ライフサイエンスコーパス: type I collagen

1 al propeptide, and C-terminal telopeptide of type I collagen).

2 usable vessels in a bioremodelable hydrogel (type I collagen).

3 synthesis, and facilitating cell adhesion to type I collagen.

4 er GFP mice, we find that fibrocytes express type I collagen.

5 hat fibrocytes are not a necessary source of type I collagen.

6 re required for efficient internalization of type I collagen.

7 NF-alpha), RAGE, periostin, fibronectin, and type I collagen.

8 h Fam20C was inactivated in cells expressing Type I collagen.

9 FKBP19 seems to interact with triple helical type I collagen.

10 ars of age stimulates fibroblasts to produce type I collagen.

11 and was further increased after adhesion to type I collagen.

12 tin, SNAIL1, SNAIL2, and the alpha2 chain of type I collagen.

13 ion of Syk activity restored MK migration on type I collagen.

14 e the production and spatial organization of type I collagen.

15 ast tumor cell line, MDA-MB-231, embedded in type I collagen.

16 cifically inhibits their capacity to degrade type I collagen.

17 ration and reduced accumulation of fibrillar type I collagen.

18 pancreatic cancer cells in three-dimensional type I collagen.

19 matrix via the upregulation of the gene for Type I Collagen.

20 profile of 3D tissues embedded within native type I collagen.

21 d the LH3 function as glucosyltransferase in type I collagen.

22 cancer cell scattering in three-dimensional type I collagen.

23 ilize integrins to attach and proliferate on type I collagen.

24 l fibroblasts led to increased expression of type I collagen.

25 serum beta C-terminal telopeptide (B-CTx) of type I collagen.

26 cise co-localization of CNA-35 micelles with type I collagen.

27 nced fibrotic reaction composed primarily of type I collagen.

28 nflammation, angiogenesis, and production of type I collagen.

29 of CUX1 results in effective suppression of type I collagen.

30 ration-suppressive properties of polymerized type I collagen.

31 ed GGT but not GT activity against denatured type I collagen.

32 he phosphorylation of PDGFR and synthesis of type I collagen.

33 as alpha smooth muscle actin (alpha-SMA) and type I collagen.

34 iaminopentane (DAP), spermine, and fibrillar type I collagen.

35 induced fibrosis by epigenetic modulation of type I collagen.

36 5 prefers to interact with Hsp47 rather than type I collagen.

37 p.G736D) substitution in the alpha1 chain of type I collagen.

38 nsistent with decreased proband secretion of type I collagen.

39 alities in the structure and/or synthesis of type I collagen.

40 anslation of collagen mRNAs and synthesis of type I collagen.

41 lity and in vitro proteolytic degradation of type I collagen.

42 ly349Cys substitution in the alpha1 chain of type I collagen.

43 s by secreting mesenchymal proteins, such as type I collagen.

44 nectin (FN) and block interaction of FN with type I collagen.

45 s or solid spiky masses when plated in 3D in type-I collagen.

46 e, where little 3-hydroxylation was found in type I collagen, 3-hydroxylation of type I collagen in a

47 inary N-terminal cross-linked telopeptide of type I collagen: 48.2 +/- 2.9 compared with 38.9 +/- 0.9

48 Our data reveal that type I collagen accumulation in shear-activated PTECs is

49 ail1, Twist1, alpha-smooth muscle actin, and type I collagen accumulation.

50 of PDL osteoblastic differentiation markers: type I collagen, alkaline phosphatase, and osteocalcin.

51 In this article, we show that the type I collagen allows PDAC cells to override checkpoint

52 , the multilayered cells express Osterix and Type I collagen alpha, resulting in generation of mature

53 ver, mature osteoblast-related expression of type I collagen alpha1 and osteocalcin was reduced in bo

54 pproximately 90% direct sequence coverage of type I collagen alpha1- and alpha2-chains, representing

55 chondral bone were determined by MicroCT and type I collagen alpha1/alpha2 ratio was determined by SD

56 lant with recombinant resistin increased the Type I collagen alpha1/alpha2 ratio.

57 ce/bone volume ratio, and an increase in the Type I collagen alpha1/alpha2, compared to normal-weight

58 f intron 36 of the Col1a1 gene, encoding the type I collagen, alpha1 chain, was responsible for the p

59 tegrin beta1 (ITGB1) subunits, as well as by type I collagen (an integrin alpha2beta1 ligand).

