel

80 n that utilizes polar type IV pili (T4P) for twitching motility and adhesion in the environment and d

81 anscription factor that positively regulates twitching motility and alginate synthesis, two phenotype

82 norrhoeae pilT mutants, pilU mutants express twitching motility and are competent for DNA transformat

83 N. gonorrhoeae type IV pilus (Tfp) mediates twitching motility and attachment.

84 a, the Pil-Chp system regulates T4P-mediated twitching motility and cAMP levels, both of which play r

85 e for organelle biogenesis but essential for twitching motility and competence for genetic transforma

86 associated properties of auto-agglutination, twitching motility and human epithelial cell adherence.

87 mutant is deficient in type IV pili-mediated twitching motility and in a "swarming motility" previous

88 rs were significantly or greatly impaired in twitching motility and in susceptibility to D3112cts.

89 Both twitching motility and infection by pilus-specific phage

90 are also required for type 4 pilus-dependent twitching motility and infection by the pilus-specific p

91 Bacteria lacking FimX are deficient in twitching motility and microcolony formation.

92 the PilC2 site has only a minor influence on twitching motility and no influence on adherence.

93 t appears that PAI-2 plays a crucial role in twitching motility and phage infection by affecting the

94 Twitching motility and phage susceptibility in the autoi

95 CDE, a gene cluster known to be required for twitching motility and potentially encoding a signal tra

96 fective in two defined multigenic processes (twitching motility and prototrophic growth) identified m

97 y of AlgZ is essential for the regulation of twitching motility and that this is independent of the r

98 cs, we simultaneously monitored the speed of twitching motility and the concentration of oxygen.

99 f spontaneous mutants that failed to express twitching motility and transformability carried mutation

100 d for Tfp biogenesis) and PilT (required for twitching motility and transformation) share significant

101 ly system, which promotes surface-associated twitching motility and virulence, is composed of inner a

102 Swimming and twitching motility are important for attachment and biof

103 stidiosa migrates via type IV-pilus-mediated twitching motility at speeds up to 5 mum min(-1) against

104 54), which is required for surface-dependent twitching motility but not alginate production, was foun

105 AlgR activates alginate production and twitching motility but represses the Rhl quorum-sensing

106 tial attachment, early biofilm formation, or twitching motility but were observed to arrest biofilm d

107 that domain in the wild-type protein reduced twitching motility by approximately 50% compared with th

108 ion of a single residue disrupts Pseudomonas twitching motility by eliminating surface pili.

109 we reveal for the first time the dynamics of twitching motility by N. gonorrhoeae in its natural envi

110 ic monoclonal antibody, which also inhibited twitching motility by P. aeruginosa bearing glycosylated

111 We reported previously that twitching motility ceases in maturing AW1 colonies and t

112 y, jerky slingshot motions characteristic of twitching motility comprise the transition region betwee

113 Thus, twitching motility contributed to the role of pili in co

114 Further, the twitching motility defect of an algR mutant was compleme

115 At present, it is not clear how twitching motility emerges from these initial minimal co

116 These results show that twitching motility enables P. aeruginosa to translocate

117 ressed by a loss-of-function mutation in the twitching motility gene pilT.

118 Two sets of candidate twitching motility genes are present within the genome,

119 Pseudomonas aeruginosa pilus biogenesis and twitching motility has revealed the requirement for seve

120 In this study the role of twitching motility in P. aeruginosa epithelial cell inva

121 ween these in vitro findings and the role of twitching motility in P. aeruginosa virulence in vivo re

122 mily of proteins, required for Tfp-dependent twitching motility in Pseudomonas aeruginosa and social

123 hown to be required for pilus biogenesis and twitching motility in Pseudomonas aeruginosa.

124 ing motility (S-motility) in Myxococcus, and twitching motility in Pseudomonas and Neisseria [6,7].

125 ovel two-point tracking algorithm to dissect twitching motility in this context.

126 To study the role of twitching motility in virulence, Pseudomonas traversal o

127 at AlgZ DNA-binding activity is required for twitching motility independently of its role in alginate

128 Microscopic analysis of twitching motility indicated that mutants which were una

129 Twitching motility is a form of surface-associated bacte

130 ation of cAMP while control of TFP-dependent twitching motility is cAMP-independent.

131 owever, the mechanism by which AlgR controls twitching motility is not completely understood.

132 eir compact colony morphology indicated that twitching motility itself was not required for full viru

133 We speculate that PE-directed twitching motility may be involved in biofilm formation

134 Each twitching motility mutant (pilU, pilT with pili, pilA la

135 ed with the invasive strain PAK and isogenic twitching motility mutants.

136 ns of propulsion has much in common with the twitching motility of heterotrophs such as Pseudomonas a

137 ility and upregulate type IV pilus-dependent twitching motility of P. aeruginosa.

138 osa PilE-mCherry fusion failed to complement twitching motility or piliation of a pilE mutant.

