ライフサイエンスコーパス: ubiquitin system

1 igase substrate receptors independent of the ubiquitin system.

2 cificity gives fundamental insights into the ubiquitin system.

3 proteins and are hence key regulators of the ubiquitin system.

4 nserved regulation of Notch signaling by the ubiquitin system.

5 and mechanisms of substrate targeting by the ubiquitin system.

6 as a DAT interacting protein using the split ubiquitin system.

7 allows for the remarkable versatility of the ubiquitin system.

8 activities of kinases, phosphatases, and the ubiquitin system.

9 reted LLO is targeted for degradation by the ubiquitin system.

10 quitination, are important regulators of the ubiquitin system.

11 dent of VHL and p53 and does not require the ubiquitin system.

12 rades proteins tagged for destruction by the ubiquitin system.

13 o physically interact with Gpa1 in the split-ubiquitin system.

14 on of proteins marked for destruction by the ubiquitin system.

15 nct mechanism for substrate targeting in the ubiquitin system.

16 of proteins targeted for proteolysis by the ubiquitin system.

17 many otherwise dissimilar E3 proteins of the ubiquitin system.

18 dvance and the mechanics of targeting by the ubiquitin system.

19 ify the relevant targeting components of the ubiquitin system.

20 le pathway is one proteolytic pathway of the ubiquitin system.

21 tes, the N-end rule pathway is a part of the ubiquitin system.

22 ther or not p53 is itself a substrate of the ubiquitin system.

23 of the receptor protein as substrate for the ubiquitin system.

24 actor at the crossroads between the SUMO and ubiquitin systems.

25 ning the highly characterized bradykinin and ubiquitin systems.

26 A libraries using yeast-two-hybrid and split-ubiquitin systems.

27 ntroduces several detailed reviews about the ubiquitin system and autophagy.

28 ight some emerging relationships between the ubiquitin system and disease, and discuss current and fu

29 lving membrane proteins, including the split ubiquitin system and fluorescence-based technologies for

30 ce for the emerging relationship between the ubiquitin system and human disease.

31 ms of signal transduction, especially in the ubiquitin system and in chromatin.

32 We conclude that human cells utilize the ubiquitin system and NDP52 to activate autophagy against

33 orts targeting the various components of the ubiquitin system and studying the role of DUBs in health

34 cular complementation assays (i.e. the split ubiquitin system and the split luciferase system).

35 s both the high substrate specificity of the ubiquitin system and the variety of regulatory mechanism

36 ide an additional layer of regulation in the ubiquitin system, and distinct conformations observed in

37 ents of the cell cycle, apoptotic machinery, ubiquitin system, and DNA damage response pathways.

38 Substrates of the ubiquitin system are degraded by the 26 S proteasome, a

39 r data suggest widespread involvement of the ubiquitin system at multiple stages of the Met activatio

40 identify Cuz1/Ynl155w as a component of the ubiquitin system, capable of interacting with both the p

41 ations in genes coding for components of the ubiquitin system cause immune dysregulation.

42 Various destabilizing factors of the ubiquitin system contribute to the synchrony and unidire

43 Protein degradation by the ubiquitin system controls the intracellular concentratio

44 The ubiquitin system for protein degradation, which has rece

45 The power of the ubiquitin system for therapeutic benefit blossomed with

46 Our study suggests that altered ubiquitin system function in the CNS contributes to the

47 The ubiquitin system has been identified as the nonlysosomal

48 Trojan horses" integrate into the eukaryotic ubiquitin system has remained a mystery.

49 overy programs that target components of the ubiquitin system have lagged behind.

50 I provide an introduction to the ubiquitin system, highlight some emerging relationships

51 egans have identified multiple roles for the ubiquitin system in early development, where ubiquitin-d

52 The importance of the ubiquitin system in health and disease has been widely r

53 ndc10-2 function and suggest a role for the ubiquitin system in kinetochore function.

54 n signals similar to those recognized by the ubiquitin system in misfolded proteins.

55 Our data reveal a new role for the ubiquitin system in mitotic spindle regulation and under

56 These results implicate the ubiquitin system in poxviral virulence.

57 ate the requirement for an active proteasome/ubiquitin system in release and maturation of infectious

58 BL1 system shares many similarities with the ubiquitin system in structures and in conjugation with e

59 findings, this study suggests a role for the ubiquitin system in the destabilization and rupture of c

60 These results implicate the ubiquitin system in the regulation of ndc10-2 function a

61 a previous report on the involvement of the ubiquitin system in the tobacco HR [2], and validates an

62 our current understanding of the role of the ubiquitin system in various human diseases ranging from

63 s that are associated with components of the ubiquitin system, including ubiquitin, ubiquitin-like pr

64 A protein substrate of the ubiquitin system is conjugated to ubiquitin through the

65 The eukaryotic ubiquitin system is conserved in archaea and involved in

66 Because the ubiquitin system is known to play an important role in r

67 ignaling pathways and how alterations in the ubiquitin system lead to the development of distinct hum

68 opment and regeneration are degraded via the ubiquitin system, little is known about the mechanisms a

69 The ubiquitin system of protein modification has emerged as

70 an important enzyme in the highly conserved ubiquitin system of proteolysis.

71 sive neighborhoods with either a prokaryotic ubiquitin-system or a HORMA domain-PCH2-like AAA+ ATPase

72 In regards to the ubiquitin system, our study may have implications on the

73 The ubiquitin system regulates essential cellular processes

74 Current drug discovery activities in the ubiquitin system seek to (i) expand the development of n

75 The ubiquitin system targets many cellular proteins.

76 ay in this pipeline, the drugs targeting the ubiquitin system that have been developed, and new appro

77 and MDP3/PAN1, implicate interactions of the ubiquitin system, the actin cytoskeleton and protein syn

78 er report has shown that inactivation of the ubiquitin system through blocking E1 (ubiquitin-activati

79 Thus, HD is linked to global changes in the ubiquitin system to a much greater extent than previousl

80 ffectors have evolved to manipulate the host ubiquitin system to alter host cell physiology or the lo

81 e UBA domains functionally interact with the ubiquitin system to control Pds1p degradation in respons

82 NS2 important for interaction with the host ubiquitin system to degrade STAT2 during infection.

83 aspect in the manipulation of the eukaryotic ubiquitin system to facilitate bacterial replication and

84 brane protein two-hybrid approach, the split-ubiquitin system, to address two aspects of the enzyme c

85 rated that a multifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-

86 While ubc4Delta and other alterations of ubiquitin system used in this work cause slight inductio

87 spite the extensive efforts in targeting the ubiquitin system, very few E2 binders have currently bee

88 Thus, HDAC6 is linked to the ubiquitin system via ubiquitin conjugation, polyubiquiti

89 The discovery of the ubiquitin system was awarded with the Nobel Prize in Che

90 iquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from pr

91 ective we provide a short description of the ubiquitin system, with specific emphasis given to its ro