ライフサイエンスコーパス: tyrosinase-related protein

1 of the melanocyte, possibly tyrosinase or a tyrosinase-related protein.

2 ified, forming a family of proteins known as tyrosinase related proteins.

3 ified, forming a family of proteins known as tyrosinase-related proteins.

4 been conserved in vertebrate tyrosinases and tyrosinase-related proteins.

5 ther lentivector delivering a self/tumor Ag, tyrosinase related protein 1 (TRP1), could stimulate eff

6 % of vesicles demonstrated colocalization of tyrosinase related protein 1 and 3-(2, 4-dinitroanilino)

7 (pJ/pJ and pcp/p6H) showed colocalization of tyrosinase related protein 1 and 3-(2,4-dinitroanilino)-

8 erum directed against the melanosomal marker tyrosinase related protein 1.

9 ses to a melanocyte differentiation antigen, tyrosinase-related protein 1 (or gp75), which is the pro

10 to controlling tyrosinase (albino locus) and tyrosinase-related protein 1 (TR-P1/gp75/brown locus), b

11 ch CD4+ T cells recognize a novel epitope in tyrosinase-related protein 1 (TRP-1), an antigen express

12 ssing of melanocyte differentiation antigen, tyrosinase-related protein 1 (TRP1).

13 ed by a low-affinity MHC class I ligand from tyrosinase-related protein 1 (TRP1).

14 eine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1) as a major determin

15 erved in the number of NC-Ms [melanin(+) and tyrosinase-related protein 1 (TYRP1)(+) cells], the diff

16 fficking of a known AP-3 cargo, CD63, and of tyrosinase-related protein 1 (Tyrp1), a melanosomal memb

17 similar in color to mice with a mutation in tyrosinase-related protein 1 (Tyrp1), a mouse model for

18 chromosome 2 where a strong candidate gene, tyrosinase-related protein 1 (TYRP1), has also been mapp

19 c for the melanocyte differentiation antigen tyrosinase-related protein 1 (Tyrp1), then constructed b

20 uestions, a mutated self-antigen, designated tyrosinase-related protein 1 (Tyrp1)-WM, derived from Ty

21 rane lacked the melanosomal membrane protein tyrosinase-related protein 1 (TYRP1).

22 dendritic morphology and down-regulation of tyrosinase-related protein 1 (TYRP1/gp75), a melanocyte

23 In treated melanocytes, tyrosinase and tyrosinase-related protein 1 accumulated in Lamp-1-posit

24 Both BRG1 and Mitf could be localized to the tyrosinase-related protein 1 and tyrosinase promoters by

25 recognized an epitope expressed in both the tyrosinase-related protein 1 and tyrosinase-related prot

26 ab27b colocalizes with the melanosome marker tyrosinase-related protein 1 and with myosin Va at the c

27 on in A-188 cells caused both tyrosinase and tyrosinase-related protein 1 to be localized to large gr

28 esults in mistranslocation of tyrosinase and tyrosinase-related protein 1 to large granular complexes

29 proteins (including TYR (tyrosinase), TYRP1 (tyrosinase-related protein 1), DCT (tyrosinase-related p

30 associated with mutations in TYRP1 (encoding tyrosinase-related protein 1).

31 Activation of tyrosinase-related protein 1, a melanocyte-specific gene

32 perinuclear vesicles carrying tyrosinase and tyrosinase-related protein 1, consistent with a role in

33 was 100% penetrance in the progeny from the tyrosinase-related protein 1-mGluR5 lines generated from

34 lines under a melanocyte-specific promoter, tyrosinase-related protein 1.

35 genic marker proteins such as tyrosinase and tyrosinase-related protein 1.

36 by the presence of wild type tyrosinase and tyrosinase-related protein 1.

37 Tumors expressed tyrosinase-related proteins 1 and 2 but not tyrosinase,

38 I-IV melanoma were assessed for tyrosinase, tyrosinase-related proteins 1 and 2, Pmel 17, and MART-1

39 ion, including those encoding tyrosinase and tyrosinase-related proteins 1 and 2.

40 Tyrosinase- related protein-1 (TRP-1) was not detected i

41 A human tyrosinase-related protein-1 (TRP-1) cDNA was inserted i

42 epitope (ISPNSVFSQWRVVCDSLEDYD) derived from tyrosinase-related protein-1 (TRP-1) using a predictive

43 iated antigens, glycoprotein 100 (gp100) and tyrosinase-related protein-1 (TRP-1), respectively, into

44 g of the melanogenic proteins tyrosinase and tyrosinase-related protein-1 (TRP-1).

