ライフサイエンスコーパス: tyrosine-phosphorylated

1 by forming a complex with cSrc and becoming tyrosine phosphorylated.

2 tified Phb1 to be serine and Phb2 serine and tyrosine phosphorylated.

3 system, yet Bright itself is not appreciably tyrosine phosphorylated.

4 ecruit actin but only C. trachomatis Tarp is tyrosine phosphorylated.

5 proteolytically processed 80-kDa fragment is tyrosine phosphorylated.

6 proteins by nuclear translocation when it is tyrosine-phosphorylated.

7 migration, cell invasion, and apoptosis, is tyrosine-phosphorylated.

8 two highly conserved tyrosine residues, was tyrosine-phosphorylated.

9 at Na(V)1.5 channels from these myocytes are tyrosine-phosphorylated.

10 related rhadinovirus TKs are constitutively tyrosine phosphorylated; a KSHV TK mutant that was hypop

11 Tyrosine-phosphorylated AAV2 vectors enter cells efficie

12 Moreover, tyrosine-phosphorylated Ack forms a stable complex with

13 ors but not benign prostate showed increased tyrosine-phosphorylated Ack1 and decreased Wwox.

14 etected and correlated with the detection of tyrosine-phosphorylated Ack1.

15 Using an antibody specific for the tyrosine-phosphorylated, activated form of PLCgamma1, we

16 rc homology 2 domain-mediated binding to the tyrosine-phosphorylated adaptor SLP65.

17 In mouse macrophages, MAYP is tyrosine phosphorylated after activation of the colony-s

18 ith signaling proteins Grb2 and Vav1, and is tyrosine phosphorylated after BCR stimulation.

19 analysis we identified 11 proteins that were tyrosine phosphorylated after GM-CSF stimulation and who

20 Here, we report that Sprouty proteins become tyrosine phosphorylated after growth factor treatment.

21 vered that the LspA proteins themselves were tyrosine phosphorylated after wild-type H. ducreyi cells

22 a protein associated with SIRPbeta1 that was tyrosine-phosphorylated after PMN stimulation and is not

23 y reduced, the 89 kDa and 75 kDa isoforms of tyrosine phosphorylated alpha-dystrobrevin (alpha-dbn) 1

24 STATc becomes tyrosine phosphorylated and accumulates in the nucleus w

25 AnkA is highly tyrosine phosphorylated and binds to the Abl interactor

26 The EGFRwt also becomes tyrosine phosphorylated and constitutively activated wit

27 E1A and the insulin receptor, IRS-4 remains tyrosine phosphorylated and constitutively associates wi

28 cquires transcriptional function by becoming tyrosine phosphorylated and imported to the nucleus foll

29 During cerebellar development, Cas is highly tyrosine phosphorylated and is concentrated in the neuri

30 also show that integrin-associated JAM-A is tyrosine phosphorylated and is rapidly dephosphorylated

31 In GIST-R, AXL is tyrosine phosphorylated and its ligand growth-arrest-spe

32 in the absence of IFN stimulation but became tyrosine phosphorylated and nuclear following IFN additi

33 We observed that Y33F Wwox mutant was still tyrosine phosphorylated and polyubiquitinated by Ack1 ac

34 In Src-transformed fibroblasts, Tks4 is tyrosine phosphorylated and predominantly localized to r

35 as mutant lacking the YDxP motifs, which are tyrosine phosphorylated and thereby interact with Crk.

36 ults in this study demonstrate that STAT3 is tyrosine phosphorylated and transcriptionally activated

37 Both proteins were tyrosine phosphorylated and were recruited within Grb2 s

38 In EGF-treated cells, Tks4 is tyrosine-phosphorylated and associated with the activate

39 stimulation via the antigen receptors, it is tyrosine-phosphorylated and binds Grb2 and the p85 subun

40 , the scaffolding protein p130Cas is rapidly tyrosine-phosphorylated and co-localizes with CD36 to me

41 d that this fusion protein is constitutively tyrosine-phosphorylated and is transforming both in vitr

42 Pressure activated PI3K, tyrosine-phosphorylated and membrane-translocated the p8

43 on cell stimulation with EGF or PDGF, Ack is tyrosine-phosphorylated and recruited to activated EGF o

44 nce of an extra copy of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A (Dyrk1A)

45 tmortem PD brain, c-Abl is active, parkin is tyrosine-phosphorylated, and AIMP2 and FBP1 accumulate i

46 androgen-independent prostate tumor samples, tyrosine-phosphorylated AR protein was detected and corr

47 strate-trapping mutant formed a complex with tyrosine-phosphorylated ASK1, suggesting that ASK1 is a

48 ture normal and transformed B cells, becomes tyrosine phosphorylated, associates with proximal signal

49 ranes contain Src and PLCgamma, which become tyrosine phosphorylated at cytokinesis, and whose activa

50 show that after binding of hepcidin, Fpn is tyrosine phosphorylated at the plasma membrane.

