ライフサイエンスコーパス: tyrosine phosphorylation

1 2) phosphatase, which in turn regulates ShcD tyrosine phosphorylation.

2 HASMC proliferation do not require cortactin tyrosine phosphorylation.

3 ellular bacterial pathogens trigger NMHC-IIA tyrosine phosphorylation.

4 receptor that triggers intracellular protein tyrosine phosphorylation.

5 -mediated Ca(2+) extrusion by promoting PMCA tyrosine phosphorylation.

6 orylation and inhibitory C-terminal sites of tyrosine phosphorylation.

7 hosphorylation of SPL Ser94 without reducing tyrosine phosphorylation.

8 g, and enhances IGF-I receptor-induced IRS-2 tyrosine phosphorylation.

9 nked to high Ser-897 phosphorylation and low tyrosine phosphorylation.

10 f CLEC-2 signaling, i.e. the CLEC-2 receptor tyrosine phosphorylation.

11 munoprecipitate and proNodal increases FGFR3 tyrosine phosphorylation.

12 ugh endocytosis and degradation triggered by tyrosine phosphorylation.

13 epair and cell cycle check point proteins by tyrosine phosphorylation.

14 yk2 and Pyk3 undergo increased autocatalytic tyrosine phosphorylation.

15 ting in Src-dependent activation of STAT3 by tyrosine phosphorylation.

16 h corresponding increases in levels of Cps2D tyrosine phosphorylation.

17 rosmotically stressed, STATc is activated by tyrosine phosphorylation.

18 es STAT1 and STAT3 despite the occurrence of tyrosine phosphorylation.

19 to date have focused on the BCR and protein tyrosine phosphorylation.

20 (/+) mouse models of IPD and is activated by tyrosine phosphorylation.

21 ed Shp2-Spry2 interaction and enhanced Spry2 tyrosine phosphorylation.

22 3 and Y250 are more specifically involved in tyrosine phosphorylation.

23 only YES kinase underwent glucose-stimulated tyrosine phosphorylation.

24 sociation with enhanced CDCP1 expression and tyrosine phosphorylation.

25 Shc activation was confirmed by its tyrosine phosphorylation.

26 ed PTPN13, activated c-Abl and triggered tau tyrosine phosphorylation.

27 inase of antiviral pathways, is inhibited by tyrosine phosphorylation.

28 ation of FAK and decreasing VHR promoted FAK tyrosine phosphorylation.

29 ina, and that it undergoes a light-dependent tyrosine phosphorylation.

30 ocks the capacitation-associated increase in tyrosine phosphorylation.

31 pacitating conditions lead to an increase in tyrosine phosphorylation.

32 undergo capacitation-associated increases in tyrosine phosphorylation.

33 Though tyrosine phosphorylation accounts for a minority of tota

34 We previously reported that tyrosine phosphorylation activates and inhibits mitochon

35 authors demonstrate iSNAP, a tool to detect tyrosine phosphorylation and activate desired protein en

36 Rwt leads to a striking increase in EGFRvIII tyrosine phosphorylation and activation while silencing

37 nalling cascade dynamics associated with Syk tyrosine phosphorylation and activation.

38 yk and Pyk2 stimulation is required for p300 tyrosine phosphorylation and activation.

39 , and inhibition of insulin-stimulated IRS-1 tyrosine phosphorylation and AKT2 phosphorylation.

40 d Cdk2/cyclin A, as well as its responses to tyrosine phosphorylation and altered p21:Cdk2/cyclin A s

41 ed and previously undocumented EGF-dependent tyrosine phosphorylation and binding events, as well as

42 hosphorylation by PKA can coexist with EphA2 tyrosine phosphorylation and block cell retraction induc

43 (B-CLL) cells, resulting in a high level of tyrosine phosphorylation and contributing to their resis

44 Thus, preventing tyrosine phosphorylation and degradation of beta-dystrog

45 on mouse genetic models, we have identified tyrosine phosphorylation and degradation of beta-dystrog

46 the structural basis for activation through tyrosine phosphorylation and dimerization.

