ライフサイエンスコーパス: ubiquitin C-terminal hydrolase

1 enes, one of which encodes a neuron-specific ubiquitin C-terminal hydrolase.

2 gy to the known de-ubiquitinating enzymes or ubiquitin C-terminal hydrolases.

3 served Cys and His domains characteristic of ubiquitin C-terminal hydrolases.

4 zymes, and UCH-L3, a member of the family of ubiquitin C-terminal hydrolases.

5 690 amino acid protein with high homology to ubiquitin C-terminal hydrolases.

6 ly weaker inhibitory activity towards UCHL5 (ubiquitin-C-terminal hydrolase-5).

7 The deubiquitylating enzyme ubiquitin C-terminal hydrolase 6 [Ubp6; ubiquitin-specif

8 form a protein complex with the unidentified ubiquitin C-terminal hydrolase and recruit UbC1 to this

9 lement-binding protein 1 (CREB1), CREB2, and ubiquitin C-terminal hydrolase (Ap-uch) have been implic

10 and the regulation of one of its components, ubiquitin C-terminal hydrolase (ap-uch), in LTD.

11 Ubiquitin C-terminal hydrolases catalyze the removal of

12 smodium falciparum homologue, members of the ubiquitin C-terminal hydrolase family, use a unique acti

13 accomplished in part by members of the UCH (ubiquitin C-terminal hydrolase) family of enzymes.

14 was immunoprecipitated with NUB1 served as a ubiquitin C-terminal hydrolase for UbC1.

15 quence of UCH-L1 is similar to that of other ubiquitin C-terminal hydrolases, including the ubiquitou

16 the unfolded state of the 52-knotted protein ubiquitin C-terminal hydrolase isoenzyme L1 (UCH-L1) and

17 Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been wid

18 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiqui

19 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiqui

20 ifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced in

21 key mechanism mediating the deficit involves ubiquitin C-terminal hydrolase L1 (UCH-L1), a deubiquiti

22 h harbor a deletion within the gene encoding ubiquitin C-terminal hydrolase L1 (Uch-L1), display sens

23 We now show that a component of the pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required

24 cantly increase the levels of Abeta, Tau and Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in mouse cereb

25 the ubiquitin-proteasome system, parkin and ubiquitin C-terminal hydrolase L1, are also associated w

26 associated with neurodegenerative diseases (ubiquitin C-terminal hydrolase L1, rat ortholog of human

27 f Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in a cohort o

28 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a highly e

29 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to

30 lenged by the linkage of the neuronal enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) to Parkinson'

31 We show that a deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1 (UCH-L1), is highly ex

32 Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the

33 Ubiquitin C-terminal hydrolase-L1 (UCHL1), a neuron-spec

34 Here, we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1), which we prev

35 ription of the binding site on ubiquitin for ubiquitin C-terminal hydrolase L3 (UCH-L3).

36 in (KIAA0603), a novel protein AK000009, the ubiquitin C-terminal hydrolase L3 (UCHL3) and an F-box/P

37 The mouse Uch-L3 (ubiquitin C-terminal hydrolase L3) gene was mapped withi

38 However, p62 has homology neither with ubiquitin C-terminal hydrolases nor with the S5a subunit

39 This might allow the ubiquitin C-terminal hydrolase to hydrolyze UbC1, in ord

40 The ubiquitin C-terminal hydrolase UCH-L1 (PGP9.5) comprises

41 PGP9.5 (UCH-L1) is a member of the ubiquitin C-terminal hydrolase (UCH) family of proteins

42 e approach to tag active DUBs, we identified ubiquitin C-terminal hydrolase (UCH) isoform L3 as the p

43 The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been lin

44 esent study measured serum concentrations of ubiquitin C-terminal hydrolase (UCH-L1) and glial fibril

45 Ubiquitin C-terminal hydrolase (UCH-L1), also called neu

46 e crystal structure of the recombinant human Ubiquitin C-terminal Hydrolase (UCH-L3) by X-ray crystal

47 Ubiquitin C-terminal hydrolases (UCH's) are a newly-defi

48 Ubiquitin C-terminal hydrolases (UCH) are deubiquitinati

49 The human ubiquitin C-terminal hydrolase, UCH-L1, is an abundant n

50 report a novel interaction between Smads and ubiquitin C-terminal hydrolase UCH37, a deubiquitinating

51 Ubiquitin C-terminal hydrolases (UCHs) are a subset of d

52 Ubiquitin C-terminal hydrolases (UCHs) cleave Ub-X bonds

53 Ubiquitin C-terminal hydrolases (UCHs) comprise a family