ライフサイエンスコーパス: two-state

1 nduced S-->D transitions are cooperative and two-state.

2 ons that shift the equilibrium between those two states.

3 e dynamic sequence of events that span these two states.

4 we can switch conductance digitally between two states.

5 was known about the difference between these two states.

6 istent with a low-energy barrier between the two states.

7 lly distributed time interval in each of the two states.

8 nted that indicates the relatedness of these two states.

9 ism underlying operation of the CCM in these two states.

10 in motions involving interconversion between two states.

11 anges in free-energy differences between the two states.

12 sing the cell to randomly switch between the two states.

13 rupt the bilayer much more than the previous two states.

14 idues are approximately equally close in the two states.

15 characterized the conversion dynamics of the two states.

16 be were found to differ the most between the two states.

17 rences in effective connectivity between the two states.

18 unclear how the same network supports these two states.

19 eatures as well as differences between these two states.

20 thin the exhibition swine populations of the two states.

21 merase exhibit a dynamic equilibrium between two states: a docked conformation and an alternative con

22 We found that RCC1 mobility is dominated by two states: a highly mobile state that is trapped within

23 We show that these two states acquire highly divergent genomic distribution

24 ctivation curves that correspond to a simple two-state activation.

25 tches are macromolecules that toggle between two states (active/inactive or folded/unfolded) upon spe

26 The switching between the two states (all-trans and cis-enriched capsules) proceed

27 ach other is far more complex than a simple, two-state allosteric model and instead is probably kinet

28 In spite of its simplicity, a two-state allosteric model was able to satisfactorily re

29 e rates of unwinding and rewinding for these two states and show that the rewinding rates from each s

30 nformational changes occurring between these two states and the resulting changes in classical electr

31 sed to derive its secondary structure in the two states and to pinpoint some subtle conformational ch

32 ctivation reduced the transition between the two states and, thus, promoted the accumulation of the A

33 Additionally, two-state and downhill folding scenarios were identified

34 In this study, kinetic models accounting for two-state and three-state mechanisms were fitted to our

35 itored at different wavelengths suggest that two-state and three-state models fail to explain the equ

36 omers exist as an intermediate between these two states, and their cytotoxicity has been implicated i

37 This enabled functional studies of the two states, and we show that while the Ub-CR conformatio

38 This also underscores the two-state approximation for apoazurin's unfolding reacti

39 These two states are interpreted as a bifurcation of magnetic

40 These two states are related: the larger the t1/2, the longer

41 HasA from Serratia marcescens cycles between two states as follows: the heme-bound holoprotein, which

42 mice on a high-fat diet and during fasting, two states associated with enhanced hepatic TG content.

43 of adult cancer survivors was recruited from two state-based cancer registries.

44 these in mind, following characterization of two states (before and after induction of a single TF of

45 The transition between these two states begins during the Carboniferous and concludes

46 gene] potassium channel UNC-103 enables this two-state behavior by limiting excitability of the egg-l

47 a generalized Rouse model, which mimics the two-state behavior in nucleic acid hairpins, can be accu

48 ectly two-state, while small deviations from two-state behavior were observed for CTL9.

49 rce (f), and temperature exhibit an apparent two-state behavior, without revealing the presence of th

50 ts experimentally detectable deviations from two-state behavior.

51 eal varying degrees of deviation from simple two-state behavior.

52 reversible covalent binding affinity using a two-state binding model.

