ライフサイエンスコーパス: two-step

1 xazin-4-ones in moderate yields (25-48% over two steps).

2 ective adenosine receptor antagonist in only two steps.

3 multilocus genotype is mapped to fitness in two steps.

4 of (+/-)-vindeburnol from tryptamine in only two steps.

5 )-binding domains were synthesized in one or two steps.

6 le network alignment algorithm that works in two steps.

7 etwork members of RS and LCS were traced for two steps.

8 The constant-infusion scan was quantified in two steps.

9 f functionalized 1,4-dioxenes is achieved in two steps.

10 ies in transfectable mammalian cell lines in two steps.

11 ivides formation of work or task groups into two steps.

12 into substituted [(18)F]fluoroarenes in just two steps.

13 single baculoviral expression vector in only two steps.

14 are converted into valuable heterocycles in two steps.

15 BM-Segphos complex as a catalyst following a two-step 1,3-dipolar cycloaddition/intramolecular alkyla

16 The proposed approach is composed of two steps: 1) a feature extraction step and 2) a statist

17 Our workflow consists of the following two steps: 1) the use of surface plasmon resonance to qu

18 The process was divided in two steps: a premiere chauffe and a bonne chauffe.

19 The sensitivity and specificity of the two-step algorithm compared to results with real-time PC

20 We developed and evaluated a two-step algorithm utilizing the multiple-antigen RDT to

21 The novel two-step algorithm, COMBI, first trains a support vector

22 n-proline have been synthesized via a direct two-step alkylation method.

23 This protocol has two steps: an aminocatalyzed addition of ketones to alky

24 e-associated microglia (DAM) that develop in two steps and may help to restrict damage in Alzheimer a

25 roblem by reducing the number of unknowns in two steps and thereby makes the overall process fast.

26 In this article, a facile two-step and one-pot synthetic route for the preparation

27 The two-step approach is not only powerful but also computat

28 This two-step approach leads to GO with a high yield (>70 wt

29 Most of them take the two-step approach of reconstructing the gene trees for m

30 Here we present a simple two-step approach that allows for the elusive overall tr

31 Here, we propose a two-step approach that combines nondestructive and quant

32 interaction in eczema was conducted using a two-step approach, which included as a first step, a bio

33 f the aldehyde precursors required a one-pot two-step approach, without isolation of the bicyclic ace

34 The proposed method is a two-step approach.

35 dentifying conserved co-regulated genes is a two-step approach.

36 This approach enables two-step assembly of a molecular 819 knot featuring eigh

37 Following our canonical two-step assembly protocol, polyU RNAs ranging in length

38 idering all available evidence, we propose a two-step assembly strategy for +ssRNA viruses: step I, a

39 A straightforward, two-step asymmetric synthesis of octahydroindoles has be

40 hedral macrotricyclic tetrathiacyclophane in two steps at an ambient temperature.

41 ta indicate a rapid, receptor-type-specific, two-step binding and activation process between GPCRs an

42 analyses of NMR spectroscopic data support a two-step binding mechanism in which a Pt(II) first rapid

43 Similarly, two-step binding processes detected by NMR are easily ca

44 This occurs in two steps: binding of monomeric DEP to Frizzled followed

45 Herein, we report the unprecedented two-step biosynthetic conversion of thiotetromycin to th

46 In this study, we describe a novel two-step biosynthetic route to obtain blastose, designed

47 s in moderate to high yields (up to 94% over two steps) by microwave-assisted copper- or palladium-ca

48 Our scheme is based on a two-step calculation in which a linear-response TDDFT ca

49 nal catalyst was created, that can perform a two-step cascade reaction.