60 0 secretion increased by 90% with binding to type I collagen and 55% with fibronectin, whereas MMP-7

61 hesion to and aggregation induced by soluble type I collagen and a delayed onset to low dose fibrilla

62 gh levels of type II collagen as compared to type I collagen and absence of Mmp-9 in the cartilage of

63 nalysis indicated that FIZZ2 could stimulate type I collagen and alpha-smooth muscle actin expression

64 19b was confirmed by decreased expression of type I collagen and by blocking TGF-beta-induced express

65 blasts, correlating with increased levels of type I collagen and c-Abl protein.

66 gen biosynthesis, which retards secretion of type I collagen and causes excessive posttranslational m

67 rkably long half-life, matrix proteins, like type I collagen and elastin, are preferential targets.

68 Adhesion to type I collagen and fibronectin by Mycobacterium tubercu

69 em mass spectrometry) showed increased renal type I collagen and fibronectin protein abundance result

70 extracellular matrix proteins, specifically type I collagen and fibronectin.

71 ockdown had impaired TGF-beta stimulation of type I collagen and fibronectin.

72 ymorphs by itself, when bound to immobilized type I collagen and on demineralized collagen wafers.

73 1), (2) significantly promoted production of type I collagen and other extracellular molecules (p < 0

74 re characterized by the expression of alpha1 type I collagen and PDGFRbeta, produce erythropoietin th

75 cosylate galactosylhydroxylysine residues in type I collagen and that an impairment of this LH3 funct

76 Channel catfish skin collagens were typical type I collagens and could have applications in food, me

77 gulation of its downstream ECM genes such as type I collagens and proteoglycans such as fibromodulin

78 em, we provide evidence that TRIP-1 binds to Type-I collagen and can promote mineralization.

79 Tissues from sclera and cornea (type I collagen) and lens capsule (type IV collagen) wer

80 PINP, PIIINP, and C-terminal telopeptide of type I collagen) and right heart catheterization.

81 CTX (C-terminal crosslinking telopeptide of type I collagen) and TRACP-5b (tartrate-resistant acid p

82 lagen type I, carboxyterminal telopeptide of type I collagen, and aminoterminal propeptide of procoll

83 up-regulation of alpha-smooth muscle actin, type I collagen, and fibronectin expression.

84 scular endothelial growth factor, periostin, Type I collagen, and fibronectin were also evaluated.

85 They also exhibited increased adhesion on type I collagen, and hyperresponsive CRP and CLEC-2-indu

86 rgely suppressed expression of alpha-SMA and type I collagen, and reduced the deposition of extracell

87 rosine-phosphorylated proteins and levels of type I collagen, and scavenged ROS in SSc fibroblasts.

88 a1 integrin in contact with dermal fibrillar type I collagen, and the activity of MMP-1 is required f

89 owth factor-beta (TGF-beta) is an inducer of type I collagen, and uncontrolled collagen production le

90 on of alpha-smooth muscle actin (alpha-SMA), type I collagen, and VE-cadherin expression, and the exp

91 Fibrils of type I collagen are formed by the packing of polypeptide

92 g the expression of Bcl-xL, whereas those on type I collagen are not.

93 ll surface HA coat impaired cell adhesion to type I collagen, as indicated by recovery of adhesion fo

94 Type-I collagen assembles in a stepwise, hierarchic fash

95 s suggest that amide I NLO chiral effects in type I collagen assemblies arise predominantly from the

96 kines and profibrogenic mediators (TIMP1 and type I collagen) at the transcriptional level.

97 ight into how LECs negotiate an interstitial type I collagen barrier and reveal an unexpected MMP2-dr

98 Fibrillar type I collagen-based hydrogels are commonly used in tis

99 her levels of carboxyterminal telopeptide of type I collagen (beta=0.22, P<0.001) and aminoterminal p

100 f the alpha2beta1 integrin, one of the major type I collagen-binding receptors in mammalian cells.

101 in, is associated with reduced expression of type I collagen both in vivo and in vitro.

102 and alphaVbeta3 blockade markedly decreased type I collagen breakdown, and impaired both monocyte ad

103 dominant bone dysplasia caused by defects in type I collagen, but in the past 10 years discoveries of

104 c cancer cells have been shown to respond to type I collagen by becoming more motile and invasive.

