ライフサイエンスコーパス: typhoid fever

1 ellin-deficient mutants of Salmonella causes typhoid fever.

2 monella enterica serovar Typhi, the cause of typhoid fever.

3 phoid fever and has been used as a model for typhoid fever.

4 of diseases ranging from gastroenteritis to typhoid fever.

5 epatitis A and B, tuberculosis, malaria, and typhoid fever.

6 e commercial kits for serologic diagnosis of typhoid fever.

7 cause systemic infection in mouse models of typhoid fever.

8 ht play an important role in protection from typhoid fever.

9 train Ty2, a human-specific pathogen causing typhoid fever.

10 ey factor influencing host susceptibility to typhoid fever.

11 ly step in the infectious process leading to typhoid fever.

12 was also depressed during the acute stage of typhoid fever.

13 y protective immune responses against murine typhoid fever.

14 cted enteric fever, of whom 89 had confirmed typhoid fever.

15 is a human-restricted pathogen which causes typhoid fever.

16 ritis, and is used as a mouse model of human typhoid fever.

17 ny NRAMP1 variants were at increased risk of typhoid fever.

18 in mice and confer protection against murine typhoid fever.

19 ca serovar Typhi causes the systemic disease typhoid fever.

20 TR carriers may have increased resistance to typhoid fever.

21 terica serovar Typhi, the etiologic agent of typhoid fever.

22 athogen that causes the murine equivalent of typhoid fever.

23 re effective as live vaccines against murine typhoid fever.

24 ve little or no effect in the mouse model of typhoid fever.

25 ouse intestine and the development of murine typhoid fever.

26 heterozygotes may decrease susceptibility to typhoid fever.

27 manifestations ranging from enterocolitis to typhoid fever.

28 liver is commonly involved in patients with typhoid fever.

29 rapeutic and prevention strategies to combat typhoid fever.

30 ca serovar Typhi is the etiological agent of typhoid fever.

31 nce factor of Salmonella Typhi, the cause of typhoid fever.

32 tryptophan metabolism in the pathogenesis of typhoid fever.

33 itulates in an animal model many symptoms of typhoid fever.

34 ing live attenuated vaccines for measles and typhoid fever.

35 nd may help the development of therapies for typhoid fever.

36 i is an exclusive human pathogen that causes typhoid fever.

37 systemic infections like gastroenteritis and typhoid fever.

38 potentially life-saving therapeutics against typhoid fever.

39 life-threatening systemic infection known as typhoid fever.

40 to protect against S. sonnei shigellosis and typhoid fever.

41 of mice that models acute and chronic human typhoid fever.

42 ic agent of human gastroenteritis and murine typhoid fever.

43 nduce many of the symptoms characteristic of typhoid fever.

44 hemophagocytes in a natural model of murine typhoid fever.

45 cimens from 30 patients were consistent with typhoid fever.

46 fication of correlates of protection against typhoid fever.

47 and devise strategies for the prevention of typhoid fever.

48 human infections including enterocolitis and typhoid fever.

49 Salmonella Typhi is the cause of typhoid fever, a disease that has challenged humans thro

50 serovar Typhi can infect only humans causing typhoid fever, a life-threatening systemic disease.

51 yphi (S. typhi) is the aetiological agent of typhoid fever, a serious invasive bacterial disease of h

52 cines provide significant protection against typhoid fever, albeit by distinct immune mechanisms.

53 s with neurologic findings, determined to be typhoid fever, along the Malawi-Mozambique border.

54 Ag from Salmonella typhi can protect against typhoid fever, although the mechanism for its efficacy i

55 vada Health District detected an outbreak of typhoid fever among persons who had not recently travell

56 yphi causes an estimated 22 million cases of typhoid fever and 216 000 deaths annually worldwide.

57 January through 30 June 1997, 8901 cases of typhoid fever and 95 associated deaths were reported in

58 VD 908-htrA as a single-dose vaccine against typhoid fever and as a possible live vector for oral del

59 s the potential to reduce both the burden of typhoid fever and associated health inequality.