50 A two-step catalytic mechanism was extrapolated: the catal

51 iling chromatids from the cleavage site in a two-step cell elongation and demonstrate the role of myo

52 onolayer-modified Si(100) electrodes using a two-step chemical procedure to preserve the open-shell s

53 thesis of uniform single-layer WS2 film by a two-step chemical vapor deposition (CVD) method followed

54 of mammalian MRPL12 that are generated by a two-step cleavage during import, involving efficient cle

55 tions, before and after vaccination, using a two-step clustering analysis of CyTOF data, which is sui

56 fferences in sequence identity between these two steps, complement known structural data, and suggest

57 We present a novel two-step computational approach for identification of ma

58 Von Willebrand factor is activated through a two-step conformational transition: first, elongation fr

59 ydrogenase and gluconate kinase catalyze the two-step conversion of glucose into the pentose phosphat

60 From a mechanistic viewpoint, a two-step coordination/proton transfer process for N-H ac

61 The approach of two-step database search for qualitative analysis and pr

62 aterial composing a given unknown mixture, a two-step database search strategy for bottom-up nanoscal

63 FA-PVSK films are processed via a two-step deposition process, known to provide high effic

64 The two-step diagnostic algorithm utilizing microscopy as a

65 Using a two-step diagnostic approach (IFA is performed if the EL

66 Here, we report a simple two-step differentiation protocol to generate kidney tub

67 everse gradients in copper vacancies using a two-step, diffusion-assisted spray pyrolysis process.

68 ysis reactions lead to 68% of walkers taking two steps directionally along a three-foothold track.

69 thymidine ethylphosphate, was synthesized in two steps directly from thymidine, via butenylation and

70 lated via a computational process based on a two-step discrete-time convolution procedure using empir

71 Herein we report a two-step electrochemical intercalation and oxidation app

72 sive silicates/silicon oxide precursors by a two-step electrodeposition process.

73 A two-step enzymatic approach to reduce immuno-reactivity

74 poallergenic milk protein products using the two-step enzymatic modification method involving thermol

75 ation (low temperature winterization), (iii) two-steps enzymatic esterification and (iv) triacylglyce

76 ession in obese offspring is determined by a two-step epigenetic inhibitory mechanism in which CpG me

77 A sample preparation method using a two-step extraction was developed for use with UV and/or

78 The two-step fabrication consists of printing a silver elect

79 Herein, the two-step fabrication of the first inkjet-printed sulfide

80 sate demanding computing, we also proposed a two-step fast screening algorithm for more efficient gen

81 The method consists of two steps, first, to determine the significance of each

82 projectiles and surface-adsorbed D atoms in two steps: first, the two atoms of the diatomic molecule

83 o construct the polymer model, we proceed in two steps: first, we introduce a minimal number of rando

84 sor genes in TNBC demonstrate the utility of two-step forward genetic screens in mice, and offer an i

85 Specifically, we have implemented a two-step fragmentation process in the inject flatapole d

86 ccess to complex chiral sulfoximines in only two steps from commercially available aldehydes.

87 variety of pyrrole-containing heterocyles in two steps from commercially available starting materials

88 are prepared in a straightforward manner in two steps from dimethyl squarate.

89 Q7R was synthesized in two steps from monofunctionalized azidobutyl-Q7 and NHS-

90 They were elaborated in two steps from vinorelbine 3 (VLN) by a modification of

91 Our objective was to establish a two-step generic protocol to modify defined amino acids

92 A two-step growth approach along with a gradual variation

93 Ws and NW density revealed the efficacy of a two-step growth temperature sequence (initiating the gro

94 In addition, a two-step hierarchical linear regression model showed tha

95 We applied a novel two-step hierarchical procedure to identify new genes im

96 etry responses are derived for two-electron, two-step homogeneous electrocatalytic reactions in the t

97 favor direct tunneling in prokaryotes and a two-step hopping mechanism in eukaryotes.

98 rst converted into 1,5-dicarbonyls through a two-step Hosomi-Sakurai allylation/oxidative cleavage se

99 uinone (TCBQ, p-chloranil), accompanied by a two-step hydrolytic dechlorination of highly toxic TCBQ

100 different aspect ratio were synthesized by a two-step hydrothermal method and the permittivity and en

101 han 5 nm) on Ti foil, has been obtained by a two-step hydrothermal synthesis method.