45 st the melanosome membrane glycoprotein gp75/tyrosinase-related protein-1 (TYRP-1) of melanocytes lea

46 melanin synthesis and expression/activity of tyrosinase-related protein-1 (Tyrp-1).

47 ressing Cre-recombinase under control of the tyrosinase-related protein-1 (Tyrp1) promoter, which is

48 lanocytes accumulate the melanosomal protein tyrosinase-related protein-1 (Tyrp1), but not other mela

49 Tyrosinase, tyrosinase-related protein-1 (Tyrp1), dopachrome tautome

50 c tissue self antigen expressed by melanoma, tyrosinase-related protein-1 (Tyrp1).

51 ng expression of melanogenic enzymes such as tyrosinase-related protein-1 (Tyrp1).

52 Tyrosinase (TYR), tyrosinase-related protein-1 (TYRP1/gp75) and dopachrome

53 9 targeting melanoma differentiation antigen tyrosinase-related protein-1 (Tyrp1; gp75) and active im

54 The MAAs studied included tyrosinase (Tyr), tyrosinase-related protein-1 and -2 (TRP-1 and TRP-2), g

55 00) had amino acid sequence homology to both tyrosinase-related protein-1 and -2.

56 o the M-box promoter elements of tyrosinase, tyrosinase-related protein-1 and dopachrome tautomerase/

57 MTS from the mouse brown locus product gp75/tyrosinase-related protein-1 and full-length OVA as a re

58 nd activity of Tyrosinase, and expression of Tyrosinase-related protein-1 and-2.

59 y the colocalization of TUNEL positivity and tyrosinase-related protein-1 immunoreactivity.

60 the skin of transgenic mice using either the Tyrosinase-Related Protein-1 or the keratin-14 (K14) pro

61 Tyrp1 gene expression and tyrosinase-related protein-1 production were also induce

62 e, melanoma antigen recognized by T cells-1, tyrosinase-related protein-1, and tyrosinase-related pro

63 dautochrome tautomerase, pMel 17/Silver and tyrosinase-related protein-1, but lack expression of the

64 er melanosomal proteins, such as tyrosinase, tyrosinase-related protein-1, dopachrome tautomerase, an

65 Immunity to the brown locus protein, gp75/ tyrosinase-related protein-1, was investigated in a syng

66 replicating mRNA) and the self/tumor antigen tyrosinase-related protein-1.

67 melanin-synthesizing enzymes tyrosinase and tyrosinase-related protein-1.

68 lanocyte differentiation antigens, including tyrosinase-related-protein-1 and gp100/pmel17, was marke

69 -eyed dilution and Pmel 17 (silver), but not tyrosinase-related protein 2 (slaty locus).

70 d have lost expression of the tyrosinase and tyrosinase-related protein 2 (TRP-2) antigens.

71 nses against the murine B16 melanoma using a tyrosinase-related protein 2 (TRP-2) peptide as a model

72 ify a normal tissue differentiation antigen, tyrosinase-related protein 2 (TRP-2), expressed by the m

73 261) express the melanoma antigens gp100 and tyrosinase-related protein 2 (TRP-2).

74 Immunization with hsp110- or grp170-tyrosinase-related protein 2 (TRP2(175-192)) peptide com

75 CD8+ T cells specific for the self/tumor Ag tyrosinase-related protein 2 (TRP2) are readily detected

76 DCs loaded with a peptide derived from tyrosinase-related protein 2 (TRP2) covalently linked to

77 Tyrosinase-related protein 2 (TRP2) is a melanosomal enz

78 arrying the lacZ reporter gene linked to the tyrosinase-related protein 2 (TRP2) promoter.

79 in both the tyrosinase-related protein 1 and tyrosinase-related protein 2 Ags in the context of the H

80 melanoma Ags MART-1, gp100, tyrosinase, and tyrosinase-related protein 2 as evaluated by specific cy

81 ous class I MHC-restricted B16 tumor peptide tyrosinase-related protein 2(180-188).