51 tein, Tarp, was found to be translocated and tyrosine phosphorylated at the site of entry and associa

52 report that upon treatment of EGF, RSK2 was tyrosine-phosphorylated at Tyr-529 and activated in 293T

53 This accumulation of tyrosine-phosphorylated BCAP at the membrane with its as

54 This tyrosine-phosphorylated BCAP is transiently enriched in

55 on and is associated with elevated levels of tyrosine phosphorylated beta-catenin and the up-regulati

56 MT through integrin-dependent association of tyrosine-phosphorylated beta-catenin and pSmad2 and sugg

57 We found that endogenous tyrosine-phosphorylated beta-catenin coimmunoprecipitate

58 horylated, enabling recruitment of SHP-2 and tyrosine-phosphorylated beta-catenin to its cytoplasmic

59 ctions, including an increased expression of tyrosine-phosphorylated beta-catenin, dissociation of be

60 ited the pervanadate-inducible expression of tyrosine-phosphorylated beta-catenin.

61 -HCC cases display a unique up-regulation of tyrosine-phosphorylated-beta-catenin, suggesting robust

62 resent study was to test our hypothesis that tyrosine-phosphorylated beta1 (pYbeta1) and nonphosphory

63 We demonstrated that FAK tyrosine-phosphorylated betaPIX and thereby increased it

64 Only STAT3 was found constitutively tyrosine phosphorylated, but not other STATs.

65 ents, the same compartments in which LRP1 is tyrosine phosphorylated by activated PDGFRbeta.

66 Lnk itself was tyrosine phosphorylated by both FLT3 ligand (FL)-activat

67 PKCdelta was tyrosine phosphorylated by either PAR1 or PAR4 in a conc

68 reyi culture supernatant fluid could also be tyrosine phosphorylated by macrophages.

69 We find that Dlg1AB but not Dlg1B is tyrosine phosphorylated by proximal tyrosine kinase Lck

70 Even though cortactin can be tyrosine phosphorylated by Src-family kinases in vitro [

71 These receptors are up-regulated and tyrosine phosphorylated by treatment with nicotine, anti

72 roteins that regulate cell migration and are tyrosine-phosphorylated by focal adhesion kinase (FAK).

73 family non-receptor tyrosine kinase, and is tyrosine-phosphorylated by Fyn on Tyr-18.

74 Our findings indicate that HuR is tyrosine-phosphorylated by JAK3, and link this modificat

75 After ligation of TLR9, DOCK8 became tyrosine-phosphorylated by Pyk2, bound the Src-family ki

76 a stable protein complex with and is heavily tyrosine-phosphorylated by the oncogenic tyrosine kinase

77 Purified GRK5 was tyrosine-phosphorylated by the wild-type PDGFRbeta to a

78 r high salt conditions resulted in increased tyrosine-phosphorylated CagA and increased secretion of

79 Concomitantly, parkin was tyrosine-phosphorylated, causing loss of its ubiquitin l

80 from buoyant fractions, decreasing AC5/6 and tyrosine-phosphorylated caveolin-1 in caveolin-1 immunop

81 more, SHP-1 in HCs coimmunoprecipitates with tyrosine phosphorylated CD22 and localizes in the same c

82 dent phosphorylation at the plasma membrane, tyrosine-phosphorylated CD3zeta accumulates on endosomal

83 eripheral T cells, contains a constitutively tyrosine-phosphorylated CD3zeta molecule termed p21.