47 latelet-endothelial cell adhesion molecule 1 tyrosine phosphorylation and diminished collagen-related

48 versely, inhibition of Src reduces kindlin-2 tyrosine phosphorylation and diminishes the kindlin-2.Sr

49 As and prevented EGFR/CD95 association, CD95 tyrosine phosphorylation and DISC formation.

50 130Cas targeting to FAs is essential for its tyrosine phosphorylation and downstream signaling.

51 hat siRNA knockdown of SOCS1 prolonged IRS-2 tyrosine phosphorylation and enhanced M2 differentiation

52 EGF-induced EGF receptor (EGFR) tyrosine phosphorylation and extracellular signal-regula

53 he activated EGFR with CD95, subsequent CD95 tyrosine phosphorylation and formation of the death-indu

54 s1, which was found to be essential for OCT2 tyrosine phosphorylation and function.

55 form of pyruvate kinase M2 (PKM2) undergoes tyrosine phosphorylation and gives rise to the Warburg e

56 dium orthovanadate prior to ethanol restored tyrosine phosphorylation and IL-1beta secretion subseque

57 A prototype that can detect tyrosine phosphorylation and immediately activate auto-i

58 ibitors both prevent parasite-induced band 3 tyrosine phosphorylation and inhibit parasite-promoted m

59 These results suggest that kindlin-2 tyrosine phosphorylation and interaction with Src serve

60 c acid, by stimulating zona occludens (ZO)-2 tyrosine phosphorylation and its dissociation from claud

61 chanistically, LECT2 reduced VEGF receptor 2 tyrosine phosphorylation and its downstream extracellula

62 kin mice with mutations that disrupt nephrin tyrosine phosphorylation and Nck1/2 binding (nephrin(Y3F

63 Anti-IgM antibodies induced transient tyrosine phosphorylation and nuclear localization of pho

64 min), and protracted compared with receptor tyrosine phosphorylation and occurs in multiple cell typ

65 rted recently, resulting in increased band 3 tyrosine phosphorylation and perturbation of the stabili

66 is, revealing key control mechanisms such as tyrosine phosphorylation and phosphoinositide 3-kinase (

67 marked inhibition of insulin-stimulated IRS1 tyrosine phosphorylation and PI3K binding after emetine

68 ximal IGF-1R signaling events, including IRS tyrosine phosphorylation and recruitment of PI3K, are no

69 Overexpression of ShcA promoted nephrin tyrosine phosphorylation and reduced nephrin signaling a

70 s unveil the negative regulation of TBK1 via tyrosine phosphorylation and the functional integration

71 Src activation increases kindlin-2 tyrosine phosphorylation and the kindlin-2.Src interacti

72 mma subunits blocked activation of Akt, GIT1 tyrosine phosphorylation, and ET-1-stimulated GIT1-eNOS

73 VEGFR2 activation, Src-dependent VE-cadherin tyrosine phosphorylation, and internalization leading to

74 ith interleukin-13 (IL-13) secretion, JAK1/2 tyrosine phosphorylation, and reduced expression of SHP1

75 Thus, GAS is thought to lack tyrosine phosphorylation, and the physiological signific

76 transferase inhibitor, showed an increase in tyrosine phosphorylation, and the sensitivity of the cor

77 Light and tyrosine phosphorylation appear to regulate PKM2 to prov

78 The importance of PI3K activity and tyrosine phosphorylation are two examples of insights co

79 pertoire and supports the concept of protein tyrosine phosphorylation as a key regulatory event in pl

80 In this study, we identify TCR-induced Dlg1 tyrosine phosphorylation as a key regulatory step requir

81 Together, our results identify tyrosine phosphorylation as an important regulatory mech

82 of exogenous IGF-1 triggers synergistic IRS1 tyrosine phosphorylation at PI3K-activating residues tha

83 We have shown previously that tyrosine phosphorylation at Tyr-64 and Tyr-155 activates

84 This event led to tyrosine phosphorylation at Tyr627 domain of GAB1 that r

85 several parameters, such as calcium release, tyrosine phosphorylation, BCR aggregation, BCR internali

86 es epidermal growth factor-induced cortactin tyrosine phosphorylation both directly and indirectly vi

87 ntagonize the activity of PTKs in regulating tyrosine phosphorylation, but can also play dominant rol

88 n receptor tyrosine kinase, EphA2, undergoes tyrosine phosphorylation, but the effect of phosphorylat

89 ects of SH2 domain overexpression on protein tyrosine phosphorylation by quantitative Western and far

90 tyrosine residues, our results unveiled the tyrosine phosphorylation cascade as a common regulatory

91 - and spleen tyrosine kinase (Syk)-dependent tyrosine phosphorylation cascade.

