ライフサイエンスコーパス: type IV secretion system

1 e delivered to the host cytosol by a Dot/Icm type IV secretion system.

2 ce factors including flagellar genes and the type IV secretion system.

3 termed virB1 through virB12, which encode a type IV secretion system.

4 teins are translocated into plant cells by a type IV secretion system.

5 in regulating expression of the virB-encoded type IV secretion system.

6 into the host cell by the pathogen's Dot/Icm type IV secretion system.

7 he Cag pathogenicity island, which encodes a type IV secretion system.

8 of AtlA in order to examine its role in the type IV secretion system.

9 ch is believed to be mediated by the Dot/Icm type IV secretion system.

10 ial proteins into host cells via the Dot/Icm type IV secretion system.

11 into the invaded host cell by the bacterial type IV secretion system.

12 a triggers an identical response through its type IV secretion system.

13 mid DNA for transit into the recipient via a type IV secretion system.

14 VipD is translocated into host cells via the type IV secretion system.

15 components of the Agrobacterium tumefaciens type IV secretion system.

16 , a process that is dependent on the Dot/Icm type IV secretion system.

17 f LL-37/hCAP18 production required an intact type IV secretion system.

18 nslocated into the host cell via the Dot/Icm type IV secretion system.

19 ilm formation, nutrient acquisition, and the type IV secretion system.

20 cter hepaticus and components of a potential type IV secretion system.

21 eption of plant signals or the assembly of a type IV secretion system.

22 in dotA and dotB, encoding components of the Type IV secretion system.

23 encoded proteins in DNA secretion by a novel type IV secretion system.

24 first such chaperone linked to the presumed type IV secretion system.

25 recruited for transport by a plasmid-encoded type IV secretion system.

26 eins into the host cell requires the Dot/Icm type IV secretion system.

27 o peptidoglycan transglycosylases from other type IV secretion systems.

28 issible and possess suites of genes encoding type IV secretion systems.

29 esicle traffic, which is a novel function of type IV secretion systems.

30 -kb resident plasmid that showed homology to type IV secretion systems.

31 in the operon and has homology to NTPases of type IV secretion systems.

32 s similarity to structural pilin subunits of type IV secretion systems.

33 family encompassing all putative NTPases of type IV secretion systems.

34 show some level of homology to components of type IV secretion systems.

35 ed, one of which may be distantly related to type IV secretion systems.

36 or pilus biogenesis and protein transport in type IV secretion systems.

37 uisition of virulence factors that include a type IV secretion system, a perosamine-based O antigen,

38 nded DNA (ssDNA) and Vir proteins requires a type IV secretion system, a protein complex spanning the

39 pneumophila virulence, including type II and type IV secretion systems, a pore-forming toxin, type IV

40 ne additional gene encoding a component of a type IV secretion system, an ortholog of Cj0041 from the

41 umber of genes, including those encoding the type IV secretion system and flagella.

42 ctor protein that is secreted by the Dot/Icm type IV secretion system and interferes with the caspase

43 wStr expresses 15 Vir proteins of a Type IV secretion system and its transcriptional regulat

44 Aggregation Substance, PrgC) and the Prg/Pcf type IV secretion system and, in turn, conjugatively tra

45 on of the conserved conjugation machinery (a type IV secretion system), and the potential to transfer

46 ized to assess the roles of urease, the VirB type IV secretion system, and lipopolysaccharide for est

47 t five iron uptake mechanisms, two potential type IV secretion systems, and 16 two-component regulato

48 her, these data suggest a model in which the type IV secretion system apparatus is made constitutivel

49 the icm/dot system and components of the lvh type IV secretion system are able to interact with one a

50 effector molecule CagA into host cells via a type IV secretion system are associated with more severe

51 at the presence of flagellin and a competent type IV secretion system are critical for Legionella to

52 and plasmid-encoded components of a putative type IV secretion system are likely to be significant in

53 Type IV secretion systems are secretion nanomachines spa

54 Four different type IV secretion systems are variously represented in t

55 Type IV secretion systems are virulence determinants in

56 11 genes (lvh ) homologous to genes of other type IV secretion systems, arranged in a similar manner.

