ライフサイエンスコーパス: tyrosine phosphatase

1 lase 65, insulin, heat shock protein 60, and tyrosine phosphatase).

2 n substrate, suggesting that in vivo it is a tyrosine phosphatase.

3 n ubiquitously expressed cytoplasmic protein tyrosine phosphatase.

4 ong T-cell regulator called lymphoid protein tyrosine phosphatase.

5 an target of rapamycine pathway, and protein tyrosine phosphatase.

6 n that underlies redox inhibition of protein tyrosine phosphatases.

7 a novel class of eukaryotic aspartyl protein tyrosine phosphatases.

8 ulation by segregation from large inhibitory tyrosine phosphatases.

9 s towards STEP compared to highly homologous tyrosine phosphatases.

10 irect interactions of Shc with both Jak3 and tyrosine phosphatases.

11 yrosine-based inhibition motifs that recruit tyrosine phosphatases.

12 m of Src homology region 2 domain-containing tyrosine phosphatase 1 (SHP-1) along with the T. cruzi T

13 ase Src homology 2 domain-containing protein tyrosine phosphatase 1 (Shp1) show increased leukocyte a

14 enib and SC-1 activated Src-homology protein tyrosine phosphatase-1 (SHP-1) and STAT3 inhibition foll

15 een Src homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) and VEGF-R2, which leads

16 ransport into hepatocytes to inhibit protein-tyrosine phosphatase 1B (PTP1B) activity, which acts to

17 ial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and beta-cate

18 es with or without expression of the protein-tyrosine phosphatase 1B (PTP1B) and in wild-type and PTP

19 d reduced levels of the phosphatases protein tyrosine phosphatase 1B (PTP1B) and phosphatase and tens

20 encer of cell signaling 1 (SOCS1) or protein-tyrosine phosphatase 1B (PTP1B) in this process.

21 Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeut

22 ased NO production via inhibition of protein tyrosine phosphatase 1B (PTP1B) is associated with reduc

23 Protein tyrosine phosphatase 1B (PTP1B) is implicated in inflamm

24 Protein-tyrosine phosphatase 1B (PTP1B) regulates food intake (F

25 w how these pillars are connected in Protein Tyrosine Phosphatase 1B (PTP1B), a drug target for diabe

26 hinery modulates an interaction with protein tyrosine phosphatase 1B (PTP1B), an ER-associated protei

27 Application of this strategy to protein tyrosine phosphatase 1B and a peptidyl-prolyl cis-trans

28 functionally active A1AT protein and protein tyrosine phosphatase 1B expression.

29 imentally validate a cryptic site in protein tyrosine phosphatase 1B using a covalent ligand and NMR

30 inhibition (glycogen phosphorylase, protein tyrosine phosphatase 1B) or by inhibiting renal sodium-d

31 or activation through recruitment of protein tyrosine phosphatase 1B.

32 Here, we report that protein tyrosine phosphatases 1B (PTP1B) directly dephosphorylat

33 osine (pY) under the assistance of a protein tyrosine phosphatase-1B (PTP-1B).

34 Protein tyrosine phosphatase-1B (PTP1B) negatively regulates ins

35 zed Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2).

36 Active Src homology 2 domain-containing tyrosine phosphatase 2 impairs the signaling function of

37 docking of Src homology 2 domain-containing tyrosine phosphatase 2 phosphatase to the cytoplasmic ta

38 the Src homology-2 domain containing protein tyrosine phosphatase 2), a ubiquitously expressed cytopl

39 of Src homology 2 domain-containing protein-tyrosine phosphatase 2, known to maintain vascular barri

40 ubiquitously expressed SH2 domain-containing tyrosine phosphatase-2 (SHP2) as a therapeutic target ha

41 The Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatas

42 ger Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) translocation to the mitoc

43 hem, thyrotroph embryonic factor and protein tyrosine phosphatase 4a1, resulted in altered GLP-1 secr

44 rt that cell-autonomous loss of the receptor tyrosine phosphatase 69D (RPTP69D) and loss of midline-l

45 ligase for STEP61 (striatal-enriched protein tyrosine phosphatase), a protein tyrosine phosphatase im

46 Lymphocyte tyrosine phosphatase, a coding variant within the tyrosi

47 are accompanied by a marked increase in STEP tyrosine phosphatase activation.