102 Twenty-three patients underwent a two-step hyperinsulinemic-euglycemic clamp (HEC) with gl

103 dry chemical device that still provides the two-step immunochemical interactions - formation of a co

104 the effectiveness and clinical outcomes of a two-step implementation of conservative oxygenation targ

105 gress kinetic analysis methodology suggested two steps in the catalytic cycle were involved as turnov

106 s) and detect peaks from the EICs, the first two steps in the data preprocessing workflow.

107 facilitate the consecutive reactions of the two-step indirect pathway of Cys-tRNA(Cys) synthesis (tR

108 In the latter two-step indirect pathway, a non-discriminating aspartyl

109 thesized by tRNA-dependent mechanism using a two-step indirect pathway, where O-phosphoseryl-tRNA syn

110 A two-step integrated protocol creates a more rapid autoin

111 Using 1 in a two-step integrated protocol yields a rapid, sensitive,

112 These two steps involve the decoration of titanium dioxide nan

113 These unique transporters are synthesized in two steps, irrespective of oligomer length, by the organ

114 ntly, even if the reaction is separated into two steps, it seems inconceivable to carry out such a ne

115 omplex was further reduced by dihydrogen via two steps; it reacted rapidly with H2 to give Cp*2Zr(OH)

116 n solid support from a protecting-group-free two-step iterative protocol, based on the inherent react

117 Collectively, these data indicate a two-step kinase activation process in which the IRAK4 ki

118 olecular dynamics simulations reveal a novel two-step kinetics due to hydrophobic mismatch, in which

119 Our results show that the two-step lipid-binding mechanism uncouples the membrane

120 metal-semiconductor junctions in MoTe2 in a two-step lithographic synthesis.

121 Cre-RMCE is functional in a two-step mechanism and with good efficiency in Ae. aegyp

122 We discuss a two-step mechanism for binding that involves diffusion a

123 binding to high-affinity spots, suggesting a two-step mechanism for SSB diffusion.

124 transition state complex, arguing against a two-step mechanism for TCR binding.

125 o early mammalian development and suggests a two-step mechanism in Cdx2 regulation.

126 op phosphorylation occurs via a noncanonical two-step mechanism in which 1) the cyclin-dependent kina

127 ons at single-molecule resolution revealed a two-step mechanism in which FtsY initially contacts memb

128 intercalator that binds DNA through a novel two-step mechanism in which the intermediate and final s

129 We show that NER initiation involves a two-step mechanism in which UvrA scans the genome and lo

130 path ECM depend on a previously undescribed two-step mechanism involving Hedgehog/Gli and unplugged/

131 These cytokines are produced by a two-step mechanism involving NF-kappaB-mediated pro-cyto

132 From the studies, we uncover a sequential, two-step mechanism of cellular reprogramming in which re

133 paused Pol II states, these data identify a two-step mechanism of Hox-driven transcription, with M1B

134 s polyubiquitin chain assembly by an ordered two-step mechanism requiring two dynamically linked E2 a

135 e common motor path are dependent on a novel two-step mechanism that determines axon decisions at a c

136 A two-step mechanism was elucidated through detailed kinet

137 nalization reactivity is rationalized from a two-step mechanism wherein each step occurs via maximal

138 d 6 nM), and both complexes bind through a two-step mechanism with a slow isomerization phase after

139 structural variant (SV) analyses revealed a two-step mechanism, a complex rearrangement followed by

140 of peroxide oxidations are rationalized by a two-step mechanism: Fe(III) + H2O2 --> Active catalyst (

141 ation processes, this reaction proceeds by a two-step mechanistic sequence involving initial in situ

142 We used a two-step Mendelian randomization approach to assess whet

143 The two-step meta-analysis did not reveal evidence of hetero

144 For this systematic review and one-step and two-step meta-analysis of individual participant data, w

145 Herein, we describe a novel two step method to construct gold-nanorod functionalized

146 idated on synthetic data and compared to the two-step method and several recent joint clustering meth

147 We develop a two-step method based on the combination of aminoarsine

148 danes is a key step in the developed one-pot two-step method for intermolecular para-selective C-H ar

