ライフサイエンスコーパス: ubiquitin-activating enzyme

1 easomal inhibitors and required a functional ubiquitin-activating enzyme.

2 rors its sequence conservation with the Uba1 ubiquitin-activating enzyme.

3 sequence homology to the N-terminal half of ubiquitin-activating enzyme.

4 similarity to the amino-terminal half of the ubiquitin-activating enzyme.

5 in a temperature-sensitive mutant of E1, the ubiquitin-activating enzyme.

6 which shares homology with the E1 family of ubiquitin-activating enzymes.

7 Ubiquitin E1 activase UBA (ubiquitin activating enzyme)-6 and E3 ligase Nedd (neura

8 of the ubiquitin system through blocking E1 (ubiquitin-activating enzyme) activity preferentially ind

9 nNOS with a purified system containing an E1 ubiquitin-activating enzyme, an E2 ubiquitin carrier pro

10 sine in an enzymatic cascade involving an E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating

11 Ubiquitinylation requires the E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating

12 cal evidence that it can function with an E1 ubiquitin-activating enzyme and E2 ubiquitin-conjugating

13 ure to blue light, upregulated the levels of ubiquitin-activating enzyme and increased conjugation ac

14 alysis in CHO-ts20 cells with a thermolabile ubiquitin-activating enzyme, and direct detection of ubi

15 T1 degradation, whereas the inhibition of E1 ubiquitin-activating enzyme by a specific inhibitor and

16 E1 ubiquitin activating enzyme catalyzes the initial step i

17 ted data on the X inactivation status of the ubiquitin activating enzyme E1 (UBE1) gene have been con

18 ct sequence and structural similarity to the ubiquitin activating enzyme E1 and the molybdopterin bio

19 n ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating en

20 53, the viral oncogene protein pp60src, or a ubiquitin activating enzyme E1, were incubated at the no

21 the hormone auxin, and is a relative of the ubiquitin activating enzyme E1.

22 tion of wild-type MCL-1 is not affected when ubiquitin-activating enzyme E1 activity is blocked.

23 Inhibition of ubiquitin-activating enzyme E1 by PYR-41 or blocking the

24 We have discovered that ubiquitin-activating enzyme E1 complements the repair de

25 vels in living cells and the inactivation of ubiquitin-activating enzyme E1 does not prevent IPS degr

26 The ubiquitin-activating enzyme E1 exists as two isoforms, E

27 gnant progression, indicating that targeting ubiquitin-activating enzyme E1 homolog has therapeutic p

28 the ability of MLN7243, a recently described ubiquitin-activating enzyme E1 inhibitor, to block overa

29 pressing a thermally inactivated form of the ubiquitin-activating enzyme E1 or (ii) following express

30 present evidence that gigaxonin binds to the ubiquitin-activating enzyme E1 through its amino-termina

31 UBEI-41, an inhibitor of the ubiquitin-activating enzyme E1, also prevented late gene

32 tion I (CFI) contained endogenous PCNA, RPA, ubiquitin-activating enzyme E1, and ubiquitin conjugase

33 bear a temperature-sensitive mutation in the ubiquitin-activating enzyme E1, at a nonpermissive tempe

34 esistant) protein, which has features of the ubiquitin-activating enzyme E1, is required for normal r

35 ch express a temperature-sensitive mutant of ubiquitin-activating enzyme E1, ubiquitination of IRS-1

36 predicted to encode a protein composed of a ubiquitin-activating enzyme E1-like domain and a Rhodane

37 d gene of particular interest was UBE1L, the ubiquitin-activating enzyme E1-like protein.

38 yses previously revealed induction of UBE1L (ubiquitin-activating enzyme E1-like) after RA treatment

39 r example, loss-of-function mutations of the ubiquitin activating enzyme (E1) or proteasome subunits

40 The ubiquitination mediated by ubiquitin activating enzyme (E1), ubiquitin conjugating

41 h requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjug

42 In addition to spectrin and ubiquitin, ubiquitin-activating enzyme (E1) and ATP were necessary

43 on of Ube2g2 distinct from binding sites for ubiquitin-activating enzyme (E1) and RING fingers.