105 sm regulates the synthesis of heterotrimeric type I collagen by coordinating the translation of colla

106 g growth factor beta1-mediated expression of type I collagen by inhibiting Twist, a prominent mesench

107 ose dependently inhibited the degradation of type I collagen by P. gingivalis.

108 sidues/1000 residues) and were identified as type-I collagens by FTIR, SDS-PAGE, and molecular weight

109 Finally, absence of the type I collagen C-propeptidase bone morphogenetic protei

110 e sex, high levels of bone resorption (serum type I collagen C-telopeptide), low hip bone mineral den

111 The included characteristics sex, serum type I collagen C-telopeptide, hip bone mineral density,

112 Excessive deposition of type I collagen causes fibrotic diseases.

113 cid compositions of rat skin and tail tendon type I collagen chains indeed showed 3-4 residues of 3Hy

114 droxylation at multiple substrate sites from type I collagen chains was high in sclera, similar to te

115 neralized tissue-associated genes, including Type I collagen (COL I), runt-related transcription fact

116 Recent studies indicate that type I collagen (COL) is important in the development of

117 Raman spectra from as-prepared type I collagen (Col-I) and Ag-NP-coated Col-I fibers on

118 eta1, tumor necrosis factor (TNF)-alpha, and type I collagen (Col-I) expression, and promoted the pro

119 reporter protein (EGFP) under control of the type I collagen (Col-I) promoter (COL-EGFP) had green st

120 MC), resulted in increased protein levels of type I collagen (Col-I).

121 ultures of mouse hepatocytes were exposed to type I collagen (COL1); cell injury was assessed by morp

122 ic factors Alpha-Actin-2 (ACTA2) and Alpha-1 Type I Collagen (COL1A1) in HSCs.

123 th altered subchondral bone architecture and type I collagen composition.

124 Type I collagen-containing fibrils are major structural

125 scratch wound assay, cell number count, and type I collagen contraction assay were used to examine t

126 onger detectable, but the structural protein type I collagen could be used to differentiate all four

127 SDS-PAGE was performed on type I collagen cross-linked in the absence and presence

128 Outcome measures were type I collagen crosslinked beta C-telopeptide (betaCTX)

129 P) and C-terminal crosslinked telopeptide of type I collagen (CTX) derived from matrix-metalloprotein

130 increase in serum C-terminal telopeptide of type I collagen (CTX) was completely reversed by ES.

131 bone resorption (C-terminal telopeptides of type I collagen (CTX)) and bone formation (procollagen t

132 resorption marker C-telopeptide fragments of type I collagen (CTX), elevated osteoclastogenesis, and

133 the bone resorption marker C-telopeptide of type I collagen (CTX-1) were observed.

134 pe I procollagen (PINP) and C-telopeptide of type I collagen (CTX-I) are markers of bone formation an

135 Production of type I collagen declines during aging, leading to skin t

136 ere most cases are due to autosomal dominant type I collagen defects, while rare, mostly recessive, f

137 findings provide a mechanistic paradigm for type I collagen degradation by MMP1 and establish a gene

138 oposed as an important direct contributor of type I collagen deposition during fibrosis based largely

139 increased glycosylation of hydroxylysine in type I collagen disturbs the lateral growth of the fibri

140 How structural mutations of type I collagen (dominant OI) or of its post-translation

141 ckout fibroblasts produce reduced amounts of type I collagen due to decreased stability of collagen a

142 inding sequence could lead to degradation of type I collagen, early embryonic lethality, and the scar

143 ) and Ser(203) in MFAP4 as being crucial for type I collagen, elastin, and tropoelastin binding.

144 Further, type I collagen enhanced the motility of Braf(V600E)/Pte

145 ion and cell invasion in a three-dimensional type I collagen environment.

146 ng with a gadolinium-based probe targeted to type I collagen (EP-3533) to image and quantify fibrosis

147 actor beta1 (TGFbeta1) induced alpha-SMA and type I collagen expression and inhibited VE-cadherin.

148 r-kappaB (NF-kappaB) transcription factor on type I collagen expression in adult normal human (ANF) a

149 in-1) and Sp3, acting as trans-activators of type I collagen expression in ANF and SF.

