ライフサイエンスコーパス: tyrosinase

1 ting CTL responses (e.g., MART-1, GP100, and tyrosinase).

2 lyelectrolyte (poly-L-lysine) and an enzyme (tyrosinase).

3 matic reaction of BPA oxidation catalyzed by tyrosinase.

4 r and non-polar region on the active site of tyrosinase.

5 ells loaded with melanoma antigens gp100 and tyrosinase.

6 melanoma antigens MART1, MAGE-3, gp100, and tyrosinase.

7 coding TCRs recognizing the melanoma antigen tyrosinase.

8 ognize an epitope of the melanocyte protein, tyrosinase.

9 us containing TYR (P=1.60x10(-18)), encoding tyrosinase.

10 nd P4 are competitive inhibitors of mushroom tyrosinase.

11 e to excess melanin production by the enzyme tyrosinase.

12 nism of the coupled binuclear copper protein tyrosinase.

13 odel of the coupled binuclear copper protein tyrosinase.

14 tinal neuron-the proapoptotic gene, Bax, and tyrosinase.

15 ude MAGE proteins, MART-1/MelanA, gp100, and tyrosinase.

16 enzymes, including cytochrome c oxidase and tyrosinase.

17 h the basis of tolerance to one such Ag from tyrosinase.

18 s in regulating the degradation/stability of tyrosinase.

19 tation, including dopachrome tautomerase and tyrosinase.

20 ion of an HLA-A*0201-associated epitope from tyrosinase.

21 might disturb the catalytic conformation of tyrosinase.

22 anoparticles followed by covalent binding of tyrosinase.

23 ners, with a focus on the melanogenic enzyme tyrosinase.

24 k that is required for copper acquisition by tyrosinase.

25 biting ATP7A and by enhancing degradation of tyrosinase.

26 equence oligopeptides at inhibiting mushroom tyrosinase.

27 oot and multiple proteins including expanded tyrosinases.

28 aracterize two Schistosoma mansoni products, tyrosinase 1 and tyrosinase 2 (SmTYR1/SmTYR2) and show t

29 histosoma mansoni products, tyrosinase 1 and tyrosinase 2 (SmTYR1/SmTYR2) and show that their dipheno

30 nfiltrating lymphocyte, which recognized the tyrosinase 368-376 peptide in the context of HLA-A2, wer

31 or the standard proteasome (Melan-A(26-35), tyrosinase(369-377), gp100(209-217)).

32 In tyrosinase, a binuclear copper enzyme, a mu-eta(2):eta(2

33 Tyrosinase, a copper-containing glycoprotein, is the rat

34 Tyrosinase, a key copper-containing enzyme involved in m

35 mulate melanocyte dendricity and activity of tyrosinase, a key enzyme in melanin biosynthesis.

36 w that the pigment-cell-specific cuproenzyme tyrosinase acquires copper only transiently and ineffici

37 Meanwhile, WFI also inhibited tyrosinase activity and NO generation in lipopolysacchar

38 Meanwhile, WLT also inhibited tyrosinase activity and NO generation in lipopolysacchar

39 silencing in isolated melanocytes increased tyrosinase activity and TYRP1/2 expression.

40 The designed biosensor is used to inhibit tyrosinase activity by Captopril, which is generally use

41 Inhibitors of tyrosinase activity have long been sought as therapeutic

42 lanin content, gp100 protein expression, and tyrosinase activity in human skin.

43 elanization effect resulting from AgNP since tyrosinase activity is essential for melanin biosynthesi

44 kinetic analysis revealed that BA inhibited tyrosinase activity non-competitively.

45 Cu-dependent tyrosinase activity was also markedly reduced in both ty

46 Melanin content, tyrosinase activity, and tyrosinase protein levels were

47 d control pigmentation via the regulation of tyrosinase activity, for example: the transcription of i

48 ibit increased levels of melanin pigment and tyrosinase activity.

49 tion of melanogenesis is due to reduction in tyrosinase activity.

