ライフサイエンスコーパス: ubiquitin

1 ed polyubiquitin (also referred to as linear ubiquitin).

2 MD simulations of different crystal forms of ubiquitin.

3 des corresponding to the RPN2 C terminus and ubiquitin.

4 mperatures, including the well-characterized ubiquitin A state, and two solution species that are dif

5 e Lysine 255 in PIPKIgamma acts as the major ubiquitin acceptor site for Smurf1.

6 d by the Ins-1 loop of Rpn11, which controls ubiquitin access to its catalytic site.

7 Here we characterize a ubiquitin-activated peptidase called DA1 that limits the

8 n ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating en

9 A PhyA mutant protected from ubiquitin addition at these sites is substantially more

10 important for proteasome function, indicate ubiquitin affinities that are consistent with the role o

11 nlike other 26S subunits), but the inhibitor ubiquitin aldehyde slowed their dissociation.

12 at are not observed with either liposomes or ubiquitin alone.

13 Thus, we propose a role for ubiquitin and HRS in the regulation of AM-induced degrad

14 ved throughout the domain in the presence of ubiquitin and liposomes combined that are not observed w

15 uccinylation can be installed selectively in ubiquitin and synthesized histone H3 with succinylation

16 In ARSACS patient fibroblasts HSP70, ubiquitin and the autophagy-lysosome pathway proteins La

17 Thus, ubiquitin and the substrate lipid bilayer act synergisti

18 Interdependent localization of SUMO, ubiquitin, and proteasomes along chromosome axes was med

19 f hippocampal aggregates of alpha-synuclein, ubiquitin, and tau, and improved the associated memory d

20 t phosphorylation of both the UBL domain and ubiquitin are required to activate parkin by releasing t

21 ubiquitin ligase mediating the deposition of ubiquitin around pathogen inclusions.

22 The compounds attenuate ubiquitin binding and thus inhibit USP7 deubiquitinase a

23 biquitin to its coiled-coil 2-leucine zipper ubiquitin binding domain.

24 -associated Optn mutant, E478G, defective in ubiquitin binding, was also defective in autophagosome f

25 n extended structure needed to facilitate E2-ubiquitin binding.

26 Split ubiquitin-binding assays detected interactions between H

27 ecruiting polyubiquitin, the proteasome, the ubiquitin-binding autophagy adaptor NBR1, the autophagy

28 nephritis was induced in wild-type (WT) and ubiquitin-binding deficient ABIN1[D485N] mice, and renal

29 ts LC3-interacting region (LIR), but not its ubiquitin-binding domain, supported T cell proliferation

30 Toll-interacting protein (TOLLIP) is a ubiquitin-binding protein that regulates innate immune r

31 biquitylation by physically associating with ubiquitin-bound RNF168.

32 Here we reveal the ubiquitin-bound structure of Rpn11 from S. cerevisiae an

33 densely packed with proteasomes and contain ubiquitin but no polyubiquitin chains.

34 In addition to these two genes, Ubiquitin C (UBC) in head and neck cancer and Transferri

35 allenge, we developed novel chemical probes, ubiquitin C-terminal fluorescein thioesters UbMES and Ub

36 cantly increase the levels of Abeta, Tau and Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in mouse cereb

37 Ubiquitin can be subjected to further posttranslational

38 Deleterious mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cance

39 The linear ubiquitin chain assembly complex, LUBAC, is the only kno

40 ts suggest that Ufd2p functions by switching ubiquitin chain linkages to allow the degradation of pro

41 Several ubiquitin chain types have remained unstudied, mainly be

42 We show that K63-linked ubiquitin chains accumulate on tankyrase 1 in late S/G2

43 Branched ubiquitin chains are particularly challenging, as multip

44 hains to tankyrase 1, while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1/BRCC36-c

45 1 is therefore important to ensure that poly-ubiquitin chains are removed only from committed substra

46 As translocation proceeds, ubiquitin chains bound to substrate are drawn to the cha

47 We investigated this idea by engineering di-ubiquitin chains containing differential proximal and di

48 Removal of ubiquitin chains is controlled by ABRO1/BRCC36 and occur

49 with the E2 enzyme UbcH5b in order to ligate ubiquitin chains on its substrates.