60 Individuals with blood culture-confirmed typhoid fever and control subjects from 2 distinct geogr

61 lts in an enteric fever that resembles human typhoid fever and has been used as a model for typhoid f

62 Patients with blood-culture-confirmed typhoid fever and healthy control subjects were genotype

63 INTERPRETATION: Typhoid fever and iNTS disease are major causes of invas

64 Typhoid fever and iNTS disease incidences were corrected

65 measure the adjusted incidence estimates of typhoid fever and invasive non-typhoidal salmonella (iNT

66 h Salmonella typhimurium provides models for typhoid fever and long-lasting protective immunity confe

67 fies a genetic association in humans between typhoid fever and MHC class II and III genes.

68 Typhoid fever and nontyphoidal bacteremia caused by Salm

69 ence of S. typhimurium in the mouse model of typhoid fever and proposed that FlgM is required to modu

70 Reporting of individual cases of typhoid fever and subtyping of isolates by PFGE resulted

71 cation of sensitive and specific markers for typhoid fever and technology to manufacture practical an

72 city limits the ability to recognize endemic typhoid fever and to detect outbreaks.

73 for causing an estimated 27 million cases of typhoid fever annually, leading to 217,000 deaths, and c

74 Vaccines for cholera and typhoid fever are available, and new vaccines are in var

75 Current serological diagnostic assays for typhoid fever are based on detecting antibodies against

76 n Salmonella Typhi, the bacteria that causes Typhoid fever, are now challenging this view.

77 protecting against S. sonnei shigellosis and typhoid fever, as compared with the current Ty21a vaccin

78 s in humans but have been used as models for typhoid fever because these organisms cause a disease in

79 ican sentinel sites with previous reports of typhoid fever: Burkina Faso (two sites), Ethiopia, Ghana

80 typhoid fever in patients who have clinical typhoid fever but are culture negative or in regions whe

81 a selective advantage in the mouse model of typhoid fever but have no such advantage in invasion of

82 almonella enterica serovar Typhi can lead to typhoid fever, but this serovar does not typically cause

83 d the ability of the mutants to cause murine typhoid fever by an oral route of infection.

84 National surveillance for typhoid fever can inform prevention and treatment recomm

85 We report a typhoid fever case with a Salmonella enterica serovar Ty

86 onella Typhi) causes an estimated 22 million typhoid fever cases and 216 000 deaths annually worldwid

87 In Blantyre, Malawi, a dramatic increase in typhoid fever cases has recently occurred, and may be li

88 plore hypotheses for the increased number of typhoid fever cases in Blantyre, we fit a mathematical m

89 munogenic vaccine that significantly reduces typhoid fever cases when assessed using a stringent cont

90 Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enteri

91 m in mice resembles the acute phase of human typhoid fever caused by Salmonella typhi, and experiment

92 Because typhoid fever-causing Salmonella have no known environme

93 e gastrointestinal illness, bloody diarrhea, typhoid fever, cholera, hepatitis, and deaths of childre

94 ory properties in serum of participants with typhoid fever confirmed the activity of this pathway, an

95 acity for detection is critical to improving typhoid fever control.

96 Here we investigate whether typhoid fever could be one such disease.

97 fewer households with >/=1 reported case of typhoid fever (cumulative incidence ratio [CIR] = 0.58,

98 to improve water pressure, the incidence of typhoid fever declined dramatically.

99 individuals as well as from 9 patients with typhoid fever did not show any amplification with the pr

100 1977 to 1986, Chile experienced an important typhoid fever epidemic, despite statistics that indicate

101 var Typhi (S. Typhi), the causative agent of typhoid fever, exhibits limited DNA sequence variation,

102 erica serotype Typhi, the causative agent of typhoid fever, expression of the Vi capsular antigen red

103 Although typhoid fever has been intensively studied, chronic typh

104 ver a century, a correlate of protection for typhoid fever has yet to be identified.

