ライフサイエンスコーパス: ubiquitin C

1 ated gene products were identified including ubiquitin C.

2 Gene expression of ubiquitin C and proteasome subunits C2, C3, and C9 was n

3 evealed transcriptional alterations of Creb, ubiquitin-C, and other housekeeping genes in PS-deficien

4 AKT, ubiquitin C, ERK1/2 and NF-kappaB occupied dominant node

5 ays provide evidence that PPARbeta regulates ubiquitin C expression, and that ubiquitination of prote

6 is, and this is due in part to regulation of ubiquitin C expression.

7 -term transcriptional silencing of the human ubiquitin C gene (UbC).

8 the assertion that the homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-o

9 s 40 promoter, and three cellular promoters: ubiquitin C, mPGK, and hEF-1a.

10 ssing transgenic mice by inserting the human ubiquitin C promoter coupled to the firefly luciferase r

11 By contrast, adenoviruses containing the ubiquitin C promoter failed to elicit these effects.

12 FP with the EF1 alpha promoter, pUB-GFP with Ubiquitin C promoter, and pEYFP-Mitotrap with CMV promot

13 nic fibroblasts, adenoviruses containing the ubiquitin C promoter, but not the cytomegalovirus immedi

14 ovirus immediate-early promoter, but not the ubiquitin C promoter, cooperated with chemotherapeutic a

15 2 and a cre/ERT2 transgene controlled by the ubiquitin C promoter.

16 ed human CLN3 under the control of the human ubiquitin C promoter.

17 virus encoded the GFP regulated by the human ubiquitin-C promoter, which is active in a wide variety

18 However, the ubiquitin-C promoter-mediated transcription is also redu

19 biquitinating enzymes based on the substrate ubiquitin C-terminal 7-amido-4-methylcoumarin (Ub-AMC).

20 as determined to be competition with Ub-AMC (ubiquitin C-terminal 7-amido-4-methylcoumarin).

21 (2) The kinetics of inhibition of UCH-L3 by ubiquitin C-terminal aldehyde (Ub-H) were determined and

22 omal protein synthesized as an 80-amino acid ubiquitin C-terminal extension protein (CEP80), function

23 allenge, we developed novel chemical probes, ubiquitin C-terminal fluorescein thioesters UbMES and Ub

24 ecies contain modified peptides in which the ubiquitin C-terminal Gly-Gly residues are retained on th

25 lement-binding protein 1 (CREB1), CREB2, and ubiquitin C-terminal hydrolase (Ap-uch) have been implic

26 and the regulation of one of its components, ubiquitin C-terminal hydrolase (ap-uch), in LTD.

27 PGP9.5 (UCH-L1) is a member of the ubiquitin C-terminal hydrolase (UCH) family of proteins

28 e approach to tag active DUBs, we identified ubiquitin C-terminal hydrolase (UCH) isoform L3 as the p

29 The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been lin

30 esent study measured serum concentrations of ubiquitin C-terminal hydrolase (UCH-L1) and glial fibril

31 Ubiquitin C-terminal hydrolase (UCH-L1), also called neu

32 e crystal structure of the recombinant human Ubiquitin C-terminal Hydrolase (UCH-L3) by X-ray crystal

33 The deubiquitylating enzyme ubiquitin C-terminal hydrolase 6 [Ubp6; ubiquitin-specif

34 form a protein complex with the unidentified ubiquitin C-terminal hydrolase and recruit UbC1 to this

35 smodium falciparum homologue, members of the ubiquitin C-terminal hydrolase family, use a unique acti

36 was immunoprecipitated with NUB1 served as a ubiquitin C-terminal hydrolase for UbC1.