50 he depolymerization kinetics of Lys48-linked ubiquitin chains relative to Lys63-linked chains.

51 ponsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1, while in G1 phase such

52 ion depends on the interaction of K29-linked ubiquitin chains with two N-terminal loops of Ufd2p.

53 Understanding the precise roles of ubiquitin chains, however, is difficult due to their com

54 97 substrate-Ub-GFP modified with K48-linked ubiquitin chains-for in vitro p97 activity assays.

55 ed to the formation of an array of polymeric ubiquitin chains.

56 the E3 ligase HOIP, which synthesizes linear ubiquitin chains.

57 ting that LUBAC amplifies and refashions the ubiquitin coat.

58 This ubiquitin coating of Shigella favors the pathogen as it

59 nd quality control, we establish heterotypic ubiquitin conjugates as important carriers of biological

60 cruitment, and selectively remove K48-linked ubiquitin conjugates from a subpopulation of damaged lys

61 rified proteasomes hydrolyzed the associated ubiquitin conjugates, Usp14 and Ube3c dissociated rapidl

62 uentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3.

63 a by XIAP is dependent on the activity of E2 ubiquitin conjugating enzyme Ubc13.

64 Here, we report that the stability of Ubiquitin-conjugating enzyme E2S (UBE2S) is regulated by

65 tein), elusive enzyme-substrate interaction (ubiquitin-conjugating enzyme UBE2D3 with substrate PCNA)

66 s insights into the structural plasticity of ubiquitin-conjugating enzymes.

67 that RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulat

68 domain in KAP1 and the proximal coupling of ubiquitin conjugation to ER degradation (CUE) domain in

69 Our data showed that the GluA1 ubiquitin-deficient mutant enhances GluA1 phosphorylatio

70 Importantly, expression of the GluA1 ubiquitin-deficient mutants inhibited the adverse effect

71 ast in response to cellular requirements for ubiquitin-dependent degradation.

72 air proteins to the CRL4-DCAF1 E3 ligase for ubiquitin-dependent proteasomal degradation.

73 Ubiquitin-dependent proteolysis of cyclin D1 is associat

74 vealed by observation of UbcH7 approximately ubiquitin-dependent substrate inhibition of chain format

75 Unlike ubiquitin, detection of endogenous SUMOylated proteins i

76 ere, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of

77 The discovery of ubiquitin, E1-like, E2-like and small-RING finger (srfp)

78 el-free proteomics to identify the SCF(Slmb) ubiquitin E3 ligase complex as a novel SMN binding partn

79 ification of SPOP, a key subunit of the CUL3 ubiquitin E3 ligase complex, as a SETD2-interacting prot

80 ere, we present evidence that the DDB1-CUL4A ubiquitin E3 ligase functions as a novel metabolic regul

81 ith the cellular hypoxic response, to be the ubiquitin E3 ligase that mediates the degradation of Plk

82 ral network activity, we demonstrated that a ubiquitin E3 ligase, murine double minute-2 (Mdm2), is r

83 trated an association with the Cullin-4-RING ubiquitin E3 ligase-4 (CRL4) complex, nucleosomes, and c

84 ncer and patient tissues is accompanied by a ubiquitin E3-ligase, AMFR, mediating loss of 11beta-hydr

85 itchy E3 ubiquitin protein ligase (ITCH)-A20 ubiquitin-editing complex inhibits receptor-interacting

86 The CI-inducing DUB, CidB, cleaves ubiquitin from substrates and is encoded in a two-gene o

87 These enzymes allow proteasomes to remove ubiquitin from substrates before they are translocated i

88 f serine 65 in parkin's UBL and serine 65 of ubiquitin fully activate ubiquitin ligase activity; howe

89 ve model linking hypermethylation of the UBB ubiquitin gene to a dependency on UBC.