139 uginosa (i.e., PlcB), while not required for twitching motility per se, is required for twitching-med

140 We also identified a twitching motility phenotype active at low-nutrient conc

141 nd altered colony morphology on swarming and twitching motility plates.

142 swarming motilities powered by flagella, and twitching motility powered by Type IV pili, little is kn

143 phosphorylated AlgR (AlgR-P) is required for twitching motility through the fimU promoter but is not

144 t not PlcH or PlcN, is required for directed twitching motility up a gradient of certain kinds of pho

145 onstrates type IV pilus-mediated directional twitching motility up a gradient of phosphatidylethanola

146 function as an oscillatory motor that powers twitching motility via cycles of pilus extension and ret

147 position 54) that does not activate fimU or twitching motility was compared to PAO1, PAO1 algRD54E,

148 that H. influenzae possesses a mechanism for twitching motility will likely profoundly influence our

149 echocystis gliding are similar to bacterial "twitching motility" and rely on type IV pilus extension

150 eudomonas aeruginosa type IV pilus-dependent twitching motility, a flagellum-independent mode of soli

151 The authors have shown that twitching motility, a pilus-mediated form of bacterial s

152 tion of this domain had a dramatic effect on twitching motility, adhesion, and piliation but did not

153 ed type III secretion system (TTSS), reduced twitching motility, and a decrease in association with,

154 Genetic competence, wild-type twitching motility, and attachment to human urogenital e

155 or microcolony formation, biofilm formation, twitching motility, and attachment.

156 re involved in adherence to host epithelium, twitching motility, and DNA transformation.

157 thiothreitol, reduced type IV pilin-mediated twitching motility, and reduced accumulation of extracel

158 ession of Tfp-associated properties, such as twitching motility, autoagglutination and the ability to

159 s, including lipase production, swarming and twitching motility, beta-hemolysis of sheep erythrocytes

160 tures of Pseudomonas aeruginosa required for twitching motility, biofilm formation and adherence.

161 of diverse functions, including attachment, twitching motility, biofilm formation, and horizontal ge

162 ce structures, involved in processes such as twitching motility, biofilm formation, bacteriophage inf

163 ence factors, including alginate production, twitching motility, biofilm formation, quorum sensing, a

164 only uses type IV pili for surface-specific twitching motility, but also as a sensor regulating surf

165 nd are important for processes as diverse as twitching motility, cellular adhesion, and colonization.

166 s with adherence to human epithelial tissue, twitching motility, competence for natural transformatio

167 in pilT, a gene required for pilus-mediated twitching motility, confer a partial defect in cortical

168 ent to explain why pilA expression, and thus twitching motility, decreases at high cell densities.

169 mutants, which are piliated but defective in twitching motility, display reduced cytotoxic capacity t

170 They are required for twitching motility, e.g., in Pseudomonas aeruginosa and

171 Tfp are required for twitching motility, efficient biofilm formation, and for

172 host cell attachment, biofilm formation, and twitching motility, making this system a promising targe

173 y due to defects in cell adhesion or loss of twitching motility, or both.

174 is required for the coordinate activation of twitching motility, rhamnolipid production, and swarming

175 utant inactivated for pilB was deficient for twitching motility, suggesting a role for PilB in this p

176 sembly but had a reduced capacity to support twitching motility, suggesting impairment of putative Pi

177 in covalent homo- or heterodimers eliminated twitching motility, suggesting that specific PilNO confi

178 onents of intersecting pathways that control twitching motility, TTSS and autolysis in P. aeruginosa.

179 ly activates fimU transcription and exhibits twitching motility, was created.

180 n addition, this strain had somewhat reduced twitching motility, was sensitive to pilus-specific bact

181 Given this new role in twitching motility, we propose that algZ (PA3385) be des

182 , competence for natural transformation, and twitching motility, whereas L-phase cells lacked these f

183 were significantly impaired in T4P-mediated twitching motility, whereas the motility of the N3 mutan

184 gellum-independent form of locomotion called twitching motility, which is dependent upon the extensio

185 K60 mutants lacking Hrp pili still exhibited twitching motility, which requires type 4 pili (Tfp), an

186 anced localized adherence, and abolished the twitching motility-dispersal phase of the autoaggregatio

187 Twitching motility-mediated biofilm expansion is a compl

188 nerate surface motions collectively known as twitching motility.

189 red for colonization of host tissues and for twitching motility.

190 the surface translocation is not swarming or twitching motility.

191 in and fibronectin but not collagen, and (v) twitching motility.

192 nnot undergo phosphorylation (AlgRD54N) lack twitching motility.

193 anide production, and type IV pilus-mediated twitching motility.

194 tion and can move on surfaces via gliding or twitching motility.

195 xanB are necessary for biofilm formation and twitching motility.

196 Importantly, these organisms exhibit twitching motility.

197 he biogenesis or function of type IV pili in twitching motility.

198 lginate biosynthetic operon, is required for twitching motility.

199 wth or early biofilm formation, swimming, or twitching motility.