150 -costimulated SSc lymphocytes induced higher type I collagen expression in fibroblasts, which was par

151 To assess the role of the stem-loop in type I collagen expression in vivo, we generated a knock

152 ia from TNFR-costimulated T lymphocytes, and type I collagen expression was quantified.

153 ype III collagen expression or a decrease in type I collagen expression were confirmed.

154 stimulation of alpha-smooth muscle actin and type I collagen expression, indicative of myofibroblast

155 pression of dominant-negative desmin reduces type I collagen expression, primarily due to decreased s

156 their translation and is necessary for high type I collagen expression.

157 ts with renal fibrosis resulted in increased type I collagen expression.

158 a decrease in aggrecan, versican, CCN2, and type I collagen expression.

159 onstrate that shortly following contact with type I collagen extracellular signal-regulated kinase (E

160 Type I collagen extracted from bone of P3H1 null mice sh

161 Type I collagen extracted from different tissues showed

162 of the A3 site in both alpha-chains, whereas type I collagen extracted from tendon of P3H1 null mice

163 Type I collagen extracted from tendon, skin, and bone of

164 Mouse tail type I collagen fibers were incubated with either catK o

165 ng as a fibronectin-independent mechanism of type I collagen fibrillogenesis following adult liver in

166 Here, we investigate type I collagen fibrillogenesis using confocal rheology-

167 t of this LH3 function significantly affects type I collagen fibrillogenesis.

168 Type I collagen fibrils are the primary components of te

169 erminal domains resulted in fragmentation of type I collagen fibrils in a three-dimensional collagen

170 Accumulation of type I collagen fibrils in tumors is associated with an

171 d by fragmentation and reduced production of type I collagen fibrils that provide strength to skin.

172 The ECM consists mostly of type I collagen fibrils, which are produced by fibroblas

173 ermal extracellular matrix with GAG bound to type I collagen fibrils.

174 lution tracking of individual MMPs degrading type I collagen fibrils.

175 train K279a also promoted the degradation of type I collagen, fibrinogen, and fibronectin in a predom

176 cell carcinoma stroma, CCN2-regulated genes type I collagen, fibronectin, and alpha-smooth muscle ac

177 g vascular endothelial growth factor (VEGF), type I collagen, fibronectin, and periostin.

178 nd from cholesteric liquid crystal-like (LC) type I collagen films.

179 molecules involved in tissue repair, such as type I collagen, FN, and periostin.

180 dings, Cyp2j4(-/-) rats show upregulation of type I collagen following unilateral ureter obstruction

181 alpha1alpha2alpha1, alpha2alpha1alpha1) of a type I collagen fragment (the binding region for the von

182 Although type I collagen functions as a barrier to invasion, panc

183 Type I collagen gels are routinely used in biophysical s

184 transgenic system to specifically delete the type I collagen gene across a broad population of hemato

185 r, fibrocytes with confirmed deletion of the type I collagen gene have readily detectable intracellul

186 MRTF-A transactivated type I collagen gene reporters as much as 100-fold in lu

187 tocytes and the epigenetic regulation of the type I collagen gene.

188 In contrast, in zebrafish three type I collagen genes exist, col1a1a, col1a1b and col1a2

189 Transcriptional mechanisms regulating type I collagen genes expression in physiopathological s

190 ave heterozygous mutations in one of the two type I collagen genes, COL1A1 and COL1A2.

191 t could benefit even those with mutations in type I collagen genes.

192 Although an alteration in type I collagen glycosylation has been implicated in sev

193 ls of alpha-smooth muscle actin (alpha-SMA), type I collagen, heat shock protein-47 (HSP-47), fibrone

194 for efficient production and folding of the type I collagen heterotrimer.

195 oreover, TGF-beta1 induced the production of type I collagen, HSP-47, FN, and periostin.

196 In vitro polymerized type I collagen hydrogels have been used extensively as

197 lysis identified five glycosylation sites in type I collagen (i.e. alpha1,2-87, alpha1,2-174, and alp

198 cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and C-terminal crosslinked telope

199 and serum pyridinoline-crosslink fragment of type I collagen (ICTP; bone-resorption biomarker) were a

200 inary N-terminal cross-linked telopeptide of type I collagen in a 1999-2002 subset with available dat

201 tate cancer cell adhesion to fibronectin and type I collagen in a FAK-dependent manner, correlating w

202 However, the biosynthesis of type I collagen in affected horse fibroblasts shows a de

203 found in type I collagen, 3-hydroxylation of type I collagen in affected horses is normal.