149 This two-step method involves ligation of adjacent DNA oligon

150 nto isatoic anhydride by an unusually facile two-step method using tetrachloro-1,4-benzoquinone (TCBQ

151 Using a facile two-step method, CZTS nanoparticles were in situ grown o

152 yces cerevisiae SynXII was assembled using a two-step method, specified by successive megachunk integ

153 phitic carbon materials were subjected to a "two-step" microwave-assisted acid digestion procedure, a

154 A two-step model of cilia action accurately predicted the

155 In this study, we outline a two-step model of resistance whereby extrinsic microenvi

156 We exploited a two-step multienzymatic stereoselective cascade reductio

157 for countries without reported data using a two-step multiple imputation method.

158 omechanics of RBCs, and demonstrate that the two-step multiscale framework presented here can be used

159 hondrins were obtained from these ketones in two steps, namely desilylation and [5,5]-spiroketal form

160 rm differentiation of selves, comment on the two-step nature of our model, offer theoretical connecti

161 Two-step nucleation pathways in which disordered, amorph

162 f D46 side chain mechanistically couples the two steps of Hh cholesteroylation.

163 our results suggest that there are at least two steps of incorporation of alpha-synuclein monomers i

164 synthase-kinase (NAGS-K) catalyzes the first two steps of L-arginine biosynthesis.

165 ns have been attributed to decoupling of the two steps of nitrification by hypoxia; however, the wate

166 lot-scale nitrifying gas-biofilters, for the two steps of nitrification.

167 metabolize ethanol (EtOH) primarily through two steps of oxidative catabolism in which alcohol dehyd

168 hanging microdisks on a polymer film through two steps of photolithography.

169 ations are truncated, conducting only one or two steps of the pathway.

170 A two-step, on-water procedure for the synthesis of ethene

171 3-substituted pyrazoles can be performed via two-step one-pot procedure.

172 A two-step, one-flask reaction of pyrrole and pentafluorob

173 The discovery of reaction conditions for the two-step, one-flask synthesis of a phlorin provides easi

174 The reaction proceeds via a two-step, one-pot process and requires 2-8 mole % of 3,3

175 eous approach toward beta-lactams based on a two-step, one-pot protocol: an intramolecular ring closu

176 Drosophila melanogaster cellularization uses two steps, only one of which involves Myosin-2.

177 e proline utilization A (PutA) catalyzes the two-step oxidation of proline to glutamate using separat

178 f MIA, alpha-oxo MIA was likely formed via a two-step oxidation reaction.

179 By employing repeated two-step oxygen (O2) plasma treatment processes with 35

180 Most bacteria utilize a two-step pathway for the specific synthesis of aminoacyl

181 particles, crystallization instead follows a two-step pathway that begins with the creation of disord

182 Z-scheme systems based on two-step photoexcitation of a hydrogen evolution photoca

183 We propose a two-step pipeline to initially assess for a treatment ef

184 bonding step, an ion implantation step and a two-step post-annealing process.

185 Here, we have developed a two-component, two-step, pre-targeting drug delivery system integrated

186 The streamlined two steps preparation process of the capture platform re

187 Key transformations involve a two-step preparation of a functionalized dihydropyridin-

188 by a simpler structure and straightforward, two-step preparation.

189 An efficient two-step procedure "imine formation/azirine-carbenoid co

190 FA coupled 3LM were formulated in a two-step procedure and characterized regarding hydrodyna

191 Through the use of a two-step procedure consisting of a tandem alkene inserti

192 Herein, we present the one-pot two-step procedure for the synthesis of a set of pyrazol

193 n templates is generally carried out using a two-step procedure involving registering a population of

194 18)F]6b (KD = 12.3 nM) was radiolabeled by a two-step procedure using a microwave system with radioch

195 For this study, a two-step procedure was employed.

196 Using this two-step procedure we evaluated all rare variants in two

197 erexpressed in Escherichia coli, and using a two-step procedure, it was possible to isolate monomeric

198 rChiA modeling was performed by a two-step procedure, using the Swiss-Model server and Mod

199 In this study, a two-step process (i.e., precursor sputter deposition fol

200 Our results support a two-step process and Ostwald's rule of stages for the cr

201 The two-step process can be performed in one pot, making it

202 Here, we describe a two-step process determining removal of Gpr161 from cili

203 (TsCDIs) and -coronenediimides (TCDIs) by a two-step process from a perylenediimide (PDI) precursor.