84 dothelial cells (ECs), beta-catenin remained tyrosine phosphorylated, coinciding with a sustained inc

85 ce of SH2 domains, GSFLVR; (ii) it binds the tyrosine phosphorylated cytoplasmic domain of band 3 (cd

86 eceptor-bound protein 2 (Grb2) SH2 domain to tyrosine-phosphorylated cytosolic domains of receptor ty

87 e (CrkL) have been proposed to interact with tyrosine phosphorylated Dab1 to mediate downstream event

88 PIP5Kbeta is tyrosine phosphorylated, dissociates from the plasma mem

89 Crk-associated substrate (Cas) is a tyrosine-phosphorylated docking protein that is indispen

90 are expressed in platelets and that Dok-2 is tyrosine-phosphorylated downstream of integrin alphaIIbb

91 (Srcasm) is a substrate of SFKs that becomes tyrosine-phosphorylated downstream of the EGF receptor.

92 i-pTyr antibody, demonstrating that they are tyrosine phosphorylated during infection of the host cel

93 of CABYR, a calcium-binding protein that is tyrosine-phosphorylated during capacitation.

94 signal transduction, TbPIP39 becomes rapidly tyrosine-phosphorylated during differentiation, and RNAi

95 recombinant proteins, we observed that c-Abl tyrosine-phosphorylated dynamin 2, and this phosphorylat

96 Importantly, we observed high levels of tyrosine-phosphorylated EGFR and MET in a panel of human

97 ve substance or shear stress, PECAM-1 became tyrosine phosphorylated, enabling recruitment of SHP-2 a

98 The tyrosine phosphorylated epidermal growth factor receptor

99 f endogenous Ack molecules is constitutively tyrosine-phosphorylated, even in starved cells.

100 Furthermore, active/tyrosine-phosphorylated FAK directly binds to PKM2 and p

101 Cell, Lapalombella et al. show that CD37 is tyrosine phosphorylated following engagement by a bivale

102 duced by TLRs in a MyD88-specific manner, is tyrosine phosphorylated following LPS stimulation, and n

103 loid differentiation factor-2 (MD-2) is also tyrosine phosphorylated following LPS stimulation.

104 of an ITIM and ITAM-like sequence, FcRH3 was tyrosine phosphorylated following pervanadate treatment,

105 ype Lnk, but not the Lnk SH2 mutant, becomes tyrosine-phosphorylated following Epo administration and

106 Lnk itself is tyrosine-phosphorylated following thrombopoietin stimula

107 Coimmunoprecipitations revealed the tyrosine phosphorylated form of src kinase Fyn was assoc

108 transformation, and moreover, the activated tyrosine phosphorylated form of Stat5 is frequently obse

109 All pY654-beta-catenin, and only the tyrosine phosphorylated form, was found complexed with H

110 the TCR zeta subunit appears as two distinct tyrosine-phosphorylated forms of 21 and 23 kDa (p21 and

111 lysis of NIH 3T3 cells revealed that the two tyrosine-phosphorylated forms of Cav-2 exhibited some di

112 nuclear import of both unphosphorylated and tyrosine-phosphorylated forms.

113 ed assembly of a complex comprising Shp2 and tyrosine-phosphorylated Gab1 in wild-type hepatocytes.

114 and SHP-2, but not SHP-1, binds directly to tyrosine-phosphorylated Gab1.

115 Correspondingly, GH-induced tyrosine-phosphorylated GHR, JAK2, and ERK1/2 were highl

116 d BMMCs, gamma-tubulin formed complexes with tyrosine-phosphorylated GIT1.

117 the prognostic role of total GIV (tGIV) and tyrosine phosphorylated GIV (pYGIV) across the various m

118 Spatially restricted signaling via tyrosine phosphorylated GIV at the FAs is enhanced durin

119 Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.

120 tase that catalyzes the dephosphorylation of tyrosine-phosphorylated GIV in vitro and inhibits ligand

121 tivated c-Src equivalently, the WT PDGFRbeta tyrosine-phosphorylated GKR2 60-fold more than the Y857F

122 on of MUC1-C/HER2 complexes and decreases in tyrosine-phosphorylated HER2 (p-HER2) levels.

123 lectively binds and enhances the activity of tyrosine-phosphorylated host STAT3.

124 aged in a protein-protein interaction with a tyrosine-phosphorylated host target.