82 , TYRP1 (tyrosinase-related protein 1), DCT (tyrosinase-related protein 2), MART1 (melanoma antigens

83 ombined with a tumor-associated peptide from tyrosinase-related protein 2, our combined adjuvant appr

84 -boost vaccination with the melanoma antigen tyrosinase-related protein 2, which also showed a signif

85 toward targets loaded with a K(b)-restricted tyrosinase-related protein 2-derived peptide correlated

86 inst FAP and a tumor cell-expressed antigen, tyrosinase-related protein 2.

87 melanoma differentiation antigens gp100 and tyrosinase-related protein 2/dopachrome tautomerase and

88 ctors encoding the endogenous tumor Ags (TA) tyrosinase-related protein-2 (TRP-2) and glycoprotein 10

89 -associated Ags for the B16 murine melanoma: tyrosinase-related protein-2 (TRP-2) and the endogenous

90 ibody responses to a melanocyte autoantigen, tyrosinase-related protein-2 (TRP-2), as it is highly ex

91 -Dopachrome tautomerase (l-DCT), also called tyrosinase-related protein-2 (TRP-2), is a melanoma anti

92 transgene specific for the melanoma antigen tyrosinase-related protein-2 (TRP-2, Dct) harbor T cells

93 o an immunodominant CTL epitope derived from tyrosinase-related protein-2 administered with CpG-ODN a

94 Additionally, analysis of tyrosinase-related protein-2 and total melanin productio

95 related protein-1 and dopachrome tautomerase/tyrosinase-related protein-2 and transactivate these gen

96 f crest-derived cells that express c-kit and tyrosinase-related protein-2 characteristic of MPs.

97 ients (29%) expressed IgG antibody titers to tyrosinase-related protein-2 compared to four of 28 non-

98 SOX10 acts as a critical transactivator of tyrosinase-related protein-2 during melanoblast developm

99 DCs pulsed with KLH and mouse tyrosinase-related protein-2 peptide results in enhanced

100 combined with melanocyte differentiation Ag tyrosinase-related protein-2 peptide-based vaccination,

101 effect is most pronounced in a setting where tyrosinase-related protein-2 peptide-pulsed DCs alone ar

102 er these conditions corresponds to increased tyrosinase-related protein-2 production.

103 enes vaccine expressing the melanoma antigen tyrosinase-related protein-2 to protect mice against int

104 Tyrosinase-related protein-2 was found to exist in two d

105 Density-dependent expression of tyrosinase-related protein-2 was independent of time of

106 T cells-1, tyrosinase-related protein-1, and tyrosinase-related protein-2, respectively.

107 immunity against a murine melanoma self Ag, tyrosinase-related protein-2, using DCs transduced with

108 tomerase gene (Dct) and its protein product, tyrosinase-related protein-2, was studied in the culture

109 disrupting the intracellular trafficking of tyrosinase-related proteins and lysosome-associated memb

110 numbers of random mutations in two syngeneic tyrosinase-related proteins are used to immunize black m

111 oplasmic sequence, which is conserved in the tyrosinase related protein family and through vertebrate

112 tional levels that induces production of the tyrosinase-related proteins that have a significant role

113 Melanocyte differentiation Ags, including tyrosinase-related protein (TRP) 1, are relevant to both

114 st the melanocyte differentiation antigen, a tyrosinase-related protein (TRP) gp75(TRP-1) (the brown

115 Two T cell epitopes derived from tumor Ags, tyrosinase-related protein (TRP)-1 and TRP-2, were shown

116 me tautomerase, that the melanogenic protein tyrosinase-related protein (TRP)-1 can oxidize (HO)2IndC

117 we combined peptide vaccines with mAb to the tyrosinase-related protein (TRP)-1 surface Ag for the tr

118 open-reading frame sequences of tyrosinase, tyrosinase-related protein (TRP)-1, TRP-2, and melanoma-

119 recognize HLA-A2-restricted CTL epitopes in tyrosinase-related protein (TRP)-2 (clone MR7) and NY-ES

120 Tyrosinase-related protein (TRP)-2 is not only expressed

121 isoaspartic acid within the melanoma antigen tyrosinase-related protein (TRP)-2 peptide-(181-188) mak

122 ining the MHC class I-presented self-peptide tyrosinase-related protein (TRP)-2(180-188) and CpG-cont

123 88 of the melanocyte differentiation antigen tyrosinase-related protein (TRP)2.

124 ion antigens, gp100, MART-1, tyrosinase, and tyrosinase-related proteins (TRP) 1 and TRP-2, we observ

125 Tyrosinase and tyrosinase-related proteins (TRPs) are a family of melan