105 la enterica, the cause of food poisoning and typhoid fever, has evolved sophisticated mechanisms to m

106 appropriate empirical therapy for suspected typhoid fever; however, resistance may be anticipated.

107 s in 10.3%, urinary tract infection in 5.9%, typhoid fever in 3.7%, skin or mucosal infection in 1.5%

108 vel manifests as increased susceptibility to typhoid fever in a Vietnamese population.

109 ng blood culture, to populations at risk for typhoid fever in Africa will improve outbreak detection,

110 hi, reproduces many of the acute symptoms of typhoid fever in an animal model.

111 An outbreak of typhoid fever in Florida involving at least 16 persons d

112 s also implicated in a 1998-1999 outbreak of typhoid fever in Florida.

113 thogen Salmonella Typhi (6,7) , the cause of typhoid fever in humans (8-12) .

114 terica serovar Typhi, the causative agent of typhoid fever in humans, forms biofilms encapsulated by

115 has been studied extensively as a model for typhoid fever in humans.

116 is an established model system for studying typhoid fever in humans.

117 ileum and subsequently disseminates to cause typhoid fever in humans.

118 phoid-like disease in mice and is a model of typhoid fever in humans.

119 use food- and waterborne gastroenteritis and typhoid fever in humans.

120 of Salmonella typhi, a licensed vaccine for typhoid fever in individuals > or = 5 years old, induces

121 The AIR of iNTS and typhoid fever in individuals younger than 15 years old w

122 Salmonella serotypes which cause typhoid fever in mice have been shown to target the gut-

123 e tests could be of use for the diagnosis of typhoid fever in patients who have clinical typhoid feve

124 he human homologue, NRAMP1, in resistance to typhoid fever in southern Vietnam.

125 st response of 29 individuals who contracted typhoid fever in the Mekong Delta region of Vietnam.

126 Typhoid fever in the United States has increasingly been

127 ort a large laboratory-confirmed outbreak of typhoid fever in Uganda with a high proportion of intest

128 Typhoid fever in United States is often associated with

129 ican countries are now thought to experience typhoid fever incidence >100 per 100,000 per year with a

130 Estimated typhoid fever incidence in the community survey was 8092

131 children in low-income households and lower typhoid fever incidence, suggesting that intermittently

132 We found that typhoid fever induced a distinct and highly reproducible

133 la enterica, the cause of food poisoning and typhoid fever, induces actin cytoskeleton rearrangements

134 a, the causative agent of food poisoning and typhoid fever, induces programmed cell death in macropha

135 Typhoid fever is a life-threatening disease, but little

136 ich result in self-limiting gastroenteritis, typhoid fever is a life-threatening systemic disease.

137 Typhoid fever is a major global health problem, the cont

138 Typhoid fever is a significant cause of morbidity and mo

139 tant S. Typhi strains among US patients with typhoid fever is associated with travel to the Indian su

140 Typhoid fever is common in developing countries.

141 typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural res

142 Currently, the laboratory diagnosis of typhoid fever is dependent upon either the isolation of

143 ar Typhi have been reported in regions where typhoid fever is endemic.

144 a strong indication that the pathogenesis of typhoid fever is fundamentally different from that of ba

145 Salmonella Typhi, the causative agent of typhoid fever, is a monophyletic, human-restricted bacte

146 Salmonella typhi, the etiologic agent of typhoid fever, is adapted to the human host and unable t

147 Typhi (S. Typhi), the aetiological agent of typhoid fever, is an exclusively human pathogen.

148 monella enterica serovar Typhi, the cause of typhoid fever, is host-adapted to humans and unable to c

149 phi, a human obligatory pathogen that causes typhoid fever, is normally unable to infect mice.

150 ible for a wide variety of diseases, such as typhoid fever, large-scale food-borne illnesses, dysente

151 which allows for intrahost dissemination and typhoid fever (low host mortality).

152 s typhoid and malaria epidemics suggest that typhoid fever might activate P vivax hypnozoites.