125 N levels inversely correlated with levels of tyrosine-phosphorylated IGF-IR in tissue lysate arrays o

126 Caspase-8 was constitutively tyrosine phosphorylated in a panel of resting epithelial

127 lymphocyte activation molecule]), which are tyrosine phosphorylated in a platelet aggregation-depend

128 Hic-5 was tyrosine phosphorylated in an Src-dependent manner after

129 Here, we observed that EGFR remains tyrosine phosphorylated in breast cancer cells that prol

130 x in some cancer cells and PDHK1 is commonly tyrosine phosphorylated in human cancers by diverse onco

131 We find that Ly108 is constitutively tyrosine phosphorylated in murine thymi in a SAP- and Fy

132 That PI-PLC-gamma1 was transiently tyrosine phosphorylated in nascent phagosomes is consist

133 cells, the overexpressed TOM1L1 was strongly tyrosine phosphorylated in non-stimulated cells, and thi

134 cleotide exchange factors Vav1 and Vav3 were tyrosine phosphorylated in platelets exposed to oxLDL.

135 exchange factor for Rac, was constitutively tyrosine phosphorylated in primary lymphomas from Bcr/Ab

136 ng protein, ARMS/Kidins220, which is rapidly tyrosine phosphorylated in primary neurons after neurotr

137 When p27 is tyrosine phosphorylated in proliferating cells or in vit

138 t that the BRI1 KINASE INHIBITOR 1 (BKI1) is tyrosine phosphorylated in response to brassinosteroid p

139 Ephexin1 becomes tyrosine phosphorylated in response to EphA signaling in

140 ltifunctional transcription factor TFII-I is tyrosine phosphorylated in response to extracellular gro

141 Since ICSBP is tyrosine phosphorylated in response to hematopoietic cyt

142 odium falciparum's lifecycle, band 3 becomes tyrosine phosphorylated in response to oxidative stress,

143 rfGAP, paxillin-kinase-linker (PKL/GIT2), is tyrosine phosphorylated in response to platelet-derived

144 1 (Dok-1), and the phosphatase SHIP are both tyrosine phosphorylated in response to T cell stimulatio

145 We also found that TbetaRI is tyrosine phosphorylated in response to TGF-beta.

146 Here we report that HIP1 is tyrosine phosphorylated in the presence of EGFR and plat

147 ce, co-immunoprecipitates with Sf-Stk and is tyrosine phosphorylated in the presence of Sf-Stk.

148 also find that at least one NPCD isoform is tyrosine phosphorylated in vivo and can serve as a subst

149 In addition, STAT-3 is tyrosine-phosphorylated in a biphasic manner, and the la

150 Finally, we showed that LRP4 becomes tyrosine-phosphorylated in agrin-stimulated muscle cells

151 stem cells and frequently overexpressed and tyrosine-phosphorylated in cancer.

152 In this study we show that YY1 is tyrosine-phosphorylated in multiple cell types.

153 he Vav guanine nucleotide exchange factor is tyrosine-phosphorylated in response to fAbeta peptides a

154 3 and STAT5 were determined to be serine and tyrosine-phosphorylated in response to IL-2 stimulation

155 (Cav-1) is a multifunctional protein that is tyrosine-phosphorylated in response to injury and has be

156 Psigma intestinal substrates that were hyper-tyrosine-phosphorylated in the PTPsigma(-/-) mice relati

157 YEF, a CSF-1R in which all eight tyrosines phosphorylated in the activated receptor were

158 STAT3 was constitutively activated (i.e., tyrosine-phosphorylated) in cholangiocarcinoma cells but

159 STAT5b was tyrosine-phosphorylated, in response to uPA, only in EGF

160 using either p-nitrophenyl phosphate or the tyrosine-phosphorylated insulin receptor as the substrat

161 By specifically recognizing the tyrosine-phosphorylated integrin beta(3), Shc has been s

162 protein levels, and promotes association of tyrosine-phosphorylated IRS-1 with PI3K.

163 The binding of Syk to tyrosine-phosphorylated ITAM subunits of immunoreceptors

164 infection reduces the abundance of JAK-1 and tyrosine-phosphorylated JAK-1.

165 C-terminal Src kinase (Csk) binds to tyrosine phosphorylated JAM-A through its Src homology 2

166 Our results strongly suggest that tyrosine-phosphorylated JAM-A is a Csk-binding protein a

167 Tyrosine-phosphorylated KIT oncoproteins interacted with

168 hese residues disrupts Shp2 interaction with tyrosine-phosphorylated ligands and inhibits its protein

169 trometry to identify the binding partners of tyrosine-phosphorylated M2.