204 revealed tissue disorganization and reduced type I collagen in bgn(-/0)fmod(-/-) TMJ subchondral bon

205 electrophoresis of in vitro cross-linking of type I collagen in solution, in the presence and absence

206 ent pericellular collagenase that can cleave type I collagen in vitro.

207 sponse demonstrated collagen-rich matrix (by type I collagen), incorporating the device components wi

208 de evidence that GRP-78 can bind to DMP1 and type I collagen independent of each other in a simulated

209 n gene have readily detectable intracellular type I collagen indicating that uptake of collagen from

210 Fibrosis with excessive amounts of type I collagen is a hallmark of many solid tumours, and

211 Normal type I collagen is a heterotrimer triple-helical molecul

212 Type I collagen is a heterotrimeric extracellular matrix

213 The A1 site (Pro-986) in the alpha1-chain of type I collagen is almost completely 3-hydroxylated in e

214 hese results demonstrate that the A1 site in type I collagen is exclusively 3-hydroxylated by P3H1, a

215 Fibrillar type I collagen is the major organic component in bone,

216 Type I collagen is the most abundant protein in the huma

217 Type I collagen is the predominant collagen in mature te

218 that the mechanism by which CUX1 suppresses type I collagen is through interfering with gene transcr

219 n that alpha2beta1 integrin, the receptor of type I collagen, is the major collagen-binding integrin

220 t inactivation of Fam20C in cells expressing type I collagen led to skeletal defects and hypophosphat

221 othelin-1, troponin I, and C-telopeptide for type I collagen levels, suggesting more severe neurohumo

222 re plated within standard bovine or rat tail type I collagen matrices (2.5 mg/mL), compressed collage

223 Primary cultures of HGFs were grown on Type I collagen matrices previously treated with MGO.

224 l as in modulating cellular invasion through type I collagen matrices.

225 ontrolling the microstructure and density of type I collagen matrices.

226 eutics incorporated into the self-assembling type I collagen matrix described here can be delivered n

227 in cell expressing actin-eGFP cultured in a type I collagen matrix, the laser was orbited around the

228 oliferation, migration, and cell adhesion on type I collagen matrix.

229 ificant increase in the expression of alpha1 type I collagen, matrix metalloprotease-1, and platelet-

230 ular mechanism that enables us to switch off type I collagen may prove beneficial in treating fibrosi

231 Sponges of bioabsorbable type I collagen membrane were exposed to papain based ge

232 IMP-2 and -3 transcript levels but inhibited type I collagen, MMP 1 and TIMP 1 mRNA levels.

233 To elucidate the function of LH3 in bone type I collagen modifications, we used a short hairpin R

234 occurs at the specific molecular loci in the type I collagen molecule and plays critical roles in con

235 rtant role of the 5' stem-loop in regulating type I collagen mRNA and protein expression and provide

236 imperfecta (OI) is a bone disease caused by type I collagen mutations and characterized by bone frag

237 sociated with preservation of the myocardial type I collagen network as a consequence of the decrease

238 Organized type I collagen networks in TGF-betaIIR knockout livers

239 at the nonlinear stiffening of reconstituted type I collagen networks is controlled by the applied st

240 Moreover, the type I collagen of Crtap(-/-) mice shows reduced binding

241 s of the distribution of 3-hydroxyproline in type I collagen of rat bone, skin, and tail tendon by ma

242 py targeted at epithelial cell production of type I collagen offers a novel pathway for abrogating th

243 as to investigate the use of self-assembling type I collagen oligomers as an injectable therapeutic d

244 We study the mechanics of type I collagen on the scale of tens to hundreds of micr

245 ted adhesion of human platelets to monomeric type I collagen or to the GFOGER peptide caused a time-d

246 important protease responsible for degrading type I collagen, osteopontin, and other bone matrix prot

247 modification, we characterized and compared type I collagen phenotypes produced by Sh clones and two

248 onstrated that inhibition of DDR1 binding to type I collagen, preserving the engagement of the other

249 matic increase in the uncleaved precursor of type I collagen (procollagen I) and a reduction in denti

250 show by inducible genetic fate mapping that type I collagen-producing submesothelial fibroblasts are

251 indicate a TGF-beta-independent mechanism of type I collagen production and suggest connective tissue

252 le actin expression, F-actin expression, and type I collagen production in fibroblasts.