53 cence imaging, we discover that SA1 displays two-state binding on DNA: searching by one-dimensional (

54 An area motor model, based on two-state Boltzmann statistics, was developed about two

55 t physical model of F1 motor as a simplified two-state Brownian ratchet using the asymmetry of torsio

56 ta, and when assembly stalls at one of these two states, but not the other, it becomes extremely toxi

57 s been characterized by a transition between two states, but the conformational path that leads to th

58 Comparison between the two states by electron microscopy identified regions of

59 tions showed that the transition between the two states can be achieved by rigid body subunit rotatio

60 These two states can be assessed by fractionating tissue or ce

61 Theses two states can each be reversibly oxidized by the redox

62 The two states can encode the two binary bits, and, using th

63 ding studies support a previously unreported two-state "catch-clamp" mechanism of Fn binding by CshA,

64 In this study we employed a simple two-state cellular model to identify genes that are asso

65 l elements computed to contribute to the non-two-state character coincide with regions where Von Will

66 the solvent-accessibility parameters in the two states clearly delineate the underlying protein moti

67 MscS has at least two states: closed, which does not allow solutes to exit

68 mation of the compact state occurs through a two-state co-operative transition following heteropolyme

69 are consistent with apparently cooperative, two-state cold unfolding.

70 for Healthcare Research and Quality funded a two-state collaborative to reduce ventilator-associated

71 that the tautomerization proceeds through a two-state concerted mechanism.

72 the N- and C-terminal domains, also induced two-state conformational exchange throughout the kinase

73 cGMP activation is adequately explained by a two-state conformational selection model, the partial ag

74 assicality and the mutual incompatibility of two states connected by time evolution.

75 lective, as no conversion is observed if the two states consist of opposite enantiomers.

76 croorganisms switch photochromically between two states, controlling numerous important biological pr

77 other folding landscape with nearly an ideal two-state (cooperative) unfolding transition.

78 rge state distribution are consistent with a two-state, cooperative unfolding transition having a mel

79 The Hill two-state cooperativity model and the McKillop-Geeves (M

80 e latch constriction, and by the loss of the two-state current signature in low pH buffers (<6.3), wh

81 A Markov model with lifetime horizon and two states, dead or alive, was created.

82 ival probability of complexes in each of the two states decayed at a single exponential rate, indicat

83 rt-finned pilot whales is often described by two states; deep foraging and shallow, non-foraging dive

84 oligomeric state, with the population of the two states depending on the local Ca(2+) concentration.

85 that the energy barriers to formation of the two states differ by only 0.7 kT, but once the high-ener

86 The two states display resistivity contrast, which is exploi

87 e often assumed to involve an all-or-nothing two-state dissociation pathway, but deviations from this

88 to reveal 1), the underlying structure of a two-state DNA-hairpin and a DNA hairpin that is bound to

89 cally described in the framework of coherent two-state electron tunneling or multistep hopping.

90 Together, these two states enable the organism to respond to two types o

91 from various detergent micelles by urea in a two-state equilibrium and where the unfolded state is in

92 enzyme and we analyse the data in terms of a two-state equilibrium between compact and extended confo

93 ) ionic strength, and is well described by a two-state equilibrium model.

94 ta indicate that the CBD exists in a dynamic two-state equilibrium, whose position as gauged by NMR c

95 The MRD data are inconsistent with global two-state exchange, indicating that conformational sampl

96 at traveling wave solutions connecting these two states exist for |c|>/=c(*).

97 ctions of the ternary complex model and the "two state" extensions.

98 of acyl-coenzyme A binding protein (ACBP), a two-state folder (folding time ~10 ms) exhibiting residu

99 ng of cold shock protein B (Csp), a showcase two-state folder, using single-molecule force-spectrosco

100 2, and find strong evidence for diffuse, yet two-state folding and binding of the N-terminal region t

101 mechanisms that purportedly underlie simple two-state folding behaviour.

102 The hairpins followed two-state folding dynamics with a closing rate increasin

103 e states and confirm earlier findings of non-two-state folding for insulin through a folding intermed

104 The resulting two-state folding model is a powerful template for measu

105 We found cooperative two-state folding on a sub-millisecond time scale throug

106 of multiple unfolding pathways in a simple, two-state folding protein.

107 the binding of brinzolamide to BCA II, a non-two-state folding protein.