200 aeruginosa upon infection of HeLa cells, and twitching motility.

201 results in colonies that continue to exhibit twitching motility.

202 the 17 kDa PilA protein and did not exhibit twitching motility.

203 result in a nonmucoid phenotype and loss of twitching motility.

204 ants are defective in type IV pilus-mediated twitching motility.

205 ct on adhesion, transformation, piliation or twitching motility.

206 cing and associations required for effective twitching motility.

207 T and pilU retain surface pili but have lost twitching motility.

208 of the P. aeruginosa pilus, which results in twitching motility.

209 tants constructed in vitro no longer display twitching motility.

210 are required for type IV pili biogenesis and twitching motility.

211 relate mechanistically to the phenomenon of twitching motility.

212 ontrols P. aeruginosa pilus biosynthesis and twitching motility.

213 use type IVa pili (T4aP) for attachment and twitching motility.

214 The bacteria move on a surface by means of twitching motility.

215 yperpiliated but defective in pilus-mediated twitching motility.

216 lagella-mediated swimming and pilus-mediated twitching motility.

217 of processes, including surface adhesion and twitching motility.

218 al, calcium-dependent regulator of bacterial twitching motility.

219 member and biogenesis component PilQ and the twitching motility/pilus retraction protein PilT.

220 strongly impaired in fly killing also lacked twitching motility; most such strains had a mutation in

221 ve toward chemoattractants using pili-based "twitching" motility and the Chp chemosensory system.

222 The "twitching" motility mode employed by many bacterial spec

223 Several bacterial pathogens require the "twitching" motility produced by filamentous type IV pili

224 acteria that move by type IV pilus-mediated (twitching) motility.

225 dition, the rpoS mutant displayed an altered twitching-motility phenotype, suggesting that the coloni

226 g, the outer membrane secretin PilQ, and the twitching-motility-regulating protein PilT.

227 y use of a microfluidic device, the speed of twitching movement by wild-type cells on a glass surface

228 During small-amplitude, 7-12 Hz whisker-twitching movements, a significant reduction in SI respo

229 scillatory activity occurring before whisker twitching movements, and continued throughout the whiske

230 , as measured by the occurrence of myoclonic twitching (MT), is the most prevalent behavioral state i

231 of the myotome, where they develop into slow-twitching muscle fibers.

232 l-angle X-ray diffraction measurements of WT twitching muscles during diastole revealed stretch-induc

233 All twitching mutants were competent for cell invasion but d

234 had a rapid onset of progressive confusion, twitching of the face and hand, and abnormal basal gangl

235 rally or bilaterally produced mild transient twitching of the forelimbs but did not affect behaviors

236 ory cortex, which reflected the synchronized twitching of the limbs and tail.

237 eir firing rates during periods of myoclonic twitching of the limbs, and a subset of these neurons ex

238 companied by a calcium transient that drives twitching or full contraction of the egg-laying muscles.

239 There is no evidence for twitching or swarming motility in A. tumefaciens.

240 life span and a male-specific wing extension/twitching phenotype that occurs in response to other mal

241 th expression of the pilus structure and the twitching phenotype, whereas a mutant lacking ComE, a Ps

242 mical results together with in vivo cAMP and twitching phenotypes of key ChpA phosphorylation site po

243 ing, and the role that sensory feedback from twitching plays in sensorimotor system development.

244 Twitching-positive cells had an extracellular 17 kDa pro

245 For twitching, powered by type-IV pilus retraction, we find

246 s analysis revealed developmental changes in twitching quantity and patterning.

247 ge-amplitude whisker movements), and whisker twitching (small-amplitude, 7- to 12-Hz whisker movement

248 r, thalamic bursting occurred during whisker twitching substantially more often than during the other

249 Pseudomonas aeruginosa is capable of twitching, swimming, and swarming motility.

250 uginosa is a ubiquitous bacterium capable of twitching, swimming, and swarming motility.

251 onal coherence from SI to VPM during whisker twitching than during the other behaviors.

252 g while leaving unaffected the low-frequency twitching that is thought to be contributed by local spi

253 To test this hypothesis, the sensitivity of twitching to various levels of cold exposure was assesse

254 pitulate movement signatures associated with twitching: Two TFP can already produce movements reminis

255 assessed by analysis of transcription during twitching up a PE gradient in comparison to transcriptio

256 In muscles, we found that the initiation of twitching was associated with a spreading calcium wave i

257 as inactivated by muscimol infusion, whisker twitching was never observed.

258 y of half of the threshold for inducing anal twitching was required.

259 In addition, myoclonic twitching was suppressed during the 30-min deprivation p

260 response to sensory feedback from myoclonic twitching, we hypothesized that the state-dependent acti

261 Furthermore, they indicate that twitching, which is characterized by discrete motor outp

262 ations predominantly affected high-frequency twitching while leaving unaffected the low-frequency twi

263 The discovery of whisker twitching will allow us to attain a better understanding