204 robed-siRNAs can be synthesized by a simple two-step process from bulk materials.

205 The two-step process has been achieved at 1,300 degrees C/90

206 induce 5' end-dependent RNA degradation is a two-step process in E. coli involving gamma-phosphate re

207 y excitatory neurons are generated through a two-step process in which Pax6-expressing radial glial c

208 es via a convenient ultrasound (US)-assisted two-step process involving 3-selenenylation/sulfenylatio

209 ults show that strand photodissociation is a two-step process involving light-activated cis-trans iso

210 he iNKT-induced pathway appeared to entail a two-step process involving NF-kappaB signaling and IL1B

211 Nitrification is a two-step process linking the reduced and oxidized sides

212 y functional theory calculations to unveil a two-step process mediated by an orbital localized on the

213 This one-pot, two-step process occurs in minutes and enables the synth

214 as developed for the DM analyses involving a two-step process that first recovers the SM data and the

215 They require a two-step process that requires network motif identificat

216 gest that new agents should be marketed in a two-step process that would include first the approval o

217 A mild and facile two-step process was employed to convert the inkjet-prin

218 Here, we report a two-step process where a large design space is divided i

219 cellular extensions via a non-proliferative two-step process while retaining cellular plasticity.

220 ved that cYY binding to CYP121 proceeds in a two-step process, and EPR spectroscopy indicates that th

221 unds are obtained under mild conditions in a two-step process, in which the final C-C bond is formed

222 RTA interacts with the ribosome via a two-step process, which involves slow and fast interacti

223 sd-rxRNA cellular uptake is a two-step process, with rapid membrane association follow

224 acids caused a transition from a one-step to two-step process.

225 step process as well as the high-temperature two-step process.

226 nd sulfonamides, respectively, in a one-pot, two-step process.

227 e (MWCNTs) nanocomposite is fabricated via a two-step process.

228 of filtered sodium by CD cells occurs via a two-step process.

229 desired 3-sulfonated coumarins in a one-pot, two-step process.

230 ceraldehyde thus demonstrating a consecutive two-step process.

231 veals that the DAM program is activated in a two-step process.

232 ens to spread from the initial outbreak in a two-step process: first, the directly surrounding hospit

233 We find that Rsn-2 adsorption is in fact a two-step process: the hydrophobic N-terminal tail recrui

234 Their survival was modelled as a two-step process: the time from diagnosis to respiratory

235 ctural details that select for direct versus two-step processes is unknown.

236 erated, thus eliminating the need for costly two-step processing.

237 We developed a two-step protocol comprising a comparative metabolite pr

238 The applicability of our "two-step" protocol was further confirmed for a commercia

239 The sequence of the final two steps provided a handle to diversify the stereochemi

240 ractions by restriction enzyme targeting and two-step proximity ligation.

241 Kinetic studies of the two-step reaction revealed that the variants show a sign

242 -ion batteries, whose lithiation undergoes a two-step reaction, whereby intercalation and conversion

243 nial into the bicyclic iridoid scaffold in a two-step reduction-cyclization sequence.

244 ribosomal proteins is coordinated through a two-step response to stress that requires cross-talk bet

245 mic distances extracted from XAS data show a two-step response to the applied pressure; a gradual dec

246 ically disentangle these models, we design a two-step reward-based decision paradigm and implement it

247 To directly test this, we used a two-step reward-learning task which dissociates model-fr

248 -phenyl oxiranyl MIDA boronate (24) comprise two steps: ring opening of the epoxide to a carbocation

249 Here we show a two-step role for Smc5/6 in recruiting and activating Sg

250 uccessfully achieved in a mild and non-toxic two-step route.