57 L, a pilus protein component of the H pylori type IV secretion system, binds to the integrin alpha(5)

58 In this classification system, type II and type IV secretion systems both possess members of a supe

59 acter pylori (Hp) strains that carry the cag type IV secretion system (cag-T4SS) to inject the cytoto

60 e human pathogen Coxiella burnetii encodes a type IV secretion system called Dot/Icm that is essentia

61 the infection process, L. pneumophila uses a type IV secretion system called Dot/Icm to translocate b

62 apid and required bacteria with a functional type IV secretion system called Dot/Icm.

63 m, the cag pathogenicity island, and another type IV secretion system called tfs3.

64 BMEI 1330, a DegP/HtrA protease; BMEII 0029, type IV secretion system component VirB5; and BMEII 0691

65 xin of Bordetella pertussis is secreted by a type IV secretion system comprised of the products of th

66 (ssDNA) is exported from the bacteria via a type IV secretion system comprised of VirB1 through VirB

67 This type IV secretion system contains 11 genes (lvh ) homolo

68 ocytes and that a functional plasmid-encoded type IV secretion system contributes to the survival and

69 We investigated the bacterial type IV secretion system core complex (T4SScc) by cellul

70 ot protein, DotL, has sequence similarity to type IV secretion system coupling proteins (T4CPs).

71 a neotomaein vitro model system for study of type IV secretion system-dependent (T4SS) pathogenesis i

72 ellular destruction by restricting fusion of type IV secretion system-dependent Brucella-containing v

73 cuole requires the function of the bacterial type IV secretion system (Dot/Icm), which transfers prot

74 are delivered into host cells by the Dot/Icm type IV secretion system during infection.

75 us, which induces ER stress by injecting the type IV secretion system effector protein VceC into host

76 Similar to other secretion systems, the Cag type IV secretion system elaborates a surface filament s

77 Although a type IV secretion system encoded by the defect in organe

78 e use electron microscopy to reconstruct the type IV secretion system encoded by the Escherichia coli

79 A type IV secretion system encoded by the virB operon and

80 The type IV secretion system encoded by the virB operon is r

81 es occurs as a result of the activities of a type IV secretion system encoded by the virB operon.

82 e related to genes from other members of the type IV secretion system family.

83 st cells by bacterial pathogens that utilize type IV secretion systems for pathogenesis.

84 The type IV secretion system gene cluster of Neisseria gonor

85 We made mutations in six putative type IV secretion system genes and assayed these strains

86 at truncated CagA and eliminated some of the type IV secretion system genes.

87 on apparatus, the molecular mechanism of the type IV secretion system has proved difficult to dissect

88 Type IV secretion systems have been demonstrated to be i

89 We show that the role of the Dot/Icm type IV secretion system in the induction of apoptosis i

90 e investigated the role of a plasmid-encoded type IV secretion system in the intracellular survival,

91 ucing ability, suggesting a role for the cag type IV secretion system in the stimulation of dendritic

92 ATPases are hexameric assemblies that power type IV secretion systems in bacteria.

93 Helicobacter pylori type IV secretion system injects the oncoprotein CagA in

94 in the CagA protein, which is injected by a type IV secretion system into host cells.

95 ber of effector proteins through its Dot/Icm type IV secretion system into the host cell cytosol.

96 ide a conformational change which drives the type IV secretion system into the host cell for delivery

97 es and whose action is influenced by a novel type IV secretion system involved in bacterial adhesion;

98 and pXFAS01 encode homologues of a complete Type IV secretion system involved in conjugation and DNA

99 The type IV secretion system is an important virulence facto

100 A type IV secretion system is central to the pathogenicity

101 The Agrobacterium tumefaciens VirB/VirD4 type IV secretion system is composed of a translocation

102 The most thoroughly studied type IV secretion system is encoded by the virB operon o

103 specialized vacuole except that the Icm/Dot type IV secretion system is essential for its formation

104 The Dot/Icm type IV secretion system is essential for pulmonary apop

105 ange are not understood, although a putative type IV secretion system is present in the genome sequen

106 the first time that a protein substrate of a type IV secretion system is recruited to a member of the

107 hat in strain K56-2, the plasmid-encoded Ptw type IV secretion system is responsible for the secretio

108 The type IV secretion system is up-regulated during infectio

109 ase in the host is completely dependent on a type IV secretion system known as the Dot/Icm complex.