108 ol yielded accurate DeltaG(f) values for the two-state folding proteins, lysozyme and cytochrome c.

109 onventional techniques were obtained for the two-state folding proteins, Rnase A and myoglobin.

110 stablished the free energy landscape of this two-state folding system.

111 impse at the nanoscale complexity underlying two-state folding, and postulate these combined methods

112 lthough the isolated C-terminal domain shows two-state folding, we find that the isolated N-terminal

113 ness of restraint revealed switching between two states: frictional coupling to retrograde flow and A

114 to a classical one-component gradient, this two-state gradient buffers against cell-to-cell variatio

115 tural basis for the difference between these two states has remained elusive, and is addressed here u

116 ever, interchanges between bacteria in these two states have been little explored.

117 We find that these two states have specific effects on the decisions to sto

118 aries of transcription units de novo using a two state hidden-Markov model (HMM).

119 ng datasets, followed by analysis based on a two-state hidden Markov model, taking advantage of the a

120 The method is based on a two-state Hidden Markov Model.

121 ning membranes, we found that there are only two states identifiable by CD, one before and another af

122 ot point during the transition between these two states.IMPORTANCE Glycoprotein spikes on the surface

123 tors are known to reversibly convert between two states in a photoinitiated process that involves a b

124 t interest to understand the nature of these two states in solution and the pathway for their interco

125 organization, all observed in living cells: two states in which the actin network exhibits segregati

126 The switching process consists of two states, in which the trans isomer has a stretched an

127 A difference in affinity for ligands in the two states influences the C<-->O "gating" equilibrium co

128 We identified two-state interconversion dynamics on the millisecond ti

129 cule when the free-energy barrier separating two states is actually crossed.

130 on occurs as the free-energy barrier between two states is crossed.

131 anslocated state, and movement between these two states is governed by the trigger loop.

132 The equilibrium between the two states is influenced by active site-proximal DNA seq

133 precise control of the bandgap between these two states is not currently achievable.

134 imental data from both protocols with simple two-state kinetic polymer theory allows to unambiguously

135 one-third complete within 35 ms, following a two-state kinetic process with no detectable intermediat

136 suitability of describing each system using two-state kinetics and predicts experimentally detectabl

137 Both genes follow similar two-state kinetics.

138 th switches that are locked in either of the two states lead to biofilms with altered architecture an

139 vestigate the folding of gpW, a protein with two-state-like, fast folding dynamics and cooperative eq

140 , the HIV virus makes a key decision between two states: lytic and lysogenic fate.

141 However, the protein folds in a kinetically two-state manner and is moderately stable at room temper

142 Folding of small proteins often occurs in a two-state manner and is well understood both experimenta

143 Fifteen of these loops melted in a two-state manner, and the associated experimental DeltaG

144 thout the chromophore, occurs in an apparent two-state manner.

145 transfer is not well modeled by the standard two-state Marcus model, since no inverted region is obse

146 The tool uses a two-state Markov model to simulate the evolution of meth

147 t activity evolves according to a stochastic two-state Markov switching-diffusion process that depend

148 A two-state mathematical model for long-chain hydrocarbons

149 hat is known to behave according to a simple two-state mechanism at the WT receptor.

150 mal Urc inactivation follows an irreversible two-state mechanism, with loss of ~20% of the helical st

151 e mechanism, while A3 unfolds by a classical two-state mechanism.

152 tein, and that the monomer unfolds through a two-state mechanism.

153 aturation experiments in solution, for which two-state mechanisms have been proposed.

154 y Junction dynamics, extracting the expected two state model and providing values for the transition

155 y concept, from a conformational change in a two-state model (1965, 1966) to dynamic allostery in the

156 centration, thus arguing against a classical two-state model as found for many globular soluble prote

157 ies in the membrane and a departure from the two-state model as the concentration increases.