48 Upregulation of CD45 tyrosine phosphatase activity in MDSCs exposed to hypoxi

49 Both in vivo and in vitro, loss of EYA tyrosine phosphatase activity leads to defective assembl

50 Along with our previous results that the tyrosine phosphatase activity of Eya is dispensable for

51 f EYA1, which has been reported to have only tyrosine phosphatase activity, has dual phosphatase acti

52 sphorylated ligands and inhibits its protein-tyrosine phosphatase activity.

53 alytic cysteine residue, which inhibited the tyrosine-phosphatase activity of SHP-1.

54 completely understood, receptor type protein tyrosine phosphatase alpha (PTP-alpha encoded by PTPRA)

55 Protein tyrosine phosphatase alpha (PTPalpha) promotes integrin-

56 Further, we identify a receptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathwa

57 ctivation through the stimulation of protein tyrosine phosphatases, an effect shared by other short-c

58 to study the signaling role of receptor type tyrosine phosphatases and found that activated PTPRG blo

59 ta validate a new approach to study receptor tyrosine phosphatases and show that, by targeting JAKs,

60 s controlled by the accessibility of ITIM to tyrosine phosphatases and that KIR binding to HLA-C must

61 ed oxidative stress and oxidation of protein tyrosine phosphatases, and ameliorated activation of per

62 Protein-tyrosine phosphatases are important reactive oxygen spec

63 pression and increased expression of protein tyrosine phosphatases as compared with naive T cells.

64 Protein-tyrosine phosphatase B (PtpB), a secretory phosphatase t

65 The second PDZ domain of the protein tyrosine phosphatase BL (PDZ2) interacts and binds the C

66 KIR2DL1 and KIR2DL1-H36A after inhibition of tyrosine phosphatase by pervanadate suggested that KIR2D

67 the expression of 85 tyrosine kinases and 42 tyrosine phosphatases by in situ hybridization 48 human

68 Classical protein-tyrosine phosphatases can exhibit substrate specificity

69 m was dependent on increased activity of the tyrosine phosphatase CD45 and CD45-dependent activation

70 The receptor-like protein tyrosine phosphatase CD45 positively regulates chemoattr

71 The receptor-like tyrosine phosphatase CD45 regulates antigen receptor sig

72 hat the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen recep

73 e kinase C-terminal Src kinase (CSK) and the tyrosine phosphatase CD45.

74 The leukocyte-specific tyrosine phosphatase, CD45, severely impacts T cell deve

75 The non-receptor isoform of protein-tyrosine phosphatase (cyt-PTPe) supports adhesion of bon

76 ith a transsynaptic binding partner, protein tyrosine phosphatase delta (PTPdelta); however, upon BDN

77 or a molecular network in which the receptor tyrosine phosphatase Dlar interacts with the WRC to coup

78 n the N-SH2 domain and the catalytic protein tyrosine phosphatase domain of SHP-1.

79 ed in the 831-862 central region of the IA-2 tyrosine phosphatase domain.

80 SHP2 protein-tyrosine phosphatase (encoded by Ptpn11) positively regu

81 Female mice lacking protein tyrosine phosphatase epsilon (PTP epsilon) are mildly os

82 novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of

83 rate preference of 16 members of the protein-tyrosine phosphatase family.

84 Here we report a novel plant tyrosine phosphatase from Arabidopsis thaliana (AtRLPH2)

85 Activation of SFKs requires depletion of tyrosine phosphatases from the area of particle engageme

86 2 inhibitory function is mediated by protein tyrosine phosphatases from the proline-, glutamic acid-,

87 rates and cellular events regulated by Eya's tyrosine phosphatase function and highlights some of the

88 the structural features of receptor protein tyrosine phosphatase-gamma (RPTPgamma) that are consiste

89 umor suppressor genes, including the protein tyrosine phosphatase gene PTPROt, which became silenced

90 ac and Rho proteins and the receptor protein-tyrosine phosphatase genes PTPRM and PTPRE.