153 Protection against typhoid fever might be best achieved by a vaccine that s

154 In the murine typhoid fever model, Deltanth/nei was fivefold attenuate

155 ibute to the virulence of the bacterium in a typhoid fever-mouse model, based on results from strains

156 Few instances of typhoid fever (n = 8), acute HIV infection (n = 5), and

157 ospitalizations, 249 IPs, and 47 deaths from typhoid fever occurred; Salmonella Typhi was isolated fr

158 lassic study by Austin Flint of a waterborne typhoid fever outbreak in North Boston in 1843.

159 This typhoid fever outbreak was detected because of an elevat

160 included in the review deal with additional typhoid fever outbreaks, tuberculosis, breast cancer, an

161 te, an important but underresearched area of typhoid fever pathogenesis.

162 of neutrophils in intestinal infiltrates of typhoid fever patients is due to a capsule-mediated redu

163 hils are scarce in intestinal infiltrates of typhoid fever patients.

164 to improvements in therapeutic treatment of typhoid fever patients.

165 common travel-related diseases (eg, malaria, typhoid fever, pneumonia, and meningococcemia) may resul

166 ica serotype Typhi, the etiological agent of typhoid fever, produces the Vi capsular antigen, a virul

167 nce factor of Salmonella Typhi (the cause of typhoid fever), recapitulates in an animal model many sy

168 Control of typhoid fever relies on clinical information, diagnosis,

169 Laboratory diagnosis of typhoid fever requires isolation and identification of S

170 , we demonstrate that the causative agent of typhoid fever, Salmonella enterica serovar Typhi, can pa

171 Typhoid fever seen in the United States was multidrug re

172 that have been drawn from the mouse model of typhoid fever should be interpreted conservatively.

173 how VAC14 regulates Salmonella invasion and typhoid fever susceptibility and may open doors to new p

174 complex (MHC) class II and class III loci on typhoid fever susceptibility was investigated.

175 as identified between the NRAMP1 alleles and typhoid fever susceptibility.

176 ulence factor that can reproduce most of the typhoid fever symptoms in experimental animals.

177 ted blood was found to be lower during acute typhoid fever than after a course of antimicrobial thera

178 In acute typhoid fever, the ability of peripheral blood leukocyte

179 s of assays that included the mouse model of typhoid fever, the mouse macrophage survival assay, an i

180 we demonstrate that, in adult patients with typhoid fever, the sensitivity of a serological test bas

181 vaccines in use in humans to protect against typhoid fever, there are none that prevent enterocolitis

182 nfection in mice is often used as a model of typhoid fever, these findings suggest that, at least in

183 -308].DRB1*04) or predisposed individuals to typhoid fever (TNFA*2 [-308].DRB1*0301) were determined.

184 rain (Ty800) was tested as a live attenuated typhoid fever vaccine in human volunteers.

185 A suspected case of typhoid fever was defined as fever and abdominal pain in

186 c, and their usefulness for the diagnosis of typhoid fever was evaluated.

187 or parasitic infection other than malaria or typhoid fever was found in 13.3% of children, nasopharyn

188 ride (LPS) of whole blood from patients with typhoid fever was investigated.

189 high, especially among newborn infants, but typhoid fever was uncommon.

190 from patients with the clinical symptoms of typhoid fever were also investigated.

191 ifty-four outbreaks of domestically acquired typhoid fever were reported between 1960 and 1999.

192 -308) were associated with susceptibility to typhoid fever, whereas HLA-DRB1*04, HLA-DQB1*0401/2, and

193 sseminated febrile illness in humans, termed typhoid fever, while Salmonella enterica serovar Typhimu

194 sera from 74 volunteers without a history of typhoid fever who were immunized orally with CVD 908-htr

195 ive bacteria, including purveyors of plague, typhoid fever, whooping cough, sexually transmitted infe

196 rologically based tests for the diagnosis of typhoid fever (Widal TO and TH, anti-serotype Typhi immu

197 evelop a hematopathological syndrome akin to typhoid fever with splenomegaly, microcytic anemia, extr

198 ent remain powerful tools for the control of typhoid fever, yet the huge economic costs and long time