ライフサイエンスコーパス: ubiquitin ligase

1 itional stress-modifying function of this E3-ubiquitin ligase.

2 Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase.

3 ent cyclin E ubiquitylation by the SCF(Fbw7) ubiquitin ligase.

4 itylation and degradation by the APC/C(Cdh1) ubiquitin ligase.

5 ng that COL12 is a substrate of the COP1/SPA ubiquitin ligase.

6 be localized, and that it functions as an E3 ubiquitin ligase.

7 teracting Protein (CHIP) is a homodimeric E3 ubiquitin ligase.

8 r degradation by the Gid4 subunit of the GID ubiquitin ligase.

9 prevent NEMO interactions with the cIAP1 E3 ubiquitin ligase.

10 AhR acts as a transcription factor or an E3 ubiquitin ligase.

11 substrate receptor component of the CRL4 E3 ubiquitin ligase.

12 to mediate ubiquitination without a separate ubiquitin ligase.

13 y targeting the protein to the SCF(Fbw1a) E3 ubiquitin ligase.

14 ubstrate-binding subunit of SCF(cyclin F) E3 ubiquitin ligase.

15 domain of DCAF1 in complex with the CRL4 E3 ubiquitin ligase.

16 d for the recruitment of RNF8/RNF168 histone ubiquitin ligases.

17 nition of eukaryotic pathogens to include E3 ubiquitin ligases.

18 t is heme-oxidized iron regulatory protein 2 ubiquitin ligase-1-interacting protein (HOIP).

19 diated by WD repeat 4-containing cullin-RING ubiquitin ligase 4 (CRL4WDR4).

20 rather than serving as only a hallmark of E3 ubiquitin ligase activation.

21 PRP19 mutants unable to bind RPA or lacking ubiquitin ligase activity also fail to support RPA ubiqu

22 direct mechanism that is independent of its ubiquitin ligase activity and the interferon pathway.

23 LOG2 ubiquitin ligase activity is necessary for GDU1-dependen

24 tion in the absence of Rqc1; however, its E3 ubiquitin ligase activity is not required.

25 gene encoding Act1, an adaptor protein with ubiquitin ligase activity that couples the IL-17 recepto

26 ion of different domains of BRCA1 and its E3 ubiquitin ligase activity to HDR and drug resistance.

27 te in Smurf is shown to be necessary for its ubiquitin ligase activity towards the substrate and also

28 homologous to the E6-AP Cterminus (HECT) E3 ubiquitin ligase activity.

29 BL and serine 65 of ubiquitin fully activate ubiquitin ligase activity; however, a structural rationa

30 DHX15 stabilized Siah2 and enhanced its E3 ubiquitin-ligase activity, resulting in AR activation.

31 estin-related trafficking adaptor (ART)-Rsp5 ubiquitin ligase adaptor network in yeast.

32 The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP)

33 ting the substrate-recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostat

34 targeting nanobody and a SOCS-box containing ubiquitin ligase adaptor to target GFP-tagged proteins f

35 MCC inhibits the ubiquitin ligase anaphase promoting complex/cyclosome (A

36 s the substrate-recruiting subunit of an SCF ubiquitin ligase and a major tumor-suppressor protein th

37 Casitas B-lineage lymphoma (CBL) is an E3 ubiquitin ligase and a molecule of adaptor that we have

38 ound that genetic alterations of FBW7, an E3 ubiquitin ligase and a tumor suppressor frequently mutat

39 deubiquitination cycle depending on opposing ubiquitin ligase and deubiquitinase activities.

40 human Claspin, is facilitated by the SCFDia2 ubiquitin ligase and is important for cell cycle re-entr

41 We characterize here a cullin 4-based E3 ubiquitin ligase and its substrate receptor, VprBP/DCAF1

42 hese studies demonstrate that UBE3B is an E3 ubiquitin ligase and reveal that the enzyme is regulated

43 rent study identified a novel E. chaffeensis ubiquitin ligase and revealed an important role for the

44 We demonstrate that the ZNF598 ubiquitin ligase and the 40S ribosomal protein RACK1 hel

45 that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent d

46 s are synthesized and processed by essential ubiquitin ligases and effectors that are mutated across

47 in less well-understood pathways, involving ubiquitin ligases and GTPase exchange factors/GTPase-act

48 ell signaling mediators, such as kinases, E3 ubiquitin ligases and phosphatases, and gene ontological

49 t counteracts ubiquitination by different E3 ubiquitin ligases and regulates alpha-synuclein degradat

50 a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes.