170 tidine side chain to selectively recognize a tyrosine-phosphorylated MAPK substrate.

171 hatase inhibition leads to the clustering of tyrosine-phosphorylated NR2B subunit along dendritic sha

172 cts with EphB2 receptors via its tail and is tyrosine phosphorylated on its tail in an EphB2-dependen

173 Although tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is

174 Studies have shown that the tyrosine-phosphorylated p46/52 isoforms of the ShcA fami

175 Tyrosine-phosphorylated PAG serves as an anchor for C-te

176 iments that infer a radical reorientation of tyrosine-phosphorylated parallel STAT1 dimers to an anti

177 f PTEN does not dephosphorylate PDGF-induced tyrosine phosphorylated PDGF receptor.

178 Upon stimulation by HCMV, tyrosine-phosphorylated PDGFR-alpha associated with the

179 Notably, tyrosine-phosphorylated PDGFRA was prominent in frozen G

180 M and tSH2 but is close to that for a singly tyrosine-phosphorylated peptide binding to a single SH2

181 te experiments using affinity binding with a tyrosine-phosphorylated peptide containing an ITIM (ICAM

182 rotein SH2-Bbeta (SH2-Bbeta (525-670)) and a tyrosine-phosphorylated peptide corresponding to the bin

183 a model substrate of VE-PTP represented by a tyrosine-phosphorylated peptide of Tie-2 dissociates VE-

184 ify temporal phosphorylation profiles of 222 tyrosine phosphorylated peptides across seven time point

185 n was compared between nonphosphorylated and tyrosine phosphorylated peptides using electrospray tand

186 ntaining thousands of serine, threonine, and tyrosine phosphorylated peptides, being present in rough

187 We identified 1,936 unique tyrosine phosphorylated peptides, corresponding to 844 u

188 osphotyrosine antibodies were used to purify tyrosine phosphorylated peptides, which were then identi

189 Nearly 70 tyrosine-phosphorylated peptides from proteins in human

190 RLPH2 displays remarkable selectivity toward tyrosine-phosphorylated peptides versus serine/threonine

191 to aspartate inhibits binding of p85alpha to tyrosine-phosphorylated peptides.

192 e phosphatase fold that unexpectedly targets tyrosine-phosphorylated peptides.

193 tream kinase, ZAP-70, and retained SLP-76 in tyrosine-phosphorylated peripheral structures.

194 In this report, we identify tyrosine-phosphorylated PKL as a protein that associates

195 t of syndecan-4 causes redistribution of the tyrosine-phosphorylated pool of p190RhoGAP between membr

196 n-stimulated cells, the mutated Syk was more tyrosine phosphorylated predominantly as a result of aut

197 Macrophage actin-associated tyrosine phosphorylated protein (MAYP) belongs to the Po

198 The tyrosine phosphorylated protein Crk-associated substrate

199 Cool-associated tyrosine-phosphorylated protein 1 (Cat-1) is a signaling

200 ably phosphorylated by Btk; however, a third tyrosine-phosphorylated protein coprecipitated with Brig

201 The GluN2B subunit is the major tyrosine-phosphorylated protein in synapses.

202 ectron microscopy studies revealed that this tyrosine-phosphorylated protein is localized to the cyto

203 The tyrosine-phosphorylated protein(s) regulates the convers

204 CARP-1 is a tyrosine-phosphorylated protein, and ERRP treatments cau

205 omes associated with an approximately 72-kDa tyrosine-phosphorylated protein, which we identify here

206 of a complex between c-Src and at least one tyrosine-phosphorylated protein.

207 s talin and vinculin, have a central core of tyrosine phosphorylated proteins and are depleted of int

208 ombining mass spectrometry identification of tyrosine phosphorylated proteins and growth inhibition i

209 lts in notable differences in the pattern of tyrosine phosphorylated proteins compared with that obta

210 o acids in cell culture (SILAC), to identify tyrosine phosphorylated proteins in isogenic human bronc

211 d in ganglioside G(M1) and cholesterol where tyrosine phosphorylated proteins occur at late anaphase

212 gressive motility, and alters the pattern of tyrosine phosphorylated proteins.

213 It has been reported that tyrosine-phosphorylated proteins (PY) of host cells are

214 this site results in decreased affinity for tyrosine-phosphorylated proteins and decreased PI3K memb

215 Clusters recruited tyrosine-phosphorylated proteins and induced spatially r

216 FR phosphorylation, decreased the numbers of tyrosine-phosphorylated proteins and levels of type I co

217 Analysis of tyrosine-phosphorylated proteins demonstrated that Crk-a

218 The prominent tyrosine-phosphorylated proteins focal adhesion kinase,

219 nt study, we performed a global profiling of tyrosine-phosphorylated proteins from mutant Kit-driven

220 identified by immunoaffinity purification of tyrosine-phosphorylated proteins in GIST cells before an

221 n intriguing set of serine-, threonine-, and tyrosine-phosphorylated proteins in the Archaea that may

222 mmunoaffinity profiling strategy to identify tyrosine-phosphorylated proteins in the KG-1 cell line.

223 differences in the profiles of 75- and 80-kD tyrosine-phosphorylated proteins in the zyxin-null cells

224 Tyrosine-phosphorylated proteins on silver-stained gels

225 4-2 PCa cells showed a small set of discrete tyrosine-phosphorylated proteins, but these proteins wer

226 pectrometry that identifies large numbers of tyrosine-phosphorylated proteins, including active kinas

227 ects that involve up-regulated expression of tyrosine-phosphorylated proteins, including beta-catenin

228 Lyn B also showed increased binding of tyrosine-phosphorylated proteins, which included the neg

229 reased Src kinase activity and PP2-sensitive tyrosine-phosphorylated proteins.

230 point contacts containing enriched levels of tyrosine-phosphorylated proteins.

231 ng large-scale gene expression profiling and tyrosine-phosphorylated proteome analyses, we characteri

232 binding of their p85 regulatory subunits to tyrosine-phosphorylated pYXXM motifs in receptor tyrosin

233 These non-catalytic tyrosine-phosphorylated receptors (NTRs) share a number

234 logy-2 (SH2) domains that mediate binding to tyrosine-phosphorylated receptors or adaptor proteins to

235 st cases, the SH2 domain mediates binding to tyrosine-phosphorylated receptors or cytosolic proteins,

236 Substantial cortical localization of tyrosine-phosphorylated RhoGDI is also observed in fibro

237 in more recruitment of the E3 ligase SCF to tyrosine-phosphorylated RIP140, which degraded RIP140 to

238 Sprouty proteins are tyrosine-phosphorylated RTK feedback inhibitors, but the

239 tor receptor 2 (FGFR2) was overexpressed and tyrosine phosphorylated selectively in FGFR2-amplified c

240 Cbl proteins bind to specific tyrosine-phosphorylated sequences in target proteins via

241 k mutant embryos exhibit decreased levels of tyrosine phosphorylated Shark at the cell periphery of L

242 erleukin-6 (IL-6) stimulate the formation of tyrosine-phosphorylated signal transducer and activator

243 We identified 188 nonredundant tyrosine-phosphorylated sites, 77 of which are novel.

244 however, was found to immunoprecipitate with tyrosine-phosphorylated SLAM.

245 binding to CD44 promotes Nanog-Stat-3 (also tyrosine phosphorylated Stat-3) complex formation, nucle

246 proteins, preventing their interaction with tyrosine-phosphorylated STAT1 (phospho-STAT1).

247 nd IFN-gamma-induced nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) and to inhibit

248 es with the impaired nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1), a key step in

249 IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-STAT1), which occurs v

250 ith interferons (IFNs), the concentration of tyrosine-phosphorylated STAT1 (YP-STAT1), which drives t

251 llowing Ad infection and found that nuclear, tyrosine-phosphorylated STAT1 accumulates at viral repli

252 nisms, with eVP24 blocking nuclear import of tyrosine-phosphorylated STAT1 and mVP40 blocking Jak1 fu

253 cking an ND all support this model: When the tyrosine-phosphorylated STAT1 disengages from DNA, the N

254 Here, we demonstrate that tyrosine-phosphorylated STAT1 is targeted by a unique me

255 and activator of transcription 3 (STAT3) and tyrosine phosphorylated STAT3 in human HCC tissues (P<0.

256 Persistently activated or tyrosine-phosphorylated STAT3 (pSTAT3) is found in 50% o

257 Cooperative binding to DNA of tyrosine-phosphorylated STAT3 and both wild-type and R26

258 se correlation of sensitivity with levels of tyrosine-phosphorylated STAT3 and of the gp130 receptor,

259 ted with a four- to fivefold higher level of tyrosine-phosphorylated STAT3 in the RACT-treated F9 Rex

260 cytosolic signaling complex of PKCdelta and tyrosine-phosphorylated Stat3.

