ライフサイエンスコーパス: ubiquitin ligase activity

1 localized to the ER membrane, and possesses ubiquitin ligase activity.

2 ears to be the RING finger, which confers E3 ubiquitin ligase activity.

3 ract with Dgrn and are substrates for its E3 ubiquitin ligase activity.

4 ental disorders associated with mutations in ubiquitin ligase activity.

5 igenetic modification directly regulating E3 ubiquitin ligase activity.

6 hibitory activity, and significantly reduced ubiquitin ligase activity.

7 -Cullin-F-box (SCF) complexes that confer E3 ubiquitin ligase activity.

8 -kappaB activation through their RING domain ubiquitin ligase activity.

9 a RING domain deletion and the abrogation of ubiquitin ligase activity.

10 ted embryos, in a manner dependent on Trim36 ubiquitin ligase activity.

11 I kappaB alpha and decreased SCF(beta-TrCP) ubiquitin ligase activity.

12 he F-box protein FSN-1, which mediates RPM-1 ubiquitin ligase activity.

13 display locomotion defects, dependent on the ubiquitin ligase activity.

14 wing to enhanced cIAP1, cIAP2 TRAF3-directed ubiquitin ligase activity.

15 HD fingers from a nuclear protein exhibit E3 ubiquitin ligase activity.

16 8 complex has a robust substrate-specific E3 ubiquitin ligase activity.

17 We showed that RabGEF1's ZnF domain has ubiquitin ligase activity.

18 on CHIP, a chaperone-binding protein with a ubiquitin ligase activity.

19 lated, and multiple subcomplexes may exhibit ubiquitin ligase activity.

20 of the sarcomere that are thought to possess ubiquitin ligase activity.

21 ha and may negatively affect its putative E3 ubiquitin ligase activity.

22 ral acidic domain of MDM2 and inhibit its E3 ubiquitin ligase activity.

23 ion but is defective in self-association and ubiquitin ligase activity.

24 Ran GTPase, and depends upon BRCA1/BARD1 E3 ubiquitin ligase activity.

25 by its N-terminal RING-CH domain, mK3 has E3 ubiquitin ligase activity.

26 urora-A Phe-31 variant exhibits an intrinsic ubiquitin ligase activity.

27 specific in vitro target of the BRCA1/BARD1 ubiquitin ligase activity.

28 ent and specific inhibitor of CHIP-dependent ubiquitin ligase activity.

29 quitin ligases, and we show that AvrPtoB has ubiquitin ligase activity.

30 thought to be due to the loss of parkin's E3 ubiquitin ligase activity.

31 and Rik1-TAP preparations exhibit robust E3 ubiquitin ligase activity.

32 1 to assemble an SCF(atrogin-1) complex with ubiquitin ligase activity.

33 gelman-associated mutations and a loss of E3 ubiquitin ligase activity.

34 heart that might be targets of its putative ubiquitin ligase activity.

35 activity, yet it does not possess intrinsic ubiquitin ligase activity.

36 cules that all possess a RING-CH domain with ubiquitin ligase activity.

37 linos demonstrated the importance of Pellino ubiquitin ligase activity.

38 uronal transmission and plasticity via their ubiquitin ligase activity.

39 lexes contain cullin 4A and Roc1 and display ubiquitin ligase activity.

40 sfolded proteins as substrates for parkin E3 ubiquitin ligase activity.

41 n of caspases and a RING domain that confers ubiquitin ligase activity.

42 at these cullins are associated in vivo with ubiquitin ligase activity.

43 er domain that possesses non-conventional E3 ubiquitin ligase activity.

44 tination in vitro, suggesting that it has E3 ubiquitin ligase activity.

45 f CIP8 is required but is not sufficient for ubiquitin ligase activity.

46 in containing a RING-H2 finger with in vitro ubiquitin ligase activity.

47 nal zinc RING-finger domain which confers E3 ubiquitin ligase activity.

48 cell cycle regulated and is dependent on its ubiquitin ligase activity.

49 ects in HIF binding and/or in pVHL-dependent ubiquitin ligase activity.

50 vity by HERC3 is independent of its inherent ubiquitin ligase activity.