51 n is regulated by the interaction between E3 ubiquitin ligases and their target substrates.

52 This function of Smurf1 requires both its ubiquitin-ligase and C2 phospholipid-binding domains, an

53 inhibitor of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendless

54 ew of nuclear proteins, chromatin modifiers, ubiquitin ligases, and a few kinases to regulate activit

55 a-synuclein ubiquitination by SIAH and Nedd4 ubiquitin ligases, and causing its accumulation and aggr

56 CUL9 is a member of the cullin family of E3 ubiquitin ligases, and it localizes predominantly in the

57 Finally, the Siah2 E3 ubiquitin ligase antagonizes drebrin function, suggestin

58 Loss-of-function mutations in CBL E3 ubiquitin ligases are found in a wide range of myeloid m

59 s an affinity purification approach in which ubiquitin ligases are fused to a polyubiquitin-binding d

60 E3 ubiquitin ligases are key enzymes within the ubiquitin p

61 nt progress in structure-function studies of ubiquitin ligases as well as exciting new discoveries of

62 CaV2.1 subunit by identifying RNF138, an E3 ubiquitin ligase, as a novel CaV2.1-binding partner.

63 (COP9 signalosome), are required to control ubiquitin ligase assembly, function, and ultimately subs

64 We identify SIAH2, a RING finger E3 ubiquitin ligase associated with the cellular hypoxic re

65 predictive of the autodegration pathway of a ubiquitin ligase (AUC = 0.69, p<10(-4)).

66 es containing a target protein binder and an ubiquitin ligase binder connected by a linker.

67 ted proteolytic degradation downstream of E3 ubiquitin ligase binding to RGS2.

68 However, the ubiquitin ligases, biochemical consequences, and physiol

69 Here we show that the mammalian ubiquitin ligase C-terminal Hsp70-interacting protein (C

70 ansport protein 20 (IFT20) interacts with E3 ubiquitin ligases c-Cbl and Cbl-b and is required for Cb

71 , UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-lin

72 abidopsis (Arabidopsis thaliana) COP1/SPA E3 ubiquitin ligase causes the degradation of multiple regu

73 ulators of T cell activation, such as the E3 ubiquitin ligase Cbl-b, have been reported to lead to in

74 The ubiquitin ligases CBL and CBL-B are negative regulators

75 ell biology approaches, we found that the E3 ubiquitin ligase CHIP is highly expressed throughout the

76 f hERG complexes containing Hsp70 and the E3 ubiquitin ligase CHIP requires the interaction of Bag1 w

77 on Neurl-4, a daughter centriole-associated ubiquitin ligase cofactor, which was required for ciliog

78 Our findings suggest that various ubiquitin ligases collaborate to keep the Cse4 level in

79 substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3(GCL)).

80 ubunit 1 (Cks1), a cofactor of the SCF(Skp2) ubiquitin ligase complex and a downstream target of MYC,

81 f these photoreceptors, such as SPA1/COP1 E3 ubiquitin ligase complex and bHLH transcription factors

82 usly ubiquitylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteaso

83 Vpr involved in binding to the DCAF1/DDB1/E3 ubiquitin ligase complex and prevention of cell cycle pr

84 he interaction of Vpr with the DCAF1/DDB1 E3 ubiquitin ligase complex and the yet-to-be-identified ho

85 t includes upregulation of several predicted ubiquitin ligase complex components such as the cullin c

86 The SCF(FBXO31) (Skp1-Cul1-Rbx1-FBXO31) ubiquitin ligase complex mediates genotoxic stress-induc

87 Thus, the SCF(FBXO17) E3 ubiquitin ligase complex negatively regulates inflammati

88 le to interact with either the DCAF1/DDB1 E3 ubiquitin ligase complex or a host factor hypothesized t

89 Mms1 is part of the E3 ubiquitin ligase complex that is linked to replication f

90 om A3G-mediated restriction by forming an E3-ubiquitin ligase complex to polyubiquitinate A3G and tri

91 Caenorhabditis elegans RPM-1 functions in a ubiquitin ligase complex with the F-box protein FSN-1 an

92 nes with the Gene Ontology term 'cullin-RING ubiquitin ligase complex' in the TQ-r module.