91 dephosphorylation via activation of protein-tyrosine phosphatase H1 (PTPH1).

92 ism in PTPN22 (R620W), which encodes the Lyp tyrosine phosphatase, has been linked to a number of aut

93 Recently, protein tyrosine phosphatases have emerged as critical regulator

94 Protein tyrosine phosphatases have received little attention in

95 atases (PTPs) includes hematopoietic protein-tyrosine phosphatase (HePTP), striatal-enriched protein-

96 phosphorylation of p38alpha by hematopoietic tyrosine phosphatase (HePTP).

97 e phosphatase receptor type gamma (PTPRG), a tyrosine phosphatase highly expressed in human primary m

98 A tyrosine phosphatase, HopAO1, secreted by P. syringae, r

99 nonreceptor type 11 Ptpn11 (Shp2), a protein tyrosine phosphatase implicated in multiple cell signali

100 hed protein tyrosine phosphatase), a protein tyrosine phosphatase implicated in several neuropsychiat

101 This is the first time a protein tyrosine phosphatase, implicated in platelet signaling,

102 he ERK phosphatase striatum-enriched protein-tyrosine phosphatase in hemideletion males.

103 al regulation of a specific class of protein tyrosine phosphatases in controlling the rate, and there

104 However, the role of protein tyrosine phosphatases in leukocyte recruitment is still

105 d neurotoxicity, a potential contribution of tyrosine phosphatases in this process has not been well

106 of reactive oxygen species-catalyzed protein-tyrosine phosphatase inactivation have remained largely

107 A decreased HCN1 surface expression, whereas tyrosine phosphatase inhibition did not.

108 ermeability via vascular endothelial-protein tyrosine phosphatase inhibition limits mycobacterial gro

109 with CFTR and were further stimulated by the tyrosine phosphatase inhibitor dephostatin.

110 cid and microcystin, but is inhibited by the tyrosine phosphatase inhibitor orthovanadate and is part

111 osphorylation, whereas administration of the tyrosine phosphatase inhibitor sodium orthovanadate prio

112 ese data reveal the potential utility of EYA tyrosine phosphatase inhibitors as therapeutic agents in

113 APB interacts with the mitochondrial protein tyrosine phosphatase-interacting protein-51 (PTPIP51) to

114 phatase 1B (PTP1B), an ER-associated protein tyrosine phosphatase involved in the negative regulation

115 To date, only one other tyrosine phosphatase is known in plants; thus AtRLPH2 re

116 STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase t

117 phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synap

118 a ubiquitously expressed cytoplasmic protein tyrosine phosphatase, is implicated in regulating M-CSF

119 ine phosphatase, a coding variant within the tyrosine phosphatases, is known to participate in AgR si

120 Receptor protein tyrosine phosphatase-kappa (PTPRK) specifically and dire

121 PTPRB is a transmembrane protein tyrosine phosphatase known to regulate blood vessel remo

122 show that the cadherin Fat2 and the receptor tyrosine phosphatase Lar function in a planar signaling

123 othelial cadherin, the transmembrane protein tyrosine phosphatase LAR, and the RAC1 guanidine-exchang

124 he Ig domains of LAR family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPdelta, and PTP

125 se that was identified, the receptor protein tyrosine phosphatase leukocyte-antigen-related (LAR), ab

126 wo catalytically inactive mutants of protein-tyrosine phosphatase-like myo-inositol phosphatases (PTP

127 The low molecular weight protein tyrosine phosphatase (LMW-PTP) is a regulator of a numbe

128 s demonstrated that the meprin A5 antigen-mu tyrosine phosphatase (MAM) domain and the O-glycan-conta

129 d in vivo binding and retention of a protein tyrosine phosphatase mu (PTPmu)-targeted, molecular magn