92 acterial pathogens often interfere with host tyrosine phosphorylation cascades to control host respon

93 ation of signal pathways mediated by protein tyrosine phosphorylation causes numerous human diseases,

94 inhibits cell-ECM adhesion-induced paxillin tyrosine phosphorylation, cell migration, and proliferat

95 reased Ser-897 phosphorylation and decreased tyrosine phosphorylation compared with EphA2 wild type.

96 Suppression of STAT3 tyrosine phosphorylation coordinately decreased the mRNA

97 Tyrosine phosphorylation decreased Ih amplitude at maxim

98 ns can serve as coreceptors for the TCR in a tyrosine phosphorylation dependent manner, and some are

99 signals in a Src family kinase Fyn-mediated tyrosine phosphorylation-dependent manner.

100 ne ephrinBs transduce reverse signaling in a tyrosine phosphorylation-dependent or -independent, as w

101 hanism by which cells regulate the cortactin tyrosine phosphorylation-dephosphorylation cycle at inva

102 further supporting a positive role for Runx1 tyrosine phosphorylation during granulopoiesis, mutation

103 Profiling of nephrin tyrosine phosphorylation dynamics in wild-type mice subj

104 can enhance lanthanide ion luminescence upon tyrosine phosphorylation enable rapid, sensitive screeni

105 een RET/PTC3 and STAT1, followed by a direct tyrosine phosphorylation event, was necessary for STAT1

106 Given the role of tyrosine phosphorylation events in different human infec

107 ponsible for the majority of known bacterial tyrosine phosphorylation events.

108 nizes IFN-alpha/beta-induced STAT1 and STAT2 tyrosine phosphorylation, gene expression, and antiviral

109 ion of the balanced modulation of reversible tyrosine phosphorylation has been implicated in the etio

110 Moreover, reduced nephrin tyrosine phosphorylation has been observed in podocytes

111 PKA-independent activation by tyrosine phosphorylation has implications for the mechan

112 ut alternative STAT functions independent of tyrosine phosphorylation have been documented, including

113 yk2(-/-) mice displayed a normal increase in tyrosine phosphorylation, implying that PYK2 is not resp

114 Conversely, dasatinib enhanced tyrosine phosphorylation in a panel of RTK and their sig

115 rotein alpha), which showed strongly reduced tyrosine phosphorylation in CD47(-/-) bone marrow stroma

116 Furthermore, LTB4 decreased insulin receptor tyrosine phosphorylation in hepatocytes, activated the N

117 tyrosine kinase(s) mediating the increase in tyrosine phosphorylation in mouse sperm.

118 Examination of Pyk2 tyrosine phosphorylation in normal polarized cells demon

119 ation of the potential role of extracellular tyrosine phosphorylation in physiological and pathologic

120 ons, balloon injury (BI) induced p115 RhoGEF tyrosine phosphorylation in rat common carotid arteries,

121 Our findings implicate tyrosine phosphorylation in regulating the electrophysio

122 proteomic analysis, PAG showed low levels of tyrosine phosphorylation in resting primary mouse CD4(+)

123 define an essential requirement for nephrin tyrosine phosphorylation in stabilizing podocyte morphol

124 We observed an increase in nephrin tyrosine phosphorylation in the presence of Shp2 in cell

125 This unique structure focuses tyrosine phosphorylation in time and space as sperm acqu

126 on of nephrin-CD16 and SHP-1 reduced nephrin tyrosine phosphorylation in transfected human embryonic

127 ersistent and enhanced levels of STAT5BN642H tyrosine phosphorylation in transformed CD8+ T cells led

128 hat IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells.