93 main (which in mammals, interacts with an E3 ubiquitin ligase complex) is not essential for the inhib

94 These screens uncovered genes that encode a ubiquitin ligase complex, components of the PtdIns 3-kin

95 in3 (CUL3), a core protein for the CUL3-RING ubiquitin ligase complex, has been reported to be a tumo

96 ator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex, reduces Aiolos and Ikaros prot

97 s substrate adaptors in a CUL3(BOP1/BOP2) E3 ubiquitin ligase complex, targeting PIF4 proteins for ub

98 the substrate recognition component of an E3 ubiquitin ligase complex, targets DMRT1 for degradation

99 teins function as adaptors of the Cullin3 E3 ubiquitin ligase complex.

100 reased activity of a CUL-6/cullin-containing ubiquitin ligase complex.

101 DB2), which is part of a multiprotein UV-DDB ubiquitin ligase complex.

102 dge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.

103 munodeficiency virus (SIV), and BIV all form ubiquitin ligase complexes to target host antiviral APOB

104 of 69 human SCF (SKP1, CUL1, F-box protein) ubiquitin ligase complexes) binds IP3R3 and targets it f

105 d8 modifications from the Cullin subunits of ubiquitin ligase complexes, reducing their activity.

106 SCF (Skp1-Cullin-F-box) ubiquitin ligases comprise several dozen modular enzymes

107 MARCH5, an OMM-associated E3 ubiquitin ligase, controls mitochondrial function.

108 COP9-Signalosome (CSN) regulates cullin-RING ubiquitin ligase (CRL) activity and assembly by cleaving

109 This approach identified the E3 ubiquitin ligase CRL2(Lrr1), a specific p97 complex, oth

110 Etv5 through inactivation of the cullin-RING ubiquitin ligase CRL4(COP1/DET1) that targets Etv5 for p

111 ectedly intimate relationship between the E3 ubiquitin ligase CRL4(CRBN) and p97 pathways.

112 ls have no impact on G1 progression, and the ubiquitin ligases CRL4(Cdt2) and SCF(Skp2) couple to deg

113 ecruited to DSBs as part of the Cullin4-DDB1 ubiquitin ligase (CRL4(Wdr70)) and stimulates distal H2B

114 substrate receptors for the Cullin5-RING E3 ubiquitin ligase (CRL5) and through a variety of CRL5-in

115 Cullin-RING ubiquitin ligases (CRLs) catalyze the ubiquitylation of

116 The Cullin-RING E3 ubiquitin ligases (CRLs) regulate homeostasis of 20% of

117 is an important regulator of cullin-RING E3 ubiquitin ligases (CRLs).

118 275-290) identified an E3 ubiquitin ligase, CUL2(LRR2), that modifies a subunit of

119 Skp1-Cul1-F-box protein (SCF) ubiquitin ligases direct cell survival decisions by cont

120 the Casitas B-cell lymphoma (CBL) family E3 ubiquitin ligases down-regulate JAK2 stability and signa

121 hat catalyse NEIL1 polyubiquitylation, Mcl-1 ubiquitin ligase E3 (Mule) and tripartite motif 26 (TRIM

122 zyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3.

123 (E1), ubiquitin conjugating enzyme (E2), and ubiquitin ligase (E3) cascade is crucial to protein degr

124 y, shRNA-mediated suppression of Atg5, an E3 ubiquitin ligase essential for autophagosome elongation,

125 mediated its binding and degradation by the ubiquitin ligase Fbxo45, resulting in loss of Par-4 proa

126 Inhibition of proteasome, GSK3 or the E3 ubiquitin ligase, FBXW7, prevented mSREBP1 reduction ind

127 dy reports the first identification of an E3 ubiquitin ligase for CaV2.1, RNF138.

128 , TRIM32, has been reported earlier as an E3 ubiquitin ligase for dysbindin in skeletal muscle.

129 Recent reports suggest that SPOP acts as a ubiquitin ligase for ERG and propose that ERG stabilizat

130 Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1alpha (HI

131 family E3 ubiquitin ligase, UBR5, as a novel ubiquitin ligase for MOAP-1.

132 The role of cullin E3-ubiquitin ligases for muscle homeostasis is best known d

133 Here, we have purified the major E3 ubiquitin ligases from human cells responsible for regul

134 Our increased understanding of ubiquitin ligase function and regulation has provided th

135 on factor, it also possesses an intrinsic E3 ubiquitin ligase function that targets, e.g., the steroi

136 gand-activated AhR but did not affect its E3 ubiquitin ligase function.

137 dependent on both Mdm2 levels and an intact ubiquitin ligase function.

138 sion of the Foxp3 gene and anergy-related E3 ubiquitin ligase genes.

139 We found that the Gid4 subunit of the ubiquitin ligase GID in the yeast Saccharomyces cerevisi

140 Here we show that expression of the E3 ubiquitin ligase Grail is upregulated in CD8(+) T cells

141 ation of a role in writing m(6) A for the E3 ubiquitin ligase HAKAI is likely to be of considerable r

142 cluded MTA, MTB, FIP37, VIRILIZER and the E3 ubiquitin ligase HAKAI.

143 Although ubiquitin ligases have been implicated in autism, their

144 chain binds to, and is a substrate for, the ubiquitin ligase HECTD2.

145 of the 40S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC.

146 iquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.

147 pro-apoptotic protease caspase-8 and the IAP ubiquitin ligases, how and when necroptosis is triggered

148 omyces cerevisiae, both pathways require the ubiquitin ligase Hrd1, a multi-spanning membrane protein

149 mediated through an interaction with the E3 ubiquitin ligase HRD1, as immunoprecipitation of Tomo-1

150 The human ubiquitin ligase HUWE1 has key roles in tumorigenesis, y

151 We previously identified ubiquitin ligase Huwe1 in the testis and showed that it

152 ver that this process depends on the HECT E3 ubiquitin ligase Hyd/UBR5, which is required for Wnt sig

153 Here, we demonstrate that four ubiquitin ligases (i.e., Ubr1, Slx5, Psh1, and Rcy1) wor

154 Here we demonstrate that the E3 ubiquitin ligase IDOL determines synaptic ApoER2 protein

155 factor 2 (TRAF2), a scaffold protein and E3 ubiquitin ligase important for inflammatory signaling.

156 Moreover, we show that Rnf12, an X-encoded ubiquitin ligase important for initiation of X-chromosom

157 anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase in neurons [Cdh1 conditional knockout (

158 ntaining SCF (SKP1-cullin1-F-box protein) E3 ubiquitin ligase in the nucleus, but not in the cytoplas

159 er of the Skp1-Cullin1-F-box (SCF) family of ubiquitin ligases in a phosphorylation-dependent manner.

160 e chemotherapeutic lenalidomide, a selective ubiquitin ligase inhibitor associated with new-onset dia

161 We further found that GP78, an E3 ubiquitin ligase, interacted with the C-terminal region

162 d1 gene product, FPC, also contain the NEDD4 ubiquitin ligase interacting protein, NDFIP2, which inte

163 Arabidopsis (Arabidopsis thaliana) COP1/SPA ubiquitin ligase is a central repressor that suppresses

164 n network.Protein stability modulation by E3 ubiquitin ligases is an important layer of functional re

165 elevant proteolytic pathway (e.g. a specific ubiquitin ligase) is itself short-lived.

166 MDM2, an E3 ubiquitin ligase, is a potent inhibitor of the p53 tumor

167 hat Ndfip1, a coactivator of Nedd4-family E3 ubiquitin ligases, is required for Treg cell stability a

168 e show that Ndfip1, a co-activator of the E3 ubiquitin ligase Itch, restricts the frequency and patho

169 s Kaposi sarcoma, expresses the MARCH family ubiquitin ligase K5.

170 H as a potential substrate for the RING-type ubiquitin ligase Keep on Going (KEG).

171 we provide evidences that CDK20 binds to the ubiquitin ligase Kelch-like ECH-associated protein 1 (KE

172 d through the action of the multi-subunit E3 ubiquitin ligase known as the anaphase-promoting complex

173 recognition by Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligases leading to subsequent proteasomal degr

174 ding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination an

175 PROTACs conjugate a target warhead to an E3 ubiquitin ligase ligand via a linker.

176 (GLUTAMINE DUMPER 1 (GDU1)) that requires a ubiquitin ligase (LOSS OF GDU 2 (LOG2).

177 asomal degradation through the action of the ubiquitin ligase Ltn1p.

178 by RBF206 Vpu was dependent on the cellular ubiquitin ligase machinery.

179 This novel mechanism indicates how a ubiquitin ligase maintains an inactive monomeric form th

180 between the ubiquitin protease Ubp2 and the ubiquitin ligases Mdm30 and Rsp5 that modulates mitochon

181 At the end of a three-enzyme cascade, ubiquitin ligases mediate the transfer of ubiquitin from

182 y identified TRIM21 as an IFNgamma-driven E3 ubiquitin ligase mediating the deposition of ubiquitin a

183 we show that STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentia

184 The E3 ubiquitin ligases MULAN and MARCH5 coordinate ubiquityla

185 We found that the E3 ubiquitin ligase murf1 is upregulated in ncx1-deficient

186 e a new framework for understanding how HECT ubiquitin ligases must be finely tuned to ensure normal

187 miR-1 directly regulates the 3'UTR of the E3 ubiquitin ligase Nedd4 Analysis of embryonic and adult f

188 show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates histone H3 on lysin

189 G1 enhanced the interaction of HER3 with the ubiquitin ligase NEDD4, while PYK2, which interacts with

190 ulated after two-third hepatectomy, with the ubiquitin ligase Nedd4-1 being a top hit.

191 The ubiquitin ligase Nedd4-like (Nedd4L, or Nedd4-2) binds t

192 ubiquitination of Kv1.3, catalyzed by the E3 ubiquitin-ligase Nedd4-2.

193 Moreover, we determined that the HECT E3 ubiquitin ligase, Nedd4L, interacts with TRP120 during i

194 Therefore, ubiquitin ligases need to be tightly controlled.

195 protein Stardust (Sdt) as a target of the E3 ubiquitin ligase Neuralized (Neur) in Drosophila melanog

196 a subset of Sdt isoforms are targeted by the ubiquitin ligase Neuralized, thus fine tuning the endocy

197 1 (HOS1), which is known to either act as E3 ubiquitin ligase or affect chromatin organization, inhib

198 ough different pathways and enzymes (such as ubiquitin ligases or the proteasome) have been identifie

199 ancer Cell, Vila et al. report that UBE2O, a ubiquitin ligase overexpressed in some human cancers, sp

200 nes, in particular the genes encoding the E3 ubiquitin ligase Parkin (PARK2, also known as PRKN) and

201 These genes encode the E3 ubiquitin ligase parkin and the protein kinase PTEN-indu

202 Mutations in E3 ubiquitin ligase Parkin have been linked to familial Par

203 As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of Par

204 45, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between thes

205 ur knowledge, this is the first report of E3 ubiquitin ligase phosphorylation inhibiting E3 ligase ac

206 ctural picture of the unraveling of parkin's ubiquitin ligase potential.

207 idence demonstrates that the MYOD-induced E3 ubiquitin ligase Praja1 (PJA1) is involved in regulating

208 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination

209 ion and that RNF138 serves as the primary E3 ubiquitin ligase promoting EA2-associated aberrant degra

210 hat a P. yoelii gene encoding a HECT-like E3 ubiquitin ligase (Pyheul) influences parasitemia and hos

211 In cultured cancer cells the E3 ubiquitin ligase Rad18 activates Trans-Lesion Synthesis

212 clusters of DNA-Pt that colocalized with the ubiquitin ligase RAD18 and the replication protein PCNA.

213 he stability of the DNA damage responsive E3 ubiquitin ligase RAD18.

214 by their ubiquitylation mediated by the Rsp5 ubiquitin-ligase, recruited by alpha-arrestin-family ada

215 RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic processes

216 We describe here that the MAGE-F1-NSE1 E3 ubiquitin ligase regulates the CIA pathway through ubiqu

217 e, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic similariti

218 RANKL represses the transcription of the E3 ubiquitin ligase RNF146 through an NF-kappaB-related inh

219 omics, we have identified the RING finger E3 ubiquitin ligase RNF157 as a target at the intersection

220 elicit a cascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation

221 53BP1 relocation is terminated by ubiquitin ligases RNF169 and RAD18 via unknown mechanism

222 NLRP11 recruits the ubiquitin ligase RNF19A to catalyze K48-linked ubiquitin

223 of PIM1 via recruitment of the SUMO-targeted ubiquitin ligase, RNF4.

224 tically, we show that MIWI binds the histone ubiquitin ligase RNF8 in a Piwi-interacting RNA (piRNA)-

225 or conditional knockout of the autism-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugatin

226 The E3 ubiquitin ligase, Roquin, is involved in immune regulati

227 In yeast, this involves the Nedd4 ubiquitin ligase Rsp5 and arrestin-related trafficking a

228 By counteracting the E3 ubiquitin ligase Rsp5, Ubp2 and Ubp15 prevent hyperubiqu

229 te a phosphodegron that is recognized by the ubiquitin ligase SCF(Cdc4).

230 ation and serves as the degron that mediates ubiquitin ligase SCF(Grr1)-dependent destruction of Med1

231 and phytochrome itself) and four families of ubiquitin ligases (SCF(EBF1/2), CUL3(LRB), CUL3(BOP), an

232 but are antagonized by IpaH9.8, a bacterial ubiquitin ligase secreted into the host cytosol.

233 nternalization is dependent on a specific E3 ubiquitin ligase, Siah-1A.

234 ended on poly-ubiquitination, but not the E3 ubiquitin ligase Siah1.

235 Meanwhile, we show that E3 ubiquitin ligase Smurf1 directly interacts with PIPKIgam

236 We previously identified the HECT-type ubiquitin ligase Smurf1 which controls diverse cellular

237 Here, we identify the E3 ubiquitin ligase Smurf2 as a physiologic regulator of To

238 s RING (really interesting new gene) type E3 ubiquitin ligase SP1 [suppressor of plastid protein impo

239 Here we show that Bre1, an ubiquitin ligase specific for histone H2B, is recruited

240 urrent mutations in the gene encoding the E3 ubiquitin ligase SPOP.

241 a signal for ubiquitination by SUMO targeted ubiquitin ligases (STUbLs).

242 cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by

243 gene family, member A (RhoA), a KCTD13/CUL3 ubiquitin ligase substrate, and is reversed by RhoA inhi

244 The gene encoding the E3 ubiquitin ligase substrate-binding adaptor speckle-type

245 Here, we show that the E3 ubiquitin ligase subunit Not4/Mot2 of the evolutionarily

246 vo Mechanistic investigations identified the ubiquitin ligase suppressor of cytokine signaling 2 (SOC

247 SPONSE BRIC-A-BRACK/TRAMTRACK/BROAD (LRB) E3 ubiquitin ligases target phytochrome B (phyB) and PIF3 p

248 Complex/Cyclosome (APC/C), a multisubunit E3 ubiquitin ligase targeting cell-cycle factors for destru

249 TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the ant

250 ties to the CUL4-RBX1-DDB1-CRBN (CRL4(CRBN)) ubiquitin ligase that enable binding, ubiquitination and

251 ove cytotoxic T-cell activity.Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signallin

252 rt that cells with mutations in RFWD3, an E3 ubiquitin ligase that interacts with and ubiquitylates r

253 complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked p

254 netic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.

255 or 6 (TRAF6) is an adaptor protein and an E3 ubiquitin ligase that mediates the activation of multipl

256 s caused by decreased expression of the MID1 ubiquitin ligase that mediates ubiquitin-specific modifi

257 Mdm2, another p53 target gene, encodes a ubiquitin ligase that negatively regulates p53 levels by

258 Arkadia (Rnf111) is an E3 ubiquitin ligase that plays a central role in the amplif

259 Here we identify KIB1 as an F-box E3 ubiquitin ligase that promotes the degradation of BIN2 w

260 es UHRF1, a histone- and DNA-binding RING E3 ubiquitin ligase that recruits DNMT1 to sites of newly r

261 VHL, is the substrate recognition unit of an ubiquitin ligase that targets the HIF transcription fact

262 etween EBOV VP40 (eVP40) and WWP1, a host E3 ubiquitin ligase that ubiquitinates VP40 and regulates V

263 CF (Skp1/Cullin 1/F-box protein) class of E3 ubiquitin ligases that are important for eukaryotic prot

264 nit 1b (CSN1b) gene increase the activity of ubiquitin ligases that contain Cullin 1.

265 Recent studies have identified various E3 ubiquitin ligases that negatively regulate the Hippo pat

266 By recruiting an ubiquitin ligase to a target protein, PROTACs promote ub

267 he Ink4a (Cdkn2a) gene, inhibits the Mdm2 E3 ubiquitin ligase to activate p53.

268 phorylation can disrupt the binding of an E3 ubiquitin ligase to an E2-conjugating enzyme, leading to

269 y generated during apoptosis that inhibits a ubiquitin ligase to overcome therapy resistance in tumor

270 ed protein decay, wherein UPF1 acts as an E3 ubiquitin ligase to repress human skeletal muscle differ

271 es indicate that MAGEs assemble with E3 RING ubiquitin ligases to form MAGE-RING ligases (MRLs) and a

272 his light version of the RQC complex, the E3 ubiquitin ligase Tom1.

273 The ubiquitin ligase TRAF6 is a key regulator of canonical I

274 ost-binding partner of this effector, the E3-ubiquitin ligase TRIM32.

275 Here, we report that the host E3-ubiquitin ligase TRIM6 promotes VP35 ubiquitination and

276 minal domain and is unable to recruit the E3 ubiquitin ligase TRIM62.

277 P35 interacts with TRIM6, a member of the E3-ubiquitin ligase tripartite motif (TRIM) family.

278 nts are degraded after ubiquitination by the ubiquitin ligase tripartite motif-containing protein 32

279 ation impedes ITCH binding to its cognate E2 ubiquitin ligase, UbcH7.

280 several ribosomal proteins, requiring the E2 ubiquitin ligase UBE2D3 to initiate RQC.

281 which regulates proteasome activity, and the ubiquitin ligase, Ube3c/Hul5, which enhances proteasomal

282 We show that CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that couples their

283 rt, through promoting the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p.

284 us to the E6-AP carboxyl terminus) family E3 ubiquitin ligase, UBR5, as a novel ubiquitin ligase for

285 K29-linked ubiquitin chains assembled by the ubiquitin ligase (Ufd4p), resulting in branched ubiquiti

286 UBE3A is an E3 ubiquitin ligase well known for its role in the proteaso

287 Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase, well known for its role in cell-cycle

288 ets are the cullins, scaffold subunits of E3 ubiquitin ligases, where neddylation as well as deneddyl

289 ssembly complex (LUBAC) is the only known E3 ubiquitin ligase which catalyses the generation of linea

290 RECQL4 is ubiquitinated by the DDB1-CUL4A E3 ubiquitin ligase, which facilitates its accumulation at

291 the substrate binding subunit of the VHL E3 ubiquitin ligase, which targets hydroxylated alpha subun

292 betaTrCP, and Skp2 Skp-F-box-cullin (SCF) E3 ubiquitin ligases, which degrade and suppress steady-sta

293 eins in SCF (Skp1/Cullin-1/F-box protein) E3 ubiquitin ligases, which modify protein substrates with

294 UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism,

295 Smurf1 is an E3 ubiquitin ligase whose role in selective bacterial autop

296 restoration of Nrdp1, a RING finger type E3 ubiquitin ligase whose suppression in GBM also correlate

297 eased gene dosages of UBE3A, which encodes a ubiquitin ligase with transcriptional co-regulatory func

298 We identified the HECT family E3 ubiquitin ligase WWP1 and all four of its WW domains as

299 Here, we show in mammalian cells that the ubiquitin ligase ZNF598 is required for ribosomes to ter

300 Our results thus demonstrate E3-ubiquitin ligase ZNRF4-mediated RIP2 degradation as a ne