130 hing of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 ph

131 Lck, C-terminal Src kinase (Csk) and protein tyrosine phosphatase N22 (PTPN22).

132 Protein Tyrosine Phosphatase N23 (PTPN23) resides in chromosomal

133 We demonstrated that protein tyrosine phosphatase non-receptor 22 (PTPN22), variants

134 interleukin 23 receptor (IL23R) and protein tyrosine phosphatase non-receptor type 22 (PTPN22) pathw

135 The human protein tyrosine phosphatase non-receptor type 4 (PTPN4) prevent

136 in prior panel testing: a pathogenic protein tyrosine phosphatase, non-receptor type 11 (PTPN11) vari

137 tablished that the gene encoding the protein tyrosine phosphatase nonreceptor 22 (PTPN22) makes an im

138 The protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) encode

139 rylated, which could be prevented by protein tyrosine phosphatase nonreceptor type 1 inhibition.

140 Gain-of-function (GOF) mutations of protein tyrosine phosphatase nonreceptor type 11 Ptpn11 (Shp2),

141 The protein tyrosine phosphatase nonreceptor type 12 (PTPN12) is a m

142 tic variant in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22 C1858T)

143 heritance of a coding variant of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene i

144 An allelic variant of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), PTPN2

145 encoded by the autoimmune-associated protein tyrosine phosphatase nonreceptor type 22 gene, PTPN22, h

146 outside of the mitochondria released protein tyrosine phosphatase, nonreceptor type 6 (SHP1, or PTPN6

147 ing from increased expression of the protein tyrosine phosphatase, nonreceptor type, 22 (PTPN22) (p <

148 We discovered that inhibition of either tyrosine phosphatases or the serine/threonine protein ph

149 activation threshold via the recruitment of tyrosine phosphatases, our results suggest a significant

150 r, due to our inability to visualize protein-tyrosine phosphatase oxidation in cells.

151 asing evidence for the importance of protein-tyrosine phosphatase oxidation in signal transduction, t

152 sphorylated by PTP1B, an ER-resident protein tyrosine phosphatase, prior to axonal transport.

153 (phosphatases of regenerating liver) protein tyrosine phosphatases (PRL-1, -2 and -3) have been ident

154 tides and readily dephosphorylates a classic tyrosine phosphatase protein substrate, suggesting that

155 found to downregulate the expression of the tyrosine phosphatase protein tyrosine phosphatase recept

156 Recently, the receptor-like protein tyrosine phosphatases, protein tyrosine phosphatase sigm

157 SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene in

158 D45 is a receptor-like member of the protein tyrosine phosphatase (PTP) family.

159 ndent activation of PTKs and induces protein-tyrosine phosphatase (PTP) inactivation.

160 signaling, we identified reversible protein tyrosine phosphatase (PTP) oxidation as the primary redo

161 tations in PTPN11, which encodes the protein tyrosine phosphatase (PTP) SHP2, are implicated in CHD a

162 sion and signaling unit comprised of protein tyrosine phosphatase (PTP)-PEST and the extracellular ma

163 it does not affect interaction with protein-tyrosine phosphatase (PTP)-PEST.

164 Protein tyrosine phosphatase (PTP)sigma (PTPRS) was shown previo

165 Protein tyrosine phosphatases (PTP) are exciting and novel targe

166 allosteric sites is demonstrated in protein tyrosine phosphatases (PTP) by creation of single alanin

167 that Mena associates constitutively with the tyrosine phosphatase PTP1B and mediates a novel negative

168 We identified the protein tyrosine phosphatase PTP1B as a therapeutic candidate fo

169 a tumor suppressor function for the protein tyrosine phosphatase PTP1B in myeloid lineage cells, wit

170 Protein tyrosine phosphatase PTP1B is a critical regulator of si

171 The protein-tyrosine phosphatase PTP1B is a negative regulator of in

172 shnan and colleagues reveal that the protein tyrosine phosphatase PTP1B is upregulated in patients wi

173 Recently, the protein tyrosine phosphatase PTP1B was identified as a novel reg

174 Here, we show that the tyrosine phosphatase PTP4A1 is highly expressed in fibro

175 C1-Ten acts as a protein tyrosine phosphatase (PTPase) at the nephrin-PI3K bindin

176 threonine phosphatase, and an active protein tyrosine phosphatase, PTPMEG.