158 We show that only the tertiary two-state model can provide a near quantitative explanat

159 rotein unfolding, in contrast to the typical two-state model described for most domain-swapping prote

160 oad transitions and cold denaturation, and a two-state model fit reveals a significant unfolded fract

161 We propose a two-state model for Cas9 binding and cleavage, in which

162 Our data lead to a two-state model for gradient formation in which pom1p mo

163 Our data are consistent with a two-state model for ligand control of histidine kinases.

164 fusion can be quantitatively modeled using a two-state model for polymers in the gel, where diffusivi

165 Our data support a two-state model for selectins in which Glu-88 must engag

166 al structures of P- and E-selectin suggest a two-state model in which ligand binding to the lectin do

167 state of the serpin were inconsistent with a two-state model of allosteric activation and suggested m

168 be explained using the Monod-Wyman-Changeux two-state model of allostery.

169 A generalized two-state model of bursty transcription that neglects Ry

170 hodopsin distributions are consistent with a two-state model of gene expression, in which cells can b

171 of Monod, Wyman, and Changeux; the tertiary two-state model of Henry et al., which is the simplest e

172 These results support the tertiary two-state model of ligand binding.

173 steric models for hemoglobin: the quaternary two-state model of Monod, Wyman, and Changeux; the terti

174 We conclude that the two-state model of motor learning is a close approximati

175 In contrast to the prevalent two-state model of T4L equilibrium, molecular brightness

176 types, can be quantitatively reproduced by a two-state model of the [Formula: see text], and thus the

177 Using our data, a stochastic two-state model of the central dogma was constructed and

178 nded, persistent structures assumed within a two-state model of water.

179 is interpreted qualitatively in terms of the two-state model proposed by H. W. Huang for the interact

180 easingly precise and the deviations from the two-state model start to be observable, we ask about the

181 QCA at the DREADD is not compatible with the two-state model that we previously applied to the M(1) W

182 leoyl-sn-glycero-3-phosphocholine (POPC) the two-state model was found to be inadequate and a three-s

183 d dimyristoyl-phosphatidylcholine (DMPC) the two-state model was sufficient to account for the observ

184 Switching is well described by a two-state model whereby the oxygen level controls the oc

185 We validate the effective two-state model with a three-state free energy landscape

186 ng mechanism cannot be described by a simple two-state model, but rather is a heterogeneous process i

187 thin measurement uncertainty by an effective two-state model, even though PGK folds by a multistate m

188 show that a remarkably simple extension of a two-state model, initially developed to reproduce thermo

189 Using a two-state model, we explore the effect of RLC phosphoryl

190 ry to think of gene regulation in terms of a two-state model, where the promoter of a gene can stocha

191 mpare them with the baseline provided by the two-state model.

192 aviors that are not compatible with discrete two-state models of core complex signaling states.

193 otection can be rationalized on the basis of two-state models that equate structural dynamics with gl

194 ch bonds have respectively been explained by two-state models.

195 analyses of oxygenation properties under the two-state Monod-Wyman-Changeux allosteric model revealed

196 erifiable fold that constrains the system to two states - monomer or dimer.

197 acid (BQCA), behaves according to a strict, two-state MWC mechanism at the M1 muscarinic acetylcholi

198 proteins, whereas the A39P mutant follows a two-state N <--> U folding mechanism consistent with the

199 pends only on the relative affinities of the two states, not on their relative intrinsic stabilities,

200 belief, proteins are multistate rather than two-state objects.

201 ompact than the heat-denatured states, these two states occupy similar volumes in IscU.