50 ed the strongest inhibitory activity against tyrosinase among the components in this fruit, with an I

51 Tyrosinase, an enzyme involved in melanin synthesis, is

52 thalmia-associated transcription factor) and tyrosinase and by elevated protein levels of tyrosinase,

53 The highly conserved tyrosinase and chitin related proteins were identified i

54 activity of copper dependent enzymes, namely tyrosinase and Cu-Zn superoxide dismutase, are decreased

55 n factor MITF and of the melanogenic enzymes tyrosinase and dopachrome tautomerase, all major players

56 CRISPR/Cas9-mediated disruption of the genes Tyrosinase and FGF8/17/18 in the sea lamprey Petromyzon

57 estricted tumor-associated antigens (TAA) of tyrosinase and gp100, depending on their HLA-DR4 status.

58 tor of tyrosine degradation, could stabilize tyrosinase and improve pigmentation in individuals with

59 e via chelating copper at the active site of tyrosinase and in flow mode by thioquinone formation.

60 Polyphenol oxidases (PPOs) such as tyrosinase and laccase catalyze the enzymatic oxidation

61 at resulted from a preserved activity of the tyrosinase and laccase combined with the electron transf

62 mmetric biosensors based on phenol oxidases (tyrosinase and laccase) has been developed.

63 The main tea catechins were incubated with tyrosinase and laccase, and product formation was monito

64 By employing tyrosinase and laccase, both from Agaricus bisporus, on

65 n larvae resulted in increased expression of tyrosinase and laccase2 mRNA after 10 days.

66 fferentiation resulted in an upregulation of tyrosinase and melanin expression levels, in comparison

67 ignificantly reduced by a DGK inhibitor, but tyrosinase and microphthalmia-associated transcription f

68 factor (MITF), and subsequent reductions in tyrosinase and other genes required for melanogenesis.

69 on the tandem enzymatic reaction of a fungal tyrosinase and the mammalian catechol-O-methyltransferas

70 Individuals with the former lack functional tyrosinase and therefore lack melanin, while individuals

71 M for chelating copper at the active site of tyrosinase and thioquinone formation, respectively.

72 s via chelating copper at the active site of tyrosinase and thioquinone formation.

73 In treated melanocytes, tyrosinase and tyrosinase-related protein 1 accumulated

74 1 pathways, the melanin-synthesizing enzymes tyrosinase and tyrosinase-related protein-1.

75 with melanosome-destined cargo, specifically tyrosinase and Tyrp-1.

76 Tyrosinase and TYRP1 are mistrafficked, however, and fai

77 Tyrosinases and catechol oxidases belong to the family o

78 a tumor antigens, MelA/MART-1, gp100/pmel17, tyrosinase, and MAGE-A3, was used to trigger functional

79 ition of DGK reduced only the mature form of tyrosinase, and the decrease of tyrosinase resulting fro

80 lanocyte-associated antigens Melan-A, gp100, tyrosinase, and TRP-2 in the blood of HLA-A2(+) vitiligo

81 Tyrosinases are ubiquitous binuclear copper enzymes that

82 ditions of an oxidase enzyme biosensor using tyrosinase as a model example.

83 Identifying tyrosinase as a potential GPR143 binding protein opens n

84 demonstrate a more flexible conformation of tyrosinase at higher temperature.

85 were achieved when 10mM cysteine and 200U/ml tyrosinase at pH 6.8 to 7.2 were used for a 60-min incub

86 ing protein tyrosine kinase activity using a tyrosinase-based amperometric biosensor (tyrosine kinase

87 ensor, a sentinel platinum sensor, a laccase/tyrosinase-based biosensor and a sentinel carbon sensor,

88 We report on the design of an amperometric tyrosinase-based biosensor using a self-assembled monola

89 n matrix and fabricate a simple amperometric tyrosinase biosensor for the detection of phenol and dop

90 We also show that a dileucine motif from tyrosinase, both in its native context and in the contex

91 es provides not only spectroscopic models of tyrosinase but also functional models.