177 FD), but that coordinate loss of the protein tyrosine phosphatase Ptpn1 (encoding PTP1B) enables a hi

178 The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an important trans

179 ast growth factor receptors FGFR2 and FGFR3, tyrosine phosphatase PTPN11, and RAS oncogene homologs H

180 Here, we identify the tyrosine phosphatase PTPN13 as a key PDZ binding partner

181 Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal tran

182 In addition, deletion of the protein tyrosine phosphatase PTPN2 in tumour cells increased the

183 f the dynamics of association of the protein tyrosine phosphatase PTPN22 and lipid phosphatase SHIP-1

184 The protein tyrosine phosphatase PTPN22(C1858T) allelic polymorphism

185 We show that CD8(+) T cells that lack the tyrosine phosphatase Ptpn22, a major predisposing gene f

186 he catalytically inactive, non-receptor-type tyrosine phosphatase PTPN23/HD-PTP.

187 T3 were through up-regulation of the protein-tyrosine phosphatase PTPN6.

188 tyrosine 207 (pTyr207)-CrkL and the protein tyrosine phosphatase PTPRC/CD45; these assays were devel

189 The protein tyrosine phosphatase PTPRJ/DEP-1 has been implicated in

190 The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptional

191 Protein tyrosine phosphatases (PTPs) are enzymes that remove pho

192 ribute to proper signal transduction.Protein-tyrosine phosphatases (PTPs) are thought to be major tar

193 Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signalin

194 led to dephosphorylating activity of protein tyrosine phosphatases (PTPs) ensures robust yet diverse

195 been recognized, the significance of protein tyrosine phosphatases (PTPs) in cellular signaling and d

196 to investigate the role of classical protein-tyrosine phosphatases (PTPs) in three-dimensional mammar

197 se interaction motif (KIM) family of protein-tyrosine phosphatases (PTPs) includes hematopoietic prot

198 ansmission was also prevented by the protein tyrosine phosphatases (PTPs) inhibitor sodium orthovanad

199 ion by orthovanadate or depletion of protein tyrosine phosphatases (PTPs) resulted in the recovery of

200 It is well known that protein tyrosine phosphatases (PTPs) that become oxidized due to

201 involves reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and r

202 thways are very tightly regulated by protein tyrosine phosphatases (PTPs) to prevent excessive activa

203 pended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccess

204 er (PRLs), the most oncogenic of all protein-tyrosine phosphatases (PTPs), play a critical role in me

205 protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs).

206 als by signaling through presynaptic protein tyrosine phosphatase receptor delta.

207 , we show that hepatic expression of Protein Tyrosine Phosphatase Receptor Gamma (PTPR-gamma) is stim

208 AP-1A, the small GTPase Rab11B, the surface tyrosine phosphatase receptor PTPRF and its adaptor PPFI

209 er hair cells were fused by P17, and protein tyrosine phosphatase receptor Q, normally linked to myos

210 einnervation by binding the neuronal protein tyrosine phosphatase receptor sigma (PTPsigma).

211 We found a CNV region in protein tyrosine phosphatase receptor type D (PTPRD) with signif

212 scoring tumor suppressor candidates, protein tyrosine phosphatase receptor type F (PTPRF).

213 Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) i

214 we address this issue by focusing on protein tyrosine phosphatase receptor type gamma (PTPRG), a tyro

215 pression of the tyrosine phosphatase protein tyrosine phosphatase receptor type J (PTPRJ), a known ex

216 ein-tyrosine phosphatase (STEP), and protein-tyrosine phosphatase receptor type R (PTPRR).

217 e RAS pathway in mice that expressed protein tyrosine phosphatase receptor-zeta (PTPRZ), whereas PTN

218 ls are transduced through the CLR-1 Lar-like tyrosine phosphatase receptor.

219 Mutations of PTPRD, a receptor-type protein tyrosine phosphatase regulating cell growth, were enrich

220 sents one of the missing pieces in the plant tyrosine phosphatase repertoire and supports the concept

221 te antigen-related (Lar), a receptor protein tyrosine phosphatase (RPTP) and the only known Drosophil

222 e brain is regulated by the Receptor Protein Tyrosine Phosphatase RPTP69d.