202 Two states of folding, fully extended fibers containing

203 njection of solutions containing selenium in two states of oxidation (either Se((IV)) or Se((VI))), p

204 he compression tests suggests that there are two states of shear-branching structures: the fractal st

205 ify a pressure-dependent equilibrium between two states of the enzyme, where an increase in pressure

206 structure refined to 1.55 A resolution shows two states of the protein with 55% displaying intact AMP

207 samples the expression space to balance the two states of the switch, and we illustrate the need for

208 We run a selection of algorithms on two state-of-the-art 5-qubit quantum computers that are

209 the SML performance is compared with that of two state-of-the-art algorithms: the adaptive Lasso (AL)

210 ased and standalone servers, SURPI leverages two state-of-the-art aligners for accelerated analyses,

211 e 10th CASP experiment; and (iii) outperform two state-of-the-art approaches and a baseline counterpa

212 ow and remotely sensed vegetation cover) and two state-of-the-art biospheric models, we show that cli

213 tify the validation rate and compare against two state-of-the-art methods, DEEP-ENCODE and RFECS.

214 les and the superiority of our approach over two state-of-the-art methods.

215 ple experimental datasets, MBBC outperformed two state-of-the-art taxonomy-independent methods, in te

216 ulation was performed by FusionQ and another two stated-of-art fusion detection tools.

217 small GTPase K-Ras4A have a single state or two states, one resembling K-Ras4B and the other N-Ras?

218 ucture reveals the auxiliary Fe-S cluster in two states: one monomer contains a [4Fe-5S] cluster, and

219 s are consistent with Rho complexes adopting two states: one that binds 57 +/- 2nt of RNA across all

220 ires the protein to convert between at least two states open to opposite sides of the membrane, it is

221 protein region monitored, we observed either two-state or three-state denaturation transitions.

222 Our findings challenge the conventional two-state paradigm and may aid future identification of

223 istance and relative orientation but also by two state parameters concerning the rotameric state of t

224 ertion is determined and is shown to mimic a two-state partition scheme with an apparent free energy

225 ine increased the unfolding flux through the two-state pathway from 38% to 65%, indicating the influe

226 ve that 38% of the unfolding flux followed a two-state pathway, giving rise to a single unfolding for

227 Ion conduction involves two states per cycle, the late M- (M2) with a deprotonat

228 coexistence of slow (three-state) and fast (two-state) phases], including the involvement of a solve

229 xhibit a spatial/temporal separation between two states: photic zone NO(3)(-) with denitrification in

230 epresentation of the protein and construct a two-state potential by combining two elastic network mod

231 The two-state potential has a cusp hypersurface in the confi

232 protein folding is often more complex than a two-state process, which leads to the spontaneous foldin

233 Thus, even this simple two-state protein demonstrates a complex mechanical unfo

234 e focused on the construction and control of two-state quantum systems, or qubits, in which each quan

235 ometry, and kinetic modeling, we showed that two states--quiescence and cell cycling--can coexist wit

236 s, NCS-1 unfolds and refolds reversibly in a two-state reaction involving only the C-domain, whereas

237 state, which determines the kinetics of the two-state reaction, remains poorly characterized.

238 /FRAP data, we have generalized the standard two-state reaction-diffusion equations by 1), accounting

239 rder of 1 s that interconvert in an apparent two-state reaction.

240 results corroborate the initially predicted two-state reactivity (TSR) scenario for these reactions.

241 hich has been postulated to be involved in a two-state reactivity model, and 2) the Mn(III/IV) reduct

242 A two-state reactivity scenario is mandatory for the oxida

243 sigma-pathways and quenches any chances for two-state reactivity, thus proceeding via the (3)Hpi pat

244 ce on the quintet surface and hence quenches two-state reactivity.

245 in contrast to complex A reported to feature two-state-reactivity with contributions from both triple

246 wding agent, folding rates are faster in the two-state regime, and at low denaturant concentrations,

247 e for high-throughput mutational analysis of two-state reversible binding processes.