92 tides that inhibited both mushroom and human tyrosinase but showed no cytotoxicity to human melanocyt

93 At 100 microM, P3 and P4 inhibited human tyrosinase by 25-35%.

94 This suggests that direct presentation of tyrosinase by radio-resistant lymph node resident cells

95 d as competitive inhibitors against mushroom tyrosinase by using the phenol ring of tyrosine to stack

96 ion mimicked the defective expression of the tyrosinase cargo in dendrites of HPS-5 melanocytes, but

97 Ubiquitous tyrosinase catalyses the aerobic oxidation of phenols to

98 Tyrosinases catalyze theo-hydroxylation and oxidation of

99 servation that phosphorylation can block the tyrosinase-catalyzed oxidation of tyrosine or tyrosyl re

100 nase II inhibitory peptide; MK2i) by using a tyrosinase-catalyzed oxidative reaction for preventing t

101 Tyrosinase catalyzes the conversion of dopamine to o-dop

102 In normal melanocytes, endogenous tyrosinase colocalized with Pmel17 and TYRP1 in the peri

103 Tyrosinase-COMT are shown to provide highly versatile an

104 The enzyme tyrosinase contains two Cu(I) centres, trigonally coordi

105 Tyrosinase did not have effect on zeta-potential or coll

106 ed human tyrosinase or on the mRNA levels of tyrosinase, dopachrome tautomerase, Pmel17, or MITF mRNA

107 differentiation markers such as melan-A and tyrosinase, enhanced aldehyde dehydrogenase (ALDH) activ

108 e tyrosinase gene (TYR), which expresses the tyrosinase enzyme and has an important role in the synth

109 We used tyrosinase enzyme as a proof of concept receptor with in

110 d using nickel oxide nanoparticles (NPs) and tyrosinase enzyme conjugate.

111 The tyrosinase enzyme functionalized NiO platform has good b

112 o filter paper and physically entrapping the tyrosinase enzyme in between these layers.

113 Afterwards, tyrosinase enzyme molecules were adsorbed on NiO NPs sur

114 n excellent electrode surface for loading of tyrosinase enzyme molecules.

115 eraction sites of ED and PAED compounds with tyrosinase enzyme.

116 sor consisting of salicylate hydroxylase and tyrosinase enzymes immobilized on carbon nanotube modifi

117 Using h3T TCR transgenic mice, with human tyrosinase epitope-reactive T cells developed on p53 kno

118 Using the human tyrosinase epitope-reactive, CD8-independent, high-affin

119 is peptide, Tyr(369)(N), is not presented by tyrosinase-expressing cells, and this has been presumed

120 Furthermore, tyrosinase expression and activity, as well as TYRP1 and

121 own of DGKzeta decreased melanin content and tyrosinase expression in melanocytic cells.

122 features consistent with those of oxygenated tyrosinase, formed through the self-assembly of monodent

123 to investigate the heat induced behaviour of tyrosinase from Agaricus bisporus.

124 Tyrosinase from Bacillus megaterium (TyrBm) was previous

125 's melanocytes caused the mislocalization of tyrosinase from melanosomes to the plasma membrane and a

126 lutaminase from Streptomyces mobaraensis and tyrosinase from Trichoderma reesei to modify the colloid

127 tory factors in terms of their modulation of tyrosinase function and we summarize current understandi

128 egulatory molecules and pathways involved in tyrosinase function.

129 dy, we identified a gene (Hs-Tyr) encoding a tyrosinase functional domain (PF00264).

130 on of epicatechin with epigallocatechin with tyrosinase gave a high, stable theaflavin content.

131 cells, as determined with the Ca(2+) sensor tyrosinase-GCaMP6.

