ライフサイエンスコーパス: tylosin

1 d), 0.10mgkg(-1) (natamycin) and 2mugkg(-1) (tylosin).

2 trend was only statistically significant for tylosin.

3 ession and changes in response to the use of tylosin.

4 and enrofloxacin, and 97% were sensitive to tylosin.

5 lycone precursor of the macrolide antibiotic tylosin.

6 ne, and low susceptibility to lincomycin and tylosin.

7 nd in several macrolide antibiotics, such as tylosin and methymycin, respectively.

8 onfers resistance to erythromycin but not to tylosin and spiramycin.

9 zed by the cleavage of the mycarose sugar of tylosin and subsequent modification of 4'-hydroxyl group

10 f three major use antibiotics (trimethoprim, tylosin, and lincomycin) to algal and cyanobacterial spe

11 macrolide antibiotics (such as erythromycin, tylosin, and narbomycin) depend ultimately on the glycos

12 tibiotic feed additives such as monensin and tylosin are added to the finishing diets of feedlot catt

13 mycin binding but have the same affinity for tylosin as wild-type ribosomes.

14 r glycosyltransferase activities involved in tylosin biosynthesis were not affected.

15 onclude that TylP acts as a repressor during tylosin biosynthesis.

16 s its application with respect to industrial tylosin biosynthesis.

17 attachment to the polyketide lactone during tylosin biosynthesis.

18 ble transcription from multiple genes of the tylosin biosynthetic cluster.

19 es has led to the assignment of tylM1 in the tylosin biosynthetic gene cluster and desVI in the methy

20 , 2.2 kb of DNA from the tylLM region of the tylosin biosynthetic gene cluster of S. fradiae has been

21 The tylosin biosynthetic gene cluster of Streptomyces fradia

22 ified by sequence analysis at one end of the tylosin biosynthetic gene cluster of Streptomyces fradia

23 The tylLM region of the tylosin biosynthetic gene cluster of Streptomyces fradia

24 specific activator that controls most of the tylosin-biosynthetic (tyl) genes that are subject to reg

25 ncodes the pathway-specific activator of the tylosin-biosynthetic (tyl) genes.

26 Importantly, TylR is the key activator of tylosin-biosynthetic genes.

27 in, valnemulin, doxycycline, lincomycin, and tylosin by broth microdilution and that to carbadox by a

28 Continued synthesis of tylosin by the disrupted strains contrasts with other re

29 acity of Streptomyces fradiae (a producer of tylosin) by importing genes from the narbomycin producer

30 These genes can be transcribed (i.e. tylosin can be produced) in a tylS-KO strain by forcing

31 ualitative analyses of sequences showed that tylosin caused microbial population shifts in both abund

32 mined the fecal microbiome of pigs receiving tylosin compared with untreated pigs using pyrosequencin

33 ze the microbiome of pigs receiving one AGP, tylosin, compared with untreated pigs.

34 Tylosin contributed most to the risk followed by lincomy

35 determination of sorbic acid, natamycin and tylosin in Dulce de leche, a traditional South American

36 ueous concentrations of chlortetracyline and tylosin in runoff decreased in consecutive rainfall even

37 nal PKS modules that produce the 16-membered tylosin macrocycle, using them as biocatalysts in the ch

38 emonstrated that L22 Lys90Trp ribosomes bind tylosin more readily than erythromycin in vivo.

39 housing pigs that were fed chlortetracyline, tylosin or bacitracin and were land applied via broadcas

40 ork, the biosynthesis of d-mycaminose in the tylosin pathway of Streptomyces fradiae was investigated

41 t TylP binds a macrolide intermediate in the tylosin pathway.

42 ion of the ole PKS loading module, or of the tylosin PKS loading module, for the erythromycin (ery) l

43 Some macrolides (such as tylosin) possess multiple sugar moieties, whereas others

44 (RT-PCR) suggests that tylS is essential for tylosin production and controls the expression of tylR (

45 is approach through the rapid improvement of tylosin production from Streptomyces fradiae.

46 Control of tylosin production in Streptomyces fradiae features inte

47 Tylosin production in Streptomyces fradiae is regulated

48 These genes all control tylosin production in Streptomyces fradiae.

49 Tylosin production levels were elevated when tylS or (es

50 Under the latter conditions, tylosin production was brought forward and enhanced, whe

51 se product is shown here to be important for tylosin production.

52 respective contributions of TylS and TylT to tylosin production.

53 S, a transcriptional activator essential for tylosin production.

54 In contrast, tylT is not essential for tylosin production.

55 ncode the synthesis or addition of all three tylosin sugars, plus polyketide ring oxidation, and at l

56 rt a second copy of the tylF gene to improve tylosin (Ty) production.

57 The macrolide antibiotic, tylosin (Ty), is produced by Streptomyces fradiae.

58 oup of tylactone, the polyketide aglycone of tylosin (Ty).

59 Although tylosin was not detected in any sample, a high rate of n

60 omycin, apramycin, tiamulin, tilmicosin, and tylosin were tested by broth microdilution against vario

61 me resulted in the production of demycinosyl-tylosin, whereas other glycosyltransferase activities in

62 els of the commercially important antibiotic tylosin, with TylP occupying the top of this cascading n

63 Thus, targeted disruption of tylU reduced tylosin yields by about 80% and bioconversion analysis w