51 alization and also significantly reduces its ubiquitin ligase activity.

52 interacted with MYCBP2 and inhibited its E3 ubiquitin ligase activity.

53 rim12-2) encodes a TRIM5-like protein with a ubiquitin ligase activity.

54 y, and this modification stimulates Trim7 E3 ubiquitin ligase activity.

55 quires PINK1 (PARK6), mitofusins, and parkin ubiquitin ligase activity.

56 adation of ubiquitinated target proteins via ubiquitin ligase activity.

57 a catalytic HECT domain essential for its E3 ubiquitin ligase activity.

58 n with a RING-H2 domain that has in vitro E3 ubiquitin ligase activity.

59 homologous to the E6-AP Cterminus (HECT) E3 ubiquitin ligase activity.

60 e important to HIV-1 restriction than its E3 ubiquitin ligase activity.

61 F4, that binds ubiquitin and supports its E3 ubiquitin ligase activity.

62 the RING domain of Rbx1 and inhibits its E3 ubiquitin ligase activity.

63 nding H3K4me3 and H3K36me2 and exhibiting E3 ubiquitin ligase activity.

64 lex associated with Cbl and inhibited its E3 ubiquitin ligase activity.

65 members contain RING domains that impart E3 ubiquitin ligase activity.

66 o the role of CAND1 in the regulation of SCF ubiquitin-ligase activity.

67 RK interactors and confirmed their predicted ubiquitin-ligase activity.

68 shown to regulate synaptogenesis through E3 ubiquitin ligase activities.

69 that regulates endocytic trafficking [6] and ubiquitin ligase activity [7, 8].

70 However, it is not known whether loss of E3 ubiquitin ligase activity accounts for the hematopoietic

71 , USP13 limits Siah2 autodegradation and its ubiquitin ligase activity against its target substrates.

72 PRP19 mutants unable to bind RPA or lacking ubiquitin ligase activity also fail to support RPA ubiqu

73 c-Cbl is a multifunctional molecule with ubiquitin ligase activity and a protein adaptor function

74 itide PI5P leads to stimulation of Cul3-SPOP ubiquitin ligase activity and also implicate PIPKIIbeta

75 Both ZNRF1 and ZNRF2 have E3 ubiquitin ligase activity and are highly expressed in th

76 The TRIM5alpha RING domain exhibits E3 ubiquitin ligase activity and assists the higher-order a

77 nhibit the BRCA1:E2 interaction show loss of ubiquitin ligase activity and correlate with disease sus

78 Purified TRIM5-21R had ubiquitin ligase activity and could autoubquitylate with

79 protein in Arabidopsis, AtCHIP, also has E3 ubiquitin ligase activity and has important roles to pla

80 Additional studies suggest that GRAIL E3 ubiquitin ligase activity and intact endocytic trafficki

81 the HSV immediate-early protein ICP0 has E3 ubiquitin ligase activity and interacts with the proteas

82 RF61p RING finger domain is necessary for E3 ubiquitin ligase activity and is required for autoubiqui

83 r-suppressor complex BRCA1/BARD1 exhibits E3 ubiquitin ligase activity and participates in cell proli

84 The heterodimer contains an E3 ubiquitin ligase activity and participates in multiple c

85 ormation of a heterodimeric complex that has ubiquitin ligase activity and plays central roles in cel

86 cruited TRAF6, leading to increased TRAF6 E3 ubiquitin ligase activity and subsequent activation of A

87 s demonstrate that ErbB2 is a target of CHIP ubiquitin ligase activity and suggest a role for CHIP E3

88 This complex possesses E3 ubiquitin ligase activity and targets cellular proteins

89 attenuation of anaphase-promoting complex/C ubiquitin ligase activity and the consequential stabiliz

90 r function of atrogin-1 was dependent on its ubiquitin ligase activity and the deposition of polyubiq

91 direct mechanism that is independent of its ubiquitin ligase activity and the interferon pathway.