132 Mutation of the tyrosinase gene (TYR) causes oculocutaneous albinism, ty

133 er animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentat

134 phenotype may be caused by mutations in the tyrosinase gene (TYR), which expresses the tyrosinase en

135 ntly stimulate melanin synthesis and enhance tyrosinase gene expression and activity ( approximately

136 Oxidation of DOPAC by tyrosinase generated furanoquinone, which was a poor pro

137 Tyrosinase-, gp100-, or TRP-2-specific CD8(+) T cells co

138 Tyrosinase greatly reduced the solubility of oat protein

139 Tyrosinase had limited crosslinking ability on both plan

140 fect virtually all proteins, such effects on tyrosinase have immediate and dramatic consequences on p

141 The biosensor is fabricated using tyrosinase immobilized in a biocompatible matrix consist

142 By covalently immobilizing the enzyme tyrosinase in a preformed cross-linked chitosan film via

143 expression of the melanoma-associated marker tyrosinase in adherent melanoma cell lines corresponding

144 tyrosinase-related proteins 1 and 2 but not tyrosinase, in addition to gp100 and MART-1, and were de

145 In a green tea extract, tyrosinase increased the proportion of theaflavins by tw

146 While oxidation by tyrosinase increased their antioxidant activity laccase

147 spectral features identical to those of oxy-tyrosinase indicates that oxy-NspF contains a Cu(2)O(2)

148 increased the proportion of EndoH sensitive tyrosinase, indicating that tyrosinase maturation was im

149 and chromatographic separation coupled with tyrosinase inhibition assay.

150 ng 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and tyrosinase inhibition kinetics, and the release of aroma

151 Mushroom tyrosinase inhibition was dose-dependent with IC(50) (ha

152 The extracts exerted weak cholinesterase and tyrosinase inhibition, and remarkable inhibition against

153 its toxicity to melanocytes rather than via tyrosinase inhibition.

154 We studied the tyrosinase-inhibition activity (activity test) and struc

155 M), which was superior to those of the known tyrosinase inhibitors (arbutin and kojic acid) and outpe

156 is broad range of applications in the use of tyrosinase inhibitors for suppressing unwanted hyperpigm

157 In searching effective tyrosinase inhibitors from natural products, the compone

158 Known tyrosinase inhibitors possess adverse side effects, and

159 gen-like activators and acetylcholinesterase/tyrosinase inhibitors.

160 good stability over time and antioxidant and tyrosinase inhibitory activities, which make it suitable

161 enolic antioxidants with metal chelating and tyrosinase inhibitory activities.

162 anthocyanin and IC50 value of 1.60mg/ml for tyrosinase inhibitory activity.

163 ameters maximizing bioactive metabolites and tyrosinase inhibitory activity.

164 lation of BA from D. indica and explored its tyrosinase inhibitory mechanism.

165 t, respectively, which also expressed strong tyrosinase inhibitory property.

166 tically and comprehensively investigated the tyrosinase-inhibitory abilities of N- and C-terminal cys

167 ning tetrapeptides exhibited the most potent tyrosinase-inhibitory abilities.

168 apeptides significantly contributed to their tyrosinase-inhibitory function.

169 ng tetrapeptide CRVI exhibited the strongest tyrosinase-inhibitory potency (with an IC50 of 2.7 +/- 0

170 embrane and also led to the incorporation of tyrosinase into exosomes and secretion into the culture

171 r(369)(D), derived from the membrane protein tyrosinase, involves retrotranslocation of glycosylated

172 fails to be presented because unglycosylated tyrosinase is degraded rapidly and relatively nonselecti

173 For the preparation of the biosensor, tyrosinase is immobilized onto screen printed electrode

174 To catalyse melanin synthesis, tyrosinase is subsequently reloaded with copper within s

175 Tyrosinase is the central and rate-limiting enzyme in me

176 Tyrosinase is the rate-limiting enzyme for the productio

177 Another member of this enzyme family, tyrosinase, is able to mono-oxygenate monophenols (monop

178 of the molecules and pathways that regulate tyrosinase levels and activity could identify target are

179 le synthesis, we report an iridium-catalysed tyrosinase-like approach to catechols, employing an oxya

180 ecies that leads to ortho-hydroxylation in a tyrosinase-like fashion and (ii) addition of stoichiomet