44 njugating enzymes (E2s) collaborate with the ubiquitin-activating enzyme (E1) and ubiquitin ligases (

45 malian cells and proposed that activities of ubiquitin-activating enzyme (E1) and ubiquitin-conjugati

46 Finally, we show that ubiquitin-activating enzyme (E1) can efficiently replace

47 ificity between ubiquitin and RUB1 and their ubiquitin-activating enzyme (E1) or E1-like activating e

48 utant cell line that contains a thermolabile ubiquitin-activating enzyme (E1) that is inactivated at

49 es a temperature sensitivity mutation in the ubiquitin-activating enzyme (E1) upon shift to the nonpe

50 Inhibition of the ubiquitin-activating enzyme (E1) with UBEI-41 resulted i

51 ivation of a heterodimeric Aos1-Uba2 enzyme (ubiquitin-activating enzyme (E1)) followed by the conjug

52 DSB signals were shown to require ubiquitin, ubiquitin-activating enzyme (E1), a CUL-3-based ubiquiti

53 substrate involves four classes of enzymes:a ubiquitin-activating enzyme (E1), a ubiquitin-conjugatin

54 sequential action of three enzymes called a ubiquitin-activating enzyme (E1), a ubiquitin-conjugatin

55 quitin conjugation activity, the activity of ubiquitin-activating enzyme (E1), as determined by thiol

56 r IkappaB(alpha)(ee) ubiquitination over the ubiquitin-activating enzyme (E1), E2UBCH7, nonspecific u

57 ite the well-defined and central role of the ubiquitin-activating enzyme (E1), no cell permeable inhi

58 hree enzymes or protein complexes called the ubiquitin-activating enzyme (E1), the ubiquitin-conjugat

59 ee-enzyme cascade; the initial step requires ubiquitin-activating enzyme (E1), which couples ubiquiti

60 Intact UCRP supports a low rate of ubiquitin-activating enzyme (E1)-dependent ATP:PPi excha

61 Moreover, the U7BR enhances ubiquitin-activating enzyme (E1)-mediated charging of Ub

62 ndent reductions in the levels of endogenous ubiquitin-activating enzyme (E1)-ubiquitin thiol esters

63 aves as a ubiquitin-protein ligase (E3), and ubiquitin-activating enzyme (E1).

64 restrictive temperature for its thermolabile ubiquitin-activating enzyme (E1).

65 S is demonstrated by the presence of (i) the ubiquitin-activating enzyme (E1); (ii) four ubiquitin ca

66 with regard to the primary sequences of the ubiquitin-activating enzymes (E1), the three-dimensional

67 cess involves a cascade of enzymes including ubiquitin-activating enzymes (E1), ubiquitin-conjugating

68 Ubiquitination is initiated by ubiquitin-activating enzymes (E1), which activate and tr

69 g domain and catalytic site of the family of ubiquitin activating enzymes, E1 (UBA1, UBA2, and UBA3).

70 nd in a mutant cell harboring a thermolabile ubiquitin-activating enzyme, E1.

71 214K, E220K, or E232K in the presence of the ubiquitin-activating enzyme, E1.

72 ith limited sequence homology to a family of ubiquitin-activating enzymes, E1.

73 We previously identified the ubiquitin-activating enzyme-E1-like protein (UBE1L) as a

74 71 kDa protein similar to the C-terminus of ubiquitin-activating enzymes (E1s), and Aos1p (activatio

75 ed out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugatin

76 rocesses using four key enzyme families: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-carrier pro

77 the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating

78 ted with a purified system containing the E1 ubiquitin activating enzyme, E2, and CHIP.

79 and accumulated in cells expressing inactive ubiquitin activating enzyme El.

80 The ubiquitin-activating enzyme exists as two isoforms: E1a,

81 UbaA (an E1 ubiquitin-activating enzyme homolog of archaea) is requi

82 Kinetic and equilibrium studies of the human ubiquitin-activating enzyme (HsUba1a) reveal that mutati

83 ng inactivation of the temperature-sensitive ubiquitin-activating enzyme, IkappaBalpha proteolysis oc

84 ne that contained a temperature-sensitive E1 ubiquitin-activating enzyme indicated that the degradati

85 iquitin coexpression and by mutations in the ubiquitin activating enzyme, indicating that their degra

86 Within this hierarchy, a single ubiquitin-activating enzyme provides charged intermediat

87 d by proteasome inhibitors and a mutation in ubiquitin-activating enzyme, suggesting that both UV-C a

88 ed cells in the absence of a functional host ubiquitin-activating enzyme, suggesting that viral entry

89 Ubiquitin activating enzyme (UAE, UBE1, or E1) and seven

90 Ubiquitin-activating enzyme (UAE or E1) activates ubiqui

91 Inactivation of the ubiquitin activating enzyme Uba1 or perturbation of mult

92 p mechanism and ternary complex formation in ubiquitin-activating enzyme Uba1.

93 Uba6 is a homolog of the ubiquitin-activating enzyme, Uba1, and activates two ubi

94 iated with incomplete phosphorylation of the ubiquitin activating enzyme Ube1, which is required for

95 The E1-like ubiquitin-activating enzyme (UBE1L) associates with inte

96 nt cell line, which expresses a thermolabile ubiquitin-activating enzyme, we observed a differential

97 erature-sensitive defect in the essential E1 ubiquitin-activating enzyme, we show that Id3 and the re