110 uter membrane of Bordetella pertussis by the type IV secretion system known as the Ptl transporter, w

111 ) is secreted from Bordetella pertussis by a type IV secretion system, known as the Ptl transporter,

112 ters, like those for type III effectors, the type IV secretion system, lipopolysaccharide synthesis,

113 unique regulation of gene expression for the type IV secretion system may be associated with intracel

114 The Ptl type IV secretion system mediates secretion of assembled

115 Both a wild-type strain (K56-2) and its type IV secretion system mutant (designated LC101) enter

116 fic VirB11 ATPase of the Helicobacter pylori type IV secretion system (named HP0525), and proposed th

117 a provide the first example of the role of a type IV secretion system of a bacterial pathogen in the

118 The vir-type IV secretion system of Agrobacterium is assembled f

119 hird system that is most similar to the VirB type IV secretion system of Bartonella henselae.

120 ral ankyrin repeat proteins secreted via the type IV secretion system of different intracellular bact

121 The type IV secretion system of Helicobacter pylori consists

122 The cag-pathogenicity-island-encoded type IV secretion system of Helicobacter pylori function

123 The Dot/Icm type IV secretion system of Legionella pneumophila injec

124 The Dot/Icm type IV secretion system of Legionella pneumophila trans

125 cretion apparatus in Brucella belongs to the type IV secretion systems present in many pathogenic bac

126 tated in the A. marginale genome and include type IV secretion system proteins, elongation factor Tu,

127 red genomic island and encodes homologues of type IV secretion system proteins.

128 The L. pneumophila type IV secretion system provided only pore-forming acti

129 ag proteins required for activity of the cag type IV secretion system, putative lipoproteins, and oth

130 Type IV secretion systems require peptidoglycan lytic tr

131 The Neisseria gonorrhoeae type IV secretion system secretes chromosomal DNA that a

132 The gonococcal type IV secretion system secretes DNA during growth.

133 Seven virB2 paralogs (of the bacterial type IV secretion system) showed human or tick cell depe

134 des nine conserved RAGEs that include F-like type IV secretion systems similar to that of the tra gen

135 tics of the canonical L. pneumophila Dot/Icm type IV secretion system: sodium sensitivity, LAMP-1 eva

136 included interruptions in virB encoding the type IV secretion system (T4SS) (n = 36) and in vjbR enc

137 The cag PAI contains genes encoding a type IV secretion system (T4SS) and a delivered effector

138 n host cell interactions through the Icm/Dot type IV secretion system (T4SS) and approximately 300 di

139 aled that PFPs could be distinguished by the type IV secretion system (T4SS) encoded and separated in

140 Legionella pneumophila utilizes a type IV secretion system (T4SS) encoded by 26 dot/icm ge

141 any bacterial pathogens require a functional type IV secretion system (T4SS) for virulence.

142 This bacterium harbors a type IV secretion system (T4SS) highly similar to the Do

143 n isogenic virB mutant deficient in the VirB type IV secretion system (T4SS) in knockout mice.

144 en partially characterized, and it encodes a type IV secretion system (T4SS) involved in DNA release.

145 The Dot/Icm type IV secretion system (T4SS) of Legionella pneumophil

146 kinases that are translocated by the Dot/Icm type IV secretion system (T4SS) of several Legionella pn

147 The type IV secretion system (T4SS) of the plant intracellul

148 The Type IV secretion system (T4SS) plays an important role

149 The organism encodes a Dot/Icm type IV secretion system (T4SS) predicted to deliver to

150 eraction data for a set of virulence related Type IV secretion system (T4SS) proteins revealed over 2

151 over 20 antigenic proteins, including three type IV secretion system (T4SS) proteins, VirB9-1, VirB9

152 prg and pcf genes of plasmid pCF10 encode a type IV secretion system (T4SS) required for conjugative

153 Pathogenic strains of H. pylori carry a type IV secretion system (T4SS) responsible for the inje

154 tem (T1SS) substrate, and pertussis toxin, a type IV secretion system (T4SS) substrate, are briefly d