223 uble mutants of Drosophila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D.

224 ic apoptosis, requiring the receptor protein tyrosine phosphatases (RPTPs): LAR and RPTPsigma.

225 by gain-of-function mutations in the protein tyrosine phosphatase SH2 domain-containing PTP (SHP2), h

226 inhibitory signaling pathways involving the tyrosine phosphatase SHP-1 and the inositol phosphatase

227 e, we identified a novel role of the protein tyrosine phosphatase SHP-1 in the regulation of murine L

228 ociated with long-lasting recruitment of the tyrosine phosphatase SHP-1 to the CD16 receptor complex.

229 In this study, we observed that loss of the tyrosine phosphatase SHP-1, a negative regulator of TCR

230 rons by PD-L1 induced phosphorylation of the tyrosine phosphatase SHP-1, inhibited sodium channels an

231 nventional T cell proliferation in vitro via tyrosine phosphatase SHP-1-dependent uncoupling of IL-2R

232 d phosphorylation, as well as recruitment of tyrosine phosphatase SHP-1.

233 ctly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

234 d for recruitment of tyrosine kinase SYK and tyrosine phosphatase SHP-1.

235 Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced acti

236 athiolation of critical residues of the ROS1 tyrosine phosphatase SHP-2.

237 itory receptor with the potential to mediate tyrosine phosphatases SHP-1/-2 dependent signaling.

238 tes Src homology domain 2 containing protein tyrosine phosphatase (SHP) 1 and suppresses production o

239 of Src homology domain 2-containing protein tyrosine phosphatase (SHP) 2 and Src homology domain 2-c

240 the Src homology 2 domain-containing protein-tyrosine phosphatases Shp1 and Shp2, knockout and transg

241 Germline activating mutations of the protein tyrosine phosphatase SHP2 (encoded by PTPN11), a positiv

242 The protein tyrosine phosphatase Shp2 (PTPN11) is crucial for normal

243 we have analyzed the function of the protein tyrosine phosphatase Shp2 in mice by deleting its gene P

244 Ablation of the tyrosine phosphatase Shp2 in the intestinal epithelium r

245 We investigated the contribution of protein tyrosine phosphatase Shp2 to lipopolysaccharide (LPS)-in

246 tpn11, which encodes the nonreceptor protein tyrosine phosphatase Shp2, show hippocampal-dependent im

247 s FGF receptor adaptor protein Frs2alpha and tyrosine phosphatase Shp2, two upstream regulators of Ra

248 y tyrosine residues that are targets for the tyrosine phosphatase SHP2, which mediates PD-1 inhibitor

249 However, Shc recruited tyrosine phosphatases SHP2 and PTP1B to Jak3 and thereby

250 ssociated binder-1 (Gab1) and SH2-containing tyrosine phosphatase (SHP2) show slower, sustained incre

251 in the human immune system, receptor protein tyrosine phosphatase sigma (PTPRS) is expressed specific

252 Receptor protein tyrosine phosphatase sigma (PTPsigma) and its subfamily

253 -like protein tyrosine phosphatases, protein tyrosine phosphatase sigma (PTPsigma) and leukocyte comm

254 Protein tyrosine phosphatase sigma (PTPsigma), along with its si

255 e trans-interacting with presynaptic protein tyrosine phosphatase sigma (PTPsigma).

256 Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neurona

257 bound to the axon guidance proteins, protein tyrosine phosphatase sigma (RPTPsigma), and Nogo recepto

258 related (LAR) phosphatase subfamily, protein tyrosine phosphatase sigma and LAR, are functional recep

259 as a positive modulator of the TrkC-protein tyrosine phosphatase sigma complex.

260 ng tyrosine kinase but contains one encoding tyrosine phosphatase (SP-PTP).