251 of 2-aryl-3-sulfonylchromans is described by two-step routes: (i) NH4OAc mediated Knoevenagel condens

252 We model this behavior with a two-step saturation mechanism and identify specific micr

253 ed to a sulfo-NHS-activated biotinylation or two-step SEEL.

254 mutational studies, we here propose a novel "two-step self-oxidative modification" mechanism, during

255 with recombinant For t 2 proteins, using the two-step sensitization protocol reported previously.

256 The two step sequence is effective on complex pyridines, pha

257 The title compounds were prepared in a two-step sequence from 4,4-dimethoxybutyronitrile and th

258 styrene has been developed on the basis of a two-step sequence involving an enantioselective hydrobor

259 ty of biarylamines and was integrated into a two-step sequence which converted phenols into biarylami

260 zed diazatetracenes are prepared using a new two-step sequence.

261 s) premodified with MnO2 nanoparticles via a two-step sequential adsorption under careful temperature

262 The conjugates were prepared through a two-step sequential click approach with a combination of

263 a transposon mutagenesis strategy based on a two-step Sleeping Beauty (SB) forward genetic screen to

264 A two-step staining approach is used to detect antigen spe

265 ure describes annulation reactions in one or two steps starting from 5-aminoimidazole-4-carbonitriles

266 UO2(2+) cation occurs readily in a one-pot, two-step stoichiometric reaction at room temperature to

267 ge material because of its easy preparation, two-step storage mechanism and high specific capacity fo

268 udoternary (GeTe)1-2x(GeSe)x(GeS)x system by two-step strategies.

269 We report a two-step strategy for diverse hydrofunctionalizations of

270 We introduce herein a new two-step strategy for in situ anchoring and activation o

271 A diastereoselective two-step strategy for the synthesis of densely functiona

272 Here we introduce a two-step strategy to resolve the reconstruction problem,

273 A two-step strategy was conducted to take advantage of the

274 r thin film of bioactive molecules through a two-step stripping and recharging cycle.

275 A novel two-step surface modification method that includes atomi

276 on myosin heavy chain polymerization during two-step surimi gelation (different setting temperatures

277 We addressed this issue and report a mild, two-step synthesis of 2,2,4,4,4-pentafluoro-3,3-dihydrox

278 ntial of the method was demonstrated via the two-step synthesis of a trifluoromethylated analog of a

279 A high yielding and practical two-step synthesis of enantiomerically pure perfluorobut

280 We have developed a rapid two-step synthesis of substituted 3-azabicyclo[3.2.0]hep

281 A two-step synthesis sequence furnishes quadruply annulate

282 A two-step synthetic scheme is developed to allow control

283 A two-step synthetic strategy toward difluoromethyl ethers

284 of juxtaposed sites is only achieved through two-step targeting.

285 The two-step task allows distinguishing between these mechan

286 tional magnetic resonance imaging during the two-step task.

287 In a two-step teleconnection, sea-ice changes lead to reorgan

288 The basic two-step terminal differentiation model of the medullary

289 simulations suggest the formation occurs via two steps: the initial formation of a neutral hydrogen m

290 dependent inactivation of BU-1 expression in two steps: the loss of H3K4me3 and then subsequent DNA c

291 ficiency of metal oxides, such as ceria, for two-step thermochemical water splitting cycles.

292 es the thermodynamic efficiency of ceria for two-step thermochemical water splitting.

293 ion of different ferroelastic variants via a two-step, three-state ferroelastic switching process (ou

294 It utilizes two steps to estimate the conditional essentiality for e

295 the temperature sensors in TRPV1 activate in two steps to favor opening, and that the binding of sodi

296 t, which goes from the classical Cu-mediated two-step transport in this system to a direct coherent t

297 dro-1H-purin-1-amines 32-33 were obtained in two steps using formamide and hydrazine, respectively.

298 By one or two steps, we semisynthesized the six trace natural comp

299 protein identification yield, an additional two-step workflow is implemented to provide sufficient a

300 rmed strong non-flowable gels which showed a two-step yielding behavior during strain-sweep rheology,