129 We observed a marked increase in tyrosine phosphorylation, including the FcRgamma chain a

130 primary mouse CD4(+) T cells; the levels of tyrosine phosphorylation increased and reached a maximum

131 Proteasomal inhibition prolonged IRS-2 tyrosine phosphorylation, increased ubiquitination of IR

132 Pharmacological modulation of tyrosine phosphorylation indicated that, the Src family

133 sformation of NIH3T3 cells by EN, reduces EN tyrosine phosphorylation, inhibits Akt and Mek1/2 signal

134 ivo, and extends the importance of regulated tyrosine phosphorylation into the extracellular environm

135 mal insulin signaling (insulin receptor [IR] tyrosine phosphorylation, IR substrate 1-phosphatidylino

136 Tyrosine phosphorylation is a vital mechanism that contr

137 Reversible tyrosine phosphorylation is a widespread post-translatio

138 Nephrin tyrosine phosphorylation is altered in human and experim

139 Low-abundance tyrosine phosphorylation is crucial to not only normal b

140 Reelin-induced tyrosine phosphorylation is responsible for enrichment o

141 Cellular signaling through protein tyrosine phosphorylation is well established in mammalia

142 icated mice where it inhibits parkin through tyrosine phosphorylation leading to the accumulation of

143 alyses showed these four proteins had higher tyrosine phosphorylation levels in response to CRP in pl

144 talytic domain, cytochrome c oxidase and its tyrosine phosphorylation, mitofusins and PGC-1alpha.

145 rotein tyrosine kinases in orchestrating the tyrosine phosphorylation networks and in target-based dr

146 ificity of these inhibitors for FGF2 because tyrosine phosphorylation of a different substrate of Tec

147 production, calcium (Ca(2+)) responses, and tyrosine phosphorylation of a number of proteins.

148 the regulatory subunit of the PI3K, through tyrosine phosphorylation of adapter protein insulin rece

149 TCRs modulated alpha7 currents via tyrosine phosphorylation of alpha7 nicotinic receptors (

150 C-2 receptors are known to activate Syk upon tyrosine phosphorylation of an immune tyrosine activatio

151 We show that tyrosine phosphorylation of any of the three tyrosines,

152 Moreover, EGFR/Src-signaling triggers the tyrosine phosphorylation of beta4 integrin, which, in tu

153 ding partner Shc1 is dependent on Syk, as is tyrosine phosphorylation of both partners.

154 Blocking the tyrosine phosphorylation of C-Raf with Src family inhibi

155 PRS preselection DP thymocytes show impaired tyrosine phosphorylation of CD3zeta, as well as impaired

156 ery early TCR signaling events including the tyrosine phosphorylation of CD3zeta.

157 f CitK that are phosphorylated and show that tyrosine phosphorylation of CitK impairs cytokinesis.

158 Together, these findings demonstrate that tyrosine phosphorylation of cortactin at Y446 residue is

159 of withdrawal, there is a marked decrease in tyrosine phosphorylation of critical intracellular and m

160 epithelial cell-cell junctions and promotes tyrosine phosphorylation of E-cadherin, beta-catenin, an

161 endothelial function, mediated by increased tyrosine phosphorylation of eNOS and excess Nox2-derived

162 s an increase in SFK activity and downstream tyrosine phosphorylation of enzymes, adaptors, and cytos

163 of modulating animal behavior, extracellular tyrosine phosphorylation of EphBs may represent a previo

164 Although tyrosine phosphorylation of extracellular proteins has b

165 Over-expression of VHR decreased tyrosine phosphorylation of FAK and decreasing VHR promo

166 t (i) the interaction of FGF2 with Tec, (ii) tyrosine phosphorylation of FGF2 mediated by Tec in vitr

167 nner leaflet along with Tec kinase-dependent tyrosine phosphorylation of FGF2, (ii) PI(4,5)P2-depende

168 process is regulated by Tec kinase-mediated tyrosine phosphorylation of FGF2.

169 timulates membrane pore formation based upon tyrosine phosphorylation of FGF2.

170 shown that non-receptor tyrosine kinases and tyrosine phosphorylation of focal adhesion proteins such

171 creasing their expression; (4) c-Abl induces tyrosine phosphorylation of HDAC2, a posttranslational m

172 Complete maturation of ULBP2 required tyrosine phosphorylation of HSP60 which was mediated by

173 nsulin treatment of alphaXBPKD cells reduced tyrosine phosphorylation of insulin receptor substrate 1

174 IGF-1 receptor (IGF-1R) but fails to promote tyrosine phosphorylation of IRS1.

175 lief of IRS1 inhibition and IGF-1R-dependent tyrosine phosphorylation of IRS1.

176 ndothelial nitric oxide (eNOS) by decreasing tyrosine phosphorylation of IRS2 (p-Tyr-IRS2) in endothe

177 Engagement of CD28 leads to tyrosine phosphorylation of its cytoplasmic region and r

178 helium and that PTK7-SFK signaling regulates tyrosine phosphorylation of junctional ROCK2.

179 Tyrosine phosphorylation of Lyn and Syk was altered in P

180 Tyrosine phosphorylation of membrane receptors and scaff

181 nhibition, and this was coupled to increased tyrosine phosphorylation of MET and RON.

182 TNF induces tyrosine phosphorylation of Mule, which subsequently dis

183 rtex (DLPFC), we found striking decreases in tyrosine phosphorylation of N-methyl-D aspartate (NMDA)

184 echanism of NLRP3 inflammasome regulation by tyrosine phosphorylation of NLRP3 at Tyr861.

185 diated activation of TrkB- and TrkB-mediated tyrosine phosphorylation of NMDA receptors.

186 on between the Notch3 and EGFR receptors and tyrosine phosphorylation of Notch3.

187 that, among the RhoGEFs tested, MCP1 induced tyrosine phosphorylation of p115 RhoGEF but not of PDZ R

188 mportantly, imatinib and nilotinib increased tyrosine phosphorylation of p130Cas, FAK, PXN and radial

189 elated drug, nilotinib, strikingly increases tyrosine phosphorylation of p130Cas, focal adhesion kina

190 e other hand, we observe no reduction in the tyrosine phosphorylation of parkin and the parkin substr

191 ifically, in the present study, we show that tyrosine phosphorylation of PKD2 at residue Y87 defines

192 1) kinase by enhancing c-Src kinase-mediated tyrosine phosphorylation of Plk1.

193 f Ca(2+) efflux is reversed by E2-stimulated tyrosine phosphorylation of PMCA.

194 ed at the trailing edge, suggesting that the tyrosine phosphorylation of Pyk2 is spatially regulated

195 Thrombin induced tyrosine phosphorylation of Pyk2, Gab1, and p115 RhoGEF,

196 degranulation, extracellular calcium uptake, tyrosine phosphorylation of several key signaling protei

197 Tyrosine phosphorylation of signaling molecules that med

198 Unexpectedly, and differently from VAV1, tyrosine phosphorylation of SOS1, ARHGEF1, and DOCK2 is

199 ls with Gal3 knockdown exhibited upregulated tyrosine phosphorylation of spleen tyrosine kinase and s

200 pylori caused an increase in the C-terminal tyrosine phosphorylation of Src homology-2 domain-contai

201 NS5-STAT2 interaction requires IFN-I-induced tyrosine phosphorylation of STAT1 and the K63-linked pol

202 reatment with interleukin-6 (IL-6) increased tyrosine phosphorylation of STAT3 and evoked a parallel

203 Erasin inhibits tyrosine phosphorylation of STAT3 with selectivity over

204 nd time-dependent manner that coincides with tyrosine phosphorylation of STAT5.

205 ll-based secondary assays, TC-2153 increased tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2

206 onsistent with this, thrombin did not induce tyrosine phosphorylation of Syk and the FcRgamma chain i

207 echanisms.One involves GRK2-RH and modulates tyrosine phosphorylation of Syk, and the other is mediat

208 orylation of FcinRIgamma or Src but enhanced tyrosine phosphorylation of Syk.

209 controls early TCR signaling events, such as tyrosine phosphorylation of TCRzeta, ZAP70, and LAT and

210 d barrier function and excessive Src-related tyrosine phosphorylation of the adherens junction protei

211 Tyrosine phosphorylation of the beta chain has been stud

212 broblasts, through a mechanism that involves tyrosine phosphorylation of the epidermal growth factor

213 In exploring the mechanism whereby tyrosine phosphorylation of the erythrocyte anion transp

214 criptional elongation based on CK2-dependent tyrosine phosphorylation of the globular domain of H2A.

215 4-induced M2 gene expression correlated with tyrosine phosphorylation of the insulin receptor substra

216 Evidence indicates that tyrosine phosphorylation of the intracellular tail of ne

217 38alpha MAPK, which also blocked KOR-induced tyrosine phosphorylation of the inwardly rectifying pota

218 effects were correlated with an increase in tyrosine phosphorylation of the previously identified PT

219 GPR30 further inhibits PMCA activity through tyrosine phosphorylation of the pump.

220 nds to the insulin receptor (IR) and induces tyrosine phosphorylation of the receptor and insulin rec

221 the KIT receptor, enhanced degranulation and tyrosine phosphorylation of the receptor were observed.

222 and Cbl-b led to an increased ligand-induced tyrosine phosphorylation of the receptor.

223 We have previously established that tyrosine phosphorylation of the transmembrane protein ne

224 ransfected into Jurkat cells showed that the tyrosine phosphorylation of the type II was the same as

225 rated that PTP1B was a negative regulator of tyrosine phosphorylation of the tyrosine kinase TRKB, th

226 Importantly, chemokine-induced tyrosine phosphorylation of these GEFs is fully mediated

227 Inhibition of PTP1B led to increased tyrosine phosphorylation of TRKB in the brain, which wou

228 ownstream of PDGFRs to enhance PDGF-mediated tyrosine phosphorylation of various signaling intermedia

229 Src tyrosine kinase activity and tyrosine phosphorylation of VE-cadherin were increased i

230 Src activity and tyrosine phosphorylation of VE-cadherin were increased i

231 t affect the ability of leukocytes to induce tyrosine phosphorylation of VE-cadherin.

232 We show that tyrosine phosphorylation of VEGFR2 is significantly elev

233 Altogether, our results indicate that tyrosine phosphorylation of WASP by Hck is required for

234 transendothelial migration, suggesting that tyrosine phosphorylation of WASP by Hck may play a role

235 We demonstrate that tyrosine phosphorylation of WASP in response to stimulat

236 ing ITCH-WBP2 interactions via EGFR-mediated tyrosine phosphorylation of WBP2 and TAZ/YAP competitive

237 We have shown previously that tyrosine phosphorylation of Wiskott-Aldrich syndrome pro

238 pid rafts, followed by abrogation of protein tyrosine phosphorylation of ZAP70, phospholipase C-gamma

239 12/15-LO-12/15(S)-HETE axis, in addition to tyrosine phosphorylation of ZO-2, also stimulates threon

240 ich links the opposing effects of serine and tyrosine phosphorylations of IRS1 and can modulate insul

241 tor-tyrosine kinase, EphA2, transactivation (tyrosine phosphorylation) of EphA2, and recruitment of t

242 t on the effect of this EGFR-dependent GSTP1 tyrosine phosphorylation on the interaction of GSTP1 wit

243 for JAK and PI3K activity but not for GP130 tyrosine phosphorylation or STAT3.

244 o significant differences were evident in IR tyrosine phosphorylation or the downstream elements, AKT

245 In addition, MCP1-induced cortactin tyrosine phosphorylation, p21Cip1 degradation and HASMC

246 inhibitors attenuated MCP1-induced cortactin tyrosine phosphorylation, p21Cip1 degradation and HASMC

247 significant, dose-dependent increase in EGFR tyrosine phosphorylation, particularly of sites correspo

248 Consistent with reduced WASP tyrosine phosphorylation, phagocytosis, chemotaxis, and

249 The BIK1 tyrosine phosphorylation plays a crucial role in BIK1-me

250 Tyrosine phosphorylation plays an important role in many

251 of keratin primary amino acid sequences, and tyrosine phosphorylation predictions, extracted from pub

252 n in these cells, we assessed altered global tyrosine phosphorylation (pY) after dasatinib exposure u

253 armacological inhibitors of dual-specificity tyrosine phosphorylation regulated kinases and cdc-like

254 selective inhibitor of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) and cel

255 inase, a fly homolog of the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A); h

256 on of the regulatory kinase dual-specificity tyrosine phosphorylation-regulated kinase 1A was shown t

257 The dual-specificity tyrosine phosphorylation-regulated kinase DYRK1A is a se

258 d negative signals from the dual-specificity tyrosine phosphorylation-regulated kinase family kinase

259 ver this included Cabyr, the calcium-binding tyrosine phosphorylation-regulated protein encoded trans

260 ince DREAM requires DYRK1A (dual-specificity tyrosine phosphorylation-regulated protein kinase 1A) ph

261 II, alpha subunit (SCN2A), dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), a

262 tified a novel role for the dual specificity tyrosine-phosphorylation-regulated kinase DYRK1A in regu

263 ivo growing human brain tumors, we show that tyrosine phosphorylation shifts the GSTP1 dimer-monomer

264 Here, we identify a tyrosine phosphorylation site at Y72 of histone H4, whic

265 Our data also show that multiple tyrosine phosphorylation sites of CDCP1 are important fo

266 horylation sites including 366 low-abundance tyrosine phosphorylation sites, with high reproducibilit

267 horylation of the receptor at all five major tyrosine phosphorylation sites.

268 fic ARIH2 transcription was regulated by the tyrosine phosphorylation states of HoxA9 and HoxA10.

269 By quantitatively assessing the tyrosine phosphorylation status of activated kinases in

270 lecular level, DUSP3 deficiency impaired Syk tyrosine phosphorylation, subsequently reducing phosphor

271 ime-dependent and spatially specific protein tyrosine phosphorylation successfully migrate.

272 cts in HEK 293T cells and observed increased tyrosine phosphorylation, suggesting increased ABL1 kina

273 modifications such as lysine acetylation and tyrosine phosphorylation, suggesting metabolic and signa

274 d STAT proteins, classically associated with tyrosine phosphorylation, support tumor development as t

275 s in greater PTPRK expression and lower EGFR tyrosine phosphorylation than either ligand alone.

276 ma membrane without blocking the increase in tyrosine phosphorylation that accompanies capacitation.

277 uorescently labeled receptors and stimulated tyrosine phosphorylation that are spatially confined to

278 moting the subsequent stimulation of protein tyrosine phosphorylation that associates with fertilizin

279 es the activity of androgen receptor (AR) by tyrosine phosphorylation to fuel the growth of hormone-r

280 3A (JHDM2a) complex, which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional

281 fficking of VEGFR2, and site-specific VEGFR2 tyrosine phosphorylation to study differences in induced

282 Insulin-stimulated Irs1 tyrosine phosphorylation (Tyr(P)(Irs1)) was enhanced by

283 we describe an inverse relationship between tyrosine phosphorylation (Tyr(P)) and serine phosphoryla

284 searched for novel host proteins undergoing tyrosine phosphorylation upon L. monocytogenes infection

285 and pathogen compete to take control of PRR tyrosine phosphorylation used to initiate antibacterial

286 tion of FcepsilonRII activated intracellular tyrosine phosphorylation via Syk in B cells but not in m

287 Imatinib and nilotinib-induced tyrosine phosphorylation was dependent on expression of

288 Increased tyrosine phosphorylation was observed at the plasma memb

289 The pattern of tyrosine phosphorylation was similar to that induced by

290 and SYK-dependent counterregulation of MyD88 tyrosine phosphorylation, we have demonstrated that the

291 Differences in tyrosine phosphorylation were associated with difference

292 ion factors, 32 new targets of EPO-modulated tyrosine phosphorylation were defined.

293 thanol treatment markedly decreased cellular tyrosine phosphorylation, whereas administration of the

294 ignaling activates binding sites, such as by tyrosine phosphorylation, which enables protein recruitm

295 Deletion of IP6K1 abolishes alpha-actinin tyrosine phosphorylation, which is known to be regulated

296 EGF leads to a striking increase in EGFRvIII tyrosine phosphorylation while silencing HB-EGF attenuat

297 By mimicking RAD51 tyrosine phosphorylation with a nonnatural amino acid, p

298 ates cell adhesion and migration by bridging tyrosine phosphorylation with cytoskeletal remodeling, t

299 in the TKI-resistant mutants suppresses EGFR tyrosine phosphorylation, with the most significant effe

300 Second, we found conservation of tyrosine phosphorylation within the RNP1 and RNP2 consen