261 Mice deficient in the tyrosine phosphatase Src homology 2 domain-containing pr

262 y a scaffold protein, spinophilin (SPL), the tyrosine phosphatase, Src homology region 2 domain-conta

263 nt study, we investigated the effects of the tyrosine phosphatase, SRC-homology 2 domain-containing p

264 rosine phosphatase striatal-enriched protein tyrosine phosphatase (STEP) are known to target the NMDA

265 essive activity of striatal-enriched protein tyrosine phosphatase (STEP) in the brain has been detect

266 n we show that the striatal-enriched protein tyrosine phosphatase (STEP) is recruited by Galphaq-coup

267 at the activity of striatal-enriched protein tyrosine phosphatase (STEP) was upregulated by cocaine,

268 osphatase (HePTP), striatal-enriched protein-tyrosine phosphatase (STEP), and protein-tyrosine phosph

269 The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein ty

270 Both the tyrosine kinase Fyn and the tyrosine phosphatase striatal-enriched protein tyrosine

271 Here, we have identified T cell protein tyrosine phosphatase (TC-PTP), also known as PTPN2, as a

272 d in growth factor signaling, T-cell protein tyrosine phosphatase (TC-PTP), and the E3 ubiquitin liga

273 e report the critical role of T-cell protein tyrosine phosphatase (TC-PTP), encoded by Ptpn2, in chem

274 Conversely, the T cell protein tyrosine phosphatase (TCPTP) dephosphorylated TbetaRII t

275 The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signali

276 signaling protein (MAVS) and T cell protein tyrosine phosphatase (TCPTP) suggests an avenue for comp

277 in ITIMs results in recruitment of a protein tyrosine phosphatase that blocks activation signals.

278 Shp2 is a nonreceptor protein tyrosine phosphatase that has been shown to influence ne

279 identify SHP2 as the ubiquitously expressed tyrosine phosphatase that preferentially binds to and de

280 ity of the receptor and non-receptor protein-tyrosine phosphatases that down-regulate Met phosphoryla

281 on is followed by the recruitment of protein tyrosine phosphatases that inactivate the RTKs and deliv

282 The induction of protein-tyrosine phosphatases, thioredoxin, SOCS, and Egr1 in L.

283 ng ligands and recruit SH2-domain-containing tyrosine phosphatases to their cytoplasmic tails.

284 Protein-tyrosine phosphatase TULA-2 has been shown to regulate r

285 (1143), and show that both c-Src and protein tyrosine phosphatase type 1D (PTP-1D) coimmunoprecipitat

286 sophila ortholog of the non-receptor protein tyrosine phosphatase type II (SHP2) to the Pi3k21B (p60)

287 EC and its phosphatases, EC-specific protein tyrosine phosphatase (VE-PTP) and Src homology phosphata

288 determined that vascular endothelial protein tyrosine phosphatase (VE-PTP) is a HIF2alpha target.

289 ve inhibitor of vascular endothelial-protein tyrosine phosphatase (VE-PTP) that promotes Tie2 activat

290 ding claudin-5, vascular endothelial-protein tyrosine phosphatase (VE-PTP), and von Willebrand factor

291 monstrated that vascular endothelial-protein tyrosine phosphatase (VE-PTP), which negatively regulate

292 hown to co-express striatal-enriched protein tyrosine phosphatase, which may have an important role i

293 ve and novel target is the Eyes absent (EYA) tyrosine phosphatase, which plays a critical role in the

294 hosphorylate STAT3, such as receptor protein tyrosine phosphatases, which are encoded by the PTPR gen

295 yte common antigen CD45, a cellular receptor tyrosine phosphatase with a central role for signal tran

296 Here, we demonstrate that targeting the CD45 tyrosine phosphatase with a tolerogenic anti-CD45RB mAb

297 PTP1B is a ubiquitously expressed tyrosine phosphatase with well-characterized functions i

298 eceptor/ligand complex from receptor protein tyrosine phosphatases with large ectodomains, such as CD

299 c-FMS, and a second IL-34 receptor, protein-tyrosine phosphatase zeta (PTP-zeta) were upregulated in

300 ious work demonstrated that receptor protein-tyrosine phosphatase zeta (RPTPzeta)/phosphacan is hypog