92 EG protein has previously been shown to have ubiquitin ligase activity and to negatively regulate pro

93 ance of RAG-mediated histone recognition and ubiquitin ligase activities, and the role played by RAG

94 lin proteins in a process that alters SCF E3 ubiquitin ligase activity, and it is presumed that Nedd8

95 damaged mitochondria, activates Parkin's E3 ubiquitin ligase activity, and recruits Parkin to the dy

96 ments show that SUMOylated Rsp5p has reduced ubiquitin ligase activity, and similarly, ubiquitylated

97 Interestingly, Xnf7 exhibited intrinsic ubiquitin ligase activity, and this activity was require

98 The BRCA1 protein displays E3 ubiquitin ligase activity, and this enzymatic function i

99 tion between FADD and TRIM21 enhances TRIM21 ubiquitin ligase activity, and together they cooperative

100 Triad1 has E3 ubiquitin ligase activity, and we found that HoxA10-over

101 rotubules, exhibits RING-finger-dependent E3-ubiquitin-ligase activity, and has C-terminal-dependent

102 Multiple DNA repair proteins having ubiquitin ligase activity are recruited to sites of DNA

103 Lipopolysaccharide-induced SCF(beta-TrCP) ubiquitin ligase activity as well as binding of beta-TrC

104 iviral activity of TRIM56 depended on its E3 ubiquitin ligase activity as well as the integrity of it

105 gs strongly support the role of Cbl, via its ubiquitin ligase activity, as a negative regulator of ac

106 Gp78-induced mitophagy required ubiquitin ligase activity, as it is not observed upon tr

107 In vitro E3 ubiquitin ligase activity assays revealed that PRT4165 i

108 BRCA1 with components that contribute to its ubiquitin ligase activity, BARD1 and the E2 ubiquitin-co

109 The P326G substitution also abrogated ubiquitin ligase activity but had a less severe effect o

110 A-G252D still preserves self-association and ubiquitin ligase activity but loses membrane localizatio

111 7 is independent of the U-box domain with E3 ubiquitin ligase activity but requires the chaperone bin

112 ssay of Hrd1p function by demanding not only ubiquitin ligase activity, but also specific activity th

113 Some viral structural proteins require ubiquitin ligase activity, but not ubiquitin conjugation

114 The RING domain of TRIM5alpha exhibits E3-ubiquitin ligase activity, but the contribution of this

115 TRIM5alpha exhibits RING domain-dependent E3 ubiquitin ligase activity, but the specific role of this

116 experimentally tested mutations affected the ubiquitin ligase activity by either destabilizing CBL or

117 Here, we investigated the function of XIAP ubiquitin-ligase activity by inactivating the RING motif

118 whose protein product possesses potential E3 ubiquitin ligase activity, by recruiting the histone dea

119 d interactions also modulate TRIM5alpha's E3 ubiquitin ligase activity, by stereochemically restricti

120 red for normal V(D)J recombination, and RAG1 ubiquitin ligase activity can contribute when the protei

121 egulated manner and activate endogenous WWP2 ubiquitin ligase activity causing degradation of unstimu

122 ent mutant (S98A) exhibited little change in ubiquitin ligase activity compared to wild-type TOPORS,

123 ired for stability of the FA core complex or ubiquitin ligase activity, CtBP1 is essential for prolif

124 enzyme, and its carboxy terminus expresses a ubiquitin ligase activity demonstrable by polyubiquityla

125 We have previously shown that BRCA1 ubiquitin ligase activity directly inhibits centrosome-d

126 ned free from ubiquitin until a threshold of ubiquitin ligase activity enables degradation.

127 tions in its RING finger domain that disrupt ubiquitin ligase activity enhance stability.