37 the unfolded state of the 52-knotted protein ubiquitin C-terminal hydrolase isoenzyme L1 (UCH-L1) and

38 Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been wid

39 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiqui

40 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiqui

41 ifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced in

42 key mechanism mediating the deficit involves ubiquitin C-terminal hydrolase L1 (UCH-L1), a deubiquiti

43 h harbor a deletion within the gene encoding ubiquitin C-terminal hydrolase L1 (Uch-L1), display sens

44 We now show that a component of the pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required

45 cantly increase the levels of Abeta, Tau and Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in mouse cereb

46 the ubiquitin-proteasome system, parkin and ubiquitin C-terminal hydrolase L1, are also associated w

47 associated with neurodegenerative diseases (ubiquitin C-terminal hydrolase L1, rat ortholog of human

48 ription of the binding site on ubiquitin for ubiquitin C-terminal hydrolase L3 (UCH-L3).

49 in (KIAA0603), a novel protein AK000009, the ubiquitin C-terminal hydrolase L3 (UCHL3) and an F-box/P

50 The mouse Uch-L3 (ubiquitin C-terminal hydrolase L3) gene was mapped withi

51 This might allow the ubiquitin C-terminal hydrolase to hydrolyze UbC1, in ord

52 The ubiquitin C-terminal hydrolase UCH-L1 (PGP9.5) comprises

53 report a novel interaction between Smads and ubiquitin C-terminal hydrolase UCH37, a deubiquitinating

54 accomplished in part by members of the UCH (ubiquitin C-terminal hydrolase) family of enzymes.

55 The human ubiquitin C-terminal hydrolase, UCH-L1, is an abundant n

56 f Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in a cohort o

57 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a highly e

58 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to

59 lenged by the linkage of the neuronal enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) to Parkinson'

60 We show that a deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1 (UCH-L1), is highly ex

61 Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the

62 Ubiquitin C-terminal hydrolase-L1 (UCHL1), a neuron-spec

63 Here, we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1), which we prev

64 enes, one of which encodes a neuron-specific ubiquitin C-terminal hydrolase.

65 Ubiquitin C-terminal hydrolases (UCH's) are a newly-defi

66 Ubiquitin C-terminal hydrolases (UCH) are deubiquitinati

67 Ubiquitin C-terminal hydrolases (UCHs) are a subset of d

68 Ubiquitin C-terminal hydrolases (UCHs) cleave Ub-X bonds

69 Ubiquitin C-terminal hydrolases (UCHs) comprise a family

70 Ubiquitin C-terminal hydrolases catalyze the removal of

71 However, p62 has homology neither with ubiquitin C-terminal hydrolases nor with the S5a subunit

72 quence of UCH-L1 is similar to that of other ubiquitin C-terminal hydrolases, including the ubiquitou

73 gy to the known de-ubiquitinating enzymes or ubiquitin C-terminal hydrolases.

74 served Cys and His domains characteristic of ubiquitin C-terminal hydrolases.

75 zymes, and UCH-L3, a member of the family of ubiquitin C-terminal hydrolases.

76 690 amino acid protein with high homology to ubiquitin C-terminal hydrolases.

77 in-ROS protein conjugates; and (iv) distinct ubiquitin C-terminal isopeptidase/hydrolase activities,

78 t peptide ubiquitination probes based on the ubiquitin C-terminal scaffold can be developed through a

79 As compared with native ubiquitin, C-terminal Tyr extension of ubiquitin results

80 ly weaker inhibitory activity towards UCHL5 (ubiquitin-C-terminal hydrolase-5).

81 The unanchored ubiquitin C termini in the aggregates are generated in s

82 ted signaling pathway, where the exposure of ubiquitin C termini within protein aggregates enables HD

83 These data suggest that binding the ubiquitin C terminus may be necessary for the function o

84 ly relevant and whether modifications of the ubiquitin C-terminus can modulate CXCR4 activation.

85 surface loops thereby allowing access of the ubiquitin C-terminus to the active site.

86 ragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some

87 In addition to these two genes, Ubiquitin C (UBC) in head and neck cancer and Transferri

88 ls and results in an exquisite dependence on ubiquitin C (UBC), the second polyubiquitin gene.