ライフサイエンスコーパス: type II keratin

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1 rved phosphorylation site of most if not all type II keratins.

2 increased to 54, including 28 type I and 26 type II keratins.

3 increased to 54, including 28 type I and 26 type II keratins.

4 We identified type II keratin 5, lamin A, the cytoplasmic domain of in

5 The type II keratin 6 (K6) features a complex expression pat

6 he type I keratin 16 (Krt16) and its partner type II keratin 6 (Krt6a, Krt6b) cause pachyonychia cong

7 The type II keratin 6 and type I keratins 16 and 17 are indu

8 The type II keratins 6a and 6b (K6a and K6b) are among the g

9 t of the K8 S73 motif (LLS/TPL) is unique to type II keratins and is conserved in epidermal K5/K6, es

10 at Lys-207, a highly conserved residue among type II keratins and other IFs, is up-regulated upon hyp

11 ay assays, the amino terminal head domain of type II keratins appears to have a special importance in

12 gulate K16 with robust downregulation of its type II keratin binding partner, K6.

13 oocytes revealed the presence of type I and type II keratins, but no other stoichiometrically associ

14 A major subset involves the type II keratin chains keratin 1, 2e, 5, or 6 crosslinke

15 Both diseases have been linked to the type II keratin cluster on chromosome 12q.

16 riginally diagnosed as EHK and mapped to the type II keratin cluster on chromosome 12q.

17 These genes have been localized to the type II keratin cluster on chromosome 12q13 by fluoresce

18 0-nm filaments, but involves specific type I-type II keratin complementarity.

19 e, we report that mice lacking all type I or type II keratins display severe barrier defects and frag

20 Type I and type II keratins form the heteropolymeric intermediate f

21 a differentiation-specific set of type I and type II keratins forming a stable network and are major

22 rms stable heterotetramers with a variety of type II keratins, further accentuating the unique nature

23 Linkage analyses mapped the defect to this type II keratin gene (peak logarithm of odds score at ph

24 gh their analysis of mice lacking the entire type II keratin gene cluster.

25 ge to chromosome 12q12-q14.1, containing the type II keratin gene cluster.

26 K3 was mapped to the type-II keratin gene cluster on 12q; and K12 to the type

27 is 9.1 kb long and located in the cluster of type II keratin genes on mouse chromosome 15, between th

28 rties of suspensions of epidermal type I and type II keratin IFs and of vimentin, a type III IF polym

29 The major type II keratin in "simple type" glandular epithelia is

30 served lysine residue on the head domains of type II keratins in the supramolecular organization of k

31 Here we show that suprabasal type II keratins, K1 and K2, are expressed in a mutually

32 Overexpression of the type-II keratin K8 up-regulated type-I keratins K18, K19

33 locus on 17q was excluded and linkage to the type II keratin locus on 12q was obtained (Z max 3.31 at

34 rine 73 occurs within a relatively conserved type II keratin motif ((68)NQSLLSPL) and becomes phospho

35 In conclusion, type II keratins of proliferating epithelia undergo phos

36 heterotetramers with either K5 or K6 as the type II keratin pairing partner.

37 follicles, we find keratin 16 along with its type II keratin partner keratin 6 in the companion layer

38 en K5 and K6, and not among any of the other type II keratins, Pro-24 is in the nonhelical head domai

39 Keratin 6hf is a type II keratin recently shown to occur in the companion

40 s, but not when lysates translated type I or type II keratin RNAs alone.

41 These type II keratins show a complex regulation with constitu

42 in an ATP-independent manner when type I and type II keratin translation reactions were mixed.

43 e Ser-23 of K8 is highly conserved among all type II keratins, we also examined if the corresponding

44 tokeratin 19, fibronectin, and hair-specific type II keratin, which have previously been shown to be

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