248 sional with dimensions that correlate with a two-state "roaming and dwelling" model of swimming behav

249 These results rule out a simple two-state scenario with the folded and unfolded ensemble

250 veals that when folding approaches a perfect two-state scenario, as in the case of the G(A) domains,

251 genetic data, we redefine the disorder into two states: severe (triglyceride concentration >10 mmol/

252 the near-identical SRP architecture of these two states, show many of the SRP-ribosome interactions a

253 ounter-rotations, that is coupled to dynamic two-state sidechain rotamer jumps, as evidenced by alter

254 rather than a simple funnel, that folding is two-state (single-exponential) when secondary structures

255 This all-or-nothing two-state solution is a hallmark of positive cooperativi

256 ionally equivalent to one of two fundamental two-state spin systems.

257 none reduction site, providing support for a two-state stabilization-change mechanism of proton pumpi

258 A two-state stable isotope labeling by amino acids in cell

259 erve that heparin binding induces a distinct two-state structural transition in tau characterized by

260 eters were found to be unchanged between the two states, such as most aspects of spatial processing,

261 ur results indicate that the Abl tandem is a two-state switch, alternating between the conformation o

262 havior characterizing the GNSs dynamics to a two-state switching between Brownian diffusion in the cy

263 vironmental changes are currently limited to two-state switching of single properties, and only a sma

264 ctivity of the entire cell into a stochastic two-state switching regime.

265 By picturing replication initiation as a two-state system and considering all possible transition

266 t it is bounded by the Shannon entropy for a two-state system.

267 to P450 17A1 was more complex than a simple two-state system.

268 al form inspired by a thermodynamic model of two-state TF-DNA binding.

269 eactive alphaIIbbeta3 pre-exists in at least two states that differ in their zero force on-rates (k(o

270 as attributable to the retention of cells in two states that exhibited different condition-specific g

271 resented, resulting in the identification of two states that might be targeted with molecular scaffol

272 The entanglement of these two states, the topological superconducting state, will

273 tes concerted conformational changes between two states: the intrinsically more stable T state with r

274 beta-lactamase sequences undergo cooperative two-state thermal denaturation and display very large de

275 Developing endothelial cells exist in one of two states: tip cells at the growing front and stalk cel

276 onsistent with TRAP SBPs undergoing a simple two-state transition from an open-unliganded to closed-l

277 ransition profiles suggest a highly specific two-state transition in which the folding and unfolding

278 is of ion mobility distributions reveals the two-state transition is a composite of transitions invol

279 g the folding reaction both in cases where a two-state transition is valid and in some cases consisti

280 The two-state transition of the TMD, from an inward- to an o

281 This result supports the tertiary two-state (TTS) model, in which the Hb subunits can adop

282 g data within the theoretical framework of a two state two path model, where two slip bonds are coupl

283 ticomponent complexes reveal an almost ideal two-state unfolding behavior.

284 These SMD simulations also reveal that two-state unfolding is initiated from both the N- and C-

285 We observe a two-state unfolding pathway for SUMO1 and SUMO2, similar

286 Significant deviation from two-state unfolding under pressure reveals an intermedia

287 conformational changes that go beyond simple two-state unfolding.

288 this structure to reversibly switch between two states upon pH changes.

289 Two state variables are responsible for generating rapid

290 levels throughout the transition in terms of two state variables.

291 A novel prediction is derived by the Two-State-Vector-Formalism (TSVF) for a particle superpo

292 dichroism measurements suggest a simplistic two-state view of the unfolding of barstar, but the use

293 onditions, the M1-envelope complex exhibited two states, viz, the original, neutral-pH state and one

294 energy, the phase separation in the athermal two-state water is driven by entropy upon increasing the

295 comparing the gene expression between these two states, we identified several genes whose expression

296 tical solution where the model is reduced to two states while retaining important characteristics of

297 vealed that NTL9 folding is almost perfectly two-state, while small deviations from two-state behavio

298 s a curvature-induced phase transition among two states with varying protein density and membrane cur

299 hat the native folding pathway involves only two states, without evidence for partially folded interm

300 Oscillation between the two states would result in rapid Na(+)/H(+) antiport.