155 he cag pathogenicity island, which encodes a type IV secretion system (T4SS) that injects the CagA on

156 kb gonococcal genetic island (GGI) encodes a type IV secretion system (T4SS) that is found in most st

157 e genes, orf12 (virB12) and orf13, encodes a type IV secretion system (T4SS) that is required for int

158 ic cag pathogenicity island, which encodes a type IV secretion system (T4SS) that translocates a pro-

159 The pathogen uses a Dot/Icm type IV secretion system (T4SS) to deliver effector prot

160 intracellular bacterial pathogens that use a type IV secretion system (T4SS) to escape host defenses

161 olar macrophages, C. burnetii uses a Dot/Icm type IV secretion system (T4SS) to generate a phagolysos

162 Our goal is to target the conserved type IV secretion system (T4SS) to identify conserved, i

163 ogen Legionella pneumophila uses the Dot/Icm type IV secretion system (T4SS) to replicate inside host

164 Neisseria gonorrhoeae uses a type IV secretion system (T4SS) to secrete chromosomal D

165 Neisseria gonorrhoeae uses a type IV secretion system (T4SS) to secrete chromosomal D

166 Agrobacterium tumefaciens uses a type IV secretion system (T4SS) to transfer T-DNA and vi

167 permissive host cells by employing a Dot/Icm type IV secretion system (T4SS) to translocate effector

168 ionnaires' disease, uses its dot/icm-encoded type IV secretion system (T4SS) to translocate effector

169 The Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS) translocates DNA and pro

170 otein VirB10 of the Agrobacterium VirB/VirD4 type IV secretion system (T4SS) undergoes a structural t

171 A and protein substrates between cells via a type IV secretion system (T4SS) whose channel subunits i

172 kely translocated into the host cytosol by a type IV secretion system (T4SS) with homology to the Dot

173 Using the Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS), a relative of the conju

174 The Brucella abortus type IV secretion system (T4SS), encoded by the virB gen

175 nside host cells by Brucella spp. requires a type IV secretion system (T4SS), encoded by the virB loc

176 The Brucella abortus type IV secretion system (T4SS), encoded by the virB ope

177 city island (cag+), which encodes CagA and a type IV secretion system (T4SS), induce more severe dise

178 The Brucella abortus virB operon, encoding a type IV secretion system (T4SS), is required for intrace

179 nce of L. pneumophila depends on its Dot/Icm type IV secretion system (T4SS), which delivers more tha

180 ecretion systems, in particular, the Dot/Icm type IV secretion system (T4SS), which is essential to e

181 eins via a specific virulence (vir) -induced type IV secretion system (T4SS).

182 mbrane proteins, two-component systems and a type IV secretion system (T4SS).

183 dent on the presence of a functional dot/icm type IV secretion system (T4SS).

184 A into the extracellular environment using a type IV secretion system (T4SS).

185 presses the elaboration of the H. pylori cag type IV secretion system (T4SS).

186 totic activity which depends on a functional type IV secretion system (T4SS).

187 es that are dependent on activity of the cag type IV secretion system (T4SS).

188 ins into its host cell cytosol via a Dot/Icm type IV secretion system (T4SS).

189 s via its cag pathogenicity island (cag PAI) type IV secretion system (T4SS).

190 jor H. pylori pathogenicity determinant, the type IV secretion system (T4SS).

191 cterium whose virulence phenotypes require a type IV secretion system (T4SS).

192 complex" during biogenesis of the VirB/VirD4 type IV secretion system (T4SS).

193 n with effectors translocated by the Dot/Icm type IV secretion system (T4SS).

194 n is required for assembly of the VirB/VirD4 type IV secretion system (T4SS).

195 red recent attention from researchers is the type IV secretion system (T4SS).