181 Furthermore, tyrosinase localized to the plasma membrane when coexpre

182 EndoH sensitive tyrosinase, indicating that tyrosinase maturation was impaired.

183 -tyrosine was the substrate, suggesting that tyrosinase may contain contains two distinct catalytic s

184 Using a novel tyrosinase minigene-tagged Sleeping Beauty transposon-me

185 we also established that proteasomes degrade tyrosinase molecules that are still glycosylated, giving

186 Instead, we find radioresistant tyrosinase mRNA expression in lymphoid compartments wher

187 osinase protein levels, but did not increase tyrosinase mRNA levels.

188 he BALB/c albino phenotype-associated Tyr(c) tyrosinase mutation appeared to contribute to the phenot

189 the C57BL/6 Tyr(c-2J/c-2J) strain, in which tyrosinase, necessary for melanogenesis, is mutated.

190 The fabricated Tyrosinase/NiO/ITO electrode exhibits high sensitivity o

191 eact with monophenols, indicating that, like tyrosinase, NspF also possesses monophenolase activity.

192 in water has been developed by immobilizing tyrosinase onto a diazonium-functionalized boron doped d

193 Silencing of tyrosinase or microphthalmia-associated transcription fa

194 y effect on the activities of purified human tyrosinase or on the mRNA levels of tyrosinase, dopachro

195 carry T cells with a HLA-A2-restricted human tyrosinase peptide (h-Tyr)-reactive TCR and develop spon

196 a proposed role for Hsp70 family members in tyrosinase post-translational modification.

197 st characterized member of a small family of tyrosinases present in fluorescent pseudomonads that are

198 ast, glycosylation alters the selectivity of tyrosinase processing by the proteasome, enhancing the p

199 understanding of how the quality control of tyrosinase processing impacts its stability and melanoge

200 We assert that the tyrosinase promoter is the distinct target for genetic m

201 Using the intermediate cell (IC)-specific tyrosinase promoter, under the control of diphtheria tox

202 cription factor, dopachrome tautomerase, and tyrosinase promoters, leading to an increase in the expr

203 In addition, omeprazole reduced tyrosinase protein abundance in the presence of cyclohex

204 Melanin content, tyrosinase activity, and tyrosinase protein levels were significantly reduced by

205 Overexpression of DGKzeta increased tyrosinase protein levels, but did not increase tyrosina

206 ore is known to be driven by the periplasmic tyrosinase PvdP.

207 ther lentivector delivering a self/tumor Ag, tyrosinase related protein 1 (TRP1), could stimulate eff

208 Melanocyte differentiation Ags, including tyrosinase-related protein (TRP) 1, are relevant to both

209 we combined peptide vaccines with mAb to the tyrosinase-related protein (TRP)-1 surface Ag for the tr

210 isoaspartic acid within the melanoma antigen tyrosinase-related protein (TRP)-2 peptide-(181-188) mak

211 ch CD4+ T cells recognize a novel epitope in tyrosinase-related protein 1 (TRP-1), an antigen express

212 ssing of melanocyte differentiation antigen, tyrosinase-related protein 1 (TRP1).

213 ed by a low-affinity MHC class I ligand from tyrosinase-related protein 1 (TRP1).

214 eine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1) as a major determin

215 fficking of a known AP-3 cargo, CD63, and of tyrosinase-related protein 1 (Tyrp1), a melanosomal memb

216 c for the melanocyte differentiation antigen tyrosinase-related protein 1 (Tyrp1), then constructed b

217 uestions, a mutated self-antigen, designated tyrosinase-related protein 1 (Tyrp1)-WM, derived from Ty

218 rane lacked the melanosomal membrane protein tyrosinase-related protein 1 (TYRP1).

219 In treated melanocytes, tyrosinase and tyrosinase-related protein 1 accumulated in Lamp-1-posit

220 was 100% penetrance in the progeny from the tyrosinase-related protein 1-mGluR5 lines generated from

221 lines under a melanocyte-specific promoter, tyrosinase-related protein 1.