90 as a transcriptional regulator but also as a ubiquitin hydrolase has been proposed for this protein.

91 urce to follow the structural transitions of ubiquitin in aqueous solution (pH = 3) at elevated solut

92 In particular, atomistic simulations of ubiquitin in solution based on CHARMM36 force field and

93 ubiquitin to Rtn4 or phosphoribosylation of ubiquitin in the absence of a ubiquitination target.

94 , and regulate steady state concentration of ubiquitin in the cell.

95 induced by protein-protein interactions with ubiquitin in the cytosol of a targeted eukaryotic cell,

96 ing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair protei

97 Molecular dynamics simulations of ubiquitin in water/glycerol solutions are used to test t

98 by combining a lysine-less internally tagged ubiquitin (INT-Ub.7KR) with SILAC-based mass spectrometr

99 Ultimately, understanding how various ubiquitin interacting proteins control inflammatory sign

100 esidues in substrates via an ADP-ribosylated ubiquitin intermediate.

101 The ADP-ribosylated moiety of ubiquitin is a substrate for the nucleotidase/phosphohyd

102 stem, the proteasome, by ubiquitin tags, but ubiquitin is also used as a signal in other cellular pro

103 , the promiscuity of binding of cisplatin to ubiquitin is revealed, with 14 different binding sites o

104 s, presumably mediated by lysine 48 (K48) of ubiquitin, is a key mechanism in synapse and neural circ

105 Here we analyzed changes in the ubiquitin landscape induced by endometrial cancer-associ

106 diated by WD repeat 4-containing cullin-RING ubiquitin ligase 4 (CRL4WDR4).

107 tion in the absence of Rqc1; however, its E3 ubiquitin ligase activity is not required.

108 gene encoding Act1, an adaptor protein with ubiquitin ligase activity that couples the IL-17 recepto

109 te in Smurf is shown to be necessary for its ubiquitin ligase activity towards the substrate and also

110 BL and serine 65 of ubiquitin fully activate ubiquitin ligase activity; however, a structural rationa

111 The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP)

112 s the substrate-recruiting subunit of an SCF ubiquitin ligase and a major tumor-suppressor protein th

113 hese studies demonstrate that UBE3B is an E3 ubiquitin ligase and reveal that the enzyme is regulated

114 rent study identified a novel E. chaffeensis ubiquitin ligase and revealed an important role for the

115 Finally, the Siah2 E3 ubiquitin ligase antagonizes drebrin function, suggestin

116 (COP9 signalosome), are required to control ubiquitin ligase assembly, function, and ultimately subs

117 We identify SIAH2, a RING finger E3 ubiquitin ligase associated with the cellular hypoxic re

118 es containing a target protein binder and an ubiquitin ligase binder connected by a linker.

119 abidopsis (Arabidopsis thaliana) COP1/SPA E3 ubiquitin ligase causes the degradation of multiple regu

120 f these photoreceptors, such as SPA1/COP1 E3 ubiquitin ligase complex and bHLH transcription factors

121 usly ubiquitylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteaso

122 Mms1 is part of the E3 ubiquitin ligase complex that is linked to replication f

123 main (which in mammals, interacts with an E3 ubiquitin ligase complex) is not essential for the inhib

124 the substrate recognition component of an E3 ubiquitin ligase complex, targets DMRT1 for degradation

125 DB2), which is part of a multiprotein UV-DDB ubiquitin ligase complex.

126 dge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.

127 Etv5 through inactivation of the cullin-RING ubiquitin ligase CRL4(COP1/DET1) that targets Etv5 for p

128 hat catalyse NEIL1 polyubiquitylation, Mcl-1 ubiquitin ligase E3 (Mule) and tripartite motif 26 (TRIM

129 zyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3.

130 y, shRNA-mediated suppression of Atg5, an E3 ubiquitin ligase essential for autophagosome elongation,

131 Recent reports suggest that SPOP acts as a ubiquitin ligase for ERG and propose that ERG stabilizat

132 Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1alpha (HI

133 We found that the Gid4 subunit of the ubiquitin ligase GID in the yeast Saccharomyces cerevisi

134 Here we show that expression of the E3 ubiquitin ligase Grail is upregulated in CD8(+) T cells

135 of the 40S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC.

136 iquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.

137 We previously identified ubiquitin ligase Huwe1 in the testis and showed that it

138 factor 2 (TRAF2), a scaffold protein and E3 ubiquitin ligase important for inflammatory signaling.

139 Moreover, we show that Rnf12, an X-encoded ubiquitin ligase important for initiation of X-chromosom

140 anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase in neurons [Cdh1 conditional knockout (

141 d1 gene product, FPC, also contain the NEDD4 ubiquitin ligase interacting protein, NDFIP2, which inte

142 Arabidopsis (Arabidopsis thaliana) COP1/SPA ubiquitin ligase is a central repressor that suppresses

143 H as a potential substrate for the RING-type ubiquitin ligase Keep on Going (KEG).

144 d through the action of the multi-subunit E3 ubiquitin ligase known as the anaphase-promoting complex

145 PROTACs conjugate a target warhead to an E3 ubiquitin ligase ligand via a linker.

146 y identified TRIM21 as an IFNgamma-driven E3 ubiquitin ligase mediating the deposition of ubiquitin a

147 miR-1 directly regulates the 3'UTR of the E3 ubiquitin ligase Nedd4 Analysis of embryonic and adult f

148 The ubiquitin ligase Nedd4-like (Nedd4L, or Nedd4-2) binds t

149 a subset of Sdt isoforms are targeted by the ubiquitin ligase Neuralized, thus fine tuning the endocy

150 1 (HOS1), which is known to either act as E3 ubiquitin ligase or affect chromatin organization, inhib

151 ancer Cell, Vila et al. report that UBE2O, a ubiquitin ligase overexpressed in some human cancers, sp

152 These genes encode the E3 ubiquitin ligase parkin and the protein kinase PTEN-indu

153 e, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic similariti

154 omics, we have identified the RING finger E3 ubiquitin ligase RNF157 as a target at the intersection

155 By counteracting the E3 ubiquitin ligase Rsp5, Ubp2 and Ubp15 prevent hyperubiqu

156 te a phosphodegron that is recognized by the ubiquitin ligase SCF(Cdc4).

157 but are antagonized by IpaH9.8, a bacterial ubiquitin ligase secreted into the host cytosol.

158 Here, we identify the E3 ubiquitin ligase Smurf2 as a physiologic regulator of To

159 Here we show that Bre1, an ubiquitin ligase specific for histone H2B, is recruited

160 gene family, member A (RhoA), a KCTD13/CUL3 ubiquitin ligase substrate, and is reversed by RhoA inhi

161 TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the ant

162 rt that cells with mutations in RFWD3, an E3 ubiquitin ligase that interacts with and ubiquitylates r

163 complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked p

164 netic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.

165 Mdm2, another p53 target gene, encodes a ubiquitin ligase that negatively regulates p53 levels by

166 Here we identify KIB1 as an F-box E3 ubiquitin ligase that promotes the degradation of BIN2 w

167 By recruiting an ubiquitin ligase to a target protein, PROTACs promote ub

168 phorylation can disrupt the binding of an E3 ubiquitin ligase to an E2-conjugating enzyme, leading to

169 y generated during apoptosis that inhibits a ubiquitin ligase to overcome therapy resistance in tumor

170 his light version of the RQC complex, the E3 ubiquitin ligase Tom1.

171 Here, we report that the host E3-ubiquitin ligase TRIM6 promotes VP35 ubiquitination and

172 nts are degraded after ubiquitination by the ubiquitin ligase tripartite motif-containing protein 32

173 We show that CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that couples their

174 rt, through promoting the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p.

175 restoration of Nrdp1, a RING finger type E3 ubiquitin ligase whose suppression in GBM also correlate

176 eased gene dosages of UBE3A, which encodes a ubiquitin ligase with transcriptional co-regulatory func

177 We identified the HECT family E3 ubiquitin ligase WWP1 and all four of its WW domains as

178 Here, we show in mammalian cells that the ubiquitin ligase ZNF598 is required for ribosomes to ter

179 elevant proteolytic pathway (e.g. a specific ubiquitin ligase) is itself short-lived.

180 MDM2, an E3 ubiquitin ligase, is a potent inhibitor of the p53 tumor

181 ding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination an

182 we show that STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentia

183 45, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between thes

184 of PIM1 via recruitment of the SUMO-targeted ubiquitin ligase, RNF4.

185 domain of DCAF1 in complex with the CRL4 E3 ubiquitin ligase.

186 ubstrate-binding subunit of SCF(cyclin F) E3 ubiquitin ligase.

187 This function of Smurf1 requires both its ubiquitin-ligase and C2 phospholipid-binding domains, an

188 The Cullin-RING E3 ubiquitin ligases (CRLs) regulate homeostasis of 20% of

189 Here, we demonstrate that four ubiquitin ligases (i.e., Ubr1, Slx5, Psh1, and Rcy1) wor

190 s are synthesized and processed by essential ubiquitin ligases and effectors that are mutated across

191 in less well-understood pathways, involving ubiquitin ligases and GTPase exchange factors/GTPase-act

192 ansport protein 20 (IFT20) interacts with E3 ubiquitin ligases c-Cbl and Cbl-b and is required for Cb

193 The ubiquitin ligases CBL and CBL-B are negative regulators

194 Our findings suggest that various ubiquitin ligases collaborate to keep the Cse4 level in

195 SCF (Skp1-Cullin-F-box) ubiquitin ligases comprise several dozen modular enzymes

196 The role of cullin E3-ubiquitin ligases for muscle homeostasis is best known d

197 Here, we have purified the major E3 ubiquitin ligases from human cells responsible for regul

198 n network.Protein stability modulation by E3 ubiquitin ligases is an important layer of functional re

199 Therefore, ubiquitin ligases need to be tightly controlled.

200 CF (Skp1/Cullin 1/F-box protein) class of E3 ubiquitin ligases that are important for eukaryotic prot

201 a-synuclein ubiquitination by SIAH and Nedd4 ubiquitin ligases, and causing its accumulation and aggr

202 pro-apoptotic protease caspase-8 and the IAP ubiquitin ligases, how and when necroptosis is triggered

203 hat Ndfip1, a coactivator of Nedd4-family E3 ubiquitin ligases, is required for Treg cell stability a

204 ets are the cullins, scaffold subunits of E3 ubiquitin ligases, where neddylation as well as deneddyl

205 eins in SCF (Skp1/Cullin-1/F-box protein) E3 ubiquitin ligases, which modify protein substrates with

206 Surprisingly, the structures revealed a ubiquitin-like beta-grasp domain that precedes the prote

207 Small ubiquitin-like modifier (SUMO) conjugation is a reversib

208 Small ubiquitin-like modifier (SUMO) modification regulates nu

209 ends on their covalent modification by small ubiquitin-like modifier (SUMO) proteins.

210 Here we demonstrate that small ubiquitin-like modifier (SUMO)- and folate-dependent nuc

211 Conjugation of SUMO (Small Ubiquitin-like Modifier) protein to cellular targets is

212 We found that the SUMO (small ubiquitin-like modifier)-modification and ubiquitin-prot

213 her human septins could be modified by small ubiquitin-like modifiers (SUMOs) and what roles this mod

214 and can also be part of mixed polymers with ubiquitin-like modifiers such as SUMO (small ubiquitin-r

215 These findings suggest that ubiquitin-like processing of Sde2 into a short-lived act

216 ess via the interaction of DSK2 with ATG8, a ubiquitin-like protein directing autophagosome formation

217 In eukaryotes, the conjugation of the ubiquitin-like protein NEDD8 onto protein targets is an

218 tion, the covalent attachment of prokaryotic ubiquitin-like protein Pup to lysine side chains of the

219 Modification by the ubiquitin-like protein SUMO affects hundreds of cellular

220 six members of the LC3 and GABARAP family of ubiquitin-like proteins (mATG8s).

221 the degradation of proteins modified with a ubiquitin linkage, which is normally not targeted to the

222 establish that two of these proteins promote ubiquitin-linked receptor downregulation after prolonged

223 ubular ER function independently of the host ubiquitin machinery.

224 Mechanistically, SUMOylation promoted ubiquitin-mediated degradation of PIM1 via recruitment o

225 apparatus that founded the modern eukaryotic ubiquitin modification systems.

226 Here we review specific ubiquitin-modifying enzymes and ubiquitination events th

227 In the absence of ubiquitin or substrate liposomes, the overall structure

228 ropriate cell survival and function, and the ubiquitin pathway has shown promise as a therapeutic tar

229 igase and revealed an important role for the ubiquitin pathway in effector-host interactions and path

230 nging, as multiple modifications on a single ubiquitin preclude the use of standard bottom-up proteom

231 ncer cells sensitive to further decreases in ubiquitin production by inhibition of the polyubiquitin

232 as increased in the absence of the Bre5-Ubp3 ubiquitin protease complex.

233 The ubiquitin proteasome mutants tir1-1 and axr1-12, which s

234 show that FDH abundance is regulated by the ubiquitin proteasome system (UPS).

235 d has an essential role in autophagy and the ubiquitin proteasome system (UPS).

236 inking cytosolic antibody recognition to the ubiquitin proteasome system brings this research into sh

237 cal intervention on E3 ligases.Targeting the ubiquitin proteasome system to modulate protein homeosta

238 K-C/EBPbeta signaling pathway as well as the ubiquitin-proteasome and autophagy-lysosome pathways, re

239 e phosphorylated TFEB for degradation by the ubiquitin-proteasome pathway.

240 induced unfolded protein response (UPR), the ubiquitin-proteasome system (UPS) and autophagy, appear

241 The ubiquitin-proteasome system (UPS) plays a critical role

242 influences cellular survival and the rate of ubiquitin-proteasome system (UPS)-mediated proteolysis f

243 ction of keratin-derived AMPs (KAMPs) by the ubiquitin-proteasome system (UPS).

244 umed that synaptic proteostasis requires the ubiquitin-proteasome system (UPS).

245 ytoplasmic DPPA3 is partially cleaved by the ubiquitin-proteasome system and an N-terminus fragment r

246 factor Bag1 promotes hERG degradation by the ubiquitin-proteasome system at the endoplasmic reticulum

247 umber variation.Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of

248 report that EXO1 is rapidly degraded by the ubiquitin-proteasome system soon after DSB induction in

249 hway and that its degradation depends on the ubiquitin-proteasome system.

250 ll ubiquitin-like modifier)-modification and ubiquitin-proteasome systems regulate the major events o

251 rtens the half-life of cytoplasmic Plk3 in a ubiquitin-proteasome-dependent manner.

252 Further, we found that the ubiquitin/proteasome pathway was responsible for MeCP2 T

253 In innate immunity, the itchy E3 ubiquitin protein ligase (ITCH)-A20 ubiquitin-editing co

254 on, ii) beta-transducin repeat containing E3 ubiquitin protein ligase nuclear accumulation, and iii)

255 Loss of the E3 ubiquitin-protein ligase UBE3A causes Angelman syndrome.

256 Hsp70-type molecular chaperones, the Pib1 E3 ubiquitin-protein ligase, and the deubiquitylating enzym

257 t degradation of the dissociated Foxp3 via a ubiquitin-proteosomal pathway and hence reversing the in

258 Here, we show that BES1 interacts with the ubiquitin receptor protein DSK2 and is targeted to the a

259 tent with the role of RPN13 as a proteasomal ubiquitin receptor, and have major implications for the

260 atures that ensure efficient proteolysis and ubiquitin recycling while preventing nonselective proteo

261 ar proteins through the conjugation of small ubiquitin-related modifier (SUMO) and comprises an impor

262 xahistidine (His6), thioredoxin (Trx), small ubiquitin-related modifier (Sumo), glutathione S-transfe

263 ubiquitin-like modifiers such as SUMO (small ubiquitin-related modifier) or NEDD8 (neural precursor c

264 bonds are restricted to a specific lysine of ubiquitin, resulting in a chain possessing more than one

265 While ubiquitin signaling at synapses is essential for neural

266 However, whether this ubiquitin signaling pathway mediates Abeta-induced loss

267 d UBC13 as components of a novel cytoplasmic ubiquitin-signaling network that suppresses synapse form

268 have emerged as an excellent example of how ubiquitin signals control inflammatory responses.

269 ing, and kinetics of the multivalent role of ubiquitin signals in control of amplitude and selectivit

270 Among them, the ubiquitin-specific protease 36 (USP36) has been implicat

271 For example, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degr

272 by host membranes and are already displaying ubiquitin, suggesting that LUBAC amplifies and refashion

273 ations in genes coding for components of the ubiquitin system cause immune dysregulation.

274 The ubiquitin system regulates essential cellular processes

275 igase substrate receptors independent of the ubiquitin system.

276 F mice develop protein aggregates containing ubiquitin-tagged proteins within cardiac myocytes relate

277 he center of this system, the proteasome, by ubiquitin tags, but ubiquitin is also used as a signal i

278 p97 is a ubiquitin-targeted ATP-dependent segregase that extracts

279 rmation and (2) participating in contacts to ubiquitin that promote an open E2 Ub conformation.HHAR

280 The addition of ubiquitin to a target protein has long been implicated i

281 impedes the binding of linear (M1-linked) di-ubiquitin to its coiled-coil 2-leucine zipper ubiquitin

282 hohydrolase, resulting in either transfer of ubiquitin to Rtn4 or phosphoribosylation of ubiquitin in

283 s of Uba1 and Uba6, we applied an orthogonal ubiquitin transfer (OUT) technology to profile their ubi

284 tor that comprises substrate recognition and ubiquitin transfer activities within a single protein to

285 In the presence of ubiquitin, two interhelical loops of the C-terminal four

286 E1 enzymes for ubiquitin (Ub) and Ub-like modifiers (Ubls) harbor two c

287 s) are repaired, with many components of the ubiquitin (Ub) conjugation, de-conjugation, and recognit

288 Tsg101 possesses an ubiquitin (Ub) E2 variant (UEV) domain with a pocket tha

289 mation.HHARI is a RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase.

290 RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligases function with Ub E2s through a

291 Ubiquitin (Ub) has a broad functional range that has bee

292 TRAF6, a TLR effector with ubiquitin (Ub) ligase activity, is overexpressed in MDS

293 of cellular proteins conjugated with either ubiquitin (Ub) or Ub-like interferon-stimulated gene pro

294 f cellular proteins with the small modifier, ubiquitin (Ub), regulates virtually every known cellular

295 rried out by a trio of enzymes, known as E1 [ubiquitin (Ub)-activating enzyme], E2 (Ub-conjugating en

296 The labeling of proteins with ubiquitin/ubiquitin-like (Ubl) proteins is crucial for s

297 The number of ubiquitin units encoded by UBI4 influences cellular surv

298 We employed a phage-displayed ubiquitin variant (UbV) library to develop inhibitors ta

299 existing combinatorial library of engineered ubiquitin variants for inhibitors of 53BP1.

300 substrates are first covalently modified by ubiquitin, which then directs them to the proteasome.