196 Thus far, well studied conjugative type IV secretion systems (T4SS) are of Gram-negative (G

197 Type IV secretion systems (T4SS) are utilized by a wide

198 Numerous bacterial pathogens use type IV secretion systems (T4SS) to deliver virulence fa

199 Bacteria use type IV secretion systems (T4SS) to translocate DNA (T-D

200 Bacteria use type IV secretion systems (T4SS) to translocate DNA and

201 Bacteria use type IV secretion systems (T4SS) to translocate macromol

202 Type IV secretion systems (T4SSs) are commonly used secr

203 Type IV secretion systems (T4SSs) are important virulenc

204 Type IV secretion systems (T4SSs) are large multisubunit

205 an (PG) hydrolases associated with bacterial type IV secretion systems (T4SSs) are thought to generat

206 Type IV secretion systems (T4SSs) are used by various ba

207 Gram-negative bacteria use type IV secretion systems (T4SSs) for a variety of macro

208 Type IV secretion systems (T4SSs) mediate horizontal gen

209 jugative transfer of mobile DNA elements via type IV secretion systems (T4SSs) to bacterial or eukary

210 Gram-negative type IV secretion systems (T4SSs) transfer proteins and

211 volutionarily conserved transporters, called type IV secretion systems (T4SSs).

212 rom one bacterium to another, is mediated by type IV secretion systems (T4SSs).

213 tiplication/defect in organelle trafficking) type IV secretion system targets the bacterial-derived M

214 Both of these responses are mediated by the type IV secretion system (TFSS) encoded by the cag patho

215 Among the newly described proteins were the type IV secretion system (TFSS) proteins VirB9, VirB10,

216 ated into gastric epithelial cells through a type IV secretion system (TFSS), and published studies s

217 revealed the presence of genes homologous to type IV secretion systems (TFSS) that have subsequently

218 s were all identified as hallmarks of F-like type IV secretion systems (TFSSs), with no homologues am

219 ed gene (cag) pathogenicity island encodes a type IV secretion system that delivers the bacterial eff

220 We describe here a Legionella pneumophila type IV secretion system that is distinct from the previ

221 The VirB transporter is a type IV secretion system that mediates the genetic trans

222 Neisseria gonorrhoeae produces a type IV secretion system that secretes chromosomal DNA.

223 The cag PAI encodes a type IV secretion system that translocates CagA into gas

224 que vacuole depends on the bacterial Dot/Icm type IV secretion system that translocates proteins acro

225 pertoire includes activation of type III and type IV secretion systems that inject effector molecules

226 nd DotU do not appear to be part of the core type IV secretion system, these proteins are necessary f

227 rgB (aggregation substance) and PrgC - and a type IV secretion system through which the plasmid is de

228 Legionella pneumophila uses a type IV secretion system to deliver effector molecules i

229 ella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cell

230 Agrobacterium tumefaciens uses a type IV secretion system to deliver oncogenic nucleoprot

231 vironment for replication and uses a Dot/Icm type IV secretion system to generate the large PV.

232 ges, replicates intracellularly, utilizing a type IV secretion system to subvert the trafficking of L

233 ncluding Legionella pneumophila, rely on the type IV secretion system to translocate a repertoire of

234 ila replicates within macrophages by using a type IV secretion system to translocate bacterial effect

235 ive agent of Legionnaire's disease, uses its type IV secretion system to translocate over 300 effecto

236 use conjugation systems, a subfamily of the type IV secretion systems, to transfer DNA to recipient

237 Bacterial type IV secretion systems translocate virulence factors

238 septic resistance; degradation of chemicals; type IV secretion systems; two-component signaling syste

239 includes ATPases from bacterial type II and type IV secretion systems, type IV pilus, and archaeal f

240 putative large membrane complex that forms a type IV secretion system used to alter the endocytic pat

241 Finally, we determined that bacterial type IV secretion system VirB and live, but not heat-kil

242 The bacterium Brucella abortus uses a type IV secretion system (VirB T4SS) to generate a repli

243 ove-described findings were dependent on the type IV secretion system (VirB) and the secreted BPE005

244 ing selection, the cagY component of the Cag type IV secretion system was mutated, disrupting a key i

245 Since IbpA is not secreted by type III or type IV secretion systems, we determined whether DR2/Fic

246 ri strains and that mutants with a defective type IV secretion system were unable to cause EGFR up-re

247 ject into gastric epithelial cells through a type IV secretion system where it can cause gastric aden

248 A second chromosomally encoded type IV secretion system with complete homology to the V

249 ne end of a cluster of genes that encode the type IV secretion system, yet both icmF and dotU lack or