261 s was not due to an increase in the level of tyrosine-phosphorylated Stat3.

262 Basal levels of nuclear localized, tyrosine phosphorylated Stat5 are present in healthy hum

263 aling protein because of its ability to bind tyrosine-phosphorylated STAT5 and act as a transcription

264 ghly represented in the CM fraction, whereas tyrosine-phosphorylated STAT5 was enriched in the non-me

265 hosphorylates IFN-alpha- and beta-activated, tyrosine-phosphorylated STAT5, leading to the subsequent

266 After IL-4 removal, tyrosine-phosphorylated STAT6 rapidly decayed in cells e

267 This persistence in tyrosine-phosphorylated STAT6 was associated with persis

268 odule, activated by many cytokines, in which tyrosine-phosphorylated STATs (pSTATs) function as trans

269 ile the transcription factor ISGF3 (IRF9 and tyrosine-phosphorylated STATs 1 and 2) drives the first

270 cription factor ISGF3, comprised of IRF9 and tyrosine-phosphorylated STATs 1 and 2, transmits the sig

271 ese findings challenge the generalization of tyrosine-phosphorylated STATs necessarily being transcri

272 ceptor engagement with a distinct profile of tyrosine-phosphorylated substrates.

273 Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target (SNT-1) on C-terminal tyr

274 Also, tyrosine-phosphorylated tau is present in the neuropatho

275 Moreover, STAT3 mutants that cannot be tyrosine-phosphorylated, that are retained in the cytopl

276 SHP-1 localized in the nonraft fractions is tyrosine phosphorylated, the SHP-1 isolated from the lip

277 oblotting suggested an increase of total and tyrosine-phosphorylated Tie-2 proteins in null mutant ve

278 he SUMOylation, the SUMOylated ErbB4 ICD was tyrosine phosphorylated to a higher extent than unmodifi

279 ty of BDNF for TrkB, which results in higher tyrosine-phosphorylated TrkB, increased recruitment of P

280 hosphorylation and expression of a number of tyrosine phosphorylated tyrosine kinases, including DDR2

281 Accordingly, SOS1, ARHGEF1, and DOCK2 are tyrosine phosphorylated upon chemokine signaling with ti

282 and a delivered effector, CagA, that becomes tyrosine phosphorylated upon delivery into host cells an

283 transmembrane adaptor protein that is highly tyrosine phosphorylated upon engagement of the TCR.

284 Its cytoplasmic domain is tyrosine phosphorylated upon ligand binding and initiate

285 MPYS is tyrosine phosphorylated upon MHC-II aggregation and asso

286 lasmic signaling molecules Dok1 and Dok2 are tyrosine phosphorylated upon NK-cell activation.

287 that PKD interacts with PLCgamma and becomes tyrosine phosphorylated upon VEGF stimulation, leading t

288 Kindlin-2 is tyrosine-phosphorylated upon cell-ECM adhesion.

289 h c-Cbl, but in contrast to c-Cbl, it is not tyrosine-phosphorylated upon glycoprotein VI (GPVI) stim

290 2A-tail mimetic peptide DYFL compared to its tyrosine-phosphorylated version.

291 Tyrosine-phosphorylated villin regulates actin dynamics,

292 ented here elucidate the molecular basis for tyrosine-phosphorylated villin-induced changes in cell m

293 Platelet EC adhesion molecule 1 (PECAM-1) is tyrosine phosphorylated when ECs are exposed to flow or

294 During engulfment, CHC is tyrosine phosphorylated, which is required for Jedi-medi

295 After Ab-mediated crosslinking, TIM-3 became tyrosine phosphorylated, which then sequentially bound a

296 al expression library for proteins that were tyrosine phosphorylated with baculoviral expressed Lyn o

297 onsive sites, 20 were previously known to be tyrosine phosphorylated with insulin treatment, includin

298 Activated Ack1 tyrosine phosphorylated Wwox, leading to rapid dissociat

299 the cytoplasmic YXXphi motif Y20HPM and the tyrosine-phosphorylated Y60TNP motif are required for MU

300 h cadherin-catenin protein complexes bearing tyrosine phosphorylated YXXM motifs.