128 Moreover, the c-Cbl mutant with impaired ubiquitin ligase activity (FLAG-70Z-Cbl) did not affect

129 ial mechanisms that govern WWP1/Tiul1 (WWP1) ubiquitin ligase activity, focusing on its ability to tr

130 nstrates a physiological requirement of XIAP ubiquitin-ligase activity for the inhibition of caspases

131 paralogues that together account for the E3 ubiquitin ligase activity found in PRC1 complexes, but n

132 The latter is achieved via MDM2's E3 ubiquitin ligase activity harbored within the MDM2 RING

133 L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a critic

134 Three families of proteins with ubiquitin ligase activity have been described (the HECT,

135 BL and serine 65 of ubiquitin fully activate ubiquitin ligase activity; however, a structural rationa

136 n and plasma membrane localization or Neurl1 ubiquitin ligase activity impair its ability to down-reg

137 melia virus and the variola virus possess E3 ubiquitin ligase activity in biochemical assays as well

138 Inhibition of c-Cbl expression or its ubiquitin ligase activity in cardiac myocytes offered pr

139 in and phospho-ubiquitin activated Parkin E3 ubiquitin ligase activity in cell-free assays.

140 ication of BRCA1, and are required for BRCA1 ubiquitin ligase activity in cells.

141 Disruption of E3 ubiquitin ligase activity in immature zebrafish mind bom

142 he E4-ORF3 protein displays no SUMO-targeted ubiquitin ligase activity in our assay system.

143 However, the requirement for Cbl ubiquitin ligase activity in this process and its mode o

144 ustrate the likely significant role of BRCA1 ubiquitin ligase activity in tumour suppression.

145 ein complex, called PHF9, which possesses E3 ubiquitin ligase activity in vitro and is essential for

146 We show that Mind bomb protein displays E3 ubiquitin ligase activity in vitro and that it is associ

147 This region supports RING E3 ubiquitin ligase activity in vitro, but whether full-len

148 RING1 displays E3 ubiquitin ligase activity in vitro, which is dependent o

149 of root cells and recombinant AtSAP5 has E3 ubiquitin ligase activity in vitro.

150 the RING domains of all the proteins have E3 ubiquitin ligase activity in vitro.

151 RC and CUL7 subcomplexes examined exhibit E3 ubiquitin ligase activity in vitro.

152 id encodes a RING-containing protein with E3 ubiquitin ligase activity in vitro.

153 Like animal CHIP proteins, AtCHIP has E3 ubiquitin ligase activity in vitro.

154 otein product contains a RING domain and has ubiquitin ligase activity in vitro.

155 hat S1P is the missing cofactor for TRAF2 E3 ubiquitin ligase activity, indicating a new paradigm for

156 -finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmen

157 and this is achieved by inhibition of the E3 ubiquitin ligase activity intrinsic to the RING of c-IAP

158 We demonstrate that E3 ubiquitin ligase activity is dispensable for EDD functio

159 et-restricted animals, indicating that WWP-1 ubiquitin ligase activity is essential for longevity.

160 Most importantly, TIF1gamma's E3 ubiquitin ligase activity is induced by histone binding.

161 monstrate that functional inhibition of Mdm2 ubiquitin ligase activity is insufficient for p53 activa

162 Our experiments show that mLANA's E3 ubiquitin ligase activity is necessary for efficient exp

163 LOG2 ubiquitin ligase activity is necessary for GDU1-dependen

164 tion in the absence of Rqc1; however, its E3 ubiquitin ligase activity is not required.

165 We further demonstrate that MAGE-L2-TRIM27 ubiquitin ligase activity is required for nucleation of

166 Parkin's E3 ubiquitin ligase activity is required to ubiquitinate ou

167 o-ubiquitination may influence its substrate ubiquitin ligase activity is undefined.

168 poptotic thymocytes, demonstrating that XIAP ubiquitin-ligase activity is a major determinant of XIAP

169 c-Cbl), adaptor protein with an intrinsic E3 ubiquitin ligase activity, is involved in FA and myofibr

170 ncodes a RING domain protein associated with ubiquitin ligase activity, lead to autosomal recessive P

171 The initial increase in parkin's E3 ubiquitin ligase activity leads to autoubiquitination of

172 ent of pharmacological inhibitors of LANA E3 ubiquitin ligase activity may allow strategies to interf

173 known enzymatic function of BRCA1 is the E3 ubiquitin ligase activity mediated by its highly conserv

174 The Rad5 ubiquitin ligase activity mediates PCNA poly-ubiquitinat

175 data indicate that Skp1 and possibly E3(SCF)ubiquitin-ligase activity modulate O(2)-dependent culmin

176 tural, since neither the inactivation of its ubiquitin ligase activity nor the inactivation of its he

177 rexpression studies demonstrate that Rabex-5 ubiquitin ligase activity, not its Rab5 GEF activity, is

178 roteasome degradation requires the intrinsic ubiquitin ligase activities of MDM2 and p300.