222 Immunization with hsp110- or grp170-tyrosinase-related protein 2 (TRP2(175-192)) peptide com

223 ombined with a tumor-associated peptide from tyrosinase-related protein 2, our combined adjuvant appr

224 -boost vaccination with the melanoma antigen tyrosinase-related protein 2, which also showed a signif

225 toward targets loaded with a K(b)-restricted tyrosinase-related protein 2-derived peptide correlated

226 melanoma differentiation antigens gp100 and tyrosinase-related protein 2/dopachrome tautomerase and

227 iated antigens, glycoprotein 100 (gp100) and tyrosinase-related protein-1 (TRP-1), respectively, into

228 melanin synthesis and expression/activity of tyrosinase-related protein-1 (Tyrp-1).

229 ressing Cre-recombinase under control of the tyrosinase-related protein-1 (Tyrp1) promoter, which is

230 c tissue self antigen expressed by melanoma, tyrosinase-related protein-1 (Tyrp1).

231 9 targeting melanoma differentiation antigen tyrosinase-related protein-1 (Tyrp1; gp75) and active im

232 melanin-synthesizing enzymes tyrosinase and tyrosinase-related protein-1.

233 ctors encoding the endogenous tumor Ags (TA) tyrosinase-related protein-2 (TRP-2) and glycoprotein 10

234 -Dopachrome tautomerase (l-DCT), also called tyrosinase-related protein-2 (TRP-2), is a melanoma anti

235 transgene specific for the melanoma antigen tyrosinase-related protein-2 (TRP-2, Dct) harbor T cells

236 Additionally, analysis of tyrosinase-related protein-2 and total melanin productio

237 combined with melanocyte differentiation Ag tyrosinase-related protein-2 peptide-based vaccination,

238 Tumors expressed tyrosinase-related proteins 1 and 2 but not tyrosinase,

239 disrupting the intracellular trafficking of tyrosinase-related proteins and lysosome-associated memb

240 enzyme of previously unknown function, is a tyrosinase required for the maturation of the pyoverdine

241 ture form of tyrosinase, and the decrease of tyrosinase resulting from DGK inhibition could be blocke

242 ne encoding the integral melanosomal protein tyrosinase, resulting in aberrant melanosome formation,

243 endent dopamine interacting with immobilized tyrosinase showed a linear dependence into a physiologic

244 e, volume of iridium oxide nanoparticles and tyrosinase solution.

245 thymus, central deletion does not shape the tyrosinase-specific CD8 T cell repertoire.

246 e melanocyte-specific protein tyrosinase, to tyrosinase-specific CD8 T cells, leading to their deleti

247 ading to abortive activation and deletion of tyrosinase-specific CD8 T cells.

248 Rescue of tyrosinase-specific T(CD8) by interference with PD-1 or

249 hese results suggest that this highly active tyrosinase-specific TCR could be of value in adoptive ce

250 Detailed insights into tyrosinase structure after performing molecular dynamics

251 These significant changes in tyrosinase structure at temperatures over 60 degrees C m

252 As AUS1 did not accept common tyrosinase substrates (tyrosine and tyramine), the enzym

253 not correlated with the acceptance of common tyrosinase substrates.

254 Furthermore, the HLA-A2(+)/human tyrosinase TCR double-transgenic mice developed spontane

255 fluorescence intensity results suggest that tyrosinase tends to form aggregates after 10min at 75 de

256 utational molecular docking studies on novel tyrosinase tetrapeptide inhibitors.

257 ioadhesion, such as enzymatic activation (by tyrosinase), the switchability from weak to strong binde

258 ALP1), part of the inflammasome cascade, and tyrosinase, the enzyme that produces melanin.

259 ues, including Met 374 in the active site of tyrosinase, the key enzyme in melanogenesis, limits enzy

260 e in the activities of adenylate cyclase and tyrosinase, the rate-limiting enzyme for melanogenesis.

261 ither the level or the enzymatic activity of tyrosinase, the rate-limiting enzyme in melanin producti

262 tyrosinase and by elevated protein levels of tyrosinase, the rate-limiting factor in melanin biogenes

263 sion significantly correlated with levels of tyrosinase, the rate-limiting melanogenic enzyme, consis

264 se, butyrylcholinesterase, lipoxygenase, and tyrosinase; the enzymes linked to neurodegeneration.

265 h down-regulates melanogenic enzymes such as tyrosinase to decrease melanin synthesis and prevent nor

266 ne of these, the melanocyte-specific protein tyrosinase, to tyrosinase-specific CD8 T cells, leading

267 ith a chimeric murine/human TCR specific for tyrosinase, together with lymphodepletion conditioning,

268 +) T cells in the skin, quantifiable loss of tyrosinase transcript, and local IFN-gamma production.

269 Despite expression of tyrosinase transcripts in the thymus, central deletion d

270 xylase, DOPA oxidase, and protein levels for tyrosinase, TRP-1, and TRP-2 were not influenced by alph

271 icrophthalmia transcription factor) and TYR (tyrosinase), two pivotal genes in melanogenesis.

272 n copper-/dioxygen-dependent enzymes such as tyrosinase (Ty) and particulate methane monooxygenase (p

273 yme (ACE), histone deacetylase (HDAC-2), and tyrosinase (TY), was selected based on their clinical im

274 We mapped the albino locus to tyrosinase (tyr) and identified polymorphisms shared bet

275 he findings that alpha-Syn can interact with tyrosinase (TYR) and inhibit tyrosine hydroxylase (TH),

276 essing of two distinct melanosomal proteins, tyrosinase (TYR) and Pmel17, to elucidate protein proces

277 Nowadays, electrochemical tyrosinase (Tyr) based biosensors constitute a promising

278 Recently, tyrosinase (Tyr) deficiency was found to worsen the drai

279 experiment, we used CRISPR-EZ to target the tyrosinase (Tyr) gene, achieving 88% bi-allelic editing

280 R strain is known to carry a mutation in the tyrosinase (Tyr) gene.

281 through autosomal recessive mutations in the Tyrosinase (TYR) gene.

282 h iridium oxide nanoparticles (IrOx NPs) and tyrosinase (Tyr) immobilized onto screen printed electro

283 ineered to include gene trap sequences and a tyrosinase (Tyr) pigmentation reporter to rescue the alb

284 Rb1 allele with mice expressing Cre from the tyrosinase (Tyr) promoter.

285 The enzyme Tyrosinase (Tyr) was used in the active layer of the bio

286 pe 3" Cu sites are found in hemocyanin (Hc), tyrosinase (Tyr), and the multicopper oxidases (MCOs), s

287 ther to serve as multimodal reporters, human tyrosinase (TYR)--the key enzyme in melanin production--

288 level or the enzymatic activity of cellular tyrosinase (Tyr).

289 (AChE) and butyrylcholinesterase (BChE), and tyrosinase (TYRO) by microtitre plate assays.

290 The enzyme molecule, tyrosinase (Tyrs) has been covalently immobilized on the

291 well maintained as the Michaelis constant of tyrosinase was determined to be 0.90 mmol/L, which is ju

292 or heavy cysteine (d(2)) in the presence of tyrosinase was developed.

293 de-MHC epitope of the melanoma-associated Ag tyrosinase were analyzed in detail.

294 Unlike tyrosinase, which also engages AP-3 for optimal melanoso

295 regulating pigmentation via the stability of tyrosinase, which depends on its processing and maturati

296 pores allowed the physical immobilization of tyrosinase, which is an enzyme that oxidizes dopamine, o

297 ation of the posttranslational processing of tyrosinase, which may be related with the protein degrad

298 GPR143 coimmunoprecipitated with tyrosinase, while confocal microscopy demonstrated coloc

299 Further, conformational analysis of tyrosinase with BA was measured by fluorescence and circ

300 d structural changes (circular dichroism) of tyrosinase with ED and plasma activated eugenol derivati