253 attenuated histamine-induced cell growth and type I collagen production.

254 Here, we show that hypoxia increases type I collagen prolyl-4-hydroxylase [C-P4H(I)], which l

255 As fibrillar type I collagen promotes pro-matrix metalloproteinase 2

256 as well as HSCs; intracellular and secreted type I collagen protein levels also decreased.

257 e bone matrix that is also distinct from the type I collagen-related form of OI.

258 via a four amino acid stretch (analogous to type I collagen residues 782-785).

259 ive carcinoma cells gain permanent access to type I collagen-rich interstitial tissues, an experiment

260 tures provide a new mechanism of adhesion to type I collagen-rich tissues that does not rely on hydro

261 When a six-triplet human type I collagen sequence containing GFPGER was introduce

262 ns that is dominated by polymeric fibrils of type I collagen, serves as the mechanical scaffold on wh

263 bitor, b-AP15, reduced the expression of FN, type I collagen, Smad2/Smad3, and the deposition of coll

264 Type-I collagen suspensions demonstrated a strong, negat

265 IL-34-Mphi and M-CSF-Mphi induce type I collagen synthesis by HSCs, the main collagen-pro

266 l modifications of LARP6 and how they affect type I collagen synthesis have not been studied.

267 luble endoglin limits TGFbeta1 signaling and type I collagen synthesis in cardiac fibroblasts and fur

268 in lung fibroblasts significantly disrupted type I collagen synthesis relative to controls.

269 ultures to histamine favored cell growth and type I collagen synthesis via the activation of H1 recep

270 uses elongation of fibroblasts, coupled with type I collagen synthesis, which is dependent on the TGF

271 regulates cell survival, proliferation, and type I collagen synthesis.

272 g matrix metalloproteinase 1 and suppressing type I collagen synthesis.

273 These experiments revealed that type I collagen synthesized by mutant cells had decrease

274 In comparison with controls, type I collagen synthesized by Sh clones (Sh collagen) s

275 n, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe,

276 ate cells (HSCs) are the major source of the type I collagen that accumulates in the damaged tissue.

277 rstitial matrix mainly composed of fibrillar type I collagen, the interactions occurring between lymp

278 The synthesis of type I collagen, the main component of bone matrix, prec

279 In addition to not binding to type I collagen, the R1R2.FN complex incorporated less e

280 olvement in the regulation of MK motility on type I collagen through a mechanism based on the activit

281 l contribution of hematopoietic cell-derived type I collagen to fibrogenesis, we use a double-transge

282 Previously, we showed that ER CRT regulates type I collagen transcript, trafficking, secretion, and

283 egulator of TGF-beta and potent inhibitor of type I collagen transcription.

284 Given that ARCN1 deficiency causes defective type I collagen transport, reduction of collagen secreti

285 sential repeating tripeptide sequence of the type I collagen triple helix results in the dominant her

286 ger residue in the repeating sequence of the type I collagen triple helix, lead to the hereditary bon

287 collagen, and type X collagen, but not with type I collagen, type II collagen, or type V collagen.

288 On a larger scale, deformations in Type I collagen vary with a periodicity consistent with

289 s and dentin depends on the self-assembly of type I collagen via the Gly-X-Y motif, the molecular mec

290 NLO) chiral effects in the amide I region of type I collagen was investigated using sum-frequency gen

291 reduction in total hydrolysis of elastin and type I collagen was measured compared with computational

292 Furthermore, type I collagen was preserved from hydrolysis when a 10-

293 cross-linked carboxyterminal telopeptide of type I collagen were also significantly reduced in the C

294 lasma cross-linked C-terminal telopeptide of type I collagen were reduced by >/= 50% in 57% of evalua

295 Levels of ROS and type I collagen were significantly higher and amounts of

296 The homotrimeric isoform of type I collagen, which consists of three alpha-1 chains,

297 X1 expression lead to aberrant expression of type I collagen, which may provide a molecular basis for

298 rly osteogenic marker genes, ALP, Runx2, and type I collagen, which play a critical role in MSC to os

299 Ovarian cortex biopsies were embedded in type I collagen with or without VEGF111 addition before

300 for unfolding regions of the alpha2 chain of type-I collagen within the context of the microfibril.