179 Comparisons of the H2A ubiquitin ligase activities of these different complexes

180 In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine c

181 ) restriction of HIV-1, we correlated the E3-ubiquitin ligase activity of a panel of TRIM5alpha(rh) R

182 osphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically.

183 gregation, the spindle checkpoint blocks the ubiquitin ligase activity of APC/C(Cdc20) in response to

184 The E3 ubiquitin ligase activity of both proteins activates NFk

185 Surprisingly, cells lacking the ubiquitin ligase activity of BRCA1 are viable and do not

186 protein phosphatase 1 alpha enhances the E3 ubiquitin ligase activity of BRCA1.

187 of centrosome function by decreasing the E3 ubiquitin ligase activity of BRCA1.

188 ion in vitro and in vivo and identify the E3 ubiquitin ligase activity of breast cancer type 1 suscep

189 These results suggest that the self-ubiquitin ligase activity of c-IAPs is inhibited by USP1

190 e show a strict requirement for Grb2 and the ubiquitin ligase activity of Cbl for cMet endocytosis.

191 These results indicate that the ubiquitin ligase activity of Cbl is critical for clathri

192 Although the ubiquitin ligase activity of CHIP requires its dimerizat

193 Likewise, the ubiquitin ligase activity of CHIP was dispensable for Ta

194 We further demonstrate the E3 ubiquitin ligase activity of COP1 on HY5 in vitro and th

195 ulation of the p38 MAPK pathway enhances the ubiquitin ligase activity of Cul3-SPOP toward multiple s

196 Reciprocally, CSN inhibits the ubiquitin ligase activity of deneddylated Cul1.

197 the exception of HERC2, which modulates the ubiquitin ligase activity of E6AP, little is known about

198 unit nuclear complex that facilitates the E3 ubiquitin ligase activity of FANCL.

199 The ubiquitin ligase activity of HACE1 in mitotic Golgi disa

200 e segments of Hrd1p, and depends on both the ubiquitin ligase activity of Hrd1p and the function of t

201 Efficient rescue required the ubiquitin ligase activity of Itch and an intact C2 domai

202 that uncouples nucleolar localization and E3 ubiquitin ligase activity of Mdm2 and leads to upregulat

203 so showed that EBNA3C enhances the intrinsic ubiquitin ligase activity of Mdm2 toward p53, which in t

204 st that MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its mos

205 Both Nbs1 and ATM, but not the ubiquitin ligase activity of Mdm2, were necessary to inh

206 We speculate that the target of the E3 ubiquitin ligase activity of Msc1 is likely to be a chro

207 nsistent with this, calcium activates the E3 ubiquitin ligase activity of Nedd4.

208 tion of virus budding was dependent upon the ubiquitin ligase activity of NEDD4L and required only th

209 Here we tested whether the ubiquitin ligase activity of parkin could lead to reduct

210 kinase activity releases the auto-inhibited ubiquitin ligase activity of Parkin remains unclear.

211 um and oxidative stressors presumably due to ubiquitin ligase activity of parkin that targets protein

212 oplasm, with Pink1 and DJ-1 promoting the E3 ubiquitin ligase activity of Parkin to degrade substrate

213 dentified previously as substrates of the E3 ubiquitin ligase activity of parkin, are unaltered in pa

214 ere, we discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex

215 tion of a mutant, pub1-1, affected by the E3 ubiquitin ligase activity of PUB1, we have shown that th

216 s demonstrate that MAGE proteins enhance the ubiquitin ligase activity of RING domain proteins.

217 plexes revealed that Bmi1 stimulates the H2A ubiquitin ligase activity of Ring2 (and Ring1).

218 ty and mono-ubiquitination, dependent on the ubiquitin ligase activity of RNF31.

219 modification of cullins by CSN inhibits the ubiquitin ligase activity of SCF complexes in vitro.

220 This interaction allows Ras to stimulate the ubiquitin ligase activity of SCF(beta-TrCP) toward its t

221 a novel adaptor that physically links the E3 ubiquitin ligase activity of Siah-1 with Skp1 and Ebi F-

222 Both the kinase activity of SIK1 and the ubiquitin ligase activity of Smurf2 are important for pr

223 The ubiquitin ligase activity of the anaphase-promoting comp

224 ctivates this checkpoint, which inhibits the ubiquitin ligase activity of the anaphase-promoting comp

225 gned chromosomes, Bub1 directly inhibits the ubiquitin ligase activity of the anaphase-promoting comp

226 mitosis, the spindle checkpoint inhibits the ubiquitin ligase activity of the anaphase-promoting comp

227 ediated interference markedly reduces the E3 ubiquitin ligase activity of the APC/C and the progressi

228 s auto-polyubiquitylation potentiates the E3 ubiquitin ligase activity of the BRCA1/BARD1 complex >20

229 Strikingly, CSN differentially regulates ubiquitin ligase activity of the DDB2 and CSA complexes

230 adation of IAPs by a mechanism involving the ubiquitin ligase activity of the IAP itself.

231 eines 8, 33 and 49 of Aurora-A abolishes the ubiquitin ligase activity of the protein.

232 The C325Y substitution severely abrogated ubiquitin ligase activity of the purified RAG1 RING fing

233 ion assays show that AvrPiz-t suppresses the ubiquitin ligase activity of the rice RING E3 ubiquitin

234 The E3 ubiquitin ligase activity of the RING domain contributes

235 To test the hypothesis that the E3-ubiquitin ligase activity of the RING domain modulates T

236 of NF-kappaB by XIAP was dependent on the E3 ubiquitin ligase activity of the RING domain.

237 esistance and imply a crucial role of the E3 ubiquitin ligase activity of this domain in MDM2-mediate

238 increased neddylation and elevated intrinsic ubiquitin ligase activity of this E3.

239 aspartic acid resulted in an increase in the ubiquitin ligase activity of TOPORS both in cells and in

240 based on cell-free systems, the role of the ubiquitin ligase activity of TRAF6 and its auto-ubiquiti

241 osphorylation status, and interfere with the ubiquitin ligase activity of TRAF6.

242 ote TLR3 signaling was independent of the E3 ubiquitin ligase activity of TRIM56.

243 These genetic findings suggest that the ubiquitin ligase activity of UBE3A must be tightly maint

244 interacts with WWP-1 and is required for the ubiquitin ligase activity of WWP-1 and the extended long

245 We also find that CCS is a target of the E3 ubiquitin ligase activity of XIAP, although interestingl

246 roximal chromatin and that disruption of the ubiquitin-ligase activity of Asr1--or mutation of ubiqui

247 creased SfIAP turnover independent of the E3 ubiquitin-ligase activity of the SfIAP RING, which also

248 a TOM complex, recruits Parkin and activates ubiquitin ligase activity on the respective organelles.

249 mind bomb (mib) mutation, which disrupts E3 ubiquitin ligase activity, or by treatment with gamma-se

250 of RAG1, which can be promoted by RAG1's own ubiquitin ligase activity, plays a significant role in g

251 itosis and suggest that a reduction in APC/C ubiquitin ligase activity promotes SAC activation.

252 itosis and suggest that a reduction in APC/C ubiquitin ligase activity promotes SAC activation.Oncoge

253 thyltransferase PRMT1, and this inhibits its ubiquitin ligase activity, reducing activation of toll-l

254 e have shown earlier that the BRCA1/BARD1 E3 ubiquitin ligase activity regulates centrosome-dependent

255 ith the kinase domain of XA21 and for its E3 ubiquitin ligase activity, respectively.

256 The FA core complex has ubiquitin ligase activity responsible for monoubiquitina

257 activation of Nrf2 through inhibition of E3 ubiquitin ligase activity, resulting in increased levels

258 DHX15 stabilized Siah2 and enhanced its E3 ubiquitin-ligase activity, resulting in AR activation.

259 Further analysis of its ubiquitin ligase activity revealed that Chfr can catalys

260 TRIM5alpha(rh) mutants without detectable E3 ubiquitin ligase activity still blocked reverse transcri

261 P0 stimulates efficient infection via its E3 ubiquitin ligase activity that causes degradation of sev

262 evidence has indicated that TRAF6 possesses ubiquitin ligase activity that controls the activation o

263 gene encoding Act1, an adaptor protein with ubiquitin ligase activity that couples the IL-17 recepto

264 gene coding for a protein with intrinsic E3 ubiquitin ligase activity that has not previously been f

265 BARD1) to form a heterodimer, which exhibits ubiquitin ligase activity that is abrogated by known can

266 ndicated that the SPL11 protein possesses E3 ubiquitin ligase activity that is dependent on an intact

267 tudies provide the first identification of a ubiquitin ligase activity that is involved in the DNA da

268 he L. pneumophila effector GobX possesses E3 ubiquitin ligase activity that is mediated by a central

269 ICP0 has a RING finger domain with E3 ubiquitin ligase activity that is necessary for IE funct

270 Similarly, Drosophila IAP1 also possesses ubiquitin ligase activity that mediates the degradation

271 ng UbcH5c as ubiquitin-conjugating enzyme, a ubiquitin ligase activity that polyubiquitinates p12 was

272 ) is an adaptor protein with an intrinsic E3 ubiquitin ligase activity that targets receptor and nonr

273 Purified p300 exhibited intrinsic ubiquitin ligase activity that was inhibited by E1A.

274 While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains specif

275 Consistent with suppression due to impaired ubiquitin ligase activity, the heat-sensitive growth def

276 In addition to E3 ubiquitin ligase activity, the Mdm2 RING preferentially

277 hanism may not be that simple since TRIM5 E3 ubiquitin ligase activity, the proteasome, autophagy, an

278 own results in a specific reduction in APC/C ubiquitin ligase activity, the stabilization of APC/C su

279 These data link the loss of ubiquitin ligase activity, through loss of E2-binding, t

280 HSel-10 serves to target the parkin ubiquitin ligase activity to cyclin E, an hSel-10-intera

281 ion of different domains of BRCA1 and its E3 ubiquitin ligase activity to HDR and drug resistance.

282 We find that D-mib uses its ubiquitin ligase activity to promote DSL ligand activity

283 role for Grb2 as an intermediary linking Cbl ubiquitin ligase activity to this process.

284 and mutant RNF170 have apparently identical ubiquitin ligase activities toward IP3 receptors.

285 G finger domain of MEKK1, which exhibited E3 ubiquitin ligase activity toward c-Jun in vitro and in v

286 orphogenesis 1 (COP1) and that COP1 exhibits ubiquitin ligase activity toward HFR1 in vitro.

287 milar to RPL5 and RPL23, and inhibits its E3 ubiquitin ligase activity toward p53.

288 in these cells, Cul3Delta9 supported reduced ubiquitin ligase activity toward RhoA compared with equi

289 We conclude that Cul3Delta9-associated ubiquitin ligase activity toward RhoA is impaired and su

290 ted TRIM32 mutations, D487N and R394H impair ubiquitin ligase activity towards dysbindin and were mis

291 n of recombinant COP1 fails to affect CIP8's ubiquitin ligase activity towards HY5 in vitro.

292 te in Smurf is shown to be necessary for its ubiquitin ligase activity towards the substrate and also

293 TRIM5alpha(AGM) ubiquitin ligase activity was essential for both the acc

294 Parkin HECT-like ubiquitin ligase activity was essential for PINK1-mediat

295 Experimental CBL ubiquitin ligase activity was in agreement with the pred

296 f the viral protein ICP0, which possesses E3 ubiquitin ligase activity, was both necessary and suffic

297 cleotide binding is not required for Mdm2 E3 ubiquitin ligase activity, we show that nucleotide bindi

298 Unexpectedly, p300/CBP ubiquitin ligase activities were absent in nuclear extra

299 degradation with both chaperone binding and ubiquitin ligase activities, which are